Tissue expression
Cell line expression
Protein structure

PTPRC

Protein tyrosine phosphatase receptor type C
CD45, GP180, LCA, T200 
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
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11326 antibodies from 56 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
1311 antibodies
Proteintech Group
57 antibodies
Invitrogen Antibodies
782 antibodies
GeneTex
134 antibodies
NSJ Bioreagents
67 antibodies
Biorbyt
1257 antibodies
antibodies-online
3260 antibodies
R&D Systems
57 antibodies
NovoPro Bioscience Inc.
26 antibodies
OriGene
420 antibodies
Abnova Corporation
168 antibodies
Cusabio Biotech Co., Ltd
17 antibodies
Boster Biological Technology
28 antibodies
Atlas Antibodies
3 antibodies
Cell Signaling Technology, Inc
45 antibodies
St John's Laboratory
165 antibodies
BioLegend
286 antibodies
Acris Antibodies GmbH
229 antibodies
Aviva Systems Biology
81 antibodies
Bethyl Laboratories
3 antibodies
FineTest Biotech
2 antibodies
Abgent
12 antibodies
ABEOMICS Inc.
5 antibodies
Enzo Life Sciences
4 antibodies
HUABIO Research
3 antibodies
Aladdin Scientific Corporation
4 antibodies
Exalpha Biologicals, Inc.
2 antibodies
Creative Diagnostics
88 antibodies
Creative Biolabs
540 antibodies
Sino Biological Inc.
2 antibodies
United States Biological
51 antibodies
Leading Biology
87 antibodies
MyBioSource
38 antibodies
EMD Millipore
16 antibodies
RabMAbs
6 antibodies
STEMCELL Technologies Inc
128 antibodies
Absolute Antibody
54 antibodies
SICGEN
2 antibodies
DIMA
1 antibody
Miltenyi Biotec
353 antibodies
Spring Bioscience
8 antibodies
eBioscience, An Affymetrix Company
178 antibodies
Abbiotec
8 antibodies
Abiocode, Inc.
2 antibodies
MS Validated Antibodies GmbH
2 antibodies
RayBiotech, Inc.
8 antibodies
MilliporeSigma / Merck KGaA
9 antibodies
International Blood Group Reference Laboratory
1 antibody
BioLegend (formerly Covance Antibody Products)
1 antibody
Rockland Immunochemicals, Inc.
12 antibodies
CPTAC
2 antibodies