orb386201

antibody from Biorbyt

Targeting: PMEL D12S53E, gp100, Pmel17, SI, SIL, SILV

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386201

Provider

Biorbyt

Product name

PMEL17 / Melanoma gp100 Antibody

Antibody type

Recombinant

Description

The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60-64 kDa), which is subsequently cleaved to generate 26kDa and 34-38kDa. By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This MAb stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antibody clone number

PMEL/1825R

Vial size

20 ug

Storage

Store the recombinant gp100 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).