NPC1

gene product
SLC65A1
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. [provided by RefSeq, Aug 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
407 antibodies from 37 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
44 antibodies
antibodies-online
134 antibodies
Proteintech Group
1 antibody
GeneTex
6 antibodies
Invitrogen Antibodies
7 antibodies
Biorbyt
18 antibodies
Abnova Corporation
5 antibodies
LifeSpan BioSciences, Inc.
54 antibodies
OriGene
4 antibodies
NovoPro Bioscience Inc.
4 antibodies
NSJ Bioreagents
3 antibodies
Aviva Systems Biology
2 antibodies
HUABIO Research
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
Abgent
6 antibodies
Acris Antibodies GmbH
3 antibodies
ProSci
3 antibodies
R&D Systems
1 antibody
FabGennix
3 antibodies
Antibodies.com
1 antibody
Boster Biological Technology
1 antibody
RabMAbs
2 antibodies
Everest Biotech
1 antibody
Creative Biolabs
15 antibodies
Abbexa
9 antibodies
BioLegend
2 antibodies
Atlas Antibodies
1 antibody
United States Biological
37 antibodies
Creative Diagnostics
7 antibodies
Leading Biology
5 antibodies
St John's Laboratory
2 antibodies
Abbiotec
1 antibody
RayBiotech, Inc.
1 antibody
MyBioSource
5 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
2 antibodies