PA1-16817

antibody from Invitrogen Antibodies

Targeting: NPC1 SLC65A1

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Supportive data in Antibodypedia)

Immunoelectron microscopy (Recommended by provider)

Antibody Data

Product number

PA1-16817

Provider

Invitrogen Antibodies

Product name

NPC1 Polyclonal Antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

By Western blot, PA1-16817 detects heterogeneously glycosylated NPC1 protein with prominent bands at ~170 and ~220 kDa. Suggested positive control: human fibroblast cell lysate.

Reactivity

Human, Mouse, Rat, Hamster, Porcine

Host

Rabbit

Isotype

IgG

Vial size

100 µL

Concentration

1 mg/mL

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

References

Submitted references

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.

Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N
Nature 2021 Aug;596(7873):570-575

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Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection.

Shoemaker CJ, Schornberg KL, Delos SE, Scully C, Pajouhesh H, Olinger GG, Johansen LM, White JM
PloS one 2013;8(2):e56265

Immunocytochemistry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Immunocytochemistry analysis of NPC1 in HeLa cells. Samples were incubated in NPC1 polyclonal antibody (Product # PA1-16817) followed by DyLight 488 (green). Nuclei were counterstained with DAPI (blue).

Immunohistochemistry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Immunohistochemical analysis of NPC1 in human brain, cortex, neurons and astrocytes. Samples were incubated in NPC1 polyclonal antibody (Product # PA1-16817).