C4BPA

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

Description

Complement component 4 binding protein alpha

Tissue specificity

Tissue enriched (liver)

Predicted location

Secreted to blood

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1:q32.2 (207104233 - 207144972)

Ensembl ID

ENSG00000123838  (ver. 103.38)

Orthologs

Mouse C4bp: ENSMUSG00000026405

UniProt

P04003

neXtProt

NX_P04003

Human splice variants
Mouse splice variants