Tissue expression
Cell line expression
Protein structure
RNF139
Ring finger protein 139HRCA1, RCA1, TRC8
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
antibodies-online | ![]() |
5 references | Monoclonal |
|
|
Novus Biologicals | ![]() |
1 references | Monoclonal |
|
|
Abnova Corporation | ![]() |
1 references | Monoclonal |
|
|
LSBio | ![]() |
Polyclonal |
|
||
Everest Biotech | ![]() |
Polyclonal |
|