Explore
Validate
Learn
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN966275 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (pTyr1248) antibody
- Antibody type
- Polyclonal
- Antigen
- The antiserum was produced against synthesized phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine1248 (P-E-YP-L-G).
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr1248
- Vial size
- 100 μg
- Concentration
- 100ug/100ul.
- Storage
- -20°C
Submitted references Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells.
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay.
Ramsauer VP, Carraway CA, Salas PJ, Carraway KL
The Journal of biological chemistry 2003 Aug 8;278(32):30142-7
The Journal of biological chemistry 2003 Aug 8;278(32):30142-7
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.
Jepson S, Komatsu M, Haq B, Arango ME, Huang D, Carraway CA, Carraway KL
Oncogene 2002 Oct 24;21(49):7524-32
Oncogene 2002 Oct 24;21(49):7524-32
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
Ren Z, Schaefer TS
The Journal of biological chemistry 2002 Oct 11;277(41):38486-93
The Journal of biological chemistry 2002 Oct 11;277(41):38486-93
Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay.
Eppenberger-Castori S, Kueng W, Benz C, Caduff R, Varga Z, Bannwart F, Fink D, Dieterich H, Hohl M, Müller H, Paris K, Schoumacher F, Eppenberger U
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001 Feb 1;19(3):645-56
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001 Feb 1;19(3):645-56
No comments: Submit comment
No validations: Submit validation data