ABIN564886

antibody from antibodies-online

Targeting: RNF139 HRCA1, RCA1, TRC8

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

ABIN564886

Provider

antibodies-online

Product name

anti-Ring Finger Protein 139 (RNF139) (AA 565-664), (partial) antibody

Antibody type

Polyclonal

Reactivity

Human

Host

Mouse

Epitope

AA 565-664, partial

Vial size

50 μL

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Handling

Aliquot to avoid repeated freezing and thawing.

References

Submitted references

The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.

Lee JP, Brauweiler A, Rudolph M, Hooper JE, Drabkin HA, Gemmill RM
Molecular cancer research : MCR 2010 Jan;8(1):93-106

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The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ
The Journal of cell biology 2009 Sep 7;186(5):685-92

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The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.

Irisawa M, Inoue J, Ozawa N, Mori K, Sato R
The Journal of biological chemistry 2009 Oct 16;284(42):28995-9004

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RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.

Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM, Drabkin HA, Gemmill RM
Oncogene 2007 Apr 5;26(16):2263-71