ADH1C

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]

Description

Alcohol dehydrogenase 1C (class I), gamma polypeptide

Tissue specificity

Group enriched (intestine, liver, stomach)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

4:q23 (99336497 - 99352746)

Ensembl ID

ENSG00000248144  (ver. 103.38)

Orthologs

-

UniProt

P00326

neXtProt

NX_P00326

Human splice variants