CABT-Z341L

antibody from Creative Diagnostics

Targeting: PTK2 FADK, FAK, FAK1, PPP1R71

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-Z341L

Provider

Creative Diagnostics

Product name

Recombinant Llama Anti-Mouse FAK Monoclonal Antibody, clone Oc91

Antibody type

Monoclonal

Description

Focal adhesion kinase is a cytosolic (non-receptor) tyrosine kinase of 125 kDa, concentrated in focal adhesions. The FERM (4.1 protein, Ezrin, Radixin, Moesin) and kinase domains form an autoinhibitory association. The FAT domain (focal adhesion targeting domain) directs the kinase to focal adhesions. FAK is found in most cells. FAK promotes cell migration by activating a signaling pathway that induces turnover of cell contacts with the underlying matrix. During apoptosis, FAK is cleaved by caspase 3 and contributes to loss of focal contacts, cell rounding and formation of blebs. At the organismal level, FAK is required for normal early embryonic development, placenta and heart development. FAK regulates numerous signaling pathways (integring signal transduction, GPRCs, LDL, netrin receptors.

Reactivity

Human, Mouse

Conjugate

Unconjugated

Antibody clone number

Oc91

Vial size

100 _g

Concentration

Lot specific

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.