Tissue expression
Cell line expression

NPC1

gene product
SLC65A1 
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. [provided by RefSeq, Aug 2009]
More gene data

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420 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
44 antibodies
Proteintech Group
1 antibody
antibodies-online
134 antibodies
GeneTex
6 antibodies
LifeSpan BioSciences, Inc.
54 antibodies
Invitrogen Antibodies
12 antibodies
Biorbyt
18 antibodies
Boster Biological Technology
3 antibodies
Abnova Corporation
5 antibodies
OriGene
4 antibodies
NovoPro Bioscience Inc.
4 antibodies
NSJ Bioreagents
3 antibodies
Aviva Systems Biology
2 antibodies
HUABIO Research
1 antibody
Abgent
6 antibodies
Cusabio Biotech Co., Ltd
6 antibodies
Acris Antibodies GmbH
3 antibodies
ProSci
3 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
R&D Systems
1 antibody
FabGennix
3 antibodies
Antibodies.com
1 antibody
RabMAbs
2 antibodies
Everest Biotech
1 antibody
Abbexa
9 antibodies
BioLegend
2 antibodies
Atlas Antibodies
1 antibody
United States Biological
37 antibodies
Creative Diagnostics
7 antibodies
Leading Biology
5 antibodies
Abbiotec
1 antibody
RayBiotech, Inc.
1 antibody
MyBioSource
5 antibodies
Creative Biolabs
15 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
EMD Millipore
2 antibodies
Rockland Immunochemicals, Inc.
1 antibody