RASSF5

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Ras association domain family member 5

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

1 (206507531 - 206589448)

Ensembl ID

ENSG00000266094  (ver. 103.38)

Orthologs

Mouse Rassf5: ENSMUSG00000026430

UniProt

Q8WWW0

neXtProt

NX_Q8WWW0

Human splice variants
Mouse splice variants

Protein structure