NPC1

gene product
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. [provided by RefSeq, Aug 2009]
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357 antibodies from 33 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
18 antibodies
antibodies-online
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GeneTex
6 antibodies
Biorbyt
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Invitrogen Antibodies
3 antibodies
LifeSpan BioSciences, Inc.
52 antibodies
Abnova Corporation
5 antibodies
NovoPro Bioscience Inc.
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OriGene
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NSJ Bioreagents
3 antibodies
Aviva Systems Biology
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Proteintech Group
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
Abgent
6 antibodies
Acris Antibodies GmbH
3 antibodies
ProSci
3 antibodies
FabGennix
3 antibodies
Antibodies.com
1 antibody
Boster Biological Technology
1 antibody
RabMAbs
2 antibodies
Everest Biotech
1 antibody
Creative Biolabs
15 antibodies
BioLegend
2 antibodies
Atlas Antibodies
1 antibody
United States Biological
37 antibodies
Creative Diagnostics
6 antibodies
St John's Laboratory
2 antibodies
Abbiotec
1 antibody
RayBiotech, Inc.
1 antibody
MyBioSource
5 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
2 antibodies