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- Antibody Data
- Antigen structure
- References [71]
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- Other assay [3]
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- Product number
- MA5-13065 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-Estrogen Receptor alpha Monoclonal Antibody (TE111.5D11)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- MA5-13070 targets Epidermal Growth Factor Receptor in FACS, ICC/IF, IHC (P), IP, and WB applications and shows reactivity with Human and Mouse samples. This antibody is not recommended for mouse lymph node tissue or human breast carcinoma in IHC applications. The MA5-13070 immunogen is hC2 20 d2 cells.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Chicken/Avian, Hamster, Porcine, Rabbit
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- TE111.5D11
- Vial size
- 500 µL
- Concentration
- 0.2 mg/ml
- Storage
- 4° C
Submitted references Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.
Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse.
Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.
Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.
MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells.
Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes.
DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome.
Immunohistochemical localization of progesterone receptor isoforms and estrogen receptor alpha in the chicken oviduct magnum during development.
Maternal protein restriction during gestation and lactation programs offspring ovarian steroidogenesis and folliculogenesis in the prepubertal gilts.
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Changes in the cellular localization of estrogen receptor alpha in the growing and regressing ovaries of Gallus domesticus during development.
Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.
Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior.
MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.
Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.
Estrogen receptor α L543A,L544A mutation changes antagonists to agonists, correlating with the ligand binding domain dimerization associated with DNA binding activity.
Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level.
Localization of estrogen receptor in the central lymphoid organs of chickens during the late stage of embryogenesis.
Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons.
Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.
Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics.
Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb.
GATA4 regulates estrogen receptor-alpha-mediated osteoblast transcription.
Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications.
The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERalpha-mediated transcriptional responses.
Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death.
Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements.
Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells.
Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.
Expression and subcellular distribution of native estrogen receptor beta in murine C2C12 cells and skeletal muscle tissue.
Coactivator function defines the active estrogen receptor alpha cistrome.
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.
Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells.
Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion.
Expression and localization of estrogen receptor alpha in the C2C12 murine skeletal muscle cell line.
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.
Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway.
Erythroid Kruppel-like factor regulates the G1 cyclin dependent kinase inhibitor p18INK4c.
Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression.
Interaction of MLL amino terminal sequences with menin is required for transformation.
Physiologically high concentrations of 17beta-estradiol enhance NF-kappaB activity in human T cells.
Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action.
Genome-wide analysis of estrogen receptor binding sites.
Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat.
Identification of estrogen receptor ligands leading to activation of non-genomic signaling pathways while exhibiting only weak transcriptional activity.
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.
Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway.
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.
Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity.
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.
Estrogen response element and the promoter context of the human and mouse lactoferrin genes influence estrogen receptor alpha-mediated transactivation activity in mammary gland cells.
Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)2-vitamin D3 in MCF-7 breast cancer cells.
Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation.
Context-dependent regulation of GATA-1 by friend of GATA-1.
Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform.
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Estrogen receptor expression in laryngeal muscle in relation to estrogen-dependent increases in synapse strength.
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.
Progesterone receptor isoforms expression pattern in human astrocytomas.
Ligand-independent activation of oestrogen receptor alpha by caveolin-1.
Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice.
Differential cellular localization of estrogen receptor alpha in uterine and mammary cells.
A therapeutic target for hormone-independent estrogen receptor-positive breast cancers.
Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF).
17 Beta-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells.
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
Classification of breast cancer cells on the basis of a functional assay for estrogen receptor.
Calmodulin is essential for estrogen receptor interaction with its motif and activation of responsive promoter.
Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4.
Svoronos N, Perales-Puchalt A, Allegrezza MJ, Rutkowski MR, Payne KK, Tesone AJ, Nguyen JM, Curiel TJ, Cadungog MG, Singhal S, Eruslanov EB, Zhang P, Tchou J, Zhang R, Conejo-Garcia JR
Cancer discovery 2017 Jan;7(1):72-85
Cancer discovery 2017 Jan;7(1):72-85
Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse.
Nanbo A, Kachi K, Yoshiyama H, Ohba Y
The Journal of general virology 2016 Nov;97(11):2989-3006
The Journal of general virology 2016 Nov;97(11):2989-3006
Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.
Malaterre J, Pereira L, Putoczki T, Millen R, Paquet-Fifield S, Germann M, Liu J, Cheasley D, Sampurno S, Stacker SA, Achen MG, Ward RL, Waring P, Mantamadiotis T, Ernst M, Ramsay RG
Oncogene 2016 May 12;35(19):2475-84
Oncogene 2016 May 12;35(19):2475-84
Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.
Irish JC, Mills JN, Turner-Ivey B, Wilson RC, Guest ST, Rutkovsky A, Dombkowski A, Kappler CS, Hardiman G, Ethier SP
Molecular oncology 2016 Jun;10(6):850-65
Molecular oncology 2016 Jun;10(6):850-65
MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells.
Aiello A, Bacci L, Re A, Ripoli C, Pierconti F, Pinto F, Masetti R, Grassi C, Gaetano C, Bassi PF, Pontecorvi A, Nanni S, Farsetti A
Scientific reports 2016 Dec 6;6:38414
Scientific reports 2016 Dec 6;6:38414
Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes.
Garcia-Cuellar MP, Büttner C, Bartenhagen C, Dugas M, Slany RK
Cell reports 2016 Apr 12;15(2):310-22
Cell reports 2016 Apr 12;15(2):310-22
DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome.
Slaats GG, Saldivar JC, Bacal J, Zeman MK, Kile AC, Hynes AM, Srivastava S, Nazmutdinova J, den Ouden K, Zagers MS, Foletto V, Verhaar MC, Miles C, Sayer JA, Cimprich KA, Giles RH
The Journal of clinical investigation 2015 Sep;125(9):3657-66
The Journal of clinical investigation 2015 Sep;125(9):3657-66
Immunohistochemical localization of progesterone receptor isoforms and estrogen receptor alpha in the chicken oviduct magnum during development.
González-Morán MG
Acta histochemica 2015 Oct;117(8):681-7
Acta histochemica 2015 Oct;117(8):681-7
Maternal protein restriction during gestation and lactation programs offspring ovarian steroidogenesis and folliculogenesis in the prepubertal gilts.
Sui S, He B, Jia Y, Li R, Cai D, Li X, Song H, Jia L, Zhao R
The Journal of steroid biochemistry and molecular biology 2014 Sep;143:267-76
The Journal of steroid biochemistry and molecular biology 2014 Sep;143:267-76
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Tannour-Louet M, Han S, Louet JF, Zhang B, Romero K, Addai J, Sahin A, Cheung SW, Lamb DJ
Nature medicine 2014 Jul;20(7):715-24
Nature medicine 2014 Jul;20(7):715-24
Changes in the cellular localization of estrogen receptor alpha in the growing and regressing ovaries of Gallus domesticus during development.
González-Morán MG
Biochemical and biophysical research communications 2014 Apr 25;447(1):197-204
Biochemical and biophysical research communications 2014 Apr 25;447(1):197-204
Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.
Gagnidze K, Weil ZM, Faustino LC, Schaafsma SM, Pfaff DW
Journal of neuroendocrinology 2013 Oct;25(10):939-55
Journal of neuroendocrinology 2013 Oct;25(10):939-55
Characterization of estrogen response element binding proteins as biomarkers of breast cancer behavior.
Kruer TL, Cummins TD, Powell DW, Wittliff JL
Clinical biochemistry 2013 Nov;46(16-17):1739-46
Clinical biochemistry 2013 Nov;46(16-17):1739-46
MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.
Maethner E, Garcia-Cuellar MP, Breitinger C, Takacova S, Divoky V, Hess JL, Slany RK
Cell reports 2013 May 30;3(5):1553-66
Cell reports 2013 May 30;3(5):1553-66
Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.
Bhat-Nakshatri P, Song EK, Collins NR, Uversky VN, Dunker AK, O'Malley BW, Geistlinger TR, Carroll JS, Brown M, Nakshatri H
BMC medical genomics 2013 Jun 11;6:21
BMC medical genomics 2013 Jun 11;6:21
Estrogen receptor α L543A,L544A mutation changes antagonists to agonists, correlating with the ligand binding domain dimerization associated with DNA binding activity.
Arao Y, Hamilton KJ, Coons LA, Korach KS
The Journal of biological chemistry 2013 Jul 19;288(29):21105-16
The Journal of biological chemistry 2013 Jul 19;288(29):21105-16
Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level.
Miranda TB, Voss TC, Sung MH, Baek S, John S, Hawkins M, Grøntved L, Schiltz RL, Hager GL
Cancer research 2013 Aug 15;73(16):5130-9
Cancer research 2013 Aug 15;73(16):5130-9
Localization of estrogen receptor in the central lymphoid organs of chickens during the late stage of embryogenesis.
Katayama M, Fukuda T, Narabara K, Abe A, Kondo Y
Bioscience, biotechnology, and biochemistry 2012;76(11):2003-7
Bioscience, biotechnology, and biochemistry 2012;76(11):2003-7
Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons.
Kam MK, Lee KY, Tam PK, Lui VC
PloS one 2012;7(5):e35799
PloS one 2012;7(5):e35799
Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.
Tuttle R, Miller KR, Maiorano JN, Termuhlen PM, Gao Y, Berberich SJ
International journal of cancer 2012 May 15;130(10):2291-9
International journal of cancer 2012 May 15;130(10):2291-9
Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics.
He HH, Meyer CA, Chen MW, Jordan VC, Brown M, Liu XS
Genome research 2012 Jun;22(6):1015-25
Genome research 2012 Jun;22(6):1015-25
Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb.
Zhao L, Glazov EA, Pattabiraman DR, Al-Owaidi F, Zhang P, Brown MA, Leo PJ, Gonda TJ
Nucleic acids research 2011 Jun;39(11):4664-79
Nucleic acids research 2011 Jun;39(11):4664-79
GATA4 regulates estrogen receptor-alpha-mediated osteoblast transcription.
Miranda-Carboni GA, Guemes M, Bailey S, Anaya E, Corselli M, Peault B, Krum SA
Molecular endocrinology (Baltimore, Md.) 2011 Jul;25(7):1126-36
Molecular endocrinology (Baltimore, Md.) 2011 Jul;25(7):1126-36
Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications.
Badve S, Collins NR, Bhat-Nakshatri P, Turbin D, Leung S, Thorat M, Dunn SE, Geistlinger TR, Carroll JS, Brown M, Bose S, Teitell MA, Nakshatri H
The American journal of pathology 2010 May;176(5):2139-49
The American journal of pathology 2010 May;176(5):2139-49
The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERalpha-mediated transcriptional responses.
Shu FJ, Sidell N, Yang D, Kallen CB
The Journal of steroid biochemistry and molecular biology 2010 Jun;120(4-5):172-9
The Journal of steroid biochemistry and molecular biology 2010 Jun;120(4-5):172-9
Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death.
Choi EJ, Kim DH, Kim JG, Kim DY, Kim JD, Seol OJ, Jeong CS, Park JW, Choi MY, Kang SG, Costa ME, Ojeda SR, Lee BJ
The Journal of biological chemistry 2010 Aug 6;285(32):25074-84
The Journal of biological chemistry 2010 Aug 6;285(32):25074-84
Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements.
Mason CE, Shu FJ, Wang C, Session RM, Kallen RG, Sidell N, Yu T, Liu MH, Cheung E, Kallen CB
Nucleic acids research 2010 Apr;38(7):2355-68
Nucleic acids research 2010 Apr;38(7):2355-68
Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells.
Flamini MI, Sanchez AM, Goglia L, Tosi V, Genazzani AR, Simoncini T
Molecular human reproduction 2009 Oct;15(10):675-85
Molecular human reproduction 2009 Oct;15(10):675-85
Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.
Salama SA, Kamel MW, Botting S, Salih SM, Borahay MA, Hamed AA, Kilic GS, Saeed M, Williams MY, Diaz-Arrastia CR
PloS one 2009 Oct 7;4(10):e7356
PloS one 2009 Oct 7;4(10):e7356
Expression and subcellular distribution of native estrogen receptor beta in murine C2C12 cells and skeletal muscle tissue.
Milanesi L, Vasconsuelo A, de Boland AR, Boland R
Steroids 2009 Jun;74(6):489-97
Steroids 2009 Jun;74(6):489-97
Coactivator function defines the active estrogen receptor alpha cistrome.
Lupien M, Eeckhoute J, Meyer CA, Krum SA, Rhodes DR, Liu XS, Brown M
Molecular and cellular biology 2009 Jun;29(12):3413-23
Molecular and cellular biology 2009 Jun;29(12):3413-23
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.
Tallack MR, Keys JR, Humbert PO, Perkins AC
The Journal of biological chemistry 2009 Jul 31;284(31):20966-74
The Journal of biological chemistry 2009 Jul 31;284(31):20966-74
Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells.
Wang C, Yu J, Kallen CB
PloS one 2008;3(10):e3523
PloS one 2008;3(10):e3523
Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion.
Giretti MS, Fu XD, De Rosa G, Sarotto I, Baldacci C, Garibaldi S, Mannella P, Biglia N, Sismondi P, Genazzani AR, Simoncini T
PloS one 2008 May 21;3(5):e2238
PloS one 2008 May 21;3(5):e2238
Expression and localization of estrogen receptor alpha in the C2C12 murine skeletal muscle cell line.
Milanesi L, Russo de Boland A, Boland R
Journal of cellular biochemistry 2008 Jul 1;104(4):1254-73
Journal of cellular biochemistry 2008 Jul 1;104(4):1254-73
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.
Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M
The EMBO journal 2008 Feb 6;27(3):535-45
The EMBO journal 2008 Feb 6;27(3):535-45
Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway.
Kazi AA, Koos RD
Endocrinology 2007 May;148(5):2363-74
Endocrinology 2007 May;148(5):2363-74
Erythroid Kruppel-like factor regulates the G1 cyclin dependent kinase inhibitor p18INK4c.
Tallack MR, Keys JR, Perkins AC
Journal of molecular biology 2007 Jun 1;369(2):313-21
Journal of molecular biology 2007 Jun 1;369(2):313-21
Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression.
Zhang Z, Teng CT
Molecular and cellular endocrinology 2007 Jan 29;264(1-2):128-41
Molecular and cellular endocrinology 2007 Jan 29;264(1-2):128-41
Interaction of MLL amino terminal sequences with menin is required for transformation.
Caslini C, Yang Z, El-Osta M, Milne TA, Slany RK, Hess JL
Cancer research 2007 Aug 1;67(15):7275-83
Cancer research 2007 Aug 1;67(15):7275-83
Physiologically high concentrations of 17beta-estradiol enhance NF-kappaB activity in human T cells.
Hirano S, Furutama D, Hanafusa T
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Apr;292(4):R1465-71
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Apr;292(4):R1465-71
Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action.
Mannella P, Brinton RD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 13;26(37):9439-47
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 13;26(37):9439-47
Genome-wide analysis of estrogen receptor binding sites.
Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M
Nature genetics 2006 Nov;38(11):1289-97
Nature genetics 2006 Nov;38(11):1289-97
Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat.
Shirai M, Yamanaka M, Shiina H, Igawa M, Kawakami T, Ishii N, Lue TF, Fujime M, Dahiya R
Biochemical and biophysical research communications 2006 Mar 17;341(3):755-62
Biochemical and biophysical research communications 2006 Mar 17;341(3):755-62
Identification of estrogen receptor ligands leading to activation of non-genomic signaling pathways while exhibiting only weak transcriptional activity.
Wessler S, Otto C, Wilck N, Stangl V, Fritzemeier KH
The Journal of steroid biochemistry and molecular biology 2006 Jan;98(1):25-35
The Journal of steroid biochemistry and molecular biology 2006 Jan;98(1):25-35
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.
Cheng AS, Jin VX, Fan M, Smith LT, Liyanarachchi S, Yan PS, Leu YW, Chan MW, Plass C, Nephew KP, Davuluri RV, Huang TH
Molecular cell 2006 Feb 3;21(3):393-404
Molecular cell 2006 Feb 3;21(3):393-404
Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway.
Simoncini T, Scorticati C, Mannella P, Fadiel A, Giretti MS, Fu XD, Baldacci C, Garibaldi S, Caruso A, Fornari L, Naftolin F, Genazzani AR
Molecular endocrinology (Baltimore, Md.) 2006 Aug;20(8):1756-71
Molecular endocrinology (Baltimore, Md.) 2006 Aug;20(8):1756-71
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.
Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF
Neoplasia (New York, N.Y.) 2005 Sep;7(9):873-82
Neoplasia (New York, N.Y.) 2005 Sep;7(9):873-82
Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity.
Sentis S, Le Romancer M, Bianchin C, Rostan MC, Corbo L
Molecular endocrinology (Baltimore, Md.) 2005 Nov;19(11):2671-84
Molecular endocrinology (Baltimore, Md.) 2005 Nov;19(11):2671-84
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.
Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M
Cell 2005 Jul 15;122(1):33-43
Cell 2005 Jul 15;122(1):33-43
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.
Milne TA, Martin ME, Brock HW, Slany RK, Hess JL
Cancer research 2005 Dec 15;65(24):11367-74
Cancer research 2005 Dec 15;65(24):11367-74
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.
Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB
Molecular cell 2005 Apr 1;18(1):71-82
Molecular cell 2005 Apr 1;18(1):71-82
Estrogen response element and the promoter context of the human and mouse lactoferrin genes influence estrogen receptor alpha-mediated transactivation activity in mammary gland cells.
Stokes K, Alston-Mills B, Teng C
Journal of molecular endocrinology 2004 Oct;33(2):315-34
Journal of molecular endocrinology 2004 Oct;33(2):315-34
Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)2-vitamin D3 in MCF-7 breast cancer cells.
Capiati DA, Rossi AM, Picotto G, Benassati S, Boland RL
Journal of cellular biochemistry 2004 Oct 1;93(2):384-97
Journal of cellular biochemistry 2004 Oct 1;93(2):384-97
Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation.
Kirma N, Luthra R, Jones J, Liu YG, Nair HB, Mandava U, Tekmal RR
Cancer research 2004 Jun 15;64(12):4162-70
Cancer research 2004 Jun 15;64(12):4162-70
Context-dependent regulation of GATA-1 by friend of GATA-1.
Letting DL, Chen YY, Rakowski C, Reedy S, Blobel GA
Proceedings of the National Academy of Sciences of the United States of America 2004 Jan 13;101(2):476-81
Proceedings of the National Academy of Sciences of the United States of America 2004 Jan 13;101(2):476-81
Molecular mechanism of estrogen receptor (ER)alpha-specific, estradiol-dependent expression of the progesterone receptor (PR) B-isoform.
Flötotto T, Niederacher D, Hohmann D, Heimerzheim T, Dall P, Djahansouzi S, Bender HG, Hanstein B
The Journal of steroid biochemistry and molecular biology 2004 Feb;88(2):131-42
The Journal of steroid biochemistry and molecular biology 2004 Feb;88(2):131-42
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Simoncini T, Rabkin E, Liao JK
Arteriosclerosis, thrombosis, and vascular biology 2003 Feb 1;23(2):198-203
Arteriosclerosis, thrombosis, and vascular biology 2003 Feb 1;23(2):198-203
Estrogen receptor expression in laryngeal muscle in relation to estrogen-dependent increases in synapse strength.
Wu KH, Tobias ML, Kelley DB
Neuroendocrinology 2003 Aug;78(2):72-80
Neuroendocrinology 2003 Aug;78(2):72-80
Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.
DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, Brown M
Cancer research 2002 Jan 1;62(1):89-98
Cancer research 2002 Jan 1;62(1):89-98
Progesterone receptor isoforms expression pattern in human astrocytomas.
González-Agüero G, Ondarza R, Gamboa-Domínguez A, Cerbón MA, Camacho-Arroyo I
Brain research bulletin 2001 Sep 1;56(1):43-8
Brain research bulletin 2001 Sep 1;56(1):43-8
Ligand-independent activation of oestrogen receptor alpha by caveolin-1.
Schlegel A, Wang C, Pestell RG, Lisanti MP
The Biochemical journal 2001 Oct 1;359(Pt 1):203-10
The Biochemical journal 2001 Oct 1;359(Pt 1):203-10
Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice.
Kirma N, Gill K, Mandava U, Tekmal RR
Cancer research 2001 Mar 1;61(5):1910-8
Cancer research 2001 Mar 1;61(5):1910-8
Differential cellular localization of estrogen receptor alpha in uterine and mammary cells.
Monje P, Zanello S, Holick M, Boland R
Molecular and cellular endocrinology 2001 Jul 5;181(1-2):117-29
Molecular and cellular endocrinology 2001 Jul 5;181(1-2):117-29
A therapeutic target for hormone-independent estrogen receptor-positive breast cancers.
Biswas DK, Cruz A, Pettit N, Mutter GL, Pardee AB
Molecular medicine (Cambridge, Mass.) 2001 Jan;7(1):59-67
Molecular medicine (Cambridge, Mass.) 2001 Jan;7(1):59-67
Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF).
Klinge CM
The Journal of steroid biochemistry and molecular biology 1999 Nov;71(1-2):1-19
The Journal of steroid biochemistry and molecular biology 1999 Nov;71(1-2):1-19
17 Beta-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells.
Suzuma I, Mandai M, Takagi H, Suzuma K, Otani A, Oh H, Kobayashi K, Honda Y
Investigative ophthalmology & visual science 1999 Aug;40(9):2122-9
Investigative ophthalmology & visual science 1999 Aug;40(9):2122-9
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R
Genes & development 1998 Nov 15;12(22):3488-98
Genes & development 1998 Nov 15;12(22):3488-98
Classification of breast cancer cells on the basis of a functional assay for estrogen receptor.
Biswas DK, Averboukh L, Sheng S, Martin K, Ewaniuk DS, Jawde TF, Wang F, Pardee AB
Molecular medicine (Cambridge, Mass.) 1998 Jul;4(7):454-67
Molecular medicine (Cambridge, Mass.) 1998 Jul;4(7):454-67
Calmodulin is essential for estrogen receptor interaction with its motif and activation of responsive promoter.
Biswas DK, Reddy PV, Pickard M, Makkad B, Pettit N, Pardee AB
The Journal of biological chemistry 1998 Dec 11;273(50):33817-24
The Journal of biological chemistry 1998 Dec 11;273(50):33817-24
Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4.
Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy SF, Brown M, Ewen ME
Molecular and cellular biology 1997 Sep;17(9):5338-47
Molecular and cellular biology 1997 Sep;17(9):5338-47
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of Estrogen Receptor using Estrogen Receptor Monoclonal Antibody (Product # MA5-13065) on Native Human MCF-7 Cells.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of Estrogen Receptor using Estrogen Receptor Monoclonal Antibody (Product # MA5-13065) on denatured Human MCF-7 Cells.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- IP-MS enrichment of ESR1 (LFQ intensity): ESR1 was enriched 68-fold from MCF7 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Product # 90409) and ESR1 antibody (Product # MA5-13065). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of antibody selectivity.
