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- Product number
- 60225-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60225-1-Ig, RRID:AB_11042594
- Product name
- PI3 kinase p85 Alpha antibody
- Antibody type
- Monoclonal
- Description
- PI3 Kinase p85 Alpha antibody (Cat. #60225-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4G3C11
- Vial size
- 20ul, 150ul
Submitted references PIK3R1 as a Gastric Cancer Biomarker Linked to CD73 (+) Treg-Mediated Immunosuppression.
GCDCA promotes hepatocellular carcinoma progression through S1PR2/PI3K/AKT-mediated polarization of M2-type macrophages.
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.
Puerarin Improves Glucose and Lipid Metabolism in Type 2 Diabetes by Regulating Gut Microbiota Homeostasis and Promoting Adipose Tissue Thermogenesis.
Luteolin prevents hyperoxaluria-induced renal injury by inhibiting crystal deposition and renal inflammation.
ANXA1 overexpression promotes B cell acute lymphoblastic leukemia progression and resistance by regulating fatty acid metabolism through PI3K/Akt signaling.
Alisol B 23-acetate alleviates high-fat diet-induced insulin resistance by activating the SIRT1/FOXO1 axis and PI3K/AKT pathway.
An Apigenin-Based Bone-Targeted System Enhances Antioxidant Capacity of Bone Marrow Mesenchymal Stem Cells via the PI3K/Akt Pathway to Alleviate Osteoporosis.
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens.
MRPL15 as a Key Gene in the Malignant Proliferation of LUAD.
Estradiol facilitates urate excretion by reducing GLUT9 expression via ERβ/TMEM106B/PI3K/AKT1 pathway in renal tubular epithelial cells.
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Exploring the mechanism of Bushen KaiXuan Tongluo formula in ameliorating diabetic kidney disease based on transcriptomics and animal experiments.
Protective effects of the ethyl acetate fraction from Madeng'ai on lipopolysaccharide-induced acute lung injury in mice: Insights from integrated multi-omics analysis.
Xylazine-Adulterated Fentanyl-Induced Brain Toxicity: Mechanism Elucidation via Network Toxicology and Molecular Docking Approaches.
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
Adipose-derived stem cells (ADSCs)-derived DKK1 promotes cutaneous wound healing by inducing M2 macrophage polarization via PI3K/AKT and JNK activation.
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Cyclovirobuxine D attenuates collagen-induced arthritis by inhibiting PI3K/AKT pathway and macrophage polarization.
Glutamine-driven upregulation of NPDC1 promotes colorectal cancer progression through PI3K/AKT signaling.
Fici hirtae radix alleviates influenza A virus-induced acute lung injury via TLR4-PI3K-AKT/p38 MAPK-NF-κB signaling pathway.
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway.
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.
Single-Nucleus RNA Sequencing Reveals SPP1(+) Macrophages Induce Cardiomyocyte Apoptosis to Promote Atrial Fibrillation Susceptibility.
Deciphering the molecular mechanisms underlying of Xin Xue Granule on LPS-induced pyrexia rats: A multi-omics analysis.
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Elucidating the PTK2-Targeted Anti-Hepatocellular Carcinoma Effects of Euphorbia helioscopia L. via Integrated Network Pharmacology, Mendelian Randomization, and Experimental Validation.
Association and Toxic Mechanism Between Foodborne OTA Exposure and Embryonic Development.
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Sildenafil suppresses osteoporosis-related bone marrow adiposity by inhibiting Adipogenic differentiation of mesenchymal stem cells.
Therapeutic Galectin-3 Apheresis Improves Sepsis Outcomes Through Coordinated Neutrophil Modulation and Endothelial Barrier Preservation: A Translational Study.
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Astragalus Polysaccharide Alleviates Cognitive Decline in D-Galactose-Induced Aging.
Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndrome.
Exploring the Therapeutic Potential of FSGTC for Osteoarthritis: A Comprehensive Study Combining Nested Case Analysis, Network Pharmacology, and Experimental Validation.
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN-Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway.
Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511.
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Therapeutic potential of isochlorogenic acid A from Taraxacum officinale in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer.
FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway.
DDX49 as a novel prognostic biomarker regulates colorectal cancer cell proliferation through the TIMM44-PI3K-AKT pathway.
B7-H7 knockdown suppresses the proliferation, metastasis, and drug resistance of B-cell non-Hodgkin lymphoma cells by inhibiting the PI3K/Akt pathway.
RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3.
Network pharmacology combined with molecular docking and experimental validation of the mechanism of action of columbianetin acetate in the treatment of ovarian cancer.
Breaking epigenetic shackles: targeting ARID1A methylation and the PI3K/AKT/mTOR-PD-L1 axis to overcome immune escape in gastric cancer.
The m6A demethylase FTO suppresses glioma proliferation by regulating the EREG/PI3K/Akt signaling pathway.
Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.
Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways.
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway.
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Suppressed autophagy of thymic cells promotes apoptosis and thymic atrophy in COPD.
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression.
Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis.
Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma.
Research on the Pharmacodynamic Substances and Mechanism of Action of Tibetan Medicine Liuwei Muxiang Powder in the Treatment of Ethanol-Induced Gastric Ulcer Model of GES1 Cell.
Artificial intelligence combined with affinity chromatography discover that 7-Epitaxol promotes autophagy in NSCLC cells by interacting with EGFR: Discovery of novel EGFR antagonist based on DL and CMC.
Single-cell RNA sequencing reveals that Danggui Buxue Tang decoction facilitates wound healing after anal fistula by promoting M2 macrophage polarization.
Natsudaidain alleviates acute lung injury through the PI3K/Akt and P53 signaling pathways by inhibiting MLE-12 apoptosis: a network pharmacology study and experimental validation.
Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation.
BUB1B promotes homologous recombination‑mediated DNA damage repair in breast cancer cells through the PI3K/AKT signaling pathway.
Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy.
Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis.
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.
Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury.
Astragaloside IV delayed the epithelial-mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways.
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway.
Deciphering the hepatoprotective mechanism of Sarcopyramis nepalensis wall against non-alcoholic fatty liver disease by network pharmacology and experimental validation.
Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.
Xiaoyao San and Guipi Tang, alone or combined, relieve postpartum depression via AGE‑RAGE‑mediated autophagy and apoptosis.
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer.
IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway.
Calcitriol Modulates Hippocampal Axon Guidance Through Enhanced EfnA4-Mediated PI3K/AKT Signaling in an Autism Mouse Model.
PTPRG-AS1 regulates the KITLG/KIT pathway through the ceRNA axis to promote the malignant progression of gastric cancer and the intervention effect of Compound Kushen injection on it.
Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro.
Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS.
Lan-Qin oral liquid alleviates influenza A virus-induced acute lung injury by regulating monocyte-derived macrophages and TLR4-PI3K-AKT-NF-κB signal pathways.
Recombinant neurotrophin-3 with the ability to penetrate the blood-brain barrier: A new strategy against Alzheimer's disease.
Bioelectrically Reprogramming Hydrogels Rejuvenate Vascularized Bone Regeneration in Senescence.
The YTHDF3-DT/miR-301a-3p /INHBA axis attenuates autophagy-dependent ferroptosis in lung adenocarcinoma.
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.
Huafengdan Inhibits Glioblastoma Cell Growth and Mobility by Acting on PLAU and CAV1 Targets.
Network pharmacology and experimental analysis reveal Ethyl caffeate delays osimertinib resistance in lung cancer by suppression of MET.
Role of PI3K/AKT signaling pathway during capacitation.
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Sirt4 Overexpression Modulates the JAK2/STAT3 and PI3K/AKT/mTOR Axes to Alleviate Sepsis-Induced Acute Lung Injury.
Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance.
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway.
Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from In Vitro and In Vivo Studies.
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments.
Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway.
Podophyllum hexandrum Royle mitigates perimenopausal symptoms in an OVX rat model by activating the PI3K/AKT/mTOR pathway and enhancing estrogen receptor expression.
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets.
Quinolinone Derivatives Suppress Angiogenesis in Human Umbilical Vein Endothelial Cells by Blocking the VEGF-Induced VEGFR2 Signaling Pathway.
Pedunculoside regulates the differentiation of neural stem cells into neurons via the PI3K/AKT/GSK-3β pathway.
T-cell differentiation stage block bias confers hypermethylation and mediastinal preference in T-cell lymphoblastic lymphoma.
The dual mechanism of m(6)A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR.
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR.
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation.
The efficacy and pharmacological mechanism of Guilingji to prevent Alzheimer's disease.
Schisandrin A ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis.
In-Depth Examination of TPBG as a New Predictive Indicator for Gastric Cancer.
Single-cell analysis combined with transcriptome sequencing identifies autophagy hub genes in macrophages after spinal cord injury.
Vitamin A enhances PI3K/Akt signaling and mitigates enterocyte apoptosis in a mouse model of necrotizing enterocolitis.
BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation.
Integrative multi-omics and network pharmacology reveal the mechanisms of Fangji Huangqi Decoction in treating IgA nephropathy.
Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K/AKT signaling pathway.
Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD.
GLP-1/GIP dual agonist tirzepatide normalizes diabetic nephropathy via PI3K/AKT mediated suppression of oxidative stress.
Icaritin alleviates motor impairment and osteoporosis in Parkinson's disease mice via the ER-PI3K/Akt pathway.
Downregulation of the PI3K/AKT/mTOR/MMP-13 pathway for promoting interface healing via lubricating microspheres.
Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Non-starch polysaccharides from Castanea mollissima Bl. ameliorate metabolic syndrome by remodeling barrier function, microbial community, and metabolites in high-fat-diet/streptozotocin-induced diabetic mice.
Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation.
Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection.
Endoplasmic reticulum stress regulates intestinal motility in acute pancreatitis by regulating the expression and phosphorylation of nNOS through IRE1α/XBP1s-PI3K/Akt signaling axis.
HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells.
Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.
BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells.
Inhibition of ALOX5-dependent ferroptosis by 6-C-methylquercetin: a potential therapeutic approach for alleviating rheumatoid arthritis.
An Extensive Analysis of Artemisia integrifolia Linn. on T2DM: Investigating Glycolipid Metabolism, Metabolic Profiling, and Molecular Docking for Potential Functional Food Applications.
Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression.
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes.
Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice.
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.
Comparison of the effects between catalase and superoxide dismutase on regulating macrophage inflammatory response and protecting osteogenic function of periodontal ligament cells.
Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway.
Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32.
The Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) 3 Regulates the Myogenic Differentiation of Yunan Black Pig Muscle Satellite Cells (MuSCs) In Vitro via Iron Homeostasis and the PI3K/AKT Pathway.
Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway.
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Oroxylin A may promote cell apoptosis and inhibit epithelial-mesenchymal transition in endometrial cancer, associated with the ERβ/PI3K/AKT pathway.
Prenyl diphosphate synthase subunit 2 is downregulated in abdominal aortic aneurysm and retards the progression of abdominal aortic aneurysm.
ETS1-mediated Regulation of SOAT1 Enhances the Malignant Phenotype of Oral Squamous Cell Carcinoma and Induces Tumor-associated Macrophages M2-like Polarization.
Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway.
Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke.
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Research on the metabolic regulation mechanism of Yangyin Qingfei decoction plus in severe pneumonia caused by Mycoplasma pneumoniae in mice.
Material basis and molecular mechanisms of Chaihuang Qingyi Huoxue Granule in the treatment of acute pancreatitis based on network pharmacology and molecular docking-based strategy.
The small protein LINC01547-ORF inhibits colorectal cancer progression by regulating the CLDN18-FAK-AKT axis.
Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway.
Effects of oridonin on sperm function and the PI3K/PDK1/AKT signaling pathway: Implications for reproductive toxicity.
Dihydroartemisinin ameliorates experimental autoimmune myasthenia gravis by regulating CD4(+) T cells and modulating gut microbiota.
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
An inulin-type polysaccharide from Atractylodis Macrocephalae Rhizoma can relieve psoriasis.
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Maternal Gestational Diabetes Mellitus and High-Fat Diet Influenced Hepatic Polyunsaturated Fatty Acids Profile in the Offspring of C57BL/6J Mice.
Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway.
The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation.
Network pharmacology, molecular docking, and untargeted metabolomics reveal molecular mechanisms of multi-targets effects of Qingfei Tongluo Plaster improving respiratory syncytial virus pneumonia.
Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway.
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation.
Spatial organization of PI3K-PI(3,4,5)P(3)-AKT signaling by focal adhesions.
Babaodan inhibits cell proliferation and metastasis and enhances anti-tumor effects of camrelizumab by inhibiting M2 phenotype macrophages in hepatocellular carcinoma.
Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.
Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation.
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway.
Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury.
Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway.
Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway.
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.
Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.
Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway.
RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway.
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.
The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Polyphyllin II inhibits breast cancer cell proliferation via the PI3K/Akt signaling pathway.
Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis.
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Spatial dimension cues derived from fibrous scaffolds trigger mechanical activation to potentiate the paracrine and regenerative functions of MSCs via the FAK-PI3K/AKT axis.
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.
ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/PI3K/AKT pathway in ovarian cancer.
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
The Mitochondrial Fusion Promoter M1 Mitigates Cigarette Smoke-Induced Airway Inflammation and Oxidative Stress via the PI3K-AKT Signaling Pathway.
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway.
Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus.
DDX19A promotes gastric cancer cell proliferation and migration by activating the PI3K/AKT pathway.
Lactate Oxidase Disrupts Lactate-Activated RAS and PI3K Oncogenic Signaling.
Oleanolic acid alleviates obesity-induced skeletal muscle atrophy via the PI3K/Akt signaling pathway.
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Nerve Growth Factor/Tyrosine Kinase A Receptor Pathway Enhances Analgesia in an Experimental Mouse Model of Bone Cancer Pain by Increasing Membrane Levels of δ-Opioid Receptors.
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Inhibitory Effect of Hernandezine on the Proliferation of Hepatocellular Carcinoma.
Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury.
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN.
Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments.
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats.
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E(2) /ERβ signaling pathways.
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer.
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway.
DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.
Enterovirus D68 capsid formation and stability requires acidic compartments.
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway.
Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.
Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathway†.
PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.
20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer.
Anti-cervical cancer effects of Compound Yangshe granule through the PI3K/AKT pathway based on network pharmacology.
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Biochemical Toxicological Study of Insulin Overdose in Rats: A Forensic Perspective.
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination.
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells.
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1.
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway.
Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease.
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Fu Brick Tea Manages HFD/STZ-Induced Type 2 Diabetes by Regulating the Gut Microbiota and Activating the IRS1/PI3K/Akt Signaling Pathway.
Combined exposure of lead and high-fat diet enhanced cognitive decline via interacting with CREB-BDNF signaling in male rats.
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration.
Upregulation of MHC-I and downregulation of PD-L1 expression by doxorubicin and deferasirox codelivered liposomal nanoparticles for chemoimmunotherapy of melanoma.
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway.
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes.
Fatty Acid-Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway.
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway.
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway.
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Daphnoretin induces reactive oxygen species-mediated apoptosis in melanoma cells.
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity.
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Naringin alleviates H(2)O(2)-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer.
miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia.
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling.
MiR-155 promotes interleukin-1β-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K/Akt pathway.
Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury.
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway.
Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway.
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.
Minimally modified low-density lipoprotein upregulates the ET(B) and α(1) receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.
Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/Akt‑dependent Tbx‑3 activation pathway.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.
cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells.
Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer.
Zou B, Xu YE, He HC, Ye ZL, Zhou DL, He CY, Huang C
Oncology research 2026;34(2):17
Oncology research 2026;34(2):17
GCDCA promotes hepatocellular carcinoma progression through S1PR2/PI3K/AKT-mediated polarization of M2-type macrophages.
Xue M, Yu W, Zhang K, Chen Y, Zhang L, Zhang H, Lu S, Tao M, Yan H, Wei L, Lv G, Gao L, Zhang L
Frontiers in immunology 2026;17:1640450
Frontiers in immunology 2026;17:1640450
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Yu X, Shi L, Qu M, Zhang Y, Zhang Y, Xu X, Liu L, Wang H, Wang H
Frontiers in cell and developmental biology 2026;14:1766915
Frontiers in cell and developmental biology 2026;14:1766915
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.
Qiao X, Xue D, Hu Z, Wang H, Mu L
Toxicology and applied pharmacology 2026 May;510:117775
Toxicology and applied pharmacology 2026 May;510:117775
Puerarin Improves Glucose and Lipid Metabolism in Type 2 Diabetes by Regulating Gut Microbiota Homeostasis and Promoting Adipose Tissue Thermogenesis.
Cheng L, Gan M, Wang H, Song Y, Bai Y, Zhang D
Phytotherapy research : PTR 2026 May;40(5):2397-2416
Phytotherapy research : PTR 2026 May;40(5):2397-2416
Luteolin prevents hyperoxaluria-induced renal injury by inhibiting crystal deposition and renal inflammation.
Jin Z, Zhu S, Wang C, Wang T, Liu J, Wu Y
The international journal of biochemistry & cell biology 2026 May;194:106909
The international journal of biochemistry & cell biology 2026 May;194:106909
ANXA1 overexpression promotes B cell acute lymphoblastic leukemia progression and resistance by regulating fatty acid metabolism through PI3K/Akt signaling.
Liu P, Ma D, Pan C, Kang Q, Wang Y, Zhang M, Wang J
Molecular and cellular biochemistry 2026 Mar;481(3):1401-1414
Molecular and cellular biochemistry 2026 Mar;481(3):1401-1414
Alisol B 23-acetate alleviates high-fat diet-induced insulin resistance by activating the SIRT1/FOXO1 axis and PI3K/AKT pathway.
He W, Kong Z, Cai J, Wang Z, Ma L, Xiao X, Luo T
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):6447-6466
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(5):6447-6466
An Apigenin-Based Bone-Targeted System Enhances Antioxidant Capacity of Bone Marrow Mesenchymal Stem Cells via the PI3K/Akt Pathway to Alleviate Osteoporosis.
Liu D, Wang Y, Zhu C, Zheng Y, Li M, Cheng Y, He X, Shi Q
ACS biomaterials science & engineering 2026 Mar 9;12(3):1732-1748
ACS biomaterials science & engineering 2026 Mar 9;12(3):1732-1748
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens.
Liu M, Xi L, Zhou Y, Chen M, Qu H, Ma B, Zhang L, Shi C, Chen G, Ren Z, Cao J, Han J
Poultry science 2026 Mar 12;105(6):106762
Poultry science 2026 Mar 12;105(6):106762
MRPL15 as a Key Gene in the Malignant Proliferation of LUAD.
Wang Z, Qian Y, Lai X, Cui W, Luo J, Zeng W, He W, Liao M
Biochemical genetics 2026 Jun;64(3):3647-3662
Biochemical genetics 2026 Jun;64(3):3647-3662
Estradiol facilitates urate excretion by reducing GLUT9 expression via ERβ/TMEM106B/PI3K/AKT1 pathway in renal tubular epithelial cells.
Liu H, Xiao Z, Yue S, Liu Y, Ouyang X, Long K, Liu N, Wang X, Min Y
The international journal of biochemistry & cell biology 2026 Jun-Jul;195-196:106940
The international journal of biochemistry & cell biology 2026 Jun-Jul;195-196:106940
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554
Journal of ethnopharmacology 2026 Jun 28;365:121554
Exploring the mechanism of Bushen KaiXuan Tongluo formula in ameliorating diabetic kidney disease based on transcriptomics and animal experiments.
Xu M, Zhao B, Wang Y, Chang Y, Li Y, Qin L, Wang H, Jia X, Zheng G, Lv C, Liu T
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Jun 15;1278:125037
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Jun 15;1278:125037
Protective effects of the ethyl acetate fraction from Madeng'ai on lipopolysaccharide-induced acute lung injury in mice: Insights from integrated multi-omics analysis.
Zhang Z, Zhu T, Cao L, Wang Y, Xing XL, Zhang Z
Journal of ethnopharmacology 2026 Jul 15;366:121650
Journal of ethnopharmacology 2026 Jul 15;366:121650
Xylazine-Adulterated Fentanyl-Induced Brain Toxicity: Mechanism Elucidation via Network Toxicology and Molecular Docking Approaches.
Wang N, Ou Y, Wang Y, Huang Z, Hu Y, Zhao S
Journal of applied toxicology : JAT 2026 Jan;46(1):354-361
Journal of applied toxicology : JAT 2026 Jan;46(1):354-361
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Li T, Wang J, Bai L, Zhao Q, Zhu D, Xu Y, Wang Y, Wang Z, Feng F, Zhou X
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
Xiao J, Wang Y
Molecular immunology 2026 Jan;189:181-191
Molecular immunology 2026 Jan;189:181-191
Adipose-derived stem cells (ADSCs)-derived DKK1 promotes cutaneous wound healing by inducing M2 macrophage polarization via PI3K/AKT and JNK activation.
Liu D, Liu N, Liu X, Liu Y, Zhang H, Zhou Z, Zheng J, Tian Y
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120077
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120077
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Yang W, Li Y, Li Z, Jiang C, Deng X, Peng D
Cell death discovery 2026 Jan 8;12(1):6
Cell death discovery 2026 Jan 8;12(1):6
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Xiang F, He Z, Yang C, Lin L, Peng Q, Zhang Z
Chinese medicine 2026 Jan 4;21(1):3
Chinese medicine 2026 Jan 4;21(1):3
Cyclovirobuxine D attenuates collagen-induced arthritis by inhibiting PI3K/AKT pathway and macrophage polarization.
Sun Y, Zhang J, Wu Y, Liu Z, Li G
Arthritis research & therapy 2026 Jan 28;28(1)
Arthritis research & therapy 2026 Jan 28;28(1)
Glutamine-driven upregulation of NPDC1 promotes colorectal cancer progression through PI3K/AKT signaling.
Qin Q, Zhang D, Xie Y, Zhang F, Huang Y, Deng R, Yang M, Zhang L, Liang H, Shi R
Journal of translational medicine 2026 Jan 24;24(1):268
Journal of translational medicine 2026 Jan 24;24(1):268
Fici hirtae radix alleviates influenza A virus-induced acute lung injury via TLR4-PI3K-AKT/p38 MAPK-NF-κB signaling pathway.
Liang WT, Li JJ, Lv ZR, Chen ZH, Yang YD, Xie TY, Ruan YJ, Tu XP, Zeng FF, Wei Shi, Yang X, Zhang FX
Journal of ethnopharmacology 2026 Jan 10;354:120522
Journal of ethnopharmacology 2026 Jan 10;354:120522
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway.
Zhou L, Xu H, Lei X, Yu H, Xia L, Liu X, He J, Lin P, Zhou Y, Chen C, Li Y
Journal of ethnopharmacology 2026 Jan 10;354:120472
Journal of ethnopharmacology 2026 Jan 10;354:120472
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Qin M, Xu S, Chen Y, Luo X, Tang X, Zhang L, Xu Q
Tissue & cell 2026 Feb;98:103150
Tissue & cell 2026 Feb;98:103150
Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.
Cai J, Zhao B, Bao Z, Li Y, Han X, Chen Y, Wu X
BMC veterinary research 2026 Feb 5;22(1)
BMC veterinary research 2026 Feb 5;22(1)
Single-Nucleus RNA Sequencing Reveals SPP1(+) Macrophages Induce Cardiomyocyte Apoptosis to Promote Atrial Fibrillation Susceptibility.
Wang W, Dong Y, Yi H, He L, Jiang Y, Long L, Xia Z, Li J
Journal of cardiovascular development and disease 2026 Feb 5;13(2)
Journal of cardiovascular development and disease 2026 Feb 5;13(2)
Deciphering the molecular mechanisms underlying of Xin Xue Granule on LPS-induced pyrexia rats: A multi-omics analysis.
Zhang K, Shi Y, Zhang X, Zhai B, Sun J, Guo D, Feng L, Yang X, Luan F, Zou J
Journal of ethnopharmacology 2026 Feb 28;357:120888
Journal of ethnopharmacology 2026 Feb 28;357:120888
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Zhao K, Zhang C, Deng C, Zhu W
International journal of molecular sciences 2026 Feb 28;27(5)
International journal of molecular sciences 2026 Feb 28;27(5)
Elucidating the PTK2-Targeted Anti-Hepatocellular Carcinoma Effects of Euphorbia helioscopia L. via Integrated Network Pharmacology, Mendelian Randomization, and Experimental Validation.
Zhu J, Qian L, Yuan C, Sun J, Pan J, Liu T, Jin Y, Li Y, Zheng L, Liu C, Lu Y
Current issues in molecular biology 2026 Feb 14;48(2)
Current issues in molecular biology 2026 Feb 14;48(2)
Association and Toxic Mechanism Between Foodborne OTA Exposure and Embryonic Development.
Yao T, Zhu X, Ma J, Song G, Hu Y, Yan Y
Journal of applied toxicology : JAT 2026 Feb 12;
Journal of applied toxicology : JAT 2026 Feb 12;
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Zhang Z, Li Y, Hu J, Tang X, Li Z, Sun X, Feng D, Yao Y, Mao C, Tao Y, Xie L, Luo H, Li Y, Yu X, Peng X, Cong L, Jiang Y
Cell death & disease 2026 Feb 11;17(1):218
Cell death & disease 2026 Feb 11;17(1):218
Sildenafil suppresses osteoporosis-related bone marrow adiposity by inhibiting Adipogenic differentiation of mesenchymal stem cells.
Wu L, Hu M, Wei E, Pan X, Zhu Q, Wu T, Xiuyun X, Lv L, Dong X, Liu H, Liu Y
Cellular signalling 2026 Aug;144:112539
Cellular signalling 2026 Aug;144:112539
Therapeutic Galectin-3 Apheresis Improves Sepsis Outcomes Through Coordinated Neutrophil Modulation and Endothelial Barrier Preservation: A Translational Study.
Sun Z, Qu J, Peng S, Hu Y, Eliaz A, Chertow GM, Eliaz I, Peng Z
MedComm 2026 Apr;7(4):e70659
MedComm 2026 Apr;7(4):e70659
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Feng J, Gao S, Hu Y, Sheng W
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Liu H, Zhu C, Yao X, Liu Y, Zhu J, Li Y, Xu H, Peng C, Shan G, Chen L, Zhou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Astragalus Polysaccharide Alleviates Cognitive Decline in D-Galactose-Induced Aging.
Tian J, Huo R, Wang Y, Wang J, Fang F, Fang C
Biological & pharmaceutical bulletin 2025;48(5):523-536
Biological & pharmaceutical bulletin 2025;48(5):523-536
Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndrome.
Lu MQ, Shi ZG, Shang J, Gao L, Gao WJ, Gao L
Combinatorial chemistry & high throughput screening 2025;28(1):166-184
Combinatorial chemistry & high throughput screening 2025;28(1):166-184
Exploring the Therapeutic Potential of FSGTC for Osteoarthritis: A Comprehensive Study Combining Nested Case Analysis, Network Pharmacology, and Experimental Validation.
He M, Liu J, Gao W, Sun Y, Chen X, Fang Y
Drug design, development and therapy 2025;19:5123-5141
Drug design, development and therapy 2025;19:5123-5141
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Huang L, Li Q, Wu J, He Y, Huang J, Xie S, Yang C, Ruan Q, Zhou Z, Deng M
Frontiers in aging neuroscience 2025;17:1568002
Frontiers in aging neuroscience 2025;17:1568002
Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN-Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway.
Zhou X, Hu X, Zhang Z, Lin S, Lin X, Zhou T, Bai Y, Hu K
Cancer management and research 2025;17:1487-1501
Cancer management and research 2025;17:1487-1501
Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511.
Deng X, Hu C, Li L, Yang G, Li C, Zhang W, Cheng G
Frontiers in pharmacology 2025;16:1586657
Frontiers in pharmacology 2025;16:1586657
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Jin Q, Li Q, Yang L, Ma F, Mao H, Wang Y, Liu T, Peng L, Li P, Zhan Y
Frontiers in pharmacology 2025;16:1538061
Frontiers in pharmacology 2025;16:1538061
Therapeutic potential of isochlorogenic acid A from Taraxacum officinale in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer.
Wang T, Sun J, Wang L, Lin Y, Wu Z, Jia Q, Zhang S, An J, Ma X, Wu Q, Su Z, Wang H
Frontiers in immunology 2025;16:1529710
Frontiers in immunology 2025;16:1529710
FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway.
Yang X, Yuan Z, Gou L, Cheng L, Wang Z, Wu P, Wang X, Ma X, Ma T, Yu Y, Wu Z, Zhang D
Frontiers in genetics 2025;16:1514205
Frontiers in genetics 2025;16:1514205
DDX49 as a novel prognostic biomarker regulates colorectal cancer cell proliferation through the TIMM44-PI3K-AKT pathway.
Huang B, Yin Z, Gao G, Li L, Yang M
Frontiers in oncology 2025;15:1707092
Frontiers in oncology 2025;15:1707092
B7-H7 knockdown suppresses the proliferation, metastasis, and drug resistance of B-cell non-Hodgkin lymphoma cells by inhibiting the PI3K/Akt pathway.
Zhai A, Zou Q, Yin J, Ge S, Xiong X, Yan T, Xie X, Wang L
Frontiers in oncology 2025;15:1665309
Frontiers in oncology 2025;15:1665309
RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3.
Lin L, Xie Z, Zhong P, Chen J, Ma N, Li L, Lin A, Chen L
Frontiers in oncology 2025;15:1604377
Frontiers in oncology 2025;15:1604377
Network pharmacology combined with molecular docking and experimental validation of the mechanism of action of columbianetin acetate in the treatment of ovarian cancer.
Hu M, Wang L, Zhang F, Xie Y, Zhang T, Liu H, Li Z, Zhang J
Frontiers in oncology 2025;15:1515976
Frontiers in oncology 2025;15:1515976
Breaking epigenetic shackles: targeting ARID1A methylation and the PI3K/AKT/mTOR-PD-L1 axis to overcome immune escape in gastric cancer.
Duan X, Huo X, Zhang Y, Lan H, Yang F, Zhang X, Zhou N
PeerJ 2025;13:e20251
PeerJ 2025;13:e20251
The m6A demethylase FTO suppresses glioma proliferation by regulating the EREG/PI3K/Akt signaling pathway.
Zhai Y, Li C, Cao L, Zhang S, Liu X, Ren J, Liu Y
Frontiers in cell and developmental biology 2025;13:1667990
Frontiers in cell and developmental biology 2025;13:1667990
Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.
Dawa ZM, Zhai T, Liu CC, Fan HN
Frontiers in medicine 2025;12:1503472
Frontiers in medicine 2025;12:1503472
Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways.
Ji J, Li Y, Xu T, Shao Q, Sun Z, Chen S, Zhang D, Wang Q, Wang X, Ma C, Cheng F
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12405-12420
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12405-12420
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
Zheng D, Ma L, Xin X, Gao Y, Dong S, Huang Y, Wu J, Huo J, Li S
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway.
Lin Y, Wang X, Li Y, Cui X, Zhu N, Li X
Molecular medicine reports 2025 Sep;32(3)
Molecular medicine reports 2025 Sep;32(3)
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Kong Y, Wang Q, Wang J, Qiu X, Yang Y, Liu J, Yang F, Qi R
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Zhang C, Song Y, Jin X, Xu Q, Ye H, Wu Z, Lin H, Hu J, Huang C, Zhou J, Lian J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Suppressed autophagy of thymic cells promotes apoptosis and thymic atrophy in COPD.
He S, Yang Z, Xie L
Heart & lung : the journal of critical care 2025 Sep-Oct;73:180-189
Heart & lung : the journal of critical care 2025 Sep-Oct;73:180-189
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Li MJ, Zhang R, Sheikho A, Tang JJ, Gao YQ, Huang WW, Gao JM
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
Yang H, Chen Y, Wu G, Ren P, Chen T, Liu J, Zhang B, Ma X, Jiang F, Li Y, Tao L, Shen X
European journal of pharmacology 2025 Sep 5;1002:177846
European journal of pharmacology 2025 Sep 5;1002:177846
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression.
Qi X, Deng M, Li M, Ma W, Zhou Y
Human cell 2025 Sep 29;38(6):166
Human cell 2025 Sep 29;38(6):166
Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.
Liu Y, Lei Y, Shang L, Yu Z, Wang L, Zhou J, Pan G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120450
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120450
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Yang Z, Ji P, Zhang W, Li C, Wu F, Hua Y, Wei Y, Cao Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis.
Fan X, Gao J, Liu S, Hua J, Shao D, Jia L, Shen Y, Wang Z, Jin Z, Wang J
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120357
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120357
Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma.
Zhang Z, Liang L, Li Y, Fan Y, Liu Y, He Z, Wu X, Cong L, Jiang Y, Wan T
Cancer gene therapy 2025 Oct;32(10):1076-1089
Cancer gene therapy 2025 Oct;32(10):1076-1089
Research on the Pharmacodynamic Substances and Mechanism of Action of Tibetan Medicine Liuwei Muxiang Powder in the Treatment of Ethanol-Induced Gastric Ulcer Model of GES1 Cell.
Lu H, Zhang T, Liang J, Zeng J, He J, Zhu J, Yuan J, Fu X, Li H, Zhong G
Chemistry & biodiversity 2025 Oct;22(10):e00722
Chemistry & biodiversity 2025 Oct;22(10):e00722
Artificial intelligence combined with affinity chromatography discover that 7-Epitaxol promotes autophagy in NSCLC cells by interacting with EGFR: Discovery of novel EGFR antagonist based on DL and CMC.
Bai H, Wu T, Lv Y, Chen W, Jiang Y, Chen F, Su P, Yu H, He L, Li Z, Han S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157127
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157127
Single-cell RNA sequencing reveals that Danggui Buxue Tang decoction facilitates wound healing after anal fistula by promoting M2 macrophage polarization.
Pang X, Wang Y, Guo J
Hereditas 2025 Oct 9;162(1):204
Hereditas 2025 Oct 9;162(1):204
Natsudaidain alleviates acute lung injury through the PI3K/Akt and P53 signaling pathways by inhibiting MLE-12 apoptosis: a network pharmacology study and experimental validation.
Xia L, Lei X, Zhou L, Liu X, Lin P, Hou T, Xu H, Su S, Yang L, Chen C, Li Y
International immunopharmacology 2025 Oct 30;164:115396
International immunopharmacology 2025 Oct 30;164:115396
Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation.
Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL
Scientific reports 2025 Oct 14;15(1):35808
Scientific reports 2025 Oct 14;15(1):35808
BUB1B promotes homologous recombination‑mediated DNA damage repair in breast cancer cells through the PI3K/AKT signaling pathway.
Luo X, Wei Y, Lin H, Xiao N, Zhao W
Oncology reports 2025 Nov;54(5)
Oncology reports 2025 Nov;54(5)
Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy.
Cai R, Wang M, Pan M, Zhang Z, Jia Q, Feng L, Yu Z, Liu L, Zhu T, Cai S, Tian H, Zhang J, Guo R, Zheng Y
Bioactive materials 2025 Nov;53:737-753
Bioactive materials 2025 Nov;53:737-753
Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis.
Wei J, Wang K, Li Y, Huang J, Deng P, Xia X, Yang C, Xu L, Xu J
Bioactive materials 2025 Nov;53:459-479
Bioactive materials 2025 Nov;53:459-479
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.
Zhang J, Xu Y, Han X, Gao Y, Wei Z, Sun X
Cancer genetics 2025 Nov;298-299:141-150
Cancer genetics 2025 Nov;298-299:141-150
Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury.
Zhu T, Qian Z, Liu Z, Zhang Q, Li H
Brain research bulletin 2025 Nov;232:111618
Brain research bulletin 2025 Nov;232:111618
Astragaloside IV delayed the epithelial-mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways.
Huang Y, Chu CL, Qiu WH, Chen JY, Cao LX, Ji SY, Zhu B, Wang GK, Shen QQ
Journal of integrative medicine 2025 Nov;23(6):694-705
Journal of integrative medicine 2025 Nov;23(6):694-705
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway.
Liu J, Xu X, Zhang L, Jiang T, Zhao Z, Xiao J
Scientific reports 2025 Nov 3;15(1):38334
Scientific reports 2025 Nov 3;15(1):38334
Deciphering the hepatoprotective mechanism of Sarcopyramis nepalensis wall against non-alcoholic fatty liver disease by network pharmacology and experimental validation.
Lai H, Zhu C, Li X, He L, Deng C, Guo L, Wang X
Scientific reports 2025 Nov 25;15(1):45324
Scientific reports 2025 Nov 25;15(1):45324
Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.
Wang X, Zhu L, Du R, Li A, Li N, Liu X, Zhang Y, Liu X, Wang Q, Han C, Qu C, Zou W, Liu J, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157378
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157378
Xiaoyao San and Guipi Tang, alone or combined, relieve postpartum depression via AGE‑RAGE‑mediated autophagy and apoptosis.
Li S, Guo Y, Zhang J, Zhang R, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157338
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157338
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Han L, Tang Z, Ma X, Zhang Q, Han Y, Wang Q, Liu J, Bian X, Gao L, Xu M, Sun X
International journal of molecular sciences 2025 Nov 18;26(22)
International journal of molecular sciences 2025 Nov 18;26(22)
Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer.
Zhang W, Gai Y, Qiao M, Rowicki M, Wei Y, Hang X, Wei Z, Yang H, Ye X, Ju H, Lu Y, Kang Y, Shen M
Signal transduction and targeted therapy 2025 Nov 18;10(1):373
Signal transduction and targeted therapy 2025 Nov 18;10(1):373
IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway.
Hu M, Wei E, Wu L, Pan X, Zhu Q, Xv X, Dong X, Wu W, Liu H, Liu Y
Journal of advanced research 2025 Nov 16;
Journal of advanced research 2025 Nov 16;
Calcitriol Modulates Hippocampal Axon Guidance Through Enhanced EfnA4-Mediated PI3K/AKT Signaling in an Autism Mouse Model.
Gong T, Sun R, Bai J, Liu X, He C, Jiang Q, Wang Q, Qi Y, Ding W, Shen J, Lei L, Shan Z
CNS neuroscience & therapeutics 2025 May;31(5):e70429
CNS neuroscience & therapeutics 2025 May;31(5):e70429
PTPRG-AS1 regulates the KITLG/KIT pathway through the ceRNA axis to promote the malignant progression of gastric cancer and the intervention effect of Compound Kushen injection on it.
Wu C, Gao Y, Jin Z, Huang Z, Wang H, Lu S, Guo S, Zhang F, Zhang J, Huang J, Tao X, Liu X, Zhang X, You L, Li Q, Wu J
Pharmacological research 2025 May;215:107743
Pharmacological research 2025 May;215:107743
Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro.
Fan W, Xu Z, Zhong M, Wu X, Chen P, Chen Z, Su W, Wu H, Li P
Cells 2025 May 8;14(10)
Cells 2025 May 8;14(10)
Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS.
Wei L, Bo L, Jiang W, Qi R, Luo C, Qian F, Ma P, Qiu J, Mao C
Cell death discovery 2025 May 27;11(1):255
Cell death discovery 2025 May 27;11(1):255
Lan-Qin oral liquid alleviates influenza A virus-induced acute lung injury by regulating monocyte-derived macrophages and TLR4-PI3K-AKT-NF-κB signal pathways.
Chen ZH, Li JJ, Liu CJ, Chen DJ, Yang YD, Xie TY, Liang WT, Tu XP, Shi W, Yang X, Chen ZF, Zhang FX
Journal of ethnopharmacology 2025 May 12;347:119787
Journal of ethnopharmacology 2025 May 12;347:119787
Recombinant neurotrophin-3 with the ability to penetrate the blood-brain barrier: A new strategy against Alzheimer's disease.
Ding X, Zuo Y, Liu Z, Sun Y, Wang L, Xie Y, Liu G, Liu C
International journal of biological macromolecules 2025 Mar;293:139359
International journal of biological macromolecules 2025 Mar;293:139359
Bioelectrically Reprogramming Hydrogels Rejuvenate Vascularized Bone Regeneration in Senescence.
Wu T, Ren M, Li Y, Yang Q, Xiang K, Liu F, Yang S
Advanced healthcare materials 2025 Mar;14(6):e2403837
Advanced healthcare materials 2025 Mar;14(6):e2403837
The YTHDF3-DT/miR-301a-3p /INHBA axis attenuates autophagy-dependent ferroptosis in lung adenocarcinoma.
Peng X, Yang R, Wang C, Peng W, Zhao Z, Shi S, Cai Q, He B, Wang L, Yu F, Wang X, Tao Y
Cancer letters 2025 Mar 31;613:217503
Cancer letters 2025 Mar 31;613:217503
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.
Shi XY, Wang XL, Zhao J, Yang SH, Zhang CH
World journal of clinical oncology 2025 Mar 24;16(3):100723
World journal of clinical oncology 2025 Mar 24;16(3):100723
Huafengdan Inhibits Glioblastoma Cell Growth and Mobility by Acting on PLAU and CAV1 Targets.
Lin D, Yu W, Yu J, Cheng S, Song Y, Wan X, Xu Y, Luo H, Sun B
Pharmaceuticals (Basel, Switzerland) 2025 Mar 18;18(3)
Pharmaceuticals (Basel, Switzerland) 2025 Mar 18;18(3)
Network pharmacology and experimental analysis reveal Ethyl caffeate delays osimertinib resistance in lung cancer by suppression of MET.
Sang S, Han Y, Zhou H, Kang X, Gong Y
Cancer cell international 2025 Mar 15;25(1):99
Cancer cell international 2025 Mar 15;25(1):99
Role of PI3K/AKT signaling pathway during capacitation.
Lee WJ, Jo JH, Uwamahoro C, Jang SI, Jung EJ, Bae JW, Moon J, Kim DH, Yi JK, Ha JJ, Oh DY, Kwon WS
Theriogenology 2025 Mar 15;235:94-102
Theriogenology 2025 Mar 15;235:94-102
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Chen H, Liu S, Xing J, Wen Y, Chen L
Bone & joint research 2025 Mar 14;14(3):245-258
Bone & joint research 2025 Mar 14;14(3):245-258
Sirt4 Overexpression Modulates the JAK2/STAT3 and PI3K/AKT/mTOR Axes to Alleviate Sepsis-Induced Acute Lung Injury.
Xie C, Wang T, Liu A, Huang B, Zeng W, Li Z, Peng S, Wu S
Cell biochemistry and biophysics 2025 Jun;83(2):1785-1798
Cell biochemistry and biophysics 2025 Jun;83(2):1785-1798
Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance.
Park S, Kim H, Shin S, Kim Y, Kang Y, Cha HN, Park SY, Park S, Oh CM
Experimental & molecular medicine 2025 Jun;57(6):1177-1188
Experimental & molecular medicine 2025 Jun;57(6):1177-1188
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
Tu M, Liu AM, Huang W, Wang D, Chen HQ, Hu XY
Journal of cell communication and signaling 2025 Jun;19(2):e70008
Journal of cell communication and signaling 2025 Jun;19(2):e70008
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
Lu S, Xiong W, Yi J, Liu S, Zhang F
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119937
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119937
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway.
Wang P, Ma Y, Rao X, Luo Q, Xiao X, Wang T, Long F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156701
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156701
Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from In Vitro and In Vivo Studies.
Li T, Shen X, Zhang T, Ren J, Wang W, Wang D, Zhang P
Journal of clinical and translational hepatology 2025 Jun 28;13(6):469-483
Journal of clinical and translational hepatology 2025 Jun 28;13(6):469-483
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments.
Zhang L, Xu SY, Shi MY, Wang H, Ding J, Tong JB, Zhu J, Li ZG, Yang QJ
International immunopharmacology 2025 Jun 17;158:114822
International immunopharmacology 2025 Jun 17;158:114822
Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway.
Chen Y, Luo C, Zhan Z, Liu S, Teng C, Mao R, Zhang S, Zhang X, Meng Q, Zhong R, Chen L, Zhang H
Journal of animal science and biotechnology 2025 Jun 13;16(1):84
Journal of animal science and biotechnology 2025 Jun 13;16(1):84
Podophyllum hexandrum Royle mitigates perimenopausal symptoms in an OVX rat model by activating the PI3K/AKT/mTOR pathway and enhancing estrogen receptor expression.
Tan CC, Cao SJ, Chao WH, Zhang B, Deng XY, Wang LN, Kang N, Qiu F
Journal of ethnopharmacology 2025 Jun 12;349:119968
Journal of ethnopharmacology 2025 Jun 12;349:119968
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets.
Hao Z, Yan M, Tuerhong R, Zhang L, Zhang Z, Alam H, Wu J, Qin Y, Zhao F, Shi L
Journal of advanced research 2025 Jul;73:517-533
Journal of advanced research 2025 Jul;73:517-533
Quinolinone Derivatives Suppress Angiogenesis in Human Umbilical Vein Endothelial Cells by Blocking the VEGF-Induced VEGFR2 Signaling Pathway.
Lin X, Chen B, Xiao X, Wang R, Yao W, Li A
Archiv der Pharmazie 2025 Jul;358(7):e70040
Archiv der Pharmazie 2025 Jul;358(7):e70040
Pedunculoside regulates the differentiation of neural stem cells into neurons via the PI3K/AKT/GSK-3β pathway.
Jiang R, Wang Y, Shen Y, Tang J, Tang X, Ma H, Yi P
Journal of pharmacological sciences 2025 Jul;158(3):276-282
Journal of pharmacological sciences 2025 Jul;158(3):276-282
T-cell differentiation stage block bias confers hypermethylation and mediastinal preference in T-cell lymphoblastic lymphoma.
Wang J, Qian B, Yu X, Zhang Y, Zhou C, Yang T, Xia L, Zhang G, Zhang YX, Wang Y, Fang Y
Clinical and translational medicine 2025 Jul;15(7):e70380
Clinical and translational medicine 2025 Jul;15(7):e70380
The dual mechanism of m(6)A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR.
Sun X, Tan Q, Yang Y, Wei J, Zhou X, Gao S, Yang F
Cell death & disease 2025 Jul 3;16(1):489
Cell death & disease 2025 Jul 3;16(1):489
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR.
Peng Q, Sun Y, Wang R, Zhang S, Hu L, Teng Y, Zhu X
Scientific reports 2025 Jul 28;15(1):27439
Scientific reports 2025 Jul 28;15(1):27439
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation.
Liu X, Liu L, Ren X, Chen Y, Yin M, Xie H, Sun T, Tan Y, Wang S, Xu D, Tang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156919
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156919
The efficacy and pharmacological mechanism of Guilingji to prevent Alzheimer's disease.
Hu F, Lei Y, Han R, Yang B, Liang Y, Luan J, Zhang B, Wang S, Gou X
Alzheimer's research & therapy 2025 Jul 14;17(1):157
Alzheimer's research & therapy 2025 Jul 14;17(1):157
Schisandrin A ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis.
Ma G, Lei M, Guo S, Zhang Y, Sun Y, Ji H, Ouyang C, Yang X, Zhang Y, Liu X, Zhao B, Guo X
Acta biochimica et biophysica Sinica 2025 Jul 1;57(10):1647-1659
Acta biochimica et biophysica Sinica 2025 Jul 1;57(10):1647-1659
In-Depth Examination of TPBG as a New Predictive Indicator for Gastric Cancer.
Yang L, Weng C, Zhang Y, Zhao Y, Chen K, Li G, Zhong X, He C
Journal of cellular and molecular medicine 2025 Jan;29(2):e70354
Journal of cellular and molecular medicine 2025 Jan;29(2):e70354
Single-cell analysis combined with transcriptome sequencing identifies autophagy hub genes in macrophages after spinal cord injury.
Ju C, Liu R, Ma Y, Dong H, Xu R, Hu H, Hao D
Clinical immunology (Orlando, Fla.) 2025 Jan;270:110412
Clinical immunology (Orlando, Fla.) 2025 Jan;270:110412
Vitamin A enhances PI3K/Akt signaling and mitigates enterocyte apoptosis in a mouse model of necrotizing enterocolitis.
Su Q, Chen L, Liu D, Xu Y, Feng J, Yu J, Zhang Z, Yu Z
Pediatric surgery international 2025 Jan 8;41(1):61
Pediatric surgery international 2025 Jan 8;41(1):61
BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation.
Xu J, Li C, Fan R, Yin J, Xie L, Peng X, Tao J, Xu W, Zhang S, Shi X, Dong K, Yu X, Chen X, Yang Y
Cell communication and signaling : CCS 2025 Jan 6;23(1):7
Cell communication and signaling : CCS 2025 Jan 6;23(1):7
Integrative multi-omics and network pharmacology reveal the mechanisms of Fangji Huangqi Decoction in treating IgA nephropathy.
Liu T, Zhuang XX, Zheng WJ, Gao JR
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118996
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118996
Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K/AKT signaling pathway.
Cui X, Zhang R, Li Y, Li P, Liu Y, Yu X, Zhou J, Wang L, Tian X, Li H, Zhang S, Lan T, Li X, Zhang G, Li J, Liu Z
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118910
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118910
Characteristics of different lipid droplet-mitochondrial contacts patterns during lipid droplet metabolism in T2DM-induced MASLD.
Xu Y, Zhang Y, Sun W, Tang Q, Feng W, Xiao H, Wang J, Yuan X, Xiang M, Gao Y, Zhang H, Lu J
Scientific reports 2025 Jan 27;15(1):3399
Scientific reports 2025 Jan 27;15(1):3399
GLP-1/GIP dual agonist tirzepatide normalizes diabetic nephropathy via PI3K/AKT mediated suppression of oxidative stress.
Tian Y, Tian R, Juan H, Guo Y, Yan P, Cheng Y, Li R, Wang B
International immunopharmacology 2025 Jan 27;146:113877
International immunopharmacology 2025 Jan 27;146:113877
Icaritin alleviates motor impairment and osteoporosis in Parkinson's disease mice via the ER-PI3K/Akt pathway.
Lin X, Zhou X, Liu X, Xia L, Cai J, Huang N, Luo Y, Wu W
Scientific reports 2025 Jan 25;15(1):3190
Scientific reports 2025 Jan 25;15(1):3190
Downregulation of the PI3K/AKT/mTOR/MMP-13 pathway for promoting interface healing via lubricating microspheres.
Yao S, Yuan H, Yang L, Zhang Y, Wang H, Li R, Ye T, Cui W, Wang L
Acta biomaterialia 2025 Jan 24;193:291-304
Acta biomaterialia 2025 Jan 24;193:291-304
Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Qu X, Yang P, Jiao L, Yin Y
Frontiers in bioscience (Landmark edition) 2025 Jan 20;30(1):25565
Frontiers in bioscience (Landmark edition) 2025 Jan 20;30(1):25565
Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.
Yang M, Zheng S, Zeng W, Zhan C, Yang Y, Yang F
Journal of toxicology and environmental health. Part A 2025 Jan 10;:1-9
Journal of toxicology and environmental health. Part A 2025 Jan 10;:1-9
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Non-starch polysaccharides from Castanea mollissima Bl. ameliorate metabolic syndrome by remodeling barrier function, microbial community, and metabolites in high-fat-diet/streptozotocin-induced diabetic mice.
Peng F, Yu Z, Du B, Niu K, Yu X, Wang S, Yang Y
Food research international (Ottawa, Ont.) 2025 Feb;202:115638
Food research international (Ottawa, Ont.) 2025 Feb;202:115638
Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation.
Tan K, Deng J, Liu Y, Zhang Y, Xiong Y, Yuan S, Liu J, Chen Z, Liu Y, Cao W
Scientific reports 2025 Feb 4;15(1):4248
Scientific reports 2025 Feb 4;15(1):4248
Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection.
Zuo Y, Jin Y, Li G, Ming Y, Fan T, Pan Y, Yao X, Peng Y
Molecular cancer 2025 Feb 25;24(1):54
Molecular cancer 2025 Feb 25;24(1):54
Endoplasmic reticulum stress regulates intestinal motility in acute pancreatitis by regulating the expression and phosphorylation of nNOS through IRE1α/XBP1s-PI3K/Akt signaling axis.
Liu H, Cao J, Li X, Zhang C, Pan C, Liang S, Fang H, Liu Y
Cellular signalling 2025 Dec;136:112123
Cellular signalling 2025 Dec;136:112123
HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells.
Wei Y, Cheng T, Liu H, Ma Y, Liu H, Du Y, Deng S
Scientific reports 2025 Dec 24;16(1):3909
Scientific reports 2025 Dec 24;16(1):3909
Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway.
Cheng L, Wang B, Chen J, Qiao X, Jiang J, Sun Y
European journal of medical research 2025 Dec 18;31(1):121
European journal of medical research 2025 Dec 18;31(1):121
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.
Zhang X, Cui J, Sun J, Fan B, Wang F, Lu C
International journal of molecular sciences 2025 Dec 16;26(24)
International journal of molecular sciences 2025 Dec 16;26(24)
BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells.
Wang Y, Mu N, Wang X, Liu J, Qu Y, Liu X, Su L
Cell communication and signaling : CCS 2025 Dec 15;23(1):528
Cell communication and signaling : CCS 2025 Dec 15;23(1):528
Inhibition of ALOX5-dependent ferroptosis by 6-C-methylquercetin: a potential therapeutic approach for alleviating rheumatoid arthritis.
Jia B, Zhou S, Liu M, Zhang M, Jiang X, Guo X, Bi Y
Free radical biology & medicine 2025 Dec 1;240:153-169
Free radical biology & medicine 2025 Dec 1;240:153-169
An Extensive Analysis of Artemisia integrifolia Linn. on T2DM: Investigating Glycolipid Metabolism, Metabolic Profiling, and Molecular Docking for Potential Functional Food Applications.
Liu M, Su F, He Y, Sun M, Bai C, Zhang W, Li B, Sun Y, Wang Q, Kuang H
Foods (Basel, Switzerland) 2025 Aug 24;14(17)
Foods (Basel, Switzerland) 2025 Aug 24;14(17)
Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression.
Xing C, Hu W, Zhao L
Journal of translational medicine 2025 Aug 21;23(1):950
Journal of translational medicine 2025 Aug 21;23(1):950
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
Li N, Liu X, Wang Q, Chen Y, Han C, Qu C, Guan X, Zou W, Wang X, Li A, Zhang Y, Zhu L, Du R, Liu J, Wang Y
Stem cell research & therapy 2025 Aug 2;16(1):419
Stem cell research & therapy 2025 Aug 2;16(1):419
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes.
Zhuang S, Liu S, Li R, Duan H
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):104-113
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):104-113
Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice.
Tao X, Chen H, Zhu Z, Ren T, Zhen H, Sun X, Song Y, Xu X, Song Z, Liu J
International journal of biological macromolecules 2025 Apr;300:140289
International journal of biological macromolecules 2025 Apr;300:140289
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.
Xiao Y, Luo T, Duan C, Wang X, Yang Y, Li R, Deng J, Zhao Q
Journal of ethnopharmacology 2025 Apr 9;345:119578
Journal of ethnopharmacology 2025 Apr 9;345:119578
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.
Liu S, Zhuang S, Li R, Duan H
Diabetology & metabolic syndrome 2025 Apr 9;17(1):122
Diabetology & metabolic syndrome 2025 Apr 9;17(1):122
Comparison of the effects between catalase and superoxide dismutase on regulating macrophage inflammatory response and protecting osteogenic function of periodontal ligament cells.
Zhu B, Song L, Li M, Cheng M, Tang W, Miao L
Biochemical and biophysical research communications 2025 Apr 5;756:151523
Biochemical and biophysical research communications 2025 Apr 5;756:151523
Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway.
Li Z, Lin K, Wang Y, Mao J, Yin Y, Li Z, Wang F, Zeng X, Li Q, Wang X, Li Z, Miao R, Lin C, Mao C
International immunopharmacology 2025 Apr 4;151:114352
International immunopharmacology 2025 Apr 4;151:114352
Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32.
Guo X, Liu S, Wu X, Yang R, Ren Q, Zhou Y, Shi K, Yuan L, Zhang N, Liu S
The Journal of pharmacy and pharmacology 2025 Apr 3;77(4):550-563
The Journal of pharmacy and pharmacology 2025 Apr 3;77(4):550-563
The Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) 3 Regulates the Myogenic Differentiation of Yunan Black Pig Muscle Satellite Cells (MuSCs) In Vitro via Iron Homeostasis and the PI3K/AKT Pathway.
Zhang W, Zhang M, Zhang J, Chen S, Zhang K, Xie X, Guo C, Shen J, Zhang X, Sun H, Guo L, Wen Y, Wang L, Hu J
Cells 2025 Apr 29;14(9)
Cells 2025 Apr 29;14(9)
Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway.
Wu X, Su D, Xu J, Ge G, Zhang Y, Wu B, Hu K, Ren J, Yang H
Journal of agricultural and food chemistry 2025 Apr 23;73(16):9677-9689
Journal of agricultural and food chemistry 2025 Apr 23;73(16):9677-9689
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Chen Q, Hu Q, Zhang F, Lu W, Yuan Z, Qiao F
Hereditas 2025 Apr 12;162(1):59
Hereditas 2025 Apr 12;162(1):59
Oroxylin A may promote cell apoptosis and inhibit epithelial-mesenchymal transition in endometrial cancer, associated with the ERβ/PI3K/AKT pathway.
Fan X, Wu L, Cheng T, Lv W, Tian J, Tao J, Tu S, Tan F, Wang Y
Scientific reports 2025 Apr 10;15(1):12225
Scientific reports 2025 Apr 10;15(1):12225
Prenyl diphosphate synthase subunit 2 is downregulated in abdominal aortic aneurysm and retards the progression of abdominal aortic aneurysm.
Yong J, Tang S, Yu L, Li M, Zhang F, Fan X
CytoJournal 2024;21:63
CytoJournal 2024;21:63
ETS1-mediated Regulation of SOAT1 Enhances the Malignant Phenotype of Oral Squamous Cell Carcinoma and Induces Tumor-associated Macrophages M2-like Polarization.
Liu Y, Shen L, Li Y, Sun X, Liang L, Jiang S, Zhang Z, Tang X, Tao Y, Xie L, Jiang Y, Cong L
International journal of biological sciences 2024;20(9):3372-3392
International journal of biological sciences 2024;20(9):3372-3392
Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway.
Zhao M, Feng L, Li W
Drug design, development and therapy 2024;18:4529-4550
Drug design, development and therapy 2024;18:4529-4550
Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke.
Yao Y, Hu L, Li D, Wang Y, Pan J, Fan D
Frontiers in neuroscience 2024;18:1520710
Frontiers in neuroscience 2024;18:1520710
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Zhou S, Zheng L, Zheng T, Zhan H, Lin Q, Wei J, Huang Y
Frontiers in pharmacology 2024;15:1447249
Frontiers in pharmacology 2024;15:1447249
Research on the metabolic regulation mechanism of Yangyin Qingfei decoction plus in severe pneumonia caused by Mycoplasma pneumoniae in mice.
Zhang T, Zhao X, Zhang X, Liang X, Guan Z, Wang G, Liu G, Wu Z
Frontiers in pharmacology 2024;15:1376812
Frontiers in pharmacology 2024;15:1376812
Material basis and molecular mechanisms of Chaihuang Qingyi Huoxue Granule in the treatment of acute pancreatitis based on network pharmacology and molecular docking-based strategy.
Yang J, Jiang YH, Zhou X, Yao JQ, Wang YY, Liu JQ, Zhang PC, Tang WF, Li Z
Frontiers in immunology 2024;15:1353695
Frontiers in immunology 2024;15:1353695
The small protein LINC01547-ORF inhibits colorectal cancer progression by regulating the CLDN18-FAK-AKT axis.
Zhang S, Xu S, Li D, Wu S, Han M, Han Y, Wang Z, Qiao D, Yuan H, Du B, Chen H, Zhang Z
American journal of cancer research 2024;14(11):5504-5520
American journal of cancer research 2024;14(11):5504-5520
Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway.
Ding Y, Li H, Cao S, Yu Y
Toxicology and applied pharmacology 2024 Sep;490:117036
Toxicology and applied pharmacology 2024 Sep;490:117036
Effects of oridonin on sperm function and the PI3K/PDK1/AKT signaling pathway: Implications for reproductive toxicity.
Hwang JM, Lee WJ, Jo JH, Uwamahoro C, Jang SI, Jung EJ, Bae JW, Kim DH, Yi JK, Ha JJ, Oh DY, Kwon WS
Reproductive toxicology (Elmsford, N.Y.) 2024 Sep;128:108659
Reproductive toxicology (Elmsford, N.Y.) 2024 Sep;128:108659
Dihydroartemisinin ameliorates experimental autoimmune myasthenia gravis by regulating CD4(+) T cells and modulating gut microbiota.
Li Y, Shan Y, Xu L, Chen W, Li Y
International immunopharmacology 2024 Sep 30;139:112699
International immunopharmacology 2024 Sep 30;139:112699
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Liu Z, Zhang Z, Tang R, Liu J, Yang Y
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Duan ZW, Liu Y, Zhang PP, Hu JY, Mo ZX, Liu WQ, Ma X, Zhou XH, Wang XH, Hu XH, Wei SL
Journal of ethnopharmacology 2024 Sep 15;331:118293
Journal of ethnopharmacology 2024 Sep 15;331:118293
An inulin-type polysaccharide from Atractylodis Macrocephalae Rhizoma can relieve psoriasis.
Tang X, Liu L, Wu Y, Zhao Y, Lu C, Zhao R
International journal of biological macromolecules 2024 Sep 14;280(Pt 1):135667
International journal of biological macromolecules 2024 Sep 14;280(Pt 1):135667
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Cao Z, Ma N, Shan M, Wang S, Du J, Cheng J, Sun P, Sun N, Jin L, Fan K, Yin W, Li H, Yin C, Sun Y
International journal of molecular sciences 2024 Sep 14;25(18)
International journal of molecular sciences 2024 Sep 14;25(18)
Maternal Gestational Diabetes Mellitus and High-Fat Diet Influenced Hepatic Polyunsaturated Fatty Acids Profile in the Offspring of C57BL/6J Mice.
Gong J, Xu W, Chen Y, Chen S, Wu Y, Chen Y, Li Y, He Y, Yu H, Xie L
Molecular nutrition & food research 2024 Oct;68(19):e2400386
Molecular nutrition & food research 2024 Oct;68(19):e2400386
Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway.
Mo RL, Li Z, Zhang P, Sheng MH, Han GC, Sun DQ
Naunyn-Schmiedeberg's archives of pharmacology 2024 Oct;397(10):8129-8143
Naunyn-Schmiedeberg's archives of pharmacology 2024 Oct;397(10):8129-8143
The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation.
Zhou Q, Guo X, Chen T, Liu Y, Ji H, Sun Y, Yang X, Ouyang C, Liu X, Lei M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117397
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117397
Network pharmacology, molecular docking, and untargeted metabolomics reveal molecular mechanisms of multi-targets effects of Qingfei Tongluo Plaster improving respiratory syncytial virus pneumonia.
Yang M, Zhang X, Liu Q, Wang Y
Chinese herbal medicines 2024 Oct;16(4):638-655
Chinese herbal medicines 2024 Oct;16(4):638-655
Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway.
Wang H, Wei Z, Xu C, Fang F, Wang Z, Zhong Y, Wang X
Scientific reports 2024 Oct 21;14(1):24787
Scientific reports 2024 Oct 21;14(1):24787
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation.
Chen Y, Jin H, Ali W, Zhuang T, Sun J, Wang T, Song J, Ma Y, Yuan Y, Bian J, Liu Z, Zou H
Poultry science 2024 Nov;103(11):104152
Poultry science 2024 Nov;103(11):104152
Spatial organization of PI3K-PI(3,4,5)P(3)-AKT signaling by focal adhesions.
Wang J, An Z, Wu Z, Zhou W, Sun P, Wu P, Dang S, Xue R, Bai X, Du Y, Chen R, Wang W, Huang P, Lam SM, Ai Y, Liu S, Shui G, Zhang Z, Liu Z, Huang J, Fang X, He K
Molecular cell 2024 Nov 21;84(22):4401-4418.e9
Molecular cell 2024 Nov 21;84(22):4401-4418.e9
Babaodan inhibits cell proliferation and metastasis and enhances anti-tumor effects of camrelizumab by inhibiting M2 phenotype macrophages in hepatocellular carcinoma.
Liu C, Lin X, Huang M, Zhang S, Che L, Lai Z, Chen X, Pu W, Yang S, Qiu Y, Yu H
Journal of ethnopharmacology 2024 Nov 15;334:118540
Journal of ethnopharmacology 2024 Nov 15;334:118540
Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.
Guo X, Lei M, Ma G, Ouyang C, Yang X, Liu C, Chen Q, Liu X
Molecular neurobiology 2024 May;61(5):2514-2529
Molecular neurobiology 2024 May;61(5):2514-2529
Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Deng B, Jiang S, Liu G, Li X, Zhao Y, Fan X, Ren J, Ning C, Xu L, Ji L, Mu X
Journal of materials chemistry. B 2024 May 8;12(18):4409-4426
Journal of materials chemistry. B 2024 May 8;12(18):4409-4426
Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Yang X, Zhang J, Li Y, Hu H, Li X, Ma T, Zhang B
Journal of ethnopharmacology 2024 May 23;326:117918
Journal of ethnopharmacology 2024 May 23;326:117918
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Fu Y, Yuan P, Zeng M, Zhang Q, Hou Y, Gao L, Wei Y, Zheng Y, Feng W, Zheng X
Heliyon 2024 May 15;10(9):e29807
Heliyon 2024 May 15;10(9):e29807
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation.
Hwang JM, Bae JW, Lee WJ, Kwon WS
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108545
Reproductive toxicology (Elmsford, N.Y.) 2024 Mar;124:108545
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Zhang Y, Wang X, Liu W, Lei T, Qiao T, Feng W, Song W
Journal of translational medicine 2024 Mar 8;22(1):251
Journal of translational medicine 2024 Mar 8;22(1):251
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
Huang Y, Wu Z, Peng Z, Liu A, Yuan W, Han D, Peng J
BMC cancer 2024 Mar 18;24(1):345
BMC cancer 2024 Mar 18;24(1):345
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L
Cell death and differentiation 2024 Jun;31(6):722-737
Cell death and differentiation 2024 Jun;31(6):722-737
Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway.
Zheng W, Ao D, Cao Q, Liu A, Lv M, Sun Z, Zhang H, Zheng W, Chen N, Zhu J
International journal of biological macromolecules 2024 Jun;269(Pt 1):132018
International journal of biological macromolecules 2024 Jun;269(Pt 1):132018
Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway.
Duan Z, Chen H, Miao W, He J, Xu D, Qi Z, Yang L, Jia W, Wu C
Journal of cell communication and signaling 2024 Jun;18(2):e12023
Journal of cell communication and signaling 2024 Jun;18(2):e12023
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury.
Gu N, Yan J, Tang W, Zhang Z, Wang L, Li Z, Wang Y, Zhu Y, Tang S, Zhong J, Cheng C, Sun X, Huang Z
Journal of neuroinflammation 2024 Jun 4;21(1):147
Journal of neuroinflammation 2024 Jun 4;21(1):147
Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.
Wang T, Liao H, Lin J, Zhang M, Chen B, Yin R, Sun J, Dai H, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155575
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155575
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
Wu J, Wang C, Sun S, Ren T, Pan L, Liu H, Hou S, Wu S, Yan X, Zhang J, Zhao X, Liu W, Zhu S, Wei S, Zhang C, Jia X, Zhang Q, Yu Z, Zhuo Y, Zhao Q, Yang C, Wang N
Protein & cell 2024 Jul 20;15(8):594-611
Protein & cell 2024 Jul 20;15(8):594-611
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway.
Xu Y, Jia K, Zhao X, Li Y, Zhang Z
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23594
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23594
Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway.
Zeng J, Pei H, Wu H, Chen W, Du R, He Z
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23544
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23544
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Wei X, Ni J, Yuan L, Li X
Oncology letters 2024 Jan;27(1):17
Oncology letters 2024 Jan;27(1):17
Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.
Wang H, Wang G, Meng Y, Liu Y, Yao X, Feng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211
Liensinine alleviates mouse intestinal injury induced by sepsis through inhibition of oxidative stress, inflammation, and cell apoptosis.
Wang G, Ma F, Xie K, Li X, Tan X, Xia Y, Wang Y, Dong J
International immunopharmacology 2024 Jan 25;127:111335
International immunopharmacology 2024 Jan 25;127:111335
Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway.
Jung EJ, Jo JH, Uwamahoro C, Jang SI, Lee WJ, Hwang JM, Bae JW, Kwon WS
Toxics 2024 Jan 15;12(1)
Toxics 2024 Jan 15;12(1)
RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP.
Lin P, Qian J, Huang CC, Xu WM, Wang YY, Gao ZR, Zheng SQ, Wang P, Jia DQ, Feng Q, Yang JL
BMC cancer 2024 Jan 12;24(1):71
BMC cancer 2024 Jan 12;24(1):71
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway.
Han S, Yuan X, Zhao F, Manyande A, Gao F, Wang J, Zhang W, Tian X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Feb;73(2):157-174
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Feb;73(2):157-174
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Lin S, Chen Z, Wu Z, Fei F, Xu Z, Tong Y, Sun W, Wang P
Neurochemical research 2024 Feb;49(2):477-491
Neurochemical research 2024 Feb;49(2):477-491
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Zheng X, Chen J, Deng M, Ning K, Peng Y, Liu Z, Li X, Zhou Z, Tang H, Li Y, Kang T, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.
Wang X, Zhang Y, Yu J, Ma Y, Xu Y, Shi J, Qi Z, Liu X
BMC genomics 2024 Feb 3;25(1):139
BMC genomics 2024 Feb 3;25(1):139
The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells.
Zhang L, Deng M, Liu J, Zhang J, Wang F, Yu W
BMC infectious diseases 2024 Feb 20;24(1):230
BMC infectious diseases 2024 Feb 20;24(1):230
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Polyphyllin II inhibits breast cancer cell proliferation via the PI3K/Akt signaling pathway.
Miao W, Wang Z, Gao J, Ohno Y
Molecular medicine reports 2024 Dec;30(6)
Molecular medicine reports 2024 Dec;30(6)
Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis.
Yao T, Wu Y, Fu L, Lv J, Lv L, Li L
Microbiological research 2024 Dec;289:127927
Microbiological research 2024 Dec;289:127927
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Liu W, Dou C, Zhang C, Chen P, Zhang S, Wang R, Han Q, Zhao H, Li D
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Spatial dimension cues derived from fibrous scaffolds trigger mechanical activation to potentiate the paracrine and regenerative functions of MSCs via the FAK-PI3K/AKT axis.
Xu S, Zhang M, Wang R, Zhang J, Wang C, Xie L, Zhao W
Acta biomaterialia 2024 Dec;190:273-292
Acta biomaterialia 2024 Dec;190:273-292
Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation.
Zhang Y, Li B, Fu Y, Cai H, Zheng Y
Cellular signalling 2024 Dec;124:111469
Cellular signalling 2024 Dec;124:111469
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.
Gu Z, Ding W, Yuan S, Peng Y, Dong B, Gu Y, Li J, Chen Y, Wang K, Liu T, Han X, Li Y
Cellular signalling 2024 Dec;124:111443
Cellular signalling 2024 Dec;124:111443
ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/PI3K/AKT pathway in ovarian cancer.
Ji Z, Li X, Gao W, Xia Q, Li J
Cellular signalling 2024 Dec;124:111404
Cellular signalling 2024 Dec;124:111404
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Li J, Tian Z, Zhang T, Jin J, Zhang X, Xie P, Lin H, Gu J, Wu Y, Wang X, Zhang S, Yan X, Guo D, Wang Z, Zhang Q
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Cellular & molecular biology letters 2024 Dec 3;29(1):148
The Mitochondrial Fusion Promoter M1 Mitigates Cigarette Smoke-Induced Airway Inflammation and Oxidative Stress via the PI3K-AKT Signaling Pathway.
Zeng T, Liu L, Xu D, Wang T, Wu Y, Qin J, Gao L, Chen M, Li X, Li D, Chen J, Shen Y, Wen F
Lung 2024 Dec 3;203(1):12
Lung 2024 Dec 3;203(1):12
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Qiu H, Gao L, Shi W, Wang J, Li B, Ke S, Chen J, Gong Y, Wu Y, Zhao W, Chen Y
Cancer letters 2024 Dec 16;611:217401
Cancer letters 2024 Dec 16;611:217401
A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway.
Zhang T, Pan W, Tan X, Yu J, Cheng S, Wei S, Fan K, Wang L, Luo H, Hu X
Biochemical pharmacology 2024 Aug;226:116398
Biochemical pharmacology 2024 Aug;226:116398
Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus.
Wu Q, Yu S, Zang S, Peng K, Wang Z
Heliyon 2024 Aug 30;10(16):e36131
Heliyon 2024 Aug 30;10(16):e36131
DDX19A promotes gastric cancer cell proliferation and migration by activating the PI3K/AKT pathway.
Cheng Y, Lu Y, Xue J, Wang X, Zhou L, Luo Y, Li Y
Cancer cell international 2024 Aug 3;24(1):272
Cancer cell international 2024 Aug 3;24(1):272
Lactate Oxidase Disrupts Lactate-Activated RAS and PI3K Oncogenic Signaling.
Keller CR, Martinez SR, Keltz A, Chen M, Li W
Cancers 2024 Aug 10;16(16)
Cancers 2024 Aug 10;16(16)
Oleanolic acid alleviates obesity-induced skeletal muscle atrophy via the PI3K/Akt signaling pathway.
Sun Y, Wei X, Zhao T, Shi H, Hao X, Wang Y, Zhang H, Yao Z, Zheng M, Ma T, Fu T, Lu J, Luo X, Yan Y, Wang H
FEBS open bio 2024 Apr;14(4):584-597
FEBS open bio 2024 Apr;14(4):584-597
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Deng JW, Yuan S, Shi LP, Chen X, Liu J, Chen ZW, Tan KY, Yang Q, Cao WF
Journal of ethnopharmacology 2024 Apr 6;323:117730
Journal of ethnopharmacology 2024 Apr 6;323:117730
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Yu JR, Liu YY, Gao YY, Qian LH, Qiu JL, Wang PP, Zhang GJ
Journal of ethnopharmacology 2024 Apr 24;324:117791
Journal of ethnopharmacology 2024 Apr 24;324:117791
Nerve Growth Factor/Tyrosine Kinase A Receptor Pathway Enhances Analgesia in an Experimental Mouse Model of Bone Cancer Pain by Increasing Membrane Levels of δ-Opioid Receptors.
Kan BF, Liu XY, Han MM, Yang CW, Zhu X, Jin Y, Wang D, Huang X, Wu WJ, Fu T, Kang F, Zhang Z, Li J
Anesthesiology 2024 Apr 1;140(4):765-785
Anesthesiology 2024 Apr 1;140(4):765-785
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Cao T, Wang L, Jiao S, Chen H, Lin C, Zhang B, Cai H
Neuropsychobiology 2023;82(6):346-358
Neuropsychobiology 2023;82(6):346-358
Inhibitory Effect of Hernandezine on the Proliferation of Hepatocellular Carcinoma.
Kuok C, Wang Q, Fong P, Qin Y, Meng L
Biological & pharmaceutical bulletin 2023;46(2):245-256
Biological & pharmaceutical bulletin 2023;46(2):245-256
Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury.
Sui X, Xie T, Xu Y, Zhang A, Zhang Y, Gu F, Li L, Xu Z, Chen J
Mediators of inflammation 2023;2023:5007488
Mediators of inflammation 2023;2023:5007488
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T
International journal of biological sciences 2023;19(14):4672-4688
International journal of biological sciences 2023;19(14):4672-4688
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Huang Y, Zhang Y, Wu Y, Xiang Q, Yu R
Drug design, development and therapy 2023;17:237-260
Drug design, development and therapy 2023;17:237-260
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
Zhang P, Huang Q, Liao P, Sun S, Yang J
American journal of translational research 2023;15(6):3900-3911
American journal of translational research 2023;15(6):3900-3911
PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN.
Wang X, Xu W, Zhu C, Cheng Y, Qi J
Journal of Cancer 2023;14(15):2833-2844
Journal of Cancer 2023;14(15):2833-2844
Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments.
Zhu M, He Q, Wang Y, Duan L, Rong K, Wu Y, Ding Y, Mi Y, Ge X, Yang X, Yu Y
Frontiers in pharmacology 2023;14:1238841
Frontiers in pharmacology 2023;14:1238841
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Ma L, La X, Zhang B, Xu W, Tian C, Fu Q, Wang M, Wu C, Chen Z, Chang H, Li JA
Frontiers in endocrinology 2023;14:1190827
Frontiers in endocrinology 2023;14:1190827
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats.
Guo X, Lei M, Zhao J, Wu M, Ren Z, Yang X, Ouyang C, Liu X, Liu C, Chen Q
Frontiers in pharmacology 2023;14:1146960
Frontiers in pharmacology 2023;14:1146960
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E(2) /ERβ signaling pathways.
Lyu Y, Wei X, Yang X, Li J, Wan G, Wang Y, Hao Z, Lu Y, Guo J, Shi J
Phytotherapy research : PTR 2023 Sep;37(9):4149-4165
Phytotherapy research : PTR 2023 Sep;37(9):4149-4165
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Huang B, Lu Y, Ni Z, Liu J, He Y, An H, Ye F, Shen J, Lin M, Chen Y, Lin J
Cancer gene therapy 2023 Sep;30(9):1260-1273
Cancer gene therapy 2023 Sep;30(9):1260-1273
Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer.
Zhou B, Yang Y, Pang X, Shi J, Jiang T, Zheng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115071
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115071
The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway.
Lee WJ, Jo JH, Jang SI, Jung EJ, Hwang JM, Bae JW, Ha JJ, Kim DH, Kwon WS
Reproductive toxicology (Elmsford, N.Y.) 2023 Sep;120:108426
Reproductive toxicology (Elmsford, N.Y.) 2023 Sep;120:108426
DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.
Li J, Zhang Y, Ye F, Qian P, Qin Z, Li D, Ye L, Feng L
Cancers 2023 Sep 27;15(19)
Cancers 2023 Sep 27;15(19)
Enterovirus D68 capsid formation and stability requires acidic compartments.
Galitska G, Jassey A, Wagner MA, Pollack N, Miller K, Jackson WT
mBio 2023 Oct 31;14(5):e0214123
mBio 2023 Oct 31;14(5):e0214123
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway.
Lei M, Guo X, Yao Y, Shu T, Ren Z, Yang X, Ouyang C, Chen Q, Liu C, Liu X
Experimental gerontology 2023 Oct 15;182:112307
Experimental gerontology 2023 Oct 15;182:112307
Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.
Li M, Xiu L, Liao W, Ren Y, Huo M, Liu H, Chen S, Li N, Gao Y, Yu X, Fan A, Zhong G
Journal of ethnopharmacology 2023 Nov 15;316:116750
Journal of ethnopharmacology 2023 Nov 15;316:116750
Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathway†.
Ma N, Liu B, Jin Y, Wang J, Qin W, Zheng F, Qin R, Li J, Hang F, Qin A
Biology of reproduction 2023 Nov 15;109(5):736-748
Biology of reproduction 2023 Nov 15;109(5):736-748
PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.
Zhang P, Jiang Y, Ye X, Zhang C, Tang Y
Experimental and therapeutic medicine 2023 May;25(5):223
Experimental and therapeutic medicine 2023 May;25(5):223
20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.
Zhang Q, Yang X, Liu J, Song J, Zhang S, Chen L, Zhang M
Food & function 2023 May 11;14(9):4191-4203
Food & function 2023 May 11;14(9):4191-4203
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose.
Yuan P, Zhang Q, Fu Y, Hou Y, Gao L, Wei Y, Feng W, Zheng X
Journal of natural medicines 2023 Mar;77(2):262-275
Journal of natural medicines 2023 Mar;77(2):262-275
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
Li Z, Zeng M, Geng K, Lai D, Xu Z, Zhou W
Molecules (Basel, Switzerland) 2023 Mar 16;28(6)
Molecules (Basel, Switzerland) 2023 Mar 16;28(6)
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.
Zhao F, Jiang H, Zhang T, Chen H, Li W, Li X, Wang P, Xu H
International journal of molecular sciences 2023 Mar 10;24(6)
International journal of molecular sciences 2023 Mar 10;24(6)
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer.
Li J, Cao X, Chu T, Lin K, Chen L, Lv J, Tan Y, Chen M, Li M, Wang K, Zheng Q, Li D
Pharmacological research 2023 Jan;187:106584
Pharmacological research 2023 Jan;187:106584
Anti-cervical cancer effects of Compound Yangshe granule through the PI3K/AKT pathway based on network pharmacology.
Ma C, Gu Y, Liu C, Tang X, Yu J, Li D, Liu J
Journal of ethnopharmacology 2023 Jan 30;301:115820
Journal of ethnopharmacology 2023 Jan 30;301:115820
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.
Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH
The Journal of clinical investigation 2023 Jan 3;133(1)
The Journal of clinical investigation 2023 Jan 3;133(1)
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Zhou XH, Cheng ZP, Lu M, Lin WY, Luo LL, Ming ZY, Hu Y
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Zhang L, Liu J, Deng M, Chen X, Jiang L, Zhang J, Tao L, Yu W, Qiu Y
Journal of translational medicine 2023 Feb 2;21(1):72
Journal of translational medicine 2023 Feb 2;21(1):72
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Wu M, Li R, Qin J, Wang Z, Guo J, Lv F, Wang G, Huang Y
Journal of molecular histology 2023 Dec;54(6):621-631
Journal of molecular histology 2023 Dec;54(6):621-631
Biochemical Toxicological Study of Insulin Overdose in Rats: A Forensic Perspective.
Bian C, He X, Wang Q, Zheng Z, Zhang Y, Xiong H, Li Y, Zhao M, Li J
Toxics 2023 Dec 23;12(1)
Toxics 2023 Dec 23;12(1)
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination.
Chen J, Li M, Chen R, Xu Z, Yang X, Gu H, Zhang L, Fu C, Zhang J, Wu Y
Chinese medicine 2023 Apr 27;18(1):46
Chinese medicine 2023 Apr 27;18(1):46
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Wang Y, Gao J, Sun L, Li Q, Kang N, Gao C, Li T
Journal of ethnopharmacology 2023 Apr 24;306:116180
Journal of ethnopharmacology 2023 Apr 24;306:116180
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Wang Y, Yuan Y, Wang C, Wang B, Zou W, Zhang N, Chen X
Frontiers in nutrition 2022;9:858261
Frontiers in nutrition 2022;9:858261
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Zhu X, Chen X, Wang G, Lei D, Chen X, Lin K, Li M, Lin H, Li D, Zheng Q
Biological & pharmaceutical bulletin 2022;45(8):1027-1035
Biological & pharmaceutical bulletin 2022;45(8):1027-1035
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Lou H, Zhang Y, Fang J, Jin Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells.
Zuo X, Wei X, Ju C, Wang X, Zhang Z, Ma Y, Zhu Z, Li X, Song Z, Luo L, Hu X, Wang Z
Oxidative medicine and cellular longevity 2022;2022:7223353
Oxidative medicine and cellular longevity 2022;2022:7223353
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Lv S, Wang L, Duan Y, Huang D, Yang D
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5764107
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5764107
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug design, development and therapy 2022;16:375-395
Drug design, development and therapy 2022;16:375-395
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1.
Yao E, Luo L, Lin C, Wen J, Li Y, Ren T, Chen Y, Huang J, Jin X
Frontiers in pharmacology 2022;13:964475
Frontiers in pharmacology 2022;13:964475
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
Dong Y, Zheng Y, Zhu L, Li T, Guan Y, Zhao S, Wang Q, Wang J, Li L
Frontiers in pharmacology 2022;13:896434
Frontiers in pharmacology 2022;13:896434
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Sun X, Chen Y, Tao X, Zhang W, Wang X, Wang X, Ruan Z, Chen Z
Frontiers in oncology 2022;12:983537
Frontiers in oncology 2022;12:983537
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Wang YN, Ye Y, Zhou D, Guo ZW, Xiong Z, Gong XX, Jiang SW, Chen H
Frontiers in cell and developmental biology 2022;10:852561
Frontiers in cell and developmental biology 2022;10:852561
lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway.
Liu L, Sun B, Zhang F, Zhong Z, Zhang Y, Li F, Zhang T, Khatib H, Wang X
Journal of agricultural and food chemistry 2022 Sep 28;70(38):12004-12013
Journal of agricultural and food chemistry 2022 Sep 28;70(38):12004-12013
Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease.
Pei H, Zeng J, Chen W, He Z, Du R
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23200
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23200
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Tu Y, Tan L, Lu T, Wang K, Wang H, Han B, Zhao Y, Chen H, Li Y, Chen H, Chen M, He C
Biochemical pharmacology 2022 Mar;197:114912
Biochemical pharmacology 2022 Mar;197:114912
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Ying J, Pan R, Tang Z, Zhu J, Ren P, Lou Y, Zhang E, Huang D, Hu P, Li D, Bao Q, Li P
Cancer medicine 2022 Mar;11(6):1454-1464
Cancer medicine 2022 Mar;11(6):1454-1464
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
Lu Y, Zhong W, Liu Y, Chen W, Zhang J, Zeng Z, Huang H, Qiao Y, Wan X, Meng X, Cai S, Dong H
International immunopharmacology 2022 Mar;104:108504
International immunopharmacology 2022 Mar;104:108504
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Cai J, Liang J, Zhang Y, Shen L, Lin H, Hu T, Zhan S, Xie M, Liang S, Xian M, Wang S
Pharmacological research 2022 Jun;180:106230
Pharmacological research 2022 Jun;180:106230
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Yu Y, Jiang L, Li J, Lei L, Li H
Journal of periodontology 2022 Jul;93(7):1036-1047
Journal of periodontology 2022 Jul;93(7):1036-1047
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Wang J, Luo X, Lu J, Wang X, Miao Y, Li Q, Wang L
Experimental cell research 2022 Jul 15;416(2):113179
Experimental cell research 2022 Jul 15;416(2):113179
Fu Brick Tea Manages HFD/STZ-Induced Type 2 Diabetes by Regulating the Gut Microbiota and Activating the IRS1/PI3K/Akt Signaling Pathway.
Qi B, Ren D, Li T, Niu P, Zhang X, Yang X, Xiao J
Journal of agricultural and food chemistry 2022 Jul 13;70(27):8274-8287
Journal of agricultural and food chemistry 2022 Jul 13;70(27):8274-8287
Combined exposure of lead and high-fat diet enhanced cognitive decline via interacting with CREB-BDNF signaling in male rats.
Liu R, Bai L, Liu M, Wang R, Wu Y, Li Q, Ba Y, Zhang H, Zhou G, Yu F, Huang H
Environmental pollution (Barking, Essex : 1987) 2022 Jul 1;304:119200
Environmental pollution (Barking, Essex : 1987) 2022 Jul 1;304:119200
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
Du X, Li C, Zhang S, Sun C, Zhang X, Chen C, Wang X, Cheng F, Wang Q
Journal of ethnopharmacology 2022 Feb 10;284:114507
Journal of ethnopharmacology 2022 Feb 10;284:114507
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration.
Sun D, Mou S, Chen L, Yang J, Wang R, Zhong A, Wang W, Tong J, Wang Z, Sun J
Biomaterials research 2022 Dec 17;26(1):83
Biomaterials research 2022 Dec 17;26(1):83
Upregulation of MHC-I and downregulation of PD-L1 expression by doxorubicin and deferasirox codelivered liposomal nanoparticles for chemoimmunotherapy of melanoma.
Song P, Han X, Zheng R, Yan J, Wu X, Wang Y, Zhang H
International journal of pharmaceutics 2022 Aug 25;624:122002
International journal of pharmaceutics 2022 Aug 25;624:122002
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
Zhang W, Lei M, Wen Q, Zhang D, Qin G, Zhou J, Chen L
The journal of headache and pain 2022 Aug 10;23(1):98
The journal of headache and pain 2022 Aug 10;23(1):98
Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway.
Teng YJ, Deng Z, Ouyang ZG, Zhou Q, Mei S, Fan XX, Wu YR, Long HP, Fang LY, Yin DL, Zhang BY, Guo YM, Zhu WH, Huang Z, Zheng P, Ning DM, Tian XF
World journal of gastrointestinal oncology 2022 Apr 15;14(4):872-886
World journal of gastrointestinal oncology 2022 Apr 15;14(4):872-886
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Xu J, Xu H, Ma K, Wang Y, Niu B, Zhang L, Li F
Frontiers in cell and developmental biology 2021;9:618045
Frontiers in cell and developmental biology 2021;9:618045
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY
Journal of immunology research 2021;2021:6696606
Journal of immunology research 2021;2021:6696606
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Zhao J, Lan W, Peng J, Guan B, Liu J, Zhang M, Zhan Z, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes.
Wang X, Zhang Z, Zhu Z, Liang Z, Zuo X, Ju C, Song Z, Li X, Hu X, Wang Z
Frontiers in neuroscience 2021;15:768262
Frontiers in neuroscience 2021;15:768262
Fatty Acid-Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway.
Wu Z, Jeong JH, Ren C, Yang L, Ding L, Li F, Jiang D, Zhu Y, Lu J
OncoTargets and therapy 2021;14:3929-3942
OncoTargets and therapy 2021;14:3929-3942
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Sun M, Xie J, Zhang D, Chen C, Lin S, Chen Y, Zhang G
Journal of Cancer 2021;12(24):7518-7526
Journal of Cancer 2021;12(24):7518-7526
Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Wu Y, You X, Lin Q, Xiong W, Guo Y, Huang Z, Dai X, Chen Z, Mei S, Long Y, Tian X, Zhou Q
Frontiers in pharmacology 2021;12:791269
Frontiers in pharmacology 2021;12:791269
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Cao T, Chen Q, Zhang B, Wu X, Zeng C, Zhang S, Cai H
Frontiers in endocrinology 2021;12:727371
Frontiers in endocrinology 2021;12:727371
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Zhang KK, Wang H, Qu D, Chen LJ, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xu JT, Xie XL, Li DR
Frontiers in pharmacology 2021;12:641917
Frontiers in pharmacology 2021;12:641917
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway.
Zhou XM, Liu CY, Liu YY, Ma QY, Zhao X, Jiang YM, Li XJ, Chen JX
Frontiers in pharmacology 2021;12:586788
Frontiers in pharmacology 2021;12:586788
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Tian X, Wu L, Jiang M, Zhang Z, Wu R, Miao J, Liu C, Gao S
Frontiers in oncology 2021;11:641399
Frontiers in oncology 2021;11:641399
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Wang D, Liu J, Jiang H
Environmental toxicology 2021 Sep;36(9):1953-1964
Environmental toxicology 2021 Sep;36(9):1953-1964
Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway.
Tong L, Li W, Zhang Y, Zhou F, Zhao Y, Zhao L, Liu J, Song Z, Yu M, Zhou C, Yu A
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Niu LT, Wang YQ, Wong CCL, Gao SX, Mo XD, Huang XJ
Translational oncology 2021 Sep;14(9):101159
Translational oncology 2021 Sep;14(9):101159
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Xian M, Cai J, Zheng K, Liu Q, Liu Y, Lin H, Liang S, Wang S
Food & function 2021 Sep 7;12(17):8056-8067
Food & function 2021 Sep 7;12(17):8056-8067
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
Huang B, Lu Y, Gui M, Guan J, Lin M, Zhao J, Mao Q, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111331
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Chen H, Pan R, Li H, Zhang W, Ren C, Lu Q, Chen H, Zhang X, Nie Y
Cell biology international 2021 Mar;45(3):623-632
Cell biology international 2021 Mar;45(3):623-632
Daphnoretin induces reactive oxygen species-mediated apoptosis in melanoma cells.
Wang H, Hu X, Li M, Pan Z, Li D, Zheng Q
Oncology letters 2021 Jun;21(6):453
Oncology letters 2021 Jun;21(6):453
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Peng MF, Tian S, Song YG, Li CX, Miao MS, Ren Z, Li M
Journal of ethnopharmacology 2021 Jun 12;273:113947
Journal of ethnopharmacology 2021 Jun 12;273:113947
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
Tang X, Chen Y, Luo H, Bian Q, Weng B, Yang A, Chu D, Ran M, Chen B
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
Liu D, Han Y, Liu L, Ren X, Zhang H, Fan S, Qin T, Li L
International journal of oncology 2021 Jan;58(1):100-110
International journal of oncology 2021 Jan;58(1):100-110
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Tang C, Luo Y, Li S, Huang B, Xu S, Li L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
Huang W, Chen K, Lu Y, Zhang D, Cheng Y, Li L, Huang W, He G, Liao H, Cai L, Tang Y, Zhao L, Pan M
Neoplasia (New York, N.Y.) 2021 Dec;23(12):1227-1239
Neoplasia (New York, N.Y.) 2021 Dec;23(12):1227-1239
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
Ma RR, Zhang H, Chen HF, Zhang GH, Tian YR, Gao P
Oncogene 2021 Apr;40(14):2524-2538
Oncogene 2021 Apr;40(14):2524-2538
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C, Liu J, Dang Y, Xia Y, He Q, Jin H, Li Y, Hu Y, Miao Y, Yue Z, Hu B
Autophagy 2021 Apr;17(4):980-1000
Autophagy 2021 Apr;17(4):980-1000
The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
Wang C, Wang C, Ren L, Chen S, Chen WH, Li Y
Life sciences 2021 Apr 1;270:119037
Life sciences 2021 Apr 1;270:119037
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Kang D, Zuo W, Wu Q, Zhu Q, Liu P
BioMed research international 2020;2020:1358674
BioMed research international 2020;2020:1358674
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Wang HM, Lu YJ, He L, Gu NJ, Wang SY, Qiu XS, Wang EH, Wu GP
Therapeutic advances in chronic disease 2020;11:2040622320957143
Therapeutic advances in chronic disease 2020;11:2040622320957143
Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity.
Wei Z, Hao Y, Yu H, Shi L, Jing X, Zhang X, Liu N, Li T, Zhang X, Yuan F
Life sciences 2020 Sep 15;257:117994
Life sciences 2020 Sep 15;257:117994
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Lv S, Yuan P, Dong J, Lu C, Li M, Qu F, Zhu Y, Yuan Z, Zhang J
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Naringin alleviates H(2)O(2)-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.
Nan LP, Wang F, Ran D, Zhou SF, Liu Y, Zhang Z, Huang ZN, Wang ZY, Wang JC, Feng XM, Zhang L
Connective tissue research 2020 Nov;61(6):554-567
Connective tissue research 2020 Nov;61(6):554-567
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Yang YL, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 May 21;21(10)
International journal of molecular sciences 2020 May 21;21(10)
Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer.
Lian J, Zou Y, Huang L, Cheng H, Huang K, Zeng J, Chen L
Oncology letters 2020 Mar;19(3):2043-2052
Oncology letters 2020 Mar;19(3):2043-2052
miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia.
Wang Y, Zhang J, Su Y, Wang C, Zhang G, Liu X, Chen Q, Lv M, Chang Y, Peng J, Hou M, Huang X, Zhang X
Molecular therapy. Nucleic acids 2020 Jun 5;20:764-776
Molecular therapy. Nucleic acids 2020 Jun 5;20:764-776
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860
Thoracic cancer 2020 Jul;11(7):1848-1860
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W
Journal of neuroinflammation 2020 Jul 14;17(1):211
Journal of neuroinflammation 2020 Jul 14;17(1):211
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.
Alarabi AB, Karim ZA, Ramirez JEM, Hernandez KR, Lozano PA, Rivera JO, Alshbool FZ, Khasawneh FT
Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):335-349
Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):335-349
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling.
Zheng J, Qu D, Wang C, Ding L, Zhou W
BMC pregnancy and childbirth 2020 Feb 10;20(1):87
BMC pregnancy and childbirth 2020 Feb 10;20(1):87
MiR-155 promotes interleukin-1β-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K/Akt pathway.
Fan Z, Liu Y, Shi Z, Deng K, Zhang H, Li Q, Cao S, Li S, Zhang H
Journal of cellular and molecular medicine 2020 Aug;24(15):8441-8451
Journal of cellular and molecular medicine 2020 Aug;24(15):8441-8451
Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury.
Zhai R, Xu H, Hu F, Wu J, Kong X, Sun X
British journal of pharmacology 2020 Aug;177(15):3389-3402
British journal of pharmacology 2020 Aug;177(15):3389-3402
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Li H, Liu S, Hu Y, Zhao B, Sun Y, Xu D
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R
Mediators of inflammation 2019;2019:8709583
Mediators of inflammation 2019;2019:8709583
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Guo Y, Pei X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway.
Zhang Y, Yang S, Cui X, Yang J, Zheng M, Jia J, Han F, Yang X, Wang J, Guo Z, Chang B, Chang B
Journal of diabetes research 2019;2019:4709715
Journal of diabetes research 2019;2019:4709715
Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway.
Wang X, Han Y, Liu J, Zhang Y, Cheng K, Guo J, Guo Q, Liu S, Sun H, Hua Y, Zhang G, Xu S, Guo F, Yang Z
Mediators of inflammation 2019;2019:4312016
Mediators of inflammation 2019;2019:4312016
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584
Inflammation 2019 Oct;42(5):1575-1584
Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.
Dong X, Yang Y, Zhou Y, Bi X, Zhao N, Zhang Z, Li L, Hang Q, Zhang R, Chen D, Cao P, Yin Z, Luo L
Cell death and differentiation 2019 Oct;26(10):2086-2099
Cell death and differentiation 2019 Oct;26(10):2086-2099
Minimally modified low-density lipoprotein upregulates the ET(B) and α(1) receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.
Zeng ZS, Lin J, Xu CB, Cao L, Chen C, Li J
The Journal of pharmacy and pharmacology 2019 Jun;71(6):937-944
The Journal of pharmacy and pharmacology 2019 Jun;71(6):937-944
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H
Annals of translational medicine 2019 Dec;7(23):756
Annals of translational medicine 2019 Dec;7(23):756
The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.
Ou B, Tao W, Yang S, Feng J, Wang J, Yang T, Wu H, Huang Y, Tan L, Huang W, Feng Z, Mei Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170
Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/Akt‑dependent Tbx‑3 activation pathway.
Ke M, He Q, Hong D, Li O, Zhu M, Ou WB, He Y, Wu Y
International journal of molecular medicine 2018 Jul;42(1):131-140
International journal of molecular medicine 2018 Jul;42(1):131-140
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.
Chen X, Zhao X, Lan F, Zhou T, Cai H, Sun H, Kong W, Kong W
Scientific reports 2017 Oct 16;7(1):13248
Scientific reports 2017 Oct 16;7(1):13248
cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells.
Zhou P, Tu L, Lin X, Hao X, Zheng Q, Zeng W, Zhang X, Zheng Y, Wang L, Li S
Viruses 2017 Nov 25;9(12)
Viruses 2017 Nov 25;9(12)
Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice.
Ma F, Liu F, Ding L, You M, Yue H, Zhou Y, Hou Y
Pharmaceutical biology 2017 Dec;55(1):1263-1273
Pharmaceutical biology 2017 Dec;55(1):1263-1273
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
Redox biology 2017 Aug;12:987-1003
Redox biology 2017 Aug;12:987-1003
MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer.
Wu ZH, Tao ZH, Zhang J, Li T, Ni C, Xie J, Zhang JF, Hu XC
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7245-54
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7245-54
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 60225-1-Ig(PIK3R1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The P85a; PIK3R1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human P85a; PIK3R1. This antibody recognizes human, mouse antigen. The P85a; PIK3R1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
