66258-1-Ig

antibody from Proteintech Group

Targeting: PTK2 FADK, FAK, FAK1, PPP1R71

Provider product page for 66258-1-Ig

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Antibody Data
Antigen structure
References [41]
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Product number: 66258-1-Ig - Provider product page
Provider: Proteintech Group
Product name: FAK antibody
Antibody type: Monoclonal
Description: KD/KO validated FAK antibody (Cat. #66258-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2C5B9
Vial size: 20ul, 150ul

PTK2 protein structure - 66258-1-Ig shown in red.

Submitted references Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis.

Zhang N, Wu P, Mu M, Niu C, Hu S
Molecular neurobiology 2024 Sep;61(9):6556-6571

A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.

Xue M, Xing L, Yang Y, Shao M, Liao F, Xu F, Chen Y, Wang S, Chen B, Yao C, Gu G, Tong C
BMC cardiovascular disorders 2024 Mar 26;24(1):180

Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.

Shi Q, Xu J, Chen C, Hu X, Wang B, Zeng F, Ren T, Huang Y, Guo W, Tang X, Ji T
Cancer letters 2024 Jun 1;591:216902

Muscone restores anoikis sensitivity in TMZ-resistant glioblastoma cells by suppressing TOP2A via the EGFR/Integrin β1/FAK signaling pathway.

Zou Y, Xu L, Wang W, Zhu X, Lin J, Li H, Chen J, Xu W, Gao H, Wu X, Yin Z, Wang Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155714

Caveolin 1 Regulates the Tight Junctions between Sertoli Cells and Promotes the Integrity of Blood-Testis Barrier in Yak via the FAK/ERK Signaling Pathway.

Yan Q, Li T, Zhang Y, Zhao X, Wang Q, Yuan L
Animals : an open access journal from MDPI 2024 Jan 5;14(2)

Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling.

Tan X, Kong D, Tao Z, Cheng F, Zhang B, Wang Z, Mei Q, Chen C, Wu K
Biomarker research 2024 Jan 25;12(1):13

Arctigenin promotes mucosal healing in ulcerative colitis through facilitating focal adhesion assembly and colonic epithelial cell migration via targeting focal adhesion kinase.

Guo Y, Liu X, Tao Y, Zhu Y, Zhang J, Yu X, Guo P, Liu S, Wei Z, Dai Y, Xia Y
International immunopharmacology 2024 Feb 15;128:111552

ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.

He Y, Gang B, Zhang M, Bai Y, Wan Z, Pan J, Liu J, Liu G, Gu W
International immunopharmacology 2024 Feb 15;128:111535

Matricellular Protein SMOC2 Potentiates BMP9-Induced Osteogenic Differentiation in Mesenchymal Stem Cells through the Enhancement of FAK/PI3K/AKT Signaling.

He WG, Deng YX, Ke KX, Cao XL, Liu SY, Yang YY, Luo HH, Yao XT, Gao X, Du Y, He BC, Chen L
Stem cells international 2023;2023:5915988

The Effect of Adipocyte-Secreted Factors in Activating Focal Adhesion Kinase-Mediated Cell Signaling Pathway towards Metastasis in Breast Cancer Cells.

Mubtasim N, Gollahon L
International journal of molecular sciences 2023 Nov 22;24(23)

Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.

Pang S, Luo Z, Dong W, Gao S, Chen W, Liu N, Zhang X, Gao X, Li J, Gao K, Shi X, Guan F, Zhang L, Zhang L
Life science alliance 2023 Mar;6(3)

Cas phosphorylation regulates focal adhesion assembly.

Kumar S, Stainer A, Dubrulle J, Simpkins C, Cooper JA
eLife 2023 Jul 25;12

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.

Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, Ren S, Wu F, Zhou C, Gao G
Experimental hematology & oncology 2023 Jul 19;12(1):61

γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5.

Chen W, Yu H, Sun C, Dong M, Zhao N, Wang Y, Yu K, Zhang J, Xu N, Liu W
Toxicology letters 2023 Jul 1;383:177-191

Lipid-anchored proteasomes control membrane protein homeostasis.

Zhang R, Pan S, Zheng S, Liao Q, Jiang Z, Wang D, Li X, Hu A, Li X, Zhu Y, Shen X, Lei J, Zhong S, Zhang X, Huang L, Wang X, Huang L, Shen L, Song BL, Zhao JW, Wang Z, Yang B, Guo X
Science advances 2023 Dec;9(48):eadj4605

Astragalus propinquus schischkin and Salvia miltiorrhiza bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway.

Zhang MX, Huang XY, Song Y, Xu WL, Li YL, Li C
Frontiers in pharmacology 2022;13:1103557

Src kinase mediates coelomocytes phagocytosis via interacting with focal adhesion kinase in Vibrio splendidus challenged Apostichopus japonicus.

Wan J, Zhao X, Liu J, Chen K, Li C
Fish & shellfish immunology 2022 May;124:411-420

LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/β-catenin signaling.

Liu W, Jiang X, Li X, Sun K, Yang Y, Yang M, Li S, Zhu X
Journal of cell science 2022 Mar 15;135(6)

Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition.

Hadjisavva R, Anastasiou O, Ioannou PS, Zheltkova M, Skourides PA
Cell reports 2022 Jul 19;40(3):111091

TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling.

Wu J, Wang Y, Yang Y, Liu F, Jiang Z, Jiang Z
International immunopharmacology 2022 Jan;102:108429

AVL9 promotes colorectal carcinoma cell migration via regulating EGFR expression.

Wu Q, Chen J, Zhou Z
Biological procedures online 2022 Jan 6;24(1):1

LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.

Tan Y, Chen Q, Pan S, An W, Xu H, Xing Y, Zhang J
BMC cancer 2022 Apr 30;22(1):474

MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart.

Thakur V, Tiburcio de Freitas J, Li Y, Zhang K, Savadelis A, Bedogni B
PloS one 2021;16(7):e0253062

CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6.

Li L, Tao X, Li Y, Gao Y, Li Q
Journal of Cancer 2021;12(11):3145-3153

TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages.

Wu J, Wang Y, Yang Y, Liu F, Chen J, Jiang Z, Jiang Z
Aging 2021 Sep 13;13(17):21571-21586

Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.

Ma S, Zhou J, Huang T, Zhang Z, Xing Q, Zhou X, Zhang K, Yao M, Cheng T, Wang X, Wen X, Guan F
Acta biomaterialia 2021 Sep 1;131:185-197

Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src.

Liu H, Zhou Y, Qiu H, Zhuang R, Han Y, Liu X, Qiu X, Wang Z, Xu L, Tan R, Hong W, Wang T
Cell death & disease 2021 Mar 17;12(4):284

NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.

Lin F, Zhou J, Li X, Wang X
Biochemical and biophysical research communications 2021 Jun 25;559:121-128

FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis.

Antoniades I, Kyriakou M, Charalambous A, Kalalidou K, Christodoulou A, Christoforou M, Skourides PA
Cell communication and signaling : CCS 2021 Jan 7;19(1):3

MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.

Ma RR, Zhang H, Chen HF, Zhang GH, Tian YR, Gao P
Oncogene 2021 Apr;40(14):2524-2538

DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.

Gong FL, Wang L, Yu LG, Dang YF, Jiang XN, Zhao L, Guo XL
Journal of cellular biochemistry 2020 Dec;121(12):4756-4771

TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.

Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584

Subcutaneous and Visceral Adipose-Derived Mesenchymal Stem Cells: Commonality and Diversity.

Ritter A, Friemel A, Roth S, Kreis NN, Hoock SC, Safdar BK, Fischer K, Möllmann C, Solbach C, Louwen F, Yuan J
Cells 2019 Oct 21;8(10)

Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer.

Wang G, Yang Q, Li M, Zhang Y, Cai Y, Liang X, Fu Y, Xiao Z, Zhou M, Xie Z, Huang H, Huang Y, Chen Y, He Q, Peng F, Chen Z
Biology open 2019 May 13;8(5)

RSRC1 suppresses gastric cancer cell proliferation and migration by regulating PTEN expression.

Yu S, Gautam N, Quan M, Gao Y
Molecular medicine reports 2019 Aug;20(2):1747-1753

Rab34 regulates adhesion, migration, and invasion of breast cancer cells.

Sun L, Xu X, Chen Y, Zhou Y, Tan R, Qiu H, Jin L, Zhang W, Fan R, Hong W, Wang T
Oncogene 2018 Jul;37(27):3698-3714

Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.

Wu Q, Yu S, Chen J, Li Y, Gao Y
IUBMB life 2018 Feb;70(2):120-128

AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.

Chen ZL, Yang J, Shen YW, Li ST, Wang X, Lv M, Wang BY, Li P, Zhao W, Qiu RY, Liu Y, Liu PJ, Yang J
Journal of cellular and molecular medicine 2018 Apr;22(4):2390-2403

Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1/2 pathway.

Chen P, Lei L, Wang J, Zou X, Zhang D, Deng L, Wu D
Cancer science 2017 Jun;108(6):1157-1168

Vascular protective effects of aqueous extracts of Tribulus terrestris on hypertensive endothelial injury.

Jiang YH, Guo JH, Wu S, Yang CH
Chinese journal of natural medicines 2017 Aug;15(8):606-614

β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.

Alekhina O, Marchese A
The Journal of biological chemistry 2016 Dec 9;291(50):26083-26097

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