Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10744-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10744-1-AP, RRID:AB_2145118
- Product name
- MRE11 antibody
- Antibody type
- Polyclonal
- Description
- MRE11 antibody (Cat. #10744-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.
MRE11A: a novel negative regulator of human DNA mismatch repair.
Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
MiR-34s negatively regulate homologous recombination through targeting RAD51.
Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, Zeng T, Chen S, Liu M, Chen H, Song Q, Li Q, Yang C, Le Y, Xing J, Zhang H, An J, Jia W, Kang L, Zhang H, Xie H, Ye J, Wu T, He F, Zhang X, Li Y, Zhou G
Cell genomics 2024 May 8;4(5):100550
Cell genomics 2024 May 8;4(5):100550
MRE11A: a novel negative regulator of human DNA mismatch repair.
Du D, Yang Y, Zhang Y, Wang G, Chen L, Guan X, Rasmussen LJ, Liu D
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Cellular & molecular biology letters 2024 Mar 14;29(1):37
Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
Ding JH, Xiao Y, Yang F, Song XQ, Xu Y, Ding XH, Ding R, Shao ZM, Di GH, Jiang YZ
Science translational medicine 2024 Jan 3;16(728):eadg7740
Science translational medicine 2024 Jan 3;16(728):eadg7740
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.
Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600
Oncogene 2023 Feb;42(8):586-600
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W
Nature communications 2022 Sep 1;13(1):5133
Nature communications 2022 Sep 1;13(1):5133
Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.
Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138
Cell death & disease 2022 Feb 10;13(2):138
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA
Nature communications 2022 Aug 30;13(1):5090
Nature communications 2022 Aug 30;13(1):5090
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
The Journal of physiology 2019 May;597(9):2391-2401
The Journal of physiology 2019 May;597(9):2391-2401
MiR-34s negatively regulate homologous recombination through targeting RAD51.
Chen S, Liu R, Wang Q, Qi Z, Hu Y, Zhou P, Wang Z
Archives of biochemistry and biophysics 2019 May 15;666:73-82
Archives of biochemistry and biophysics 2019 May 15;666:73-82
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 10744-1-AP(MRE11A antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MRE11 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MRE11. This antibody recognizes human,mouse,rat antigen. The MRE11 antibody has been validated for the following applications: ELISA, WB, IHC analysis.