C2

gene product
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. [provided by RefSeq, Mar 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
450 antibodies from 27 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
158 antibodies
Novus Biologicals
58 antibodies
R&D Systems
3 antibodies
GeneTex
2 antibodies
OriGene
15 antibodies
LifeSpan BioSciences, Inc.
71 antibodies
Aviva Systems Biology
4 antibodies
Invitrogen Antibodies
7 antibodies
Signalway Antibody LLC
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Biorbyt
15 antibodies
Creative Biolabs
49 antibodies
Abnova Corporation
10 antibodies
Acris Antibodies GmbH
2 antibodies
Abgent
1 antibody
ProSci
3 antibodies
St John's Laboratory
2 antibodies
Abbiotec
3 antibodies
Enzo Life Sciences
3 antibodies
MyBioSource
3 antibodies
Creative Diagnostics
6 antibodies
United States Biological
13 antibodies
GenWay
1 antibody
RayBiotech, Inc.
1 antibody
Sino Biological Inc.
1 antibody
Sigma-Aldrich
4 antibodies