CASP9

gene product
APAF-3, ICE-LAP6, MCH6, PPP1R56
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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AntibodyRefsTypeAVIWBELICCIPIHCFC
Invitrogen Antibodies
24 antibodies
Novus Biologicals
17 antibodies
GeneTex
17 antibodies
NovoPro Bioscience Inc.
8 antibodies
Abnova Corporation
28 antibodies
Enzo Life Sciences
12 antibodies
Proteintech Group
3 antibodies
Boster Biological Technology
7 antibodies
Cell Signaling Technology, Inc
11 antibodies
antibodies-online
398 antibodies
Biorbyt
67 antibodies
LifeSpan BioSciences, Inc.
206 antibodies