ERBB2

gene product
CD340, HER-2, HER2, NEU, NGL
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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Invitrogen Antibodies
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376 antibodies
Proteintech Group
5 antibodies
R&D Systems
46 antibodies
OriGene
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antibodies-online
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NSJ Bioreagents
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Abnova Corporation
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Atlas Antibodies
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Cell Signaling Technology, Inc
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Boster Biological Technology
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Aviva Systems Biology
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LifeSpan BioSciences, Inc.
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Signalway Antibody LLC
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St John's Laboratory
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Rockland Immunochemicals, Inc.
3 antibodies
ProSci
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Bioworld Technology, Inc
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SignalChem
2 antibodies
Abbexa
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BioLegend
18 antibodies
Enzo Life Sciences
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Creative Biolabs
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RabMAbs
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FabGennix
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Abbkine Scientific Co.Ltd.
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Sino Biological Inc.
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Antibodies.com
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Creative Diagnostics
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MyBioSource
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Leading Biology
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ABEOMICS Inc.
4 antibodies
EMD Millipore
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GenWay
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Abbiotec
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RayBiotech, Inc.
9 antibodies
SICGEN
1 antibody
United States Biological
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Spring Bioscience
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Absolute Antibody
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Miltenyi Biotec
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DB Biotech
1 antibody
Sigma-Aldrich
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Nordic BioSite
4 antibodies
eBioscience, An Affymetrix Company
3 antibodies
Exalpha Biologicals, Inc.
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CPTAC
4 antibodies
MedChemExpress LLC
2 antibodies