CFI

gene product
C3b-INA, FI, IF, KAF
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008]
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566 antibodies from 28 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
4 antibodies
antibodies-online
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1 antibody
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25 antibodies
Affinity Biosciences
1 antibody
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51 antibodies
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10 antibodies
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112 antibodies
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11 antibodies
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2 antibodies
NSJ Bioreagents
1 antibody
Aviva Systems Biology
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St John's Laboratory
2 antibodies
Abgent
3 antibodies
ProSci
1 antibody
Creative Biolabs
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Invitrogen Antibodies
6 antibodies
GenWay
3 antibodies
Creative Diagnostics
4 antibodies
Bioworld Technology, Inc
1 antibody
RayBiotech, Inc.
1 antibody
MyBioSource
3 antibodies
Sigma-Aldrich
3 antibodies
Abbiotec
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
United States Biological
13 antibodies