Explore
Validate
Learn
Western blot
Immunocytochemistry
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN151734 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) antibody
- Antibody type
- Polyclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity.
The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes.
The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2'deoxycytidine (decitabine) are differentially regulated by cell cycle progression.
SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells.
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells.
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.
An essential role for DNA methyltransferase DNMT3B in cancer cell survival.
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Liu Y, Sun L, Fong P, Yang J, Zhang Z, Yin S, Jiang S, Liu X, Ju H, Huang L, Bai J, Gong K, Yan S, Zhang C, Shao G
Oncotarget 2017 Mar 21;8(12):19712-19722
Oncotarget 2017 Mar 21;8(12):19712-19722
Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity.
Hoang TV, Horowitz ER, Chaffee BR, Qi P, Flake RE, Bruney DG, Rasor BJ, Rosalez SE, Wagner BD, Robinson ML
Epigenetics 2017 Jan 2;12(1):27-40
Epigenetics 2017 Jan 2;12(1):27-40
The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.
Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB
Oncogene 2015 Aug 6;34(32):4278-84
Oncogene 2015 Aug 6;34(32):4278-84
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M
Molecular cancer therapeutics 2012 Feb;11(2):370-82
Molecular cancer therapeutics 2012 Feb;11(2):370-82
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.
Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B
Carcinogenesis 2011 Oct;32(10):1450-8
Carcinogenesis 2011 Oct;32(10):1450-8
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes.
Kinney SM, Chin HG, Vaisvila R, Bitinaite J, Zheng Y, Estève PO, Feng S, Stroud H, Jacobsen SE, Pradhan S
The Journal of biological chemistry 2011 Jul 15;286(28):24685-93
The Journal of biological chemistry 2011 Jul 15;286(28):24685-93
The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2'deoxycytidine (decitabine) are differentially regulated by cell cycle progression.
Al-Salihi M, Yu M, Burnett DM, Alexander A, Samlowski WE, Fitzpatrick FA
Epigenetics 2011 Aug;6(8):1021-8
Epigenetics 2011 Aug;6(8):1021-8
SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.
Kim DH, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W
American journal of physiology. Renal physiology 2011 Aug;301(2):F427-35
American journal of physiology. Renal physiology 2011 Aug;301(2):F427-35
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR
Molecular cancer research : MCR 2008 Aug;6(8):1365-74
Molecular cancer research : MCR 2008 Aug;6(8):1365-74
DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.
Morey SR, Smiraglia DJ, James SR, Yu J, Moser MT, Foster BA, Karpf AR
Cancer research 2006 Dec 15;66(24):11659-67
Cancer research 2006 Dec 15;66(24):11659-67
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells.
Xiong Y, Dowdy SC, Podratz KC, Jin F, Attewell JR, Eberhardt NL, Jiang SW
Cancer research 2005 Apr 1;65(7):2684-9
Cancer research 2005 Apr 1;65(7):2684-9
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR
Nature genetics 2003 Jan;33(1):61-5
Nature genetics 2003 Jan;33(1):61-5
Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells.
Qiu YY, Mirkin BL, Dwivedi RS
Cancer detection and prevention 2002;26(6):444-53
Cancer detection and prevention 2002;26(6):444-53
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.
Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA
Gene 2002 Sep 18;298(1):91-9
Gene 2002 Sep 18;298(1):91-9
An essential role for DNA methyltransferase DNMT3B in cancer cell survival.
Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, MacLeod AR
The Journal of biological chemistry 2002 Aug 2;277(31):28176-81
The Journal of biological chemistry 2002 Aug 2;277(31):28176-81
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B
Nature 2002 Apr 4;416(6880):552-6
Nature 2002 Apr 4;416(6880):552-6
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
