NB100-64339

antibody from Novus Biologicals
Targeting: C3 ARMD9, C3a, C3b, CPAMD1
Provider product page for NB100-64339
Western blot
ELISA
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NB100-64339 - Provider product page
Provider
Novus Biologicals
Proper citation
Novus Cat#NB100-64339, RRID:AB_960741
Product name
Mouse Monoclonal Complement C3c Antibody
Antibody type
Monoclonal
Description
Protein A purified. NB100-64339 recognizes 135kDa complement component 3c (C3c), present in blood serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
Reactivity
Human
Host
Mouse
Isotype
IgG
Vial size
0.05 mg
Concentration
1.0 mg/ml
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
C3 protein structure - NB100-64339 shown in red.