PTK2

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Description

Protein tyrosine kinase 2

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8:q24.3 (140657900 - 141002216)

Ensembl ID

ENSG00000169398  (ver. 103.38)

Orthologs

Mouse Ptk2: ENSMUSG00000022607

UniProt

Q05397

neXtProt

NX_Q05397

Human splice variants
Mouse splice variants