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- References [164]
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- Product number
- 60225-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60225-1-Ig, RRID:AB_11042594
- Product name
- PI3 kinase p85 Alpha antibody
- Antibody type
- Monoclonal
- Description
- PI3 Kinase p85 Alpha antibody (Cat. #60225-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4G3C11
- Vial size
- 20ul, 150ul
Submitted references Research on the metabolic regulation mechanism of Yangyin Qingfei decoction plus in severe pneumonia caused by Mycoplasma pneumoniae in mice.
Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.
Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation.
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway.
Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway.
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.
Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.
Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway.
RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Oleanolic acid alleviates obesity-induced skeletal muscle atrophy via the PI3K/Akt signaling pathway.
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Inhibitory Effect of Hernandezine on the Proliferation of Hepatocellular Carcinoma.
Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury.
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN.
Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments.
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats.
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E(2) /ERβ signaling pathways.
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer.
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway.
DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.
Enterovirus D68 capsid formation and stability requires acidic compartments.
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway.
Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.
Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathway†.
PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.
20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer.
Anti-cervical cancer effects of Compound Yangshe granule through the PI3K/AKT pathway based on network pharmacology.
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Biochemical Toxicological Study of Insulin Overdose in Rats: A Forensic Perspective.
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination.
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells.
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1.
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway.
Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease.
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Fu Brick Tea Manages HFD/STZ-Induced Type 2 Diabetes by Regulating the Gut Microbiota and Activating the IRS1/PI3K/Akt Signaling Pathway.
Combined exposure of lead and high-fat diet enhanced cognitive decline via interacting with CREB-BDNF signaling in male rats.
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration.
Upregulation of MHC-I and downregulation of PD-L1 expression by doxorubicin and deferasirox codelivered liposomal nanoparticles for chemoimmunotherapy of melanoma.
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway.
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes.
Fatty Acid-Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway.
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway.
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Daphnoretin induces reactive oxygen species-mediated apoptosis in melanoma cells.
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity.
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Naringin alleviates H(2)O(2)-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer.
miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia.
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling.
MiR-155 promotes interleukin-1β-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K/Akt pathway.
Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury.
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway.
Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway.
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.
Minimally modified low-density lipoprotein upregulates the ET(B) and α(1) receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.
cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells.
Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer.
Zhang T, Zhao X, Zhang X, Liang X, Guan Z, Wang G, Liu G, Wu Z
Frontiers in pharmacology 2024;15:1376812
Frontiers in pharmacology 2024;15:1376812
Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.
Guo X, Lei M, Ma G, Ouyang C, Yang X, Liu C, Chen Q, Liu X
Molecular neurobiology 2024 May;61(5):2514-2529
Molecular neurobiology 2024 May;61(5):2514-2529
Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Yang X, Zhang J, Li Y, Hu H, Li X, Ma T, Zhang B
Journal of ethnopharmacology 2024 May 23;326:117918
Journal of ethnopharmacology 2024 May 23;326:117918
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Fu Y, Yuan P, Zeng M, Zhang Q, Hou Y, Gao L, Wei Y, Zheng Y, Feng W, Zheng X
Heliyon 2024 May 15;10(9):e29807
Heliyon 2024 May 15;10(9):e29807
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation.
Hwang JM, Bae JW, Lee WJ, Kwon WS
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108545
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108545
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Zhang Y, Wang X, Liu W, Lei T, Qiao T, Feng W, Song W
Journal of translational medicine 2024 Mar 8;22(1):251
Journal of translational medicine 2024 Mar 8;22(1):251
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
Huang Y, Wu Z, Peng Z, Liu A, Yuan W, Han D, Peng J
BMC cancer 2024 Mar 18;24(1):345
BMC cancer 2024 Mar 18;24(1):345
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L
Cell death and differentiation 2024 Jun;31(6):722-737
Cell death and differentiation 2024 Jun;31(6):722-737
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.
Wang T, Liao H, Lin J, Zhang M, Chen B, Yin R, Sun J, Dai H, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155575
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155575
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
Wu J, Wang C, Sun S, Ren T, Pan L, Liu H, Hou S, Wu S, Yan X, Zhang J, Zhao X, Liu W, Zhu S, Wei S, Zhang C, Jia X, Zhang Q, Yu Z, Zhuo Y, Zhao Q, Yang C, Wang N
Protein & cell 2024 Jul 20;15(8):594-611
Protein & cell 2024 Jul 20;15(8):594-611
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway.
Xu Y, Jia K, Zhao X, Li Y, Zhang Z
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23594
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23594
Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway.
Zeng J, Pei H, Wu H, Chen W, Du R, He Z
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23544
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23544
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Wei X, Ni J, Yuan L, Li X
Oncology letters 2024 Jan;27(1):17
Oncology letters 2024 Jan;27(1):17
Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.
Wang H, Wang G, Meng Y, Liu Y, Yao X, Feng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211
Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.
Wang G, Ma F, Xie K, Li X, Tan X, Xia Y, Wang Y, Dong J
International immunopharmacology 2024 Jan 25;127:111335
International immunopharmacology 2024 Jan 25;127:111335
Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway.
Jung EJ, Jo JH, Uwamahoro C, Jang SI, Lee WJ, Hwang JM, Bae JW, Kwon WS
Toxics 2024 Jan 15;12(1)
Toxics 2024 Jan 15;12(1)
RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP.
Lin P, Qian J, Huang CC, Xu WM, Wang YY, Gao ZR, Zheng SQ, Wang P, Jia DQ, Feng Q, Yang JL
BMC cancer 2024 Jan 12;24(1):71
BMC cancer 2024 Jan 12;24(1):71
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Lin S, Chen Z, Wu Z, Fei F, Xu Z, Tong Y, Sun W, Wang P
Neurochemical research 2024 Feb;49(2):477-491
Neurochemical research 2024 Feb;49(2):477-491
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Zheng X, Chen J, Deng M, Ning K, Peng Y, Liu Z, Li X, Zhou Z, Tang H, Li Y, Kang T, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells.
Zhang L, Deng M, Liu J, Zhang J, Wang F, Yu W
BMC infectious diseases 2024 Feb 20;24(1):230
BMC infectious diseases 2024 Feb 20;24(1):230
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Oleanolic acid alleviates obesity-induced skeletal muscle atrophy via the PI3K/Akt signaling pathway.
Sun Y, Wei X, Zhao T, Shi H, Hao X, Wang Y, Zhang H, Yao Z, Zheng M, Ma T, Fu T, Lu J, Luo X, Yan Y, Wang H
FEBS open bio 2024 Apr;14(4):584-597
FEBS open bio 2024 Apr;14(4):584-597
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Deng JW, Yuan S, Shi LP, Chen X, Liu J, Chen ZW, Tan KY, Yang Q, Cao WF
Journal of ethnopharmacology 2024 Apr 6;323:117730
Journal of ethnopharmacology 2024 Apr 6;323:117730
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Yu JR, Liu YY, Gao YY, Qian LH, Qiu JL, Wang PP, Zhang GJ
Journal of ethnopharmacology 2024 Apr 24;324:117791
Journal of ethnopharmacology 2024 Apr 24;324:117791
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Cao T, Wang L, Jiao S, Chen H, Lin C, Zhang B, Cai H
Neuropsychobiology 2023;82(6):346-358
Neuropsychobiology 2023;82(6):346-358
Inhibitory Effect of Hernandezine on the Proliferation of Hepatocellular Carcinoma.
Kuok C, Wang Q, Fong P, Qin Y, Meng L
Biological & pharmaceutical bulletin 2023;46(2):245-256
Biological & pharmaceutical bulletin 2023;46(2):245-256
Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury.
Sui X, Xie T, Xu Y, Zhang A, Zhang Y, Gu F, Li L, Xu Z, Chen J
Mediators of inflammation 2023;2023:5007488
Mediators of inflammation 2023;2023:5007488
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T
International journal of biological sciences 2023;19(14):4672-4688
International journal of biological sciences 2023;19(14):4672-4688
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Huang Y, Zhang Y, Wu Y, Xiang Q, Yu R
Drug design, development and therapy 2023;17:237-260
Drug design, development and therapy 2023;17:237-260
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
Zhang P, Huang Q, Liao P, Sun S, Yang J
American journal of translational research 2023;15(6):3900-3911
American journal of translational research 2023;15(6):3900-3911
PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN.
Wang X, Xu W, Zhu C, Cheng Y, Qi J
Journal of Cancer 2023;14(15):2833-2844
Journal of Cancer 2023;14(15):2833-2844
Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments.
Zhu M, He Q, Wang Y, Duan L, Rong K, Wu Y, Ding Y, Mi Y, Ge X, Yang X, Yu Y
Frontiers in pharmacology 2023;14:1238841
Frontiers in pharmacology 2023;14:1238841
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Ma L, La X, Zhang B, Xu W, Tian C, Fu Q, Wang M, Wu C, Chen Z, Chang H, Li JA
Frontiers in endocrinology 2023;14:1190827
Frontiers in endocrinology 2023;14:1190827
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats.
Guo X, Lei M, Zhao J, Wu M, Ren Z, Yang X, Ouyang C, Liu X, Liu C, Chen Q
Frontiers in pharmacology 2023;14:1146960
Frontiers in pharmacology 2023;14:1146960
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E(2) /ERβ signaling pathways.
Lyu Y, Wei X, Yang X, Li J, Wan G, Wang Y, Hao Z, Lu Y, Guo J, Shi J
Phytotherapy research : PTR 2023 Sep;37(9):4149-4165
Phytotherapy research : PTR 2023 Sep;37(9):4149-4165
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Huang B, Lu Y, Ni Z, Liu J, He Y, An H, Ye F, Shen J, Lin M, Chen Y, Lin J
Cancer gene therapy 2023 Sep;30(9):1260-1273
Cancer gene therapy 2023 Sep;30(9):1260-1273
Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer.
Zhou B, Yang Y, Pang X, Shi J, Jiang T, Zheng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115071
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115071
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway.
Lee WJ, Jo JH, Jang SI, Jung EJ, Hwang JM, Bae JW, Ha JJ, Kim DH, Kwon WS
Reproductive toxicology (Elmsford, N.Y.) 2023 Sep;120:108426
Reproductive toxicology (Elmsford, N.Y.) 2023 Sep;120:108426
DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.
Li J, Zhang Y, Ye F, Qian P, Qin Z, Li D, Ye L, Feng L
Cancers 2023 Sep 27;15(19)
Cancers 2023 Sep 27;15(19)
Enterovirus D68 capsid formation and stability requires acidic compartments.
Galitska G, Jassey A, Wagner MA, Pollack N, Miller K, Jackson WT
mBio 2023 Oct 31;14(5):e0214123
mBio 2023 Oct 31;14(5):e0214123
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway.
Lei M, Guo X, Yao Y, Shu T, Ren Z, Yang X, Ouyang C, Chen Q, Liu C, Liu X
Experimental gerontology 2023 Oct 15;182:112307
Experimental gerontology 2023 Oct 15;182:112307
Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.
Li M, Xiu L, Liao W, Ren Y, Huo M, Liu H, Chen S, Li N, Gao Y, Yu X, Fan A, Zhong G
Journal of ethnopharmacology 2023 Nov 15;316:116750
Journal of ethnopharmacology 2023 Nov 15;316:116750
Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathway†.
Ma N, Liu B, Jin Y, Wang J, Qin W, Zheng F, Qin R, Li J, Hang F, Qin A
Biology of reproduction 2023 Nov 15;109(5):736-748
Biology of reproduction 2023 Nov 15;109(5):736-748
PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.
Zhang P, Jiang Y, Ye X, Zhang C, Tang Y
Experimental and therapeutic medicine 2023 May;25(5):223
Experimental and therapeutic medicine 2023 May;25(5):223
20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.
Zhang Q, Yang X, Liu J, Song J, Zhang S, Chen L, Zhang M
Food & function 2023 May 11;14(9):4191-4203
Food & function 2023 May 11;14(9):4191-4203
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose.
Yuan P, Zhang Q, Fu Y, Hou Y, Gao L, Wei Y, Feng W, Zheng X
Journal of natural medicines 2023 Mar;77(2):262-275
Journal of natural medicines 2023 Mar;77(2):262-275
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
Li Z, Zeng M, Geng K, Lai D, Xu Z, Zhou W
Molecules (Basel, Switzerland) 2023 Mar 16;28(6)
Molecules (Basel, Switzerland) 2023 Mar 16;28(6)
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.
Zhao F, Jiang H, Zhang T, Chen H, Li W, Li X, Wang P, Xu H
International journal of molecular sciences 2023 Mar 10;24(6)
International journal of molecular sciences 2023 Mar 10;24(6)
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer.
Li J, Cao X, Chu T, Lin K, Chen L, Lv J, Tan Y, Chen M, Li M, Wang K, Zheng Q, Li D
Pharmacological research 2023 Jan;187:106584
Pharmacological research 2023 Jan;187:106584
Anti-cervical cancer effects of Compound Yangshe granule through the PI3K/AKT pathway based on network pharmacology.
Ma C, Gu Y, Liu C, Tang X, Yu J, Li D, Liu J
Journal of ethnopharmacology 2023 Jan 30;301:115820
Journal of ethnopharmacology 2023 Jan 30;301:115820
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.
Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH
The Journal of clinical investigation 2023 Jan 3;133(1)
The Journal of clinical investigation 2023 Jan 3;133(1)
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Zhou XH, Cheng ZP, Lu M, Lin WY, Luo LL, Ming ZY, Hu Y
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Zhang L, Liu J, Deng M, Chen X, Jiang L, Zhang J, Tao L, Yu W, Qiu Y
Journal of translational medicine 2023 Feb 2;21(1):72
Journal of translational medicine 2023 Feb 2;21(1):72
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Wu M, Li R, Qin J, Wang Z, Guo J, Lv F, Wang G, Huang Y
Journal of molecular histology 2023 Dec;54(6):621-631
Journal of molecular histology 2023 Dec;54(6):621-631
Biochemical Toxicological Study of Insulin Overdose in Rats: A Forensic Perspective.
Bian C, He X, Wang Q, Zheng Z, Zhang Y, Xiong H, Li Y, Zhao M, Li J
Toxics 2023 Dec 23;12(1)
Toxics 2023 Dec 23;12(1)
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination.
Chen J, Li M, Chen R, Xu Z, Yang X, Gu H, Zhang L, Fu C, Zhang J, Wu Y
Chinese medicine 2023 Apr 27;18(1):46
Chinese medicine 2023 Apr 27;18(1):46
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Wang Y, Gao J, Sun L, Li Q, Kang N, Gao C, Li T
Journal of ethnopharmacology 2023 Apr 24;306:116180
Journal of ethnopharmacology 2023 Apr 24;306:116180
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Wang Y, Yuan Y, Wang C, Wang B, Zou W, Zhang N, Chen X
Frontiers in nutrition 2022;9:858261
Frontiers in nutrition 2022;9:858261
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Zhu X, Chen X, Wang G, Lei D, Chen X, Lin K, Li M, Lin H, Li D, Zheng Q
Biological & pharmaceutical bulletin 2022;45(8):1027-1035
Biological & pharmaceutical bulletin 2022;45(8):1027-1035
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Lou H, Zhang Y, Fang J, Jin Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells.
Zuo X, Wei X, Ju C, Wang X, Zhang Z, Ma Y, Zhu Z, Li X, Song Z, Luo L, Hu X, Wang Z
Oxidative medicine and cellular longevity 2022;2022:7223353
Oxidative medicine and cellular longevity 2022;2022:7223353
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Lv S, Wang L, Duan Y, Huang D, Yang D
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5764107
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5764107
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug design, development and therapy 2022;16:375-395
Drug design, development and therapy 2022;16:375-395
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1.
Yao E, Luo L, Lin C, Wen J, Li Y, Ren T, Chen Y, Huang J, Jin X
Frontiers in pharmacology 2022;13:964475
Frontiers in pharmacology 2022;13:964475
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
Dong Y, Zheng Y, Zhu L, Li T, Guan Y, Zhao S, Wang Q, Wang J, Li L
Frontiers in pharmacology 2022;13:896434
Frontiers in pharmacology 2022;13:896434
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Sun X, Chen Y, Tao X, Zhang W, Wang X, Wang X, Ruan Z, Chen Z
Frontiers in oncology 2022;12:983537
Frontiers in oncology 2022;12:983537
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Wang YN, Ye Y, Zhou D, Guo ZW, Xiong Z, Gong XX, Jiang SW, Chen H
Frontiers in cell and developmental biology 2022;10:852561
Frontiers in cell and developmental biology 2022;10:852561
lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway.
Liu L, Sun B, Zhang F, Zhong Z, Zhang Y, Li F, Zhang T, Khatib H, Wang X
Journal of agricultural and food chemistry 2022 Sep 28;70(38):12004-12013
Journal of agricultural and food chemistry 2022 Sep 28;70(38):12004-12013
Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease.
Pei H, Zeng J, Chen W, He Z, Du R
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23200
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23200
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Tu Y, Tan L, Lu T, Wang K, Wang H, Han B, Zhao Y, Chen H, Li Y, Chen H, Chen M, He C
Biochemical pharmacology 2022 Mar;197:114912
Biochemical pharmacology 2022 Mar;197:114912
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Ying J, Pan R, Tang Z, Zhu J, Ren P, Lou Y, Zhang E, Huang D, Hu P, Li D, Bao Q, Li P
Cancer medicine 2022 Mar;11(6):1454-1464
Cancer medicine 2022 Mar;11(6):1454-1464
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Lu Y, Zhong W, Liu Y, Chen W, Zhang J, Zeng Z, Huang H, Qiao Y, Wan X, Meng X, Cai S, Dong H
International immunopharmacology 2022 Mar;104:108504
International immunopharmacology 2022 Mar;104:108504
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Cai J, Liang J, Zhang Y, Shen L, Lin H, Hu T, Zhan S, Xie M, Liang S, Xian M, Wang S
Pharmacological research 2022 Jun;180:106230
Pharmacological research 2022 Jun;180:106230
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Yu Y, Jiang L, Li J, Lei L, Li H
Journal of periodontology 2022 Jul;93(7):1036-1047
Journal of periodontology 2022 Jul;93(7):1036-1047
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Wang J, Luo X, Lu J, Wang X, Miao Y, Li Q, Wang L
Experimental cell research 2022 Jul 15;416(2):113179
Experimental cell research 2022 Jul 15;416(2):113179
Fu Brick Tea Manages HFD/STZ-Induced Type 2 Diabetes by Regulating the Gut Microbiota and Activating the IRS1/PI3K/Akt Signaling Pathway.
Qi B, Ren D, Li T, Niu P, Zhang X, Yang X, Xiao J
Journal of agricultural and food chemistry 2022 Jul 13;70(27):8274-8287
Journal of agricultural and food chemistry 2022 Jul 13;70(27):8274-8287
Combined exposure of lead and high-fat diet enhanced cognitive decline via interacting with CREB-BDNF signaling in male rats.
Liu R, Bai L, Liu M, Wang R, Wu Y, Li Q, Ba Y, Zhang H, Zhou G, Yu F, Huang H
Environmental pollution (Barking, Essex : 1987) 2022 Jul 1;304:119200
Environmental pollution (Barking, Essex : 1987) 2022 Jul 1;304:119200
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
Du X, Li C, Zhang S, Sun C, Zhang X, Chen C, Wang X, Cheng F, Wang Q
Journal of ethnopharmacology 2022 Feb 10;284:114507
Journal of ethnopharmacology 2022 Feb 10;284:114507
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration.
Sun D, Mou S, Chen L, Yang J, Wang R, Zhong A, Wang W, Tong J, Wang Z, Sun J
Biomaterials research 2022 Dec 17;26(1):83
Biomaterials research 2022 Dec 17;26(1):83
Upregulation of MHC-I and downregulation of PD-L1 expression by doxorubicin and deferasirox codelivered liposomal nanoparticles for chemoimmunotherapy of melanoma.
Song P, Han X, Zheng R, Yan J, Wu X, Wang Y, Zhang H
International journal of pharmaceutics 2022 Aug 25;624:122002
International journal of pharmaceutics 2022 Aug 25;624:122002
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
Zhang W, Lei M, Wen Q, Zhang D, Qin G, Zhou J, Chen L
The journal of headache and pain 2022 Aug 10;23(1):98
The journal of headache and pain 2022 Aug 10;23(1):98
Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway.
Teng YJ, Deng Z, Ouyang ZG, Zhou Q, Mei S, Fan XX, Wu YR, Long HP, Fang LY, Yin DL, Zhang BY, Guo YM, Zhu WH, Huang Z, Zheng P, Ning DM, Tian XF
World journal of gastrointestinal oncology 2022 Apr 15;14(4):872-886
World journal of gastrointestinal oncology 2022 Apr 15;14(4):872-886
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Xu J, Xu H, Ma K, Wang Y, Niu B, Zhang L, Li F
Frontiers in cell and developmental biology 2021;9:618045
Frontiers in cell and developmental biology 2021;9:618045
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY
Journal of immunology research 2021;2021:6696606
Journal of immunology research 2021;2021:6696606
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Zhao J, Lan W, Peng J, Guan B, Liu J, Zhang M, Zhan Z, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes.
Wang X, Zhang Z, Zhu Z, Liang Z, Zuo X, Ju C, Song Z, Li X, Hu X, Wang Z
Frontiers in neuroscience 2021;15:768262
Frontiers in neuroscience 2021;15:768262
Fatty Acid-Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway.
Wu Z, Jeong JH, Ren C, Yang L, Ding L, Li F, Jiang D, Zhu Y, Lu J
OncoTargets and therapy 2021;14:3929-3942
OncoTargets and therapy 2021;14:3929-3942
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Sun M, Xie J, Zhang D, Chen C, Lin S, Chen Y, Zhang G
Journal of Cancer 2021;12(24):7518-7526
Journal of Cancer 2021;12(24):7518-7526
Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Wu Y, You X, Lin Q, Xiong W, Guo Y, Huang Z, Dai X, Chen Z, Mei S, Long Y, Tian X, Zhou Q
Frontiers in pharmacology 2021;12:791269
Frontiers in pharmacology 2021;12:791269
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Cao T, Chen Q, Zhang B, Wu X, Zeng C, Zhang S, Cai H
Frontiers in endocrinology 2021;12:727371
Frontiers in endocrinology 2021;12:727371
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Zhang KK, Wang H, Qu D, Chen LJ, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xu JT, Xie XL, Li DR
Frontiers in pharmacology 2021;12:641917
Frontiers in pharmacology 2021;12:641917
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway.
Zhou XM, Liu CY, Liu YY, Ma QY, Zhao X, Jiang YM, Li XJ, Chen JX
Frontiers in pharmacology 2021;12:586788
Frontiers in pharmacology 2021;12:586788
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Tian X, Wu L, Jiang M, Zhang Z, Wu R, Miao J, Liu C, Gao S
Frontiers in oncology 2021;11:641399
Frontiers in oncology 2021;11:641399
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Wang D, Liu J, Jiang H
Environmental toxicology 2021 Sep;36(9):1953-1964
Environmental toxicology 2021 Sep;36(9):1953-1964
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Niu LT, Wang YQ, Wong CCL, Gao SX, Mo XD, Huang XJ
Translational oncology 2021 Sep;14(9):101159
Translational oncology 2021 Sep;14(9):101159
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Xian M, Cai J, Zheng K, Liu Q, Liu Y, Lin H, Liang S, Wang S
Food & function 2021 Sep 7;12(17):8056-8067
Food & function 2021 Sep 7;12(17):8056-8067
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
Huang B, Lu Y, Gui M, Guan J, Lin M, Zhao J, Mao Q, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111331
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Chen H, Pan R, Li H, Zhang W, Ren C, Lu Q, Chen H, Zhang X, Nie Y
Cell biology international 2021 Mar;45(3):623-632
Cell biology international 2021 Mar;45(3):623-632
Daphnoretin induces reactive oxygen species-mediated apoptosis in melanoma cells.
Wang H, Hu X, Li M, Pan Z, Li D, Zheng Q
Oncology letters 2021 Jun;21(6):453
Oncology letters 2021 Jun;21(6):453
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Peng MF, Tian S, Song YG, Li CX, Miao MS, Ren Z, Li M
Journal of ethnopharmacology 2021 Jun 12;273:113947
Journal of ethnopharmacology 2021 Jun 12;273:113947
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
Tang X, Chen Y, Luo H, Bian Q, Weng B, Yang A, Chu D, Ran M, Chen B
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
Liu D, Han Y, Liu L, Ren X, Zhang H, Fan S, Qin T, Li L
International journal of oncology 2021 Jan;58(1):100-110
International journal of oncology 2021 Jan;58(1):100-110
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Tang C, Luo Y, Li S, Huang B, Xu S, Li L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
Huang W, Chen K, Lu Y, Zhang D, Cheng Y, Li L, Huang W, He G, Liao H, Cai L, Tang Y, Zhao L, Pan M
Neoplasia (New York, N.Y.) 2021 Dec;23(12):1227-1239
Neoplasia (New York, N.Y.) 2021 Dec;23(12):1227-1239
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
Ma RR, Zhang H, Chen HF, Zhang GH, Tian YR, Gao P
Oncogene 2021 Apr;40(14):2524-2538
Oncogene 2021 Apr;40(14):2524-2538
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C, Liu J, Dang Y, Xia Y, He Q, Jin H, Li Y, Hu Y, Miao Y, Yue Z, Hu B
Autophagy 2021 Apr;17(4):980-1000
Autophagy 2021 Apr;17(4):980-1000
The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
Wang C, Wang C, Ren L, Chen S, Chen WH, Li Y
Life sciences 2021 Apr 1;270:119037
Life sciences 2021 Apr 1;270:119037
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Kang D, Zuo W, Wu Q, Zhu Q, Liu P
BioMed research international 2020;2020:1358674
BioMed research international 2020;2020:1358674
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Wang HM, Lu YJ, He L, Gu NJ, Wang SY, Qiu XS, Wang EH, Wu GP
Therapeutic advances in chronic disease 2020;11:2040622320957143
Therapeutic advances in chronic disease 2020;11:2040622320957143
Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity.
Wei Z, Hao Y, Yu H, Shi L, Jing X, Zhang X, Liu N, Li T, Zhang X, Yuan F
Life sciences 2020 Sep 15;257:117994
Life sciences 2020 Sep 15;257:117994
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Lv S, Yuan P, Dong J, Lu C, Li M, Qu F, Zhu Y, Yuan Z, Zhang J
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Naringin alleviates H(2)O(2)-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.
Nan LP, Wang F, Ran D, Zhou SF, Liu Y, Zhang Z, Huang ZN, Wang ZY, Wang JC, Feng XM, Zhang L
Connective tissue research 2020 Nov;61(6):554-567
Connective tissue research 2020 Nov;61(6):554-567
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Yang YL, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 May 21;21(10)
International journal of molecular sciences 2020 May 21;21(10)
Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer.
Lian J, Zou Y, Huang L, Cheng H, Huang K, Zeng J, Chen L
Oncology letters 2020 Mar;19(3):2043-2052
Oncology letters 2020 Mar;19(3):2043-2052
miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia.
Wang Y, Zhang J, Su Y, Wang C, Zhang G, Liu X, Chen Q, Lv M, Chang Y, Peng J, Hou M, Huang X, Zhang X
Molecular therapy. Nucleic acids 2020 Jun 5;20:764-776
Molecular therapy. Nucleic acids 2020 Jun 5;20:764-776
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860
Thoracic cancer 2020 Jul;11(7):1848-1860
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W
Journal of neuroinflammation 2020 Jul 14;17(1):211
Journal of neuroinflammation 2020 Jul 14;17(1):211
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.
Alarabi AB, Karim ZA, Ramirez JEM, Hernandez KR, Lozano PA, Rivera JO, Alshbool FZ, Khasawneh FT
Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):335-349
Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):335-349
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling.
Zheng J, Qu D, Wang C, Ding L, Zhou W
BMC pregnancy and childbirth 2020 Feb 10;20(1):87
BMC pregnancy and childbirth 2020 Feb 10;20(1):87
MiR-155 promotes interleukin-1β-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K/Akt pathway.
Fan Z, Liu Y, Shi Z, Deng K, Zhang H, Li Q, Cao S, Li S, Zhang H
Journal of cellular and molecular medicine 2020 Aug;24(15):8441-8451
Journal of cellular and molecular medicine 2020 Aug;24(15):8441-8451
Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury.
Zhai R, Xu H, Hu F, Wu J, Kong X, Sun X
British journal of pharmacology 2020 Aug;177(15):3389-3402
British journal of pharmacology 2020 Aug;177(15):3389-3402
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Li H, Liu S, Hu Y, Zhao B, Sun Y, Xu D
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R
Mediators of inflammation 2019;2019:8709583
Mediators of inflammation 2019;2019:8709583
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Guo Y, Pei X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway.
Zhang Y, Yang S, Cui X, Yang J, Zheng M, Jia J, Han F, Yang X, Wang J, Guo Z, Chang B, Chang B
Journal of diabetes research 2019;2019:4709715
Journal of diabetes research 2019;2019:4709715
Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway.
Wang X, Han Y, Liu J, Zhang Y, Cheng K, Guo J, Guo Q, Liu S, Sun H, Hua Y, Zhang G, Xu S, Guo F, Yang Z
Mediators of inflammation 2019;2019:4312016
Mediators of inflammation 2019;2019:4312016
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584
Inflammation 2019 Oct;42(5):1575-1584
Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.
Dong X, Yang Y, Zhou Y, Bi X, Zhao N, Zhang Z, Li L, Hang Q, Zhang R, Chen D, Cao P, Yin Z, Luo L
Cell death and differentiation 2019 Oct;26(10):2086-2099
Cell death and differentiation 2019 Oct;26(10):2086-2099
Minimally modified low-density lipoprotein upregulates the ET(B) and α(1) receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.
Zeng ZS, Lin J, Xu CB, Cao L, Chen C, Li J
The Journal of pharmacy and pharmacology 2019 Jun;71(6):937-944
The Journal of pharmacy and pharmacology 2019 Jun;71(6):937-944
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H
Annals of translational medicine 2019 Dec;7(23):756
Annals of translational medicine 2019 Dec;7(23):756
The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.
Ou B, Tao W, Yang S, Feng J, Wang J, Yang T, Wu H, Huang Y, Tan L, Huang W, Feng Z, Mei Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.
Chen X, Zhao X, Lan F, Zhou T, Cai H, Sun H, Kong W, Kong W
Scientific reports 2017 Oct 16;7(1):13248
Scientific reports 2017 Oct 16;7(1):13248
cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells.
Zhou P, Tu L, Lin X, Hao X, Zheng Q, Zeng W, Zhang X, Zheng Y, Wang L, Li S
Viruses 2017 Nov 25;9(12)
Viruses 2017 Nov 25;9(12)
Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice.
Ma F, Liu F, Ding L, You M, Yue H, Zhou Y, Hou Y
Pharmaceutical biology 2017 Dec;55(1):1263-1273
Pharmaceutical biology 2017 Dec;55(1):1263-1273
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
Redox biology 2017 Aug;12:987-1003
Redox biology 2017 Aug;12:987-1003
MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer.
Wu ZH, Tao ZH, Zhang J, Li T, Ni C, Xie J, Zhang JF, Hu XC
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7245-54
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7245-54
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 60225-1-Ig(PIK3R1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The P85a; PIK3R1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human P85a; PIK3R1. This antibody recognizes human, mouse antigen. The P85a; PIK3R1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
