Antibody data
- Antibody Data
- Antigen structure
- References [92]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 12636-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12636-1-AP, RRID:AB_2173668
- Product name
- FAK antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FAK antibody (Cat. #12636-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
Genetic dependencies associated with transcription factor activities in human cancer cell lines.
FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1.
Mechanisms of HIV-mediated blood-brain barrier compromise and leukocyte transmigration under the current antiretroviral era.
A Spatiotemporal Controllable Biomimetic Skin for Accelerating Wound Repair.
Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling.
[Protective effect of FAK inhibitor PF-562271 against human umbilical vein endothelial cell injury induced by aging platelets].
Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.
Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication.
FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells.
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.
Equine β-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway.
The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells.
Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
A Novel Blood-Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis.
Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity.
Superhydrophilic and topography-regulatable surface grafting on PEEK to improve cellular affinity.
Focal adhesion kinase induces cardiac remodeling through NF-κB-mediated inflammatory responses in diabetic cardiomyopathy.
Integrin β6 mediates epithelial-mesenchymal transition in diabetic kidney disease.
Proximity Labeling to Identify β-Arrestin1 Binding Partners Downstream of Ligand-Activated G Protein-Coupled Receptors.
Response of Human Gingival Fibroblasts and Porphyromonas gingivalis to UVC-Activated Titanium Surfaces.
Dynamic Tensile Stress Promotes Regeneration of Achilles Tendon in a Panda Rope Bridge Technique Mice Model.
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells.
Regulation of integrin α5β1-mediated Staphylococcus aureus cellular invasion by the septin cytoskeleton.
Investigation of nanotopography on SOCE mediated cell migration via live-cell : Imaging on opaque implant surface.
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.
Peptide deregulated in hypertrophic scar-1 alleviates hypertrophic scar fibrosis by targeting focal adhesion kinase and pyruvate kinase M2 and remodeling the metabolic landscape.
G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by chemokine receptor CXCR4.
Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation.
The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network.
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition.
In Vivo and In Vitro Fibroblasts' Behavior and Capsular Formation in Correlation with Smooth and Textured Silicone Surfaces.
Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
Anti-inflammation of torachrysone-8-O-β-ᴅ-glucoside by hurdling over morphological changes of macrophages.
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Matrix Stiffening Enhances DNCB-Induced IL-6 Secretion in Keratinocytes Through Activation of ERK and PI3K/Akt Pathway.
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
N2E4, a Monoclonal Antibody Targeting Neuropilin-2, Inhibits Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma via Suppressing FAK/Erk/HIF-1α Signaling.
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling.
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Polystyrene microplastics induced male reproductive toxicity in mice.
Mg-Fe layered double hydroxides modified titanium enhanced the adhesion of human gingival fibroblasts through regulation of local pH level.
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma.
Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
Croton tiglium essential oil compounds have anti-proliferative and pro-apoptotic effects in A549 lung cancer cell lines.
Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber.
Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses.
EGFR/FAK and c-Src signalling pathways mediate the internalisation of Staphylococcus aureus by osteoblasts.
A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.
BK ablation attenuates osteoblast bone formation via integrin pathway.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.
Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.
Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility.
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Surface changes of nanotopography by carbon ion implantation to enhance the biocompatibility of silicone rubber: an in vitro study of the optimum ion fluence and adsorbed protein.
Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines.
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow.
HMGA2 upregulation mediates Cd-induced migration and invasion in A549 cells and in lung tissues of mice.
SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis.
RELM-β promotes human pulmonary artery smooth muscle cell proliferation via FAK-stimulated surviving.
β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
Quantitative profiling of spreading-coupled protein tyrosine phosphorylation in migratory cells.
Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway.
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells.
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.
Focal adhesion kinase antisense oligodeoxynucleotides inhibit human pulmonary artery smooth muscle cells proliferation and promote human pulmonary artery smooth muscle cells apoptosis.
Zhao X, Mai Z, Liu L, Lu Y, Cui L, Yu J
International journal of biological sciences 2024;20(1):231-248
International journal of biological sciences 2024;20(1):231-248
Genetic dependencies associated with transcription factor activities in human cancer cell lines.
Thatikonda V, Supper V, Wachter J, Kaya O, Kombara A, Bilgilier C, Ravichandran MC, Lipp JJ, Sharma R, Badertscher L, Boghossian AS, Rees MG, Ronan MM, Roth JA, Grosche S, Neumüller RA, Mair B, Mauri F, Popa A
Cell reports 2024 May 28;43(5):114175
Cell reports 2024 May 28;43(5):114175
FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
Lin C, Yang H, Luo Q, Liu Q
Clinical and translational science 2024 Mar;17(3):e13767
Clinical and translational science 2024 Mar;17(3):e13767
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1.
Huang K, Li Z, He X, Dai J, Huang B, Shi Y, Fan D, Zhang Z, Liu Y, Li N, Zhang Z, Peng J, Liu C, Zeng R, Cen Z, Wang T, Yang W, Cen M, Li J, Yuan S, Zhang L, Hu D, Huang S, Chen P, Lai P, Lin L, Wen J, Zhao Z, Huang X, Yuan L, Zhou L, Wu H, Huang L, Feng K, Wang J, Liao B, Cai W, Deng X, Li Y, Li J, Hu Z, Yang L, Li J, Zhuo Y, Zhang F, Lin L, Luo Y, Zhang W, Ni Q, Hong X, Chang G, Zhang Y, Guan D, Cai W, Lu Y, Li F, Yan L, Ren M, Li L, Chen S
Cell metabolism 2024 Mar 5;36(3):598-616.e9
Cell metabolism 2024 Mar 5;36(3):598-616.e9
Mechanisms of HIV-mediated blood-brain barrier compromise and leukocyte transmigration under the current antiretroviral era.
Hernandez C, Gorska AM, Eugenin E
iScience 2024 Mar 15;27(3):109236
iScience 2024 Mar 15;27(3):109236
A Spatiotemporal Controllable Biomimetic Skin for Accelerating Wound Repair.
Chen Y, Lu W, Zhou Y, Hu Z, Wu H, Gao Q, Shi J, Wu W, Lv S, Yao K, He Y, Xie Z
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(23):e2310556
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(23):e2310556
Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling.
Zhang S, Liu C, Liu D, Ning X, Li H, Zhang X, Lu Y, Zhang P, Chen S, Cai Z
Molecular biotechnology 2024 Feb 8;
Molecular biotechnology 2024 Feb 8;
[Protective effect of FAK inhibitor PF-562271 against human umbilical vein endothelial cell injury induced by aging platelets].
Bai Y, Gang B, Zhang M, Wan Z, Liu G, Gu W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Feb 20;44(2):252-259
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Feb 20;44(2):252-259
Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Gao S, He L, Lam CK, Taylor MRG, Mestroni L, Lombardi R, Chen SN
Cells 2024 Feb 2;13(3)
Cells 2024 Feb 2;13(3)
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.
Kersey AL, Cheng DY, Deo KA, Dubell CR, Wang TC, Jaiswal MK, Kim MH, Murali A, Hargett SE, Mallick S, Lele TP, Singh I, Gaharwar AK
Biomaterials 2024 Apr;306:122473
Biomaterials 2024 Apr;306:122473
Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication.
Hu R, Huang Y, Geng Y, Liu Z, Li F, Zhang Z, Ma W, Song K, Dong H, Song Y, Zhang M
Journal of ethnopharmacology 2024 Apr 6;323:117654
Journal of ethnopharmacology 2024 Apr 6;323:117654
FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells.
Xu C, Zhang W, Liu C
PloS one 2023;18(4):e0284871
PloS one 2023;18(4):e0284871
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.
Chen Y, Jin L, Ma Y, Liu Y, Zhu Q, Huang Y, Feng W
Cancer science 2023 Sep;114(9):3568-3582
Cancer science 2023 Sep;114(9):3568-3582
Equine β-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway.
Pei L, Hou Y, Feng Y, Li F, Su H, Zhang Y, Song Y, Liu K, Cao G
International immunopharmacology 2023 Oct;123:110793
International immunopharmacology 2023 Oct;123:110793
The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells.
Liu GY, Wang H, Ran R, Wang YC, Li Y
Biochemical and biophysical research communications 2023 Oct 8;676:182-189
Biochemical and biophysical research communications 2023 Oct 8;676:182-189
Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.
Liu Y, Yao X, Zhao Y, Fang D, Shi L, Yang L, Song G, Cai K, Li L, Deng Q, Li M, Luo Z
Cell reports 2023 Oct 31;42(10):113213
Cell reports 2023 Oct 31;42(10):113213
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Zhang F, Zou H, Li X, Liu J, Xie Y, Chen M, Yu J, Wu X, Guo B
Human cell 2023 May;36(3):1024-1040
Human cell 2023 May;36(3):1024-1040
A Novel Blood-Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis.
Lu L, Wang L, Zhao L, Liao J, Zhao C, Xu X, Wang F, Zhang X
International journal of molecular sciences 2023 May 15;24(10)
International journal of molecular sciences 2023 May 15;24(10)
Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity.
El Hayek E, Castillo E, In JG, Garcia M, Cerrato J, Brearley A, Gonzalez-Estrella J, Herbert G, Bleske B, Benavidez A, Hsiao H, Yin L, Campen MJ, Yu X
Toxicological sciences : an official journal of the Society of Toxicology 2023 May 12;193(1):90-102
Toxicological sciences : an official journal of the Society of Toxicology 2023 May 12;193(1):90-102
Superhydrophilic and topography-regulatable surface grafting on PEEK to improve cellular affinity.
Zhang B, Leng J, Ouyang Z, Yang Z, Zhang Q, Li Q, Li D, Zhao H
Biomaterials advances 2023 Mar;146:213310
Biomaterials advances 2023 Mar;146:213310
Focal adhesion kinase induces cardiac remodeling through NF-κB-mediated inflammatory responses in diabetic cardiomyopathy.
Jin B, Wang J, Chen Y, Zuo W, Hong B, Li J, Huang F, Zhang M, Wang Y
International immunopharmacology 2023 Jul;120:110280
International immunopharmacology 2023 Jul;120:110280
Integrin β6 mediates epithelial-mesenchymal transition in diabetic kidney disease.
Li X, Miao Y, Li T, Liu X, Xu L, Guo J, Yu X, Sun B, Zhu Y, Ai D, Chen L
Molecular and cellular endocrinology 2023 Jul 15;572:111955
Molecular and cellular endocrinology 2023 Jul 15;572:111955
Proximity Labeling to Identify β-Arrestin1 Binding Partners Downstream of Ligand-Activated G Protein-Coupled Receptors.
Zhuo Y, Robleto VL, Marchese A
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
Response of Human Gingival Fibroblasts and Porphyromonas gingivalis to UVC-Activated Titanium Surfaces.
Wen Y, Dong H, Lin J, Zhuang X, Xian R, Li P, Li S
Journal of functional biomaterials 2023 Feb 28;14(3)
Journal of functional biomaterials 2023 Feb 28;14(3)
Dynamic Tensile Stress Promotes Regeneration of Achilles Tendon in a Panda Rope Bridge Technique Mice Model.
Li Z, Sun X, Shen C, Deng Z, Tang K, Xie Y, Chen L, Nie M
Annals of biomedical engineering 2023 Dec;51(12):2735-2748
Annals of biomedical engineering 2023 Dec;51(12):2735-2748
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells.
Guo X, Fan A, Qi X, Liu D, Huang J, Lin W
Bioorganic chemistry 2023 Dec;141:106873
Bioorganic chemistry 2023 Dec;141:106873
Regulation of integrin α5β1-mediated Staphylococcus aureus cellular invasion by the septin cytoskeleton.
Robertin S, Brokatzky D, Lobato-Márquez D, Mostowy S
European journal of cell biology 2023 Dec;102(4):151359
European journal of cell biology 2023 Dec;102(4):151359
Investigation of nanotopography on SOCE mediated cell migration via live-cell : Imaging on opaque implant surface.
Zhang Y, Li K, Li G, Wang Y, He Y, Song W, Zhang Y
Journal of nanobiotechnology 2023 Dec 8;21(1):471
Journal of nanobiotechnology 2023 Dec 8;21(1):471
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.
Zhang C, Chen S, Wang W, Gao Y
Functional & integrative genomics 2023 Aug 8;23(3):269
Functional & integrative genomics 2023 Aug 8;23(3):269
Peptide deregulated in hypertrophic scar-1 alleviates hypertrophic scar fibrosis by targeting focal adhesion kinase and pyruvate kinase M2 and remodeling the metabolic landscape.
Li J, Yin Y, Zhang E, Gui M, Chen L, Li J
International journal of biological macromolecules 2023 Apr 30;235:123809
International journal of biological macromolecules 2023 Apr 30;235:123809
G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by chemokine receptor CXCR4.
Zhuo Y, Crecelius JM, Marchese A
The Journal of biological chemistry 2022 Sep;298(9):102351
The Journal of biological chemistry 2022 Sep;298(9):102351
Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
Sato Y, Kawashima K, Fukui E, Matsumoto H, Yoshizawa F, Sato Y
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119294
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119294
Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation.
Zhai C, Zhang N, Wang J, Cao M, Luan J, Liu H, Zhang Q, Zhu Y, Xue Y, Li S
Lung 2022 Oct;200(5):619-631
Lung 2022 Oct;200(5):619-631
The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network.
Chatzifrangkeskou M, Skourides PA
Scientific reports 2022 Nov 8;12(1):19028
Scientific reports 2022 Nov 8;12(1):19028
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition.
Zhu TY, Wu XT, Chen C, Liu XQ, Zhu L, Luo JG, Kong LY
ACS medicinal chemistry letters 2022 Mar 10;13(3):449-456
ACS medicinal chemistry letters 2022 Mar 10;13(3):449-456
In Vivo and In Vitro Fibroblasts' Behavior and Capsular Formation in Correlation with Smooth and Textured Silicone Surfaces.
Huang SQ, Chen Y, Zhu Q, Zhang YM, Lei ZY, Zhou X, Fan DL
Aesthetic plastic surgery 2022 Jun;46(3):1164-1177
Aesthetic plastic surgery 2022 Jun;46(3):1164-1177
Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling.
Yao Q, Wang H, Chen H, Li Z, Jiang Y, Li Z, Wang J, Xing Y, Liu F, Yu D, Yin S
Molecular neurobiology 2022 Jan;59(1):386-404
Molecular neurobiology 2022 Jan;59(1):386-404
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Microbiology spectrum 2022 Feb 23;10(1):e0226521
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
Wang J, He Z, Liu X, Xu J, Jiang X, Quan G, Jiang J
Cell death & disease 2022 Aug 18;13(8):718
Cell death & disease 2022 Aug 18;13(8):718
Anti-inflammation of torachrysone-8-O-β-ᴅ-glucoside by hurdling over morphological changes of macrophages.
Zhao W, Xu D, Zhang L, Meng H, Zheng Q, Wang J
International immunopharmacology 2022 Apr;105:108548
International immunopharmacology 2022 Apr;105:108548
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Matrix Stiffening Enhances DNCB-Induced IL-6 Secretion in Keratinocytes Through Activation of ERK and PI3K/Akt Pathway.
Chung H, Oh S, Shin HW, Lee Y, Lee H, Seok SH
Frontiers in immunology 2021;12:759992
Frontiers in immunology 2021;12:759992
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Zeng T, Cao Y, Gu T, Chen L, Tian Y, Li G, Shen J, Tao Z, Lu L
Frontiers in genetics 2021;12:693780
Frontiers in genetics 2021;12:693780
N2E4, a Monoclonal Antibody Targeting Neuropilin-2, Inhibits Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma via Suppressing FAK/Erk/HIF-1α Signaling.
Wang L, Wang L, Wang S, Zhou Z, Liu Z, Xu P, Luo X, Wu T, Luo F, Yan J
Frontiers in oncology 2021;11:657008
Frontiers in oncology 2021;11:657008
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
Yu S, Hu Q, Fan K, Yang C, Gao Y
Journal of cell communication and signaling 2021 Sep;15(3):383-392
Journal of cell communication and signaling 2021 Sep;15(3):383-392
Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling.
Liu A, Xie H, Li R, Ren L, Yang B, Dai L, Lu W, Liu B, Ren D, Zhang X, Chen Q, Huang Y, Shi K
Molecular therapy oncolytics 2021 Sep 24;22:195-208
Molecular therapy oncolytics 2021 Sep 24;22:195-208
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M
European journal of medicinal chemistry 2021 Oct 15;222:113573
European journal of medicinal chemistry 2021 Oct 15;222:113573
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198
Cell death discovery 2021 Jul 29;7(1):198
Polystyrene microplastics induced male reproductive toxicity in mice.
Jin H, Ma T, Sha X, Liu Z, Zhou Y, Meng X, Chen Y, Han X, Ding J
Journal of hazardous materials 2021 Jan 5;401:123430
Journal of hazardous materials 2021 Jan 5;401:123430
Mg-Fe layered double hydroxides modified titanium enhanced the adhesion of human gingival fibroblasts through regulation of local pH level.
Yin Y, Jian L, Li B, Liang C, Han X, Zhao X, Wang D
Materials science & engineering. C, Materials for biological applications 2021 Dec;131:112485
Materials science & engineering. C, Materials for biological applications 2021 Dec;131:112485
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.
Chen L, Qian J, You Q, Ma J
Bioengineered 2021 Dec;12(2):10089-10100
Bioengineered 2021 Dec;12(2):10089-10100
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
Liu Y, Wang L, Zhang X, Deng Y, Pan L, Li H, Shi X, Wang T
Scientific reports 2021 Apr 26;11(1):8963
Scientific reports 2021 Apr 26;11(1):8963
Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma.
Zhao L, Chen H, Lu L, Zhao C, Malichewe CV, Wang L, Guo X, Zhang X
Life sciences 2021 Apr 1;270:119113
Life sciences 2021 Apr 1;270:119113
Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
Wu X, Bian F, Hu H, Zhu T, Li C, Zhou Q
PloS one 2020;15(6):e0225173
PloS one 2020;15(6):e0225173
Croton tiglium essential oil compounds have anti-proliferative and pro-apoptotic effects in A549 lung cancer cell lines.
Niu QL, Sun H, Liu C, Li J, Liang CX, Zhang RR, Ge FR, Liu W
PloS one 2020;15(5):e0231437
PloS one 2020;15(5):e0231437
Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber.
Zhou X, Zhou X, Yan R, Shi X, Du Y, Chen Y, Yu Y, Fan D, Zhang Y
Biomedical materials (Bristol, England) 2020 Sep 26;15(6):065003
Biomedical materials (Bristol, England) 2020 Sep 26;15(6):065003
Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses.
Mahmoud N, Saeed MEM, Sugimoto Y, Klinger A, Fleischer E, Efferth T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Oct;77:153271
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Oct;77:153271
EGFR/FAK and c-Src signalling pathways mediate the internalisation of Staphylococcus aureus by osteoblasts.
Ji Z, Su J, Hou Y, Yao Z, Yu B, Zhang X
Cellular microbiology 2020 Oct;22(10):e13240
Cellular microbiology 2020 Oct;22(10):e13240
A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.
Zhuo Y, Gurevich VV, Vishnivetskiy SA, Klug CS, Marchese A
The Journal of biological chemistry 2020 Oct 9;295(41):14111-14124
The Journal of biological chemistry 2020 Oct 9;295(41):14111-14124
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Zhao J, Han Y, Wang Z, Zhang R, Wang G, Mao Y
Biotechnology letters 2020 Dec;42(12):2749-2758
Biotechnology letters 2020 Dec;42(12):2749-2758
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.
Zheng D, Chang X, Liu Y, Xu J, Gou W, Li Z, Zuo D, Zhang W, Wu Y
Cancer biology & therapy 2019;20(4):513-523
Cancer biology & therapy 2019;20(4):513-523
BK ablation attenuates osteoblast bone formation via integrin pathway.
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Cell death & disease 2019 Sep 30;10(10):738
Cell death & disease 2019 Sep 30;10(10):738
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Liu SQ, Xu CY, Wu WH, Fu ZH, He SW, Qin MB, Huang JA
International journal of oncology 2019 Jan;54(1):41-52
International journal of oncology 2019 Jan;54(1):41-52
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Wang L, Shi H, Liu Y, Zhang W, Duan X, Li M, Shi X, Wang T
International journal of oncology 2019 Aug;55(2):473-487
International journal of oncology 2019 Aug;55(2):473-487
Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.
Ai WL, Dong LY, Wang J, Li ZW, Wang X, Gao J, Wu Y, An W
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3780-3791
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3780-3791
Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
Liu J, Shuang Y, Li C, Zhou X, Huang Y, Zhang L
Clinical and experimental pharmacology & physiology 2018 May;45(5):461-466
Clinical and experimental pharmacology & physiology 2018 May;45(5):461-466
Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.
Wu B, Zhang L, Zhu YH, Zhang YE, Zheng F, Yang JY, Guo LY, Li XY, Wang L, Tang JM, Chen SY, Wang JN
International journal of cardiology 2018 Jan 15;251:82-89
International journal of cardiology 2018 Jan 15;251:82-89
Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility.
Yu M, Li W, Wang Q, Wang Y, Lu F
Oncogene 2018 Aug;37(35):4838-4853
Oncogene 2018 Aug;37(35):4838-4853
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
Pan X, Zhang R, Xie C, Gan M, Yao S, Yao Y, Jin J, Han T, Huang Y, Gong Y, Wang J, Yu B
American journal of translational research 2017;9(9):4217-4226
American journal of translational research 2017;9(9):4217-4226
Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
Yin L, Qi Y, Xu Y, Xu L, Han X, Tao X, Song S, Peng J
Frontiers in pharmacology 2017;8:665
Frontiers in pharmacology 2017;8:665
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Surface changes of nanotopography by carbon ion implantation to enhance the biocompatibility of silicone rubber: an in vitro study of the optimum ion fluence and adsorbed protein.
Li X, Zhou X, Chen Y, Yu S, Chen X, Xia X, Shi X, Zhang Y, Fan D
Journal of materials science. Materials in medicine 2017 Sep 15;28(10):167
Journal of materials science. Materials in medicine 2017 Sep 15;28(10):167
Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines.
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Scientific reports 2017 Sep 11;7(1):11127
Scientific reports 2017 Sep 11;7(1):11127
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
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Oncogene 2017 Oct 5;36(40):5609-5619
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The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow.
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Scientific reports 2017 Nov 8;7(1):14996
Scientific reports 2017 Nov 8;7(1):14996
HMGA2 upregulation mediates Cd-induced migration and invasion in A549 cells and in lung tissues of mice.
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Chemico-biological interactions 2017 Nov 1;277:1-7
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International journal of molecular medicine 2017 May;39(5):1277-1284
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Stem cells and development 2017 May 15;26(10):762-775
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Cancer letters 2017 Jun 1;395:31-44
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Experimental cell research 2017 Feb 1;351(1):43-50
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Chinese medical journal 2005 Jan 5;118(1):20-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 12636-1-AP(FAK antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FAK (IP:12636-1-AP, 3ug; Detection:12636-1-AP 1:2000) with mouse brain tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FAK antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FAK. This antibody recognizes human,mouse,rat antigen. The FAK antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.