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- References [141]
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- Immunohistochemistry [1]
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- Product number
- 66169-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Caspase 9/p35/p10 antibody
- Antibody type
- Monoclonal
- Description
- Caspase 9/p35/p10 antibody (Cat. #66169-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1B7G2
- Vial size
- 20ul, 150ul
Submitted references Echinacoside regulates the IRE1/XBP1 signaling pathway through HSP72 to reduce endoplasmic reticulum stress and improve diabetic kidney disease.
Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.
Multifunctional platinum(IV) complexes reverse cisplatin resistance in triple- negative breast cancer via ferroptosis and apoptosis.
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Decoding the healing secrets of Gegenqinlian decoction: A promising approach to radiation-induced intestinal injury.
Identification of MDM4 as a Prognostic Biomarker and a Target for Therapeutics in Colorectal Cancer.
Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation.
Discovery of α-carboline fused benzofuran-containing anticancer agents as rapid apoptosis inducers through intrinsic pathway.
Fascin-1 Limits Secondary Damage by Preventing Oxidative‑Stress‑Induced Microglial Death After Spinal Cord Injury.
Blackened Panax quinquefolius L. Saponins and Their Cytotoxic Effect on HepG2 Cells.
Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.
EOAI3402143 inhibits lung adenocarcinoma progression through the NF-κB/NR4A1 pathway.
Major vault protein inhibits CSFV replication by promoting cell apoptosis.
Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.
The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
The ester derivative Palmitoylcarnitine abrogates cervical cancer cell survival by enhancing lipotoxicity and mitochondrial dysfunction.
Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis.
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
Polydopamine-Based Nanoparticles for Synergistic Chemotherapy of Prostate Cancer.
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells.
Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress.
OTUD6B promotes cholangiocarcinoma growth by regulating STAT3 phosphorylation through deubiquitination of PTK2.
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer.
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts.
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd.
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
3'-Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma.
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.
Effects of sulforaphane on prostate cancer stem cells-like properties: In vitro and molecular docking studies.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Establishment of sheep nasal mucosa explant model and its application in antiviral research.
Crebanine induces ROS-dependent apoptosis in human hepatocellular carcinoma cells via the AKT/FoxO3a signaling pathway.
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
CPT1A modulates PI3K/Akt/mTOR pathway to promote preeclampsia.
An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway.
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice.
Simple Nano-Luciferase-Based Assay for the Rapid and High-Throughput Detection of SARS-CoV-2 3C-Like Protease.
PM2.5 exposure exacerbates mice thoracic aortic aneurysm and dissection by inducing smooth muscle cell apoptosis via the MAPK pathway.
MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells.
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Protective Roles of Xijiao Dihuang Tang on Coronary Artery Injury in Kawasaki Disease.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction.
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Chemical Composition, Antitumor Properties, and Mechanism of the Essential Oil from Plagiomnium acutum T. Kop.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Role of Nrf2 Nucleus Translocation in Beauvericin-Induced Cell Damage in Rat Hepatocytes.
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system.
Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
LS-HB-Mediated Photodynamic Therapy Inhibits Proliferation and Induces Cell Apoptosis in Melanoma.
MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer.
Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Lianhuaqingwen alleviates p53-mediated apoptosis in alveolar epithelial cells to prevent LPS-induced ALI.
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT.
Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells.
Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach.
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Oxidative stress-mediated apoptosis is involved in bisphenol S-induced reproductive toxicity in male C57BL/6 mice.
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Autophagy Induction by Trichodermic Acid Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis in Colon Cancer Cells.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Protective effect of Idelalisib on carbon tetrachloride-induced liver fibrosis via microRNA-124-3P/phosphatidylinositol-3-hydroxykinase signalling pathway.
Integration of exonuclease III-powered three-dimensional DNA walker with single-molecule detection for multiple initiator caspases assay.
A Natural Degradant of Curcumin, Feruloylacetone Inhibits Cell Proliferation via Inducing Cell Cycle Arrest and a Mitochondrial Apoptotic Pathway in HCT116 Colon Cancer Cells.
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Niclosamide: drug repurposing for human chondrosarcoma treatment via the caspase-dependent mitochondrial apoptotic pathway.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore.
Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway.
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Rosmarinic Acid as a Candidate in a Phenotypic Profiling Cardio-/Cytotoxicity Cell Model Induced by Doxorubicin.
Pseudolaric acid B induces apoptosis in human rhabdomyosarcoma RD cells.
Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.
Leukemia cells apoptosis by a newly discovered heterogeneous polysaccharide from Angelica sinensis (Oliv.) Diels.
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Caspase-8 Induces Lysosome-Associated Cell Death in Cancer Cells.
Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer.
Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection.
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Restoration of p53 acetylation by HDAC inhibition permits the necrosis/apoptosis switch of pancreatic ainar cell during experimental pancreatitis in mice.
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Melatonin alleviates weanling stress in mice: Involvement of intestinal microbiota.
Pseudo-Ginsenoside Rh2 induces A549 cells apoptosis via the Ras/Raf/ERK/p53 pathway.
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells.
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.
Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.
Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells.
Geng R, Ma C, Wen L, Dai W, Liu J, Yang J, Hu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158062
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158062
Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.
Xia Q, Dong S, Xu W, Lai Q, Song H, Zhang W
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168128
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168128
Multifunctional platinum(IV) complexes reverse cisplatin resistance in triple- negative breast cancer via ferroptosis and apoptosis.
Cao G, Zhou J, Qian Y, Yang Y, Hu W, Huang X, Liu Q, Liu Z
Journal of inorganic biochemistry 2026 Jul;280:113295
Journal of inorganic biochemistry 2026 Jul;280:113295
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Xu J, Liu W, Chen L, Zhang J, Zhang D, Huang X, Zhang G
Cell death and differentiation 2026 Jan;33(1):126-139
Cell death and differentiation 2026 Jan;33(1):126-139
Decoding the healing secrets of Gegenqinlian decoction: A promising approach to radiation-induced intestinal injury.
Zhang M, Wang SJ, Du XQ, Li GA, Yu YY, Zhang YQ, Liu WJ, Song F, Cao W, Sun Y, Li XQ
Journal of ethnopharmacology 2026 Jan 10;354:120473
Journal of ethnopharmacology 2026 Jan 10;354:120473
Identification of MDM4 as a Prognostic Biomarker and a Target for Therapeutics in Colorectal Cancer.
Shang X, Zheng X, Jiang A, Zhao N, Chen Y, Liu N, Chen M, Liang X, Ruan Z, Tian T, Fu X, Yao Y
Biotechnology and applied biochemistry 2026 Feb;73(1):28-42
Biotechnology and applied biochemistry 2026 Feb;73(1):28-42
Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation.
Jiang Y, Wang W, Li Q, Xia T, Xia B, Huang C, Lu X, Yin L, You Q, Yang R
Clinical and experimental pharmacology & physiology 2026 Feb;53(2):e70106
Clinical and experimental pharmacology & physiology 2026 Feb;53(2):e70106
Discovery of α-carboline fused benzofuran-containing anticancer agents as rapid apoptosis inducers through intrinsic pathway.
Lin F, Luo Z, Wu Q, Lv L, Chen Z, He Y, Yuan HX, Zhao Y, Nie S
European journal of medicinal chemistry 2026 Feb 5;303:118464
European journal of medicinal chemistry 2026 Feb 5;303:118464
Fascin-1 Limits Secondary Damage by Preventing Oxidative‑Stress‑Induced Microglial Death After Spinal Cord Injury.
Zhan F, Xu D, Shi T, Niu H, Wang S, Feng E, Cao Y
Neurochemical research 2026 Feb 17;51(2):75
Neurochemical research 2026 Feb 17;51(2):75
Blackened Panax quinquefolius L. Saponins and Their Cytotoxic Effect on HepG2 Cells.
Tian Y, Gao J, Liu Y, Liu R
Molecules (Basel, Switzerland) 2026 Apr 1;31(7)
Molecules (Basel, Switzerland) 2026 Apr 1;31(7)
Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.
Yuan HJ, Xiang GH, Liu Y, Li Y, Liu WL, Wei JX, Xue YT, Hao H
PloS one 2025;20(1):e0317738
PloS one 2025;20(1):e0317738
EOAI3402143 inhibits lung adenocarcinoma progression through the NF-κB/NR4A1 pathway.
Xu J, Liu W, Chen L, Zhang J, Zhang D, Huang H, Zhang X, Huang X, Zhang G
Acta biochimica et biophysica Sinica 2025 Oct 9;58(4):833-44
Acta biochimica et biophysica Sinica 2025 Oct 9;58(4):833-44
Major vault protein inhibits CSFV replication by promoting cell apoptosis.
Luo B, Su N, Quan Y, Li N, Chen C, Zhang L, Xu L, Guo K
Veterinary microbiology 2025 Nov;310:110745
Veterinary microbiology 2025 Nov;310:110745
Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.
Zhi Y, Ren Y, Xia X, Tian Q, Meng Y, Tao S
Microbial pathogenesis 2025 Nov;208:107957
Microbial pathogenesis 2025 Nov;208:107957
The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways.
Wu N, Wang L, Yu S, Wei X, Xu H, Xu S, Jia P, Zhang X
Cell biology and toxicology 2025 Nov 27;41(1):159
Cell biology and toxicology 2025 Nov 27;41(1):159
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Tang Z, Guo C, Wen N, Jin H, Dong Y, Xu B, Ma X, Han L, Liu J
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Wen Y, Zou Z, Li Y, Zhang D, Liu Z, Liu H, Li X, Wu W, Zeng L, Zou Q, Yi W
International journal of biological macromolecules 2025 May;310(Pt 1):143307
International journal of biological macromolecules 2025 May;310(Pt 1):143307
The ester derivative Palmitoylcarnitine abrogates cervical cancer cell survival by enhancing lipotoxicity and mitochondrial dysfunction.
Eswaran S, Mascarenhas R, Kabekkodu SP
Cell communication and signaling : CCS 2025 May 3;23(1):213
Cell communication and signaling : CCS 2025 May 3;23(1):213
Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis.
Ju J, Xu N, Li B, Shi D, Cai J, Zheng Q, Ye L, Zhang S, Wang C
Acta biochimica et biophysica Sinica 2025 Jun 20;57(10):1611-1624
Acta biochimica et biophysica Sinica 2025 Jun 20;57(10):1611-1624
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC.
Liu W, Xu J, Chen L, Zhang D, Zhang J, Lu L, Zhang X, Huang X, Zhang G
Biochemical pharmacology 2025 Jul;237:116925
Biochemical pharmacology 2025 Jul;237:116925
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
Zhang Y, Tang D, Yang C, Lin C, Yuan Y, He M, Chen Y, Mao Z, Ying Y, Ma X, Kong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.
Gao L, Shi Q, Sun B, Zhang X, Zheng P, Zhou L, Tian G, Li H
JACC. Basic to translational science 2025 Aug;10(8):101257
JACC. Basic to translational science 2025 Aug;10(8):101257
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
Zhu S, Zhang X, Liu W, Zhou Z, Xiong S, Chen X, Peng C
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
Polydopamine-Based Nanoparticles for Synergistic Chemotherapy of Prostate Cancer.
Hu K, Zhang D, Ma W, Gu Y, Zhao J, Mu X
International journal of nanomedicine 2024;19:6717-6730
International journal of nanomedicine 2024;19:6717-6730
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells.
Tao Y, Niu Q, Yao Y, Wang K, Dong H, Zhao X, Zeng Z, Li H
Frontiers in pharmacology 2024;15:1528100
Frontiers in pharmacology 2024;15:1528100
Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.
Yao B, Ma J, Ran Q, Chen H, He X
Frontiers in pharmacology 2024;15:1483518
Frontiers in pharmacology 2024;15:1483518
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Cao Z, Ma N, Shan M, Wang S, Du J, Cheng J, Sun P, Sun N, Jin L, Fan K, Yin W, Li H, Yin C, Sun Y
International journal of molecular sciences 2024 Sep 14;25(18)
International journal of molecular sciences 2024 Sep 14;25(18)
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
Ye P, Liu H, Qin Y, Li Z, Huang Z, Bu X, Peng Q, Duan N, Wang W, Wang X
Chemico-biological interactions 2024 Sep 1;400:111166
Chemico-biological interactions 2024 Sep 1;400:111166
The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress.
Jia S, Wen X, Zhu M, Fu X
Cellular and molecular life sciences : CMLS 2024 Oct 26;81(1):440
Cellular and molecular life sciences : CMLS 2024 Oct 26;81(1):440
OTUD6B promotes cholangiocarcinoma growth by regulating STAT3 phosphorylation through deubiquitination of PTK2.
Xing G, Chen H, Guo Z, Cui Y, Li Y, Shen J
Cell biology international 2024 Nov;48(11):1766-1778
Cell biology international 2024 Nov;48(11):1766-1778
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Jin L, Gan D, He W, Wu N, Xiang S, Wei Y, Eriani G, Ji Y, Guan MX, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.
Man S, Bi J, Liu F, Xie W, Ma L
Molecular nutrition & food research 2024 Mar;68(6):e2300706
Molecular nutrition & food research 2024 Mar;68(6):e2300706
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y
Cancer communications (London, England) 2024 Mar;44(3):408-432
Cancer communications (London, England) 2024 Mar;44(3):408-432
Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer.
Wang Y, Fan J, Liu Y, Du J, Liang B, Wang H, Song Z
Aging 2024 Mar 22;16(7):5967-5986
Aging 2024 Mar 22;16(7):5967-5986
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L
iScience 2024 Mar 15;27(3):109246
iScience 2024 Mar 15;27(3):109246
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts.
Zhu Y, Zhao T, Wu Y, Xie S, Sun W, Wu J
Journal of periodontal research 2024 Jun;59(3):599-610
Journal of periodontal research 2024 Jun;59(3):599-610
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd.
Peng HX, Chai F, Chen KH, Huang YX, Wei GJ, Yuan H, Pang YF, Luo SH, Wang CF, Chen WC
Biological trace element research 2024 Jun;202(6):2616-2629
Biological trace element research 2024 Jun;202(6):2616-2629
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Wang Q, Li A, Yu H, Wang C, Wang T, Zhang J
International journal of molecular sciences 2024 Jun 26;25(13)
International journal of molecular sciences 2024 Jun 26;25(13)
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624
mSphere 2024 Jun 25;9(6):e0023624
3'-Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma.
Koh YC, Huang WZ, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2024 Jan;68(1):e2300108
Molecular nutrition & food research 2024 Jan;68(1):e2300108
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Liu S, Tao Y, Wu S, Lin J, Fu S, Lu J, Zhang J, Fu B, Zhang E, Xu J, Wang J, Li L, Zhang L, Wang Z
Chinese medicine 2024 Jan 9;19(1):7
Chinese medicine 2024 Jan 9;19(1):7
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Lin N, Sun L, Chai J, Qi H, Zhao Y, Ma J, Xia M, Hu X
Cancer cell international 2024 Jan 18;24(1):38
Cancer cell international 2024 Jan 18;24(1):38
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
Huang Y, Chan S, Chen S, Liu X, Li M, Zheng L, Dong Z, Yang Z, Liu Z, Zhou D, Zhang X, Zhang B
Journal of translational medicine 2024 Feb 3;22(1):133
Journal of translational medicine 2024 Feb 3;22(1):133
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.
Chen SJ, Ren LK, Fei XB, Liu P, Wang X, Zhu CH, Pan YZ
Aging 2024 Feb 1;16(3):2617-2637
Aging 2024 Feb 1;16(3):2617-2637
Effects of sulforaphane on prostate cancer stem cells-like properties: In vitro and molecular docking studies.
Xuan Y, Xu J, Que H, Zhu J
Archives of biochemistry and biophysics 2024 Dec;762:110216
Archives of biochemistry and biophysics 2024 Dec;762:110216
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Wang X, Fu Y, Yang X, Chen Y, Zeng N, Hu S, Ouyang S, Pan X, Wu S
Scientific reports 2024 Apr 27;14(1):9723
Scientific reports 2024 Apr 27;14(1):9723
Establishment of sheep nasal mucosa explant model and its application in antiviral research.
Zheng J, Lin J, Ma Y, Yang C, Zhong Q, Li Y, Yang Q
Frontiers in microbiology 2023;14:1124936
Frontiers in microbiology 2023;14:1124936
Crebanine induces ROS-dependent apoptosis in human hepatocellular carcinoma cells via the AKT/FoxO3a signaling pathway.
Tan J, Xiang Y, Xiong Y, Zhang Y, Qiao B, Zhang H
Frontiers in pharmacology 2023;14:1069093
Frontiers in pharmacology 2023;14:1069093
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Li X, Wang G, Zhou X, Zhao H, Chen X, Cui Q, Li M, Gao X, Wei X, Ye L, Li D, Hong P
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Lin H, Han H, Yang M, Wen Z, Chen Q, Ma Y, Wang X, Wang C, Yin T, Wang X, Lu G, Chen H, Qi J, Yang Y
European journal of medicinal chemistry 2023 Mar 5;249:115166
European journal of medicinal chemistry 2023 Mar 5;249:115166
CPT1A modulates PI3K/Akt/mTOR pathway to promote preeclampsia.
Chen M, Chao B, Xu J, Liu Z, Tao Y, He J, Wang J, Yang H, Luo X, Qi H
Placenta 2023 Mar 3;133:23-31
Placenta 2023 Mar 3;133:23-31
An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.
Ruan GY, Ye LX, Lin JS, Lin HY, Yu LR, Wang CY, Mao XD, Zhang SH, Sun PM
Journal of translational medicine 2023 Mar 17;21(1):204
Journal of translational medicine 2023 Mar 17;21(1):204
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C
Inflammation 2023 Jun;46(3):1061-1076
Inflammation 2023 Jun;46(3):1061-1076
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway.
Song QQ, Lin LP, Chen YL, Qian JC, Wei K, Su JW, Ding JH, Lu M, Liu Y, Tan RX, Hu G
Acta pharmacologica Sinica 2023 Jun;44(6):1262-1276
Acta pharmacologica Sinica 2023 Jun;44(6):1262-1276
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
Lin A, Guo Y, Zhang H, Lin P, Tao K, Jiang L, Xu D, Chen B
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166687
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166687
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice.
Li H, Liu Y, Zhou J, Liu S, Liu Y, Yang Y, Wang W, Che Y, Inam M, Guan L
International journal of biological macromolecules 2023 Jan 31;226:1444-1454
International journal of biological macromolecules 2023 Jan 31;226:1444-1454
Simple Nano-Luciferase-Based Assay for the Rapid and High-Throughput Detection of SARS-CoV-2 3C-Like Protease.
Liu J, Ge C, Zha L, Lin L, Li R
Analytical chemistry 2023 Jan 17;95(2):714-719
Analytical chemistry 2023 Jan 17;95(2):714-719
PM2.5 exposure exacerbates mice thoracic aortic aneurysm and dissection by inducing smooth muscle cell apoptosis via the MAPK pathway.
Ming Y, Zhou X, Liu G, Abudupataer M, Zhu S, Xiang B, Yin X, Lai H, Sun Y, Wang C, Li J, Zhu K
Chemosphere 2023 Feb;313:137500
Chemosphere 2023 Feb;313:137500
MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells.
Hu Z, Linn N, Li Q, Zhang K, Liao J, Han Q, Zhang H, Guo J, Hu L, Pan J, Li Y, Tang Z
The Science of the total environment 2023 Feb 1;858(Pt 3):160157
The Science of the total environment 2023 Feb 1;858(Pt 3):160157
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer medicine 2023 Aug;12(15):16337-16358
Cancer medicine 2023 Aug;12(15):16337-16358
Protective Roles of Xijiao Dihuang Tang on Coronary Artery Injury in Kawasaki Disease.
Zhang J, Zhuge Y, Rong X, Ni C, Niu C, Wen Z, Lin H, Chu M, Jia C
Cardiovascular drugs and therapy 2023 Apr;37(2):257-270
Cardiovascular drugs and therapy 2023 Apr;37(2):257-270
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
Qu XQ, Chen QF, Shi QQ, Luo QQ, Zheng SY, Li YH, Bai LY, Gan S, Zhou XY
Frontiers in immunology 2022;13:901566
Frontiers in immunology 2022;13:901566
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
Li Y, Deng Y, Zhang X, Fu H, Han X, Guo W, Zhao W, Zhao X, Yu C, Li H, Lei K, Wang T
Frontiers in pharmacology 2022;13:897465
Frontiers in pharmacology 2022;13:897465
Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction.
Pan B, Xia Y, Fang S, Ai J, Wang K, Zhang J, Du C, Chen Y, Liu L, Yan S
Frontiers in pharmacology 2022;13:1043252
Frontiers in pharmacology 2022;13:1043252
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
Guo K, Liu R, Jing R, Wang L, Li X, Zhang K, Fu M, Ye J, Hu Z, Zhao W, Xu N
Frontiers in pharmacology 2022;13:1036013
Frontiers in pharmacology 2022;13:1036013
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Zheng CM, Lu KC, Chen YJ, Li CY, Lee YH, Chiu HW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Zhao Y, Lin J, Li J, Bwalya C, Xu Y, Niu Y, Zhang Y, Wu J, Xu Y, Chen J, Ye S, Lin L
International journal of molecular sciences 2022 Oct 18;23(20)
International journal of molecular sciences 2022 Oct 18;23(20)
Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Yu R, Zhong J, Zhou Q, Ren W, Liu Z, Bian Y
Chemico-biological interactions 2022 Oct 1;366:110135
Chemico-biological interactions 2022 Oct 1;366:110135
Chemical Composition, Antitumor Properties, and Mechanism of the Essential Oil from Plagiomnium acutum T. Kop.
Li M, Wang L, Li S, Hua C, Gao H, Ning D, Li C, Zhang C, Jiang F
International journal of molecular sciences 2022 Nov 26;23(23)
International journal of molecular sciences 2022 Nov 26;23(23)
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Tian Y, Wu H, Cao Y, Li R, Zou K, Xu W, Lu L
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Wang X, Li X, Xia Y, Wang D, Li X, Liu L, Zheng Q, Li D, Jiang Q
Journal of natural products 2022 May 27;85(5):1351-1362
Journal of natural products 2022 May 27;85(5):1351-1362
Role of Nrf2 Nucleus Translocation in Beauvericin-Induced Cell Damage in Rat Hepatocytes.
Shi J, Wang Y, Xu W, Cai G, Zou H, Yuan Y, Gu J, Liu Z, Bian J
Toxins 2022 May 25;14(6)
Toxins 2022 May 25;14(6)
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Li Z, Xiao Z, Feng Y, Wang Q, Teng M
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system.
Wu N, Tu Y, Fan G, Ding J, Luo J, Wang W, Zhang C, Yuan C, Zhang H, Chen P, Tan S, Xiao H
Asian journal of pharmaceutical sciences 2022 Mar;17(2):253-267
Asian journal of pharmaceutical sciences 2022 Mar;17(2):253-267
Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
Qin J, Xia PF, Yuan XZ, Wang SG
Journal of hazardous materials 2022 Mar 5;425:127842
Journal of hazardous materials 2022 Mar 5;425:127842
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z
Cell biology and toxicology 2022 Jun;38(3):531-551
Cell biology and toxicology 2022 Jun;38(3):531-551
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Wu J, Yang C, Yang M, Liang Z, Wu Y, Kong X, Fan H, Wang S, Ning C, Xiao W, Jin Y, Yi J, Yuan Z
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
LS-HB-Mediated Photodynamic Therapy Inhibits Proliferation and Induces Cell Apoptosis in Melanoma.
Wang L, Wang L, Zhang Y, Zhao Z, Liu C, Li M, Liu J, Wang S, Yang D, Luo F, Yan J
Molecular pharmaceutics 2022 Jul 4;19(7):2607-2619
Molecular pharmaceutics 2022 Jul 4;19(7):2607-2619
MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer.
Zhao C, Miao J, Sun R, Liang R, Chen W, Gao Y, Wang X, Han S, Zhao W, Lei T, Huang C
Aging 2022 Jul 22;14(14):5878-5894
Aging 2022 Jul 22;14(14):5878-5894
Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.
Wang L, Cheng L, Ma L, Ahmad Farooqi A, Qiao G, Zhang Y, Ye H, Liu M, Huang J, Yang X, Lin X, Cao S
Phytotherapy research : PTR 2022 Jan;36(1):525-542
Phytotherapy research : PTR 2022 Jan;36(1):525-542
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
Lin Z, Yang S, Zhou Y, Hou Z, Li L, Meng M, Ge C, Zeng B, Lai J, Gao H, Zhao Y, Xie Y, He S, Tang W, Li R, Tan J, Wang W
Translational oncology 2022 Feb;16:101331
Translational oncology 2022 Feb;16:101331
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Qin J, Sun X, Ma Y, Cheng Y, Ma Q, Jing W, Qu S, Liu L
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Lu QJ, Li JY, Lin HX, Cai YS, Liu CS, Fu LP, Liu G, Yuan LX
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
Lianhuaqingwen alleviates p53-mediated apoptosis in alveolar epithelial cells to prevent LPS-induced ALI.
Yang R, Yang H, Li W, Yue F, Chen H, Hao Y, Hu K
The Journal of pharmacy and pharmacology 2022 Aug 19;74(8):1117-1124
The Journal of pharmacy and pharmacology 2022 Aug 19;74(8):1117-1124
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Xu J, Zhan T, Zheng W, Huang YK, Chen K, Zhang XH, Ren P, Huang X
Acta cirurgica brasileira 2021;35(12):e351202
Acta cirurgica brasileira 2021;35(12):e351202
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Ma N, Yang X, Qi C, Yu Q, Zhu C, Ren H
Oxidative medicine and cellular longevity 2021;2021:8847844
Oxidative medicine and cellular longevity 2021;2021:8847844
Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT.
Ye J, Qi L, Liang J, Zong K, Liu W, Li R, Feng R, Zhai W
Journal of Cancer 2021;12(12):3548-3557
Journal of Cancer 2021;12(12):3548-3557
Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells.
Jin Y, Zhou Q, Geng J, Meng Q, Wei Z, Ding M, Zhou J, Zeng Y, Cao W, Liu F, Yu Y
Frontiers in pharmacology 2021;12:792360
Frontiers in pharmacology 2021;12:792360
Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach.
Yang R, Yang H, Wei J, Li W, Yue F, Song Y, He X, Hu K
Frontiers in pharmacology 2021;12:717652
Frontiers in pharmacology 2021;12:717652
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
Yang M, Li WY, Xie J, Wang ZL, Wen YL, Zhao CC, Tao L, Li LF, Tian Y, Sheng J
Frontiers in pharmacology 2021;12:639256
Frontiers in pharmacology 2021;12:639256
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Yang J, Zhang M, Yang D, Ma Y, Tang Y, Xing M, Li L, Chen L, Jin Y, Ma C
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Oxidative stress-mediated apoptosis is involved in bisphenol S-induced reproductive toxicity in male C57BL/6 mice.
Dai W, He QZ, Zhu BQ, Zeng HC
Journal of applied toxicology : JAT 2021 Nov;41(11):1839-1851
Journal of applied toxicology : JAT 2021 Nov;41(11):1839-1851
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Pan X, Zhou Y, Duan X, Cui J, Liu J, Song X, Ma W, Zhang W, Liu Y, Fan Y
Research in veterinary science 2021 Nov;140:47-55
Research in veterinary science 2021 Nov;140:47-55
Autophagy Induction by Trichodermic Acid Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis in Colon Cancer Cells.
Qu J, Zeng C, Zou T, Chen X, Yang X, Lin Z
International journal of molecular sciences 2021 May 25;22(11)
International journal of molecular sciences 2021 May 25;22(11)
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393
Journal of bone oncology 2021 Dec;31:100393
Protective effect of Idelalisib on carbon tetrachloride-induced liver fibrosis via microRNA-124-3P/phosphatidylinositol-3-hydroxykinase signalling pathway.
Li X, Li H, Zhang S, Zhang R, Li J, Wei Y, Yang C, Zhang F, Zhou H
Journal of cellular and molecular medicine 2021 Dec;25(24):11185-11197
Journal of cellular and molecular medicine 2021 Dec;25(24):11185-11197
Integration of exonuclease III-powered three-dimensional DNA walker with single-molecule detection for multiple initiator caspases assay.
Liu M, Xu R, Liu W, Qiu JG, Wang Y, Ma F, Zhang CY
Chemical science 2021 Dec 8;12(47):15645-15654
Chemical science 2021 Dec 8;12(47):15645-15654
A Natural Degradant of Curcumin, Feruloylacetone Inhibits Cell Proliferation via Inducing Cell Cycle Arrest and a Mitochondrial Apoptotic Pathway in HCT116 Colon Cancer Cells.
Chou YT, Koh YC, Nagabhushanam K, Ho CT, Pan MH
Molecules (Basel, Switzerland) 2021 Aug 12;26(16)
Molecules (Basel, Switzerland) 2021 Aug 12;26(16)
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Chen Y, Liang J, Liang X, Chen J, Wang Y, Cao J, Sun C, Ye J, Chen Q
Food science & nutrition 2021 Apr;9(4):1860-1869
Food science & nutrition 2021 Apr;9(4):1860-1869
Niclosamide: drug repurposing for human chondrosarcoma treatment via the caspase-dependent mitochondrial apoptotic pathway.
Yu QS, Xin HR, Qiu RL, Deng ZL, Deng F, Yan ZJ
American journal of translational research 2020;12(7):3688-3701
American journal of translational research 2020;12(7):3688-3701
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Wu X, Yu H, Zhou H, Li Z, Huang H, Xiao F, Xu S, Yang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Jiang N, Zhao H, Han Y, Li L, Xiong S, Zeng L, Xiao Y, Wei L, Xiong X, Gao P, Yang M, Liu Y, Sun L
Cell proliferation 2020 Nov;53(11):e12909
Cell proliferation 2020 Nov;53(11):e12909
Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore.
Zhao Y, Guo Y, Chen Y, Liu S, Wu N, Jia D
International journal of molecular medicine 2020 May;45(5):1514-1524
International journal of molecular medicine 2020 May;45(5):1514-1524
Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway.
Ji J, Wu L, Feng J, Mo W, Wu J, Yu Q, Li S, Zhang J, Dai W, Xu X, Mao Y, Xu S, Chen K, Li J, Guo C
International immunopharmacology 2020 Jul;84:106529
International immunopharmacology 2020 Jul;84:106529
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665
BMC cancer 2020 Jul 16;20(1):665
Rosmarinic Acid as a Candidate in a Phenotypic Profiling Cardio-/Cytotoxicity Cell Model Induced by Doxorubicin.
Zhang Q, Li J, Peng S, Zhang Y, Qiao Y
Molecules (Basel, Switzerland) 2020 Feb 14;25(4)
Molecules (Basel, Switzerland) 2020 Feb 14;25(4)
Pseudolaric acid B induces apoptosis in human rhabdomyosarcoma RD cells.
Liu C, Wang F, Wang B, Wu T, Wang Y, Huo W, Zhang S, Su Y, Liu J, Liu Y, Yu J
Oncology letters 2020 Dec;20(6):358
Oncology letters 2020 Dec;20(6):358
Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.
Wu L, Mo W, Feng J, Li J, Yu Q, Li S, Zhang J, Chen K, Ji J, Dai W, Wu J, Xu X, Mao Y, Guo C
British journal of pharmacology 2020 Aug;177(16):3760-3777
British journal of pharmacology 2020 Aug;177(16):3760-3777
Leukemia cells apoptosis by a newly discovered heterogeneous polysaccharide from Angelica sinensis (Oliv.) Diels.
Liu W, Xiao K, Ren L, Sui Y, Chen J, Zhang T, Li XQ, Cao W
Carbohydrate polymers 2020 Aug 1;241:116279
Carbohydrate polymers 2020 Aug 1;241:116279
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Bai L, Liang J, Li L, Li E
Oncology reports 2020 Apr;43(4):1208-1220
Oncology reports 2020 Apr;43(4):1208-1220
Caspase-8 Induces Lysosome-Associated Cell Death in Cancer Cells.
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Journal of virology 2019 Nov 15;93(22)
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European journal of pharmacology 2019 Nov 15;863:172701
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Neurotoxicology 2015 Jul;49:149-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 66169-1-Ig( Caspase 9 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Caspase 9 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human Caspase 9. This antibody recognizes human antigen. The Caspase 9 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
