M19774

antibody from Boster Biological Technology

Targeting: PMEL D12S53E, gp100, Pmel17, SI, SIL, SILV

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

M19774

Provider

Boster Biological Technology

Product name

Anti-gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Monoclonal Antibody

Antibody type

Monoclonal

Description

Mouse Monoclonal Antibody [Clone SPM286] antibody for PMEL17/PMEL detection. Host: Mouse.Size: 100ug/vial. Tested applications: IF. Reactive species: Equine. PMEL17/PMEL information: Molecular Weight: 70255 MW; Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes; Tissue Specificity: Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.

Reactivity

Human

Host

Mouse

Antibody clone number

SPM286

Vial size

100ug/vial

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.