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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 304112 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#304112, RRID:AB_314416
- Product name
- APC anti-human CD45RA
- Antibody type
- Monoclonal
- Antigen
- CD45RA
- Description
- CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naive T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity.
Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies.
Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study.
NKp80 defines and stimulates a reactive subset of CD8 T cells.
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow.
Profound enhancement of the IL-12/IL-18 pathway of IFN-gamma secretion in human CD8+ memory T cell subsets via IL-15.
Guerau-de-Arellano M, Smith KM, Godlewski J, Liu Y, Winger R, Lawler SE, Whitacre CC, Racke MK, Lovett-Racke AE
Brain : a journal of neurology 2011 Dec;134(Pt 12):3578-89
Brain : a journal of neurology 2011 Dec;134(Pt 12):3578-89
Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies.
Alanio C, Lemaitre F, Law HK, Hasan M, Albert ML
Blood 2010 May 6;115(18):3718-25
Blood 2010 May 6;115(18):3718-25
Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study.
Iannello A, Boulassel MR, Samarani S, Debbeche O, Tremblay C, Toma E, Routy JP, Ahmad A
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 1;184(1):114-26
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 1;184(1):114-26
NKp80 defines and stimulates a reactive subset of CD8 T cells.
Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee HG, Steinle A
Blood 2009 Jan 8;113(2):358-69
Blood 2009 Jan 8;113(2):358-69
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow.
Palendira U, Chinn R, Raza W, Piper K, Pratt G, Machado L, Bell A, Khan N, Hislop AD, Steyn R, Rickinson AB, Buckley CD, Moss P
Blood 2008 Oct 15;112(8):3293-302
Blood 2008 Oct 15;112(8):3293-302
Profound enhancement of the IL-12/IL-18 pathway of IFN-gamma secretion in human CD8+ memory T cell subsets via IL-15.
Smeltz RB
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 15;178(8):4786-92
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 15;178(8):4786-92
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with HI100 APC
- Conjugate
- Red dye
