Tissue expression
Cell line expression
Protein structure
NPC1
NPC intracellular cholesterol transporter 1SLC65A1
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. [provided by RefSeq, Aug 2009]
Top validated antibodies |
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Novus Biologicals | NB400-148 | 37 references | Polyclonal |
WB
ICC
IP
IHC
IEM
|
|
Proteintech Group | 13926-1-AP | 20 references | Polyclonal |
WB
EL
ICC
IHC |
|
antibodies-online | ABIN152916 | 32 references | Polyclonal |
WB
ICC
IHC
IEM |
|
GeneTex | GTX30687 | 2 references | Polyclonal |
WB
ICC
IHC
IEM |
|
Invitrogen Antibodies | PA1-16817 | 2 references | Polyclonal |
WB
ICC
IP
IHC
IEM
|
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider