FNab09245

antibody from FineTest Biotech

Targeting: UHRF1 FLJ21925, ICBP90, Np95, RNF106, TDRD22

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

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Validation data

Product number: FNab09245 - Provider product page
Provider: FineTest Biotech
Product name: UHRF1 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: ubiquitin-like with PHD and ring fi nger domains 1
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months (Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months (Avoid repeated freeze / thaw cycles.)

UHRF1 protein structure - FNab09245 shown in red.