CFI

gene product
C3b-INA, FI, IF, KAF
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
617 antibodies from 30 providers.

Antibody properties

General

Applications

or Cancel
Antibody
GeneTex
4 antibodies
antibodies-online
184 antibodies
Boster Biological Technology
1 antibody
Novus Biologicals
61 antibodies
R&D Systems
1 antibody
Biorbyt
25 antibodies
Affinity Biosciences
1 antibody
OriGene
52 antibodies
Abnova Corporation
10 antibodies
LifeSpan BioSciences, Inc.
137 antibodies
Acris Antibodies GmbH
11 antibodies
Atlas Antibodies
2 antibodies
NSJ Bioreagents
1 antibody
Absolute Antibody
5 antibodies
Aviva Systems Biology
6 antibodies
St John's Laboratory
2 antibodies
Abgent
3 antibodies
ProSci
1 antibody
Creative Biolabs
61 antibodies
Invitrogen Antibodies
6 antibodies
GenWay
3 antibodies
Creative Diagnostics
4 antibodies
Bioworld Technology, Inc
1 antibody
RayBiotech, Inc.
1 antibody
MyBioSource
3 antibodies
Sigma-Aldrich
3 antibodies
Abbiotec
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
United States Biological
13 antibodies