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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN359974 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (Middle Region) antibody
- Antibody type
- Polyclonal
- Description
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- Middle Region
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.
Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia.
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production.
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
XLA patients with BTK splice-site mutations produce low levels of wild-type BTK transcripts.
Márquez JA, Smith CI, Petoukhov MV, Lo Surdo P, Mattsson PT, Knekt M, Westlund A, Scheffzek K, Saraste M, Svergun DI
The EMBO journal 2003 Sep 15;22(18):4616-24
The EMBO journal 2003 Sep 15;22(18):4616-24
Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia.
Goodman PA, Wood CM, Vassilev AO, Mao C, Uckun FM
Leukemia & lymphoma 2003 Jun;44(6):1011-8
Leukemia & lymphoma 2003 Jun;44(6):1011-8
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production.
Horwood NJ, Mahon T, McDaid JP, Campbell J, Mano H, Brennan FM, Webster D, Foxwell BM
The Journal of experimental medicine 2003 Jun 16;197(12):1603-11
The Journal of experimental medicine 2003 Jun 16;197(12):1603-11
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA
The Journal of biological chemistry 2003 Jul 11;278(28):26258-64
The Journal of biological chemistry 2003 Jul 11;278(28):26258-64
XLA patients with BTK splice-site mutations produce low levels of wild-type BTK transcripts.
Noordzij JG, de Bruin-Versteeg S, Hartwig NG, Weemaes CM, Gerritsen EJ, Bernatowska E, van Lierde S, de Groot R, van Dongen JJ
Journal of clinical immunology 2002 Sep;22(5):306-18
Journal of clinical immunology 2002 Sep;22(5):306-18
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