Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
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- Product number
- 26971-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- DNMT3B antibody
- Antibody type
- Polyclonal
- Description
- DNMT3B antibody (Cat. #26971-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting CPS1 attenuates lung cancer metastasis by regulating EMT through an epigenetic mechanism.
A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.
Molecular basis for the inhibition of de novo DNA methylation by TCL1A.
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Dexmedetomidine Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting DNMT3B-Mediated Hypermethylation of the KLF4 Promoter.
Epigenetic reprogramming by organic arsenic CZ2 elicits potent antitumor responses in DLBCL through TMS1 restoration.
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β-Thalassemia.
DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.
Shexiang Tongxin dropping pills attenuate cardiac remodeling in myocardial infarction rats by inhibiting Glycolysis via ITGB2 methylation.
UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis.
Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors.
Helicobacter pylori-induced aberrant methylation of ID4 mediated by DNMT3B drives gastric cancer progression via DEC1-SHH signaling pathway.
Genetic regulation of ARID3B confers cleft lip with/without cleft palate susceptibility through LLPS-mediated transcriptional program.
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Prenatal BPA exposure disrupts androgen synthesis in testicular Leydig cells via epigenetic modifications of steroidogenic factor 1.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cells.
C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.
IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.
DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.
Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer.
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
The up-regulation of SYNCRIP promotes the proliferation and tumorigenesis via DNMT3A/p16 in colorectal cancer.
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization.
Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function.
HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.
Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia-Induced Pulmonary Hypertension.
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1.
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter.
The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model.
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting.
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling.
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar.
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
miR-29b-3p Increases Radiosensitivity in Stemness Cancer Cells via Modulating Oncogenes Axis.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Ding Y, Tian Y, Li M, Fu Y, Wang T, Du X, Wang M, Dong L, Gao F, Liu B, Lu Y, Zhang C, Mao L, Jiang J, Li L, Liao L, Li K
Theranostics 2026;16(4):1740-1761
Theranostics 2026;16(4):1740-1761
A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.
Chang A, Peng H, Chen Y, Zhang H, Xu X, Zhang K, Yang J, Li W, Wang X, Dong X, Ni J
Biomaterials 2026 Oct;333:124215
Biomaterials 2026 Oct;333:124215
Molecular basis for the inhibition of de novo DNA methylation by TCL1A.
Liu Q, Li J, Wang X, Li Y, Wu Y, Han Z, Guo Z, Guo L, Wang X, Yuan G, Gao Z, Li L, Deng D
Nature communications 2026 Mar 5;17(1)
Nature communications 2026 Mar 5;17(1)
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Wang Y, Xiong Y, Liu S, Bao L, Qiu X, Korboukh I, Song X, Toffessi Tcheuyap V, Wu S, Chen M, Brugarolas J, Jin J, Wang Y, Luo W
Cell reports. Medicine 2026 Mar 17;7(3):102630
Cell reports. Medicine 2026 Mar 17;7(3):102630
Dexmedetomidine Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting DNMT3B-Mediated Hypermethylation of the KLF4 Promoter.
Chen X, Hong J
Cardiovascular drugs and therapy 2026 Mar 10;
Cardiovascular drugs and therapy 2026 Mar 10;
Epigenetic reprogramming by organic arsenic CZ2 elicits potent antitumor responses in DLBCL through TMS1 restoration.
Mei W, Zhang M, Zhang D
Bioorganic chemistry 2026 Jun 15;174:109734
Bioorganic chemistry 2026 Jun 15;174:109734
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β-Thalassemia.
Shen Y, Wei J, Tang S, Wu D, Zong L, Ma S, Xiong Q, Gong R, Xu S, Peng C, Feng Q, Liu S, Liu Q, Ye Y, Zhao Q, Luo C, Huang P, Li Z, Kong X, Lan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(11):e13469
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(11):e13469
DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.
Guan K, Zhao S, Zhang G, Wang Y, Song D, Ding Y
iScience 2026 Feb 20;29(2):114347
iScience 2026 Feb 20;29(2):114347
Shexiang Tongxin dropping pills attenuate cardiac remodeling in myocardial infarction rats by inhibiting Glycolysis via ITGB2 methylation.
Xu X, Sun L, Zhang H, Pan H, Zhai C
Cytotechnology 2026 Apr;78(2):53
Cytotechnology 2026 Apr;78(2):53
UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis.
Pang P, Chen J, Li Q, Su Z, Lin J, Zeng Y, Zhang W, Xiao Z, Chen Z, Liu Z, Lin Y, Zheng G, Yu W, Xie Z
Journal of advanced research 2026 Apr 17;
Journal of advanced research 2026 Apr 17;
Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors.
Madigan JP, Andrews SG, Farrell RB, Forsythe SD, Sharma R, Ceribelli M, Thomas CJ, Shamsian KN, Lin S, Cheng KC, Sadowski SM
bioRxiv : the preprint server for biology 2025 Sep 25;
bioRxiv : the preprint server for biology 2025 Sep 25;
Helicobacter pylori-induced aberrant methylation of ID4 mediated by DNMT3B drives gastric cancer progression via DEC1-SHH signaling pathway.
Luan M, Zhu W, Feng Z, Jing F, Xing Y, Ma X, Wang Y, Ning B, Jia Y
Cell death & disease 2025 Oct 7;16(1):713
Cell death & disease 2025 Oct 7;16(1):713
Genetic regulation of ARID3B confers cleft lip with/without cleft palate susceptibility through LLPS-mediated transcriptional program.
Li X, Li D, Lou S, Lin J, Gao Y, Vona B, Mi C, Wang L, Ma L, Du M, Pan Y
Cell reports 2025 Oct 28;44(10):116377
Cell reports 2025 Oct 28;44(10):116377
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Yang L, Wang W, Zhang A
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Prenatal BPA exposure disrupts androgen synthesis in testicular Leydig cells via epigenetic modifications of steroidogenic factor 1.
Hong Z, Xu Y, Xu Y, Ding M, Zhao Z, Wang C, Liu Z, Wu J
Ecotoxicology and environmental safety 2025 Nov 15;307:119409
Ecotoxicology and environmental safety 2025 Nov 15;307:119409
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cells.
Li Z, Wang Y, Yu Z, Luo Y, Zhao Y, Xue E, Zhan J, Lu H, Sun F
Cell communication and signaling : CCS 2025 Jun 20;23(1):297
Cell communication and signaling : CCS 2025 Jun 20;23(1):297
C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.
Liu Y, Huang C, Luo M, Lu W, Zhang B, Bai L, Zheng S, Tan Y, Li S, Wang H, Gong L, Guan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503434
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503434
IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.
Wang X, Yang Y, Zhou X, Yu S, Luo X, Lu L, Gao Z, Yang J
Cell death discovery 2025 Jan 16;11(1):9
Cell death discovery 2025 Jan 16;11(1):9
DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.
Yao TF, Wang ZY, Sun L, Yu SX, Yu HD, Yang ZZ, Li WZ, Niu L, Sun D, Shi YH, Li JQ, Liu WQ, Liu XZ, Zuo ZF
The Journal of biological chemistry 2025 Feb;301(2):108137
The Journal of biological chemistry 2025 Feb;301(2):108137
Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer.
Ganapathy K, Harrs CF, Harris S, Staklinski SJ, Khatib A, Park JY, Chakrabarti R
Heliyon 2025 Feb 15;11(3):e41948
Heliyon 2025 Feb 15;11(3):e41948
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926
International journal of biological sciences 2024;20(5):1905-1926
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
Zhao Y, Zheng Y, Fu J, Zhang J, Shao H, Liu S, Lai J, Zhou X, Liang R, Jia L, Cui W, Yang J, Wu C, Wang L
British journal of cancer 2024 Sep;131(4):655-667
British journal of cancer 2024 Sep;131(4):655-667
The up-regulation of SYNCRIP promotes the proliferation and tumorigenesis via DNMT3A/p16 in colorectal cancer.
Li C, Lu T, Chen H, Yu Z, Chen C
Scientific reports 2024 Sep 16;14(1):21570
Scientific reports 2024 Sep 16;14(1):21570
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization.
Li B, Xia C, He W, Liu J, Duan R, Ji Z, Pan X, Zhou Y, Yu G, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2401931
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(44):e2401931
Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function.
Wang N, Jiang Q, Xie L, Cheng B, Liu QW, Jiang R
Andrology 2024 Jan;12(1):222-230
Andrology 2024 Jan;12(1):222-230
HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.
Hu X, Zhang S, Zhang X, Liu H, Diao Y, Li L
Oncology reports 2024 Dec;52(6)
Oncology reports 2024 Dec;52(6)
Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia-Induced Pulmonary Hypertension.
Yu J, Hong S, Yang L, Ye S, Yu Z, Zhang Z, Wang Z, Huang S, Chen Y, Bian T, Wu Y
Journal of the American Heart Association 2024 Dec 3;13(23):e036969
Journal of the American Heart Association 2024 Dec 3;13(23):e036969
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.
Zhang L, Zou W, Zhang S, Wu H, Gao Y, Zhang J, Zheng J
Cellular & molecular biology letters 2024 Dec 18;29(1):154
Cellular & molecular biology letters 2024 Dec 18;29(1):154
Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
Yamauchi T, Okano Y, Terada D, Yasukochi S, Tsuruta A, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S, Ohdo S
Cancer & metabolism 2024 Aug 7;12(1):23
Cancer & metabolism 2024 Aug 7;12(1):23
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1.
Chen J, Yang X, Li Q, Ma J, Li H, Wang L, Chen Z, Quan Z
Free radical biology & medicine 2024 Aug 1;220:139-153
Free radical biology & medicine 2024 Aug 1;220:139-153
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter.
Ren G, Li H, Hong D, Hu F, Jin R, Wu S, Sun W, Jin H, Zhao L, Zhang X, Liu D, Huang C, Huang H
BMC cancer 2023 Sep 23;23(1):898
BMC cancer 2023 Sep 23;23(1):898
The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model.
Li Y, Ma L, Deng Y, Du Z, Guo B, Yue J, Liu X, Zhang Y
Neuropharmacology 2023 Nov 15;239:109682
Neuropharmacology 2023 Nov 15;239:109682
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
Zhao Y, Fan X, Wang Q, Zhen J, Li X, Zhou P, Lang Y, Sheng Q, Zhang T, Huang T, Zhao Y, Lv Z, Wang R
Redox biology 2023 Jun;62:102674
Redox biology 2023 Jun;62:102674
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting.
Chen Y, Lu J, Xu Y, Huang Y, Wang D, Liang P, Ren S, Hu X, Qin Y, Ke W, Jauch R, Hutchins AP, Wang M, Tang F, Zhao XY
Protein & cell 2023 Jun 28;14(7):477-496
Protein & cell 2023 Jun 28;14(7):477-496
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Fu Y, Song Y, Zhang J, Wei LP, Sun XR
Journal of reproductive immunology 2023 Feb;155:103784
Journal of reproductive immunology 2023 Feb;155:103784
ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling.
He BF, Wu YX, Hu WP, Hua JL, Han Y, Zhang J
Free radical biology & medicine 2023 Feb 1;195:359-370
Free radical biology & medicine 2023 Feb 1;195:359-370
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
Feng X, Guo J, An G, Wu Y, Liu Z, Meng B, He N, Zhao X, Chen S, Zhu Y, Xia J, Li X, Yu Z, Li R, Ren G, Chen J, Wu M, He Y, Qiu L, Zhou J, Zhou W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491
LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar.
Wu K, Ma F, Shen J, Zhang H, Wan Y, He X, Yang A, Xiong J, Jiao Y, Bai Z, Ma S, Jiang Y, Zhang H, Hao Y
Acta biochimica et biophysica Sinica 2022 Dec 25;54(12):1-9
Acta biochimica et biophysica Sinica 2022 Dec 25;54(12):1-9
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
Wang HF, Jiang J, Wu JS, Zhang M, Pang X, Dai L, Tang YL, Liang XH
Cancers 2022 Aug 27;14(17)
Cancers 2022 Aug 27;14(17)
miR-29b-3p Increases Radiosensitivity in Stemness Cancer Cells via Modulating Oncogenes Axis.
Pan D, Du Y, Li R, Shen A, Liu X, Li C, Hu B
Frontiers in cell and developmental biology 2021;9:741074
Frontiers in cell and developmental biology 2021;9:741074
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Wang L, Xu L, Wang Y
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
Zhu Y, Wang X, Zhou X, Ding L, Liu D, Xu H
Biological research 2021 Aug 6;54(1):25
Biological research 2021 Aug 6;54(1):25
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)
Brain sciences 2020 Sep 5;10(9)
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Wang X, Wang Z, Wang Q, Wang H, Liang H, Liu D
Research in veterinary science 2017 Oct;114:363-369
Research in veterinary science 2017 Oct;114:363-369
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