Antibody data
- Antibody Data
- Antigen structure
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- Product number
- orb153753 - Provider product page
- Provider
- Biorbyt
- Product name
- BRAF antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody to BRAF. B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system. It has been observed that MAPK is activated by B-Raf in response to nerve growth factor. More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity. Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.
- Reactivity
- Human, Mouse, Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 ul
- Storage
- Store at -20°C. Avoid freeze / thaw cycles.
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