orb153753

antibody from Biorbyt
Targeting: BRAF BRAF1
Provider product page for orb153753
Western blot
Immunohistochemistry

Antibody data

Product number
orb153753 - Provider product page
Provider
Biorbyt
Product name
BRAF antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal antibody to BRAF. B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system. It has been observed that MAPK is activated by B-Raf in response to nerve growth factor. More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity. Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.
Reactivity
Human, Mouse, Rat
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 ul
Storage
Store at -20°C. Avoid freeze / thaw cycles.
BRAF protein structure - orb153753 shown in red.