C3

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

Description

Complement C3

Tissue specificity

Tissue enriched (liver)

Predicted location

Intracellular, Secreted to blood

Protein family

Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (6677704 - 6730562)

Ensembl ID

ENSG00000125730  (ver. 103.38)

Orthologs

Mouse C3: ENSMUSG00000024164

UniProt

P01024

neXtProt

NX_P01024

Human splice variants
Mouse splice variants

Protein structure