Tissue expression
Cell line expression

UHRF1

gene product
FLJ21925, ICBP90, Np95, RNF106, TDRD22 
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
More gene data

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408 antibodies from 33 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
4 antibodies
Novus Biologicals
9 antibodies
antibodies-online
140 antibodies
Proteintech Group
1 antibody
Invitrogen Antibodies
27 antibodies
Affinity Biosciences
1 antibody
Abnova Corporation
4 antibodies
Bioworld Technology, Inc
2 antibodies
LifeSpan BioSciences, Inc.
49 antibodies
Biorbyt
20 antibodies
Boster Biological Technology
3 antibodies
OriGene
5 antibodies
NSJ Bioreagents
5 antibodies
NovoPro Bioscience Inc.
2 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Cusabio Biotech Co., Ltd
3 antibodies
Abgent
4 antibodies
Aviva Systems Biology
3 antibodies
Bethyl Laboratories
2 antibodies
Atlas Antibodies
2 antibodies
ProSci
2 antibodies
Antibodies.com
1 antibody
Cell Signaling Technology, Inc
1 antibody
United States Biological
73 antibodies
MyBioSource
6 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Arigo
1 antibody
Abbexa
9 antibodies
Abiocode, Inc.
3 antibodies
Creative Diagnostics
3 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Creative Biolabs
16 antibodies
Acris Antibodies GmbH
1 antibody