Tissue expression
Cell line expression
Protein structure
PMEL
Premelanosome proteinD12S53E, gp100, Pmel17, SI, SIL, SILV
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Top validated antibodies |
|||||
Novus Biologicals | NBP2-33172 | Monoclonal |
WB
EL
ICC
IP
IHC
FC
PA
|
||
Invitrogen Antibodies | MA5-13232 | 50 references | Monoclonal |
WB
IHC
OA
|
|
OriGene | AM50168PU-S | Monoclonal |
WB
ICC
IP
IHC
FC
|
||
NovoPro Bioscience Inc. | 131090 | Monoclonal |
WB
EL
IP
IHC
FC
|
||
Abgent | AH10203 | Monoclonal |
WB
EL
IP
IHC
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider