14667-1-AP

antibody from Proteintech Group

Targeting: DCN DSPG2, SLRR1B

Provider product page for 14667-1-AP

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Antibody data

Antibody Data
Antigen structure
References [49]
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Western blot [1]
Immunohistochemistry [1]

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Product number: 14667-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14667-1-AP, RRID:AB_2090265
Product name: Decorin antibody
Antibody type: Polyclonal
Description: KD/KO validated Decorin antibody (Cat. #14667-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DCN protein structure - 14667-1-AP shown in red.

Submitted references Diminished expression of decorin drives enzalutamide resistance in CRPC by suppressing ACSL4-dependent lipid remodeling and ferroptosis.

Zhang P, Wu L, Nie J, Qi Z, Wang L, Zheng H, Guo Z, Yu Y
International immunopharmacology 2026 May 15;177:116496

Decorin inhibits the migration and invasion of the LPS + high glucose-induced primary trophoblast cell through ADAMTS12.

Chen Q, Hu T, Luo H
In vitro cellular & developmental biology. Animal 2026 Mar 24;

Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.

Liu Z, Shen Y, Luo AD, Ao WL, Guan SQ, Lei F, Xu ZC, Yu CY, Xu P, Huang H
Neurochemical research 2026 Feb 17;51(2):74

VEGF-sustained regulation and hydrogel-activated graded porous titanium scaffold for functional regeneration of the tendon-bone interface.

Lin T, Li J, Luo L, Sang H, Vashisth MK, Shen J, Luo X, Xu L, Pan J, Huang W
Materials today. Bio 2026 Apr;37:102903

Overexpression of Decorin Optimizes the Treatment Efficacy of Umbilical Cord Mesenchymal Stem Cells in Bleomycin-Induced Pulmonary Fibrosis in Rats.

Zhi Y, Shu M, Tang P, Li Y, Guo M, Deng J, Mo H, Wu M, Liu B, Mai Y, Ling J, Zhao X, Zhang X, Zuo W
Stem cells international 2025;2025:6324980

USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins.

Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q
International journal of nanomedicine 2025;20:1615-1634

Development of a prognostic model for hepatocellular carcinoma based on microvascular invasion characteristic genes by spatial transcriptomics sequencing.

Mu X, Pan L, Wang X, Liu C, Li Y, Cai Y, He Z
Frontiers in immunology 2025;16:1529569

FAP(+) fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus.

Ma J, Huang Y, Chen J, Li Y, Yao R, Li X, Liang Q, Chen X, Peng C, Liu K, Zhai Y, Zhang X, Ma X, Wang X, Huang Q, He F
Nature communications 2025 Oct 23;16(1):9387

PA2G4 in CAFs promotes biochemical recurrence of prostate cancer via H3K18la.

Ji S, Xi Z, Li T, Jia G, Zhang Y, Zheng C, Wang W, Ni W, Zhang Y, Zhou Z, Wu W, Jiang Q
Cell & bioscience 2025 Nov 4;15(1):152

Association between cancer-associated fibroblasts and prognosis of neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma: a bioinformatics analysis based on single-cell RNA sequencing.

Huang Z, Cong Z, Luo J, Qiu B, Wang K, Gao C, Xu Y, Yang N, Zou Z, Hu L, Shen Y
Cancer cell international 2025 Mar 1;25(1):74

Mesenchymal Stem Cells and Fibroblasts Contribute to Microvascular Proliferation in Glioblastoma and are Correlated with Immunosuppression and Poor Outcome.

Poon CC, Herbrich SM, Chen Y, Hossain A, Fuller GN, Jindal S, Basu S, Ledbetter D, Macaluso M, Phillips LM, Gumin J, He Z, Parker Kerrigan BC, Singh SK, Singh P, Zaman MF, Ng Tang D, Goswami S, Lang FF, Sharma P
Cancer immunology research 2025 Jun 4;13(6):804-820

Controlled decorin delivery from injectable microgels promotes scarless vocal fold repair.

Friedman RM, Brown EA, Bonelli HM, Gupta Y, Aronson MR, McDaid K, Oh HM, Bandora EA, Zur KB, Gottardi R
bioRxiv : the preprint server for biology 2025 Jun 28;

Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway.

Xia M, Yuan Y, Fang D, Tan X, Zhao F, Li X, Gao P, Zhou Z, Nan T, Xin Z, Li X, Guan R
The world journal of men's health 2025 Jul;43(3):580-594

Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis.

Lin L, Huang T, Li L, Lin Y, Chen F, Zheng Z, Zhou J, Wang Y, You W, Duan Y, An Y, He S, Ye W
Journal of translational medicine 2025 Feb 4;23(1):159

Ultrastructural Aspects of Corneal Functional Recovery in Rats Following Intrastromal Keratocyte Injection.

Ma Q, Riau AK, Young RD, Bell JS, Shebanova O, Terrill NJ, Yam GHF, Han E, Meek KM, Mehta JS, Boote C
Investigative ophthalmology & visual science 2025 Feb 3;66(2):45

CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis.

Li Z, Jiang J, Cai K, Qiao Y, Zhang X, Wang L, Kang Y, Wu X, Zhao B, Wang X, Zhang T, Lin Z, Wu J, Lu S, Gao H, Jin H, Xu C, Huangfu X, James Z, Chen Q, Zheng X, Liu NN, Zhao J
Bone research 2025 Feb 24;13(1):26

Overexpression of decorin gene influences the biological behaviors of follicular thyroid carcinoma cells.

Lin Q, Ma Y, Guo R, Guo H, Wang X, Yang T
Oncology letters 2025 Aug;30(2):374

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors.

Zhao C, Hu X, Guan X, Fu X, Wang T, Li M, Liu X, Zhao J, Wu D, Zhang F, Fu J, Li J, Zhang T, Jiang X, Yan C, Jia W, Yang E, Chen J
Nature communications 2025 Aug 23;16(1):7870

Generation of a novel lung fibrosis model using precision-cut lung slices from transgenic TGFβ1 mice.

Liu Y, Papagianis PC, de Kuijper ZSC, Chitty JG, Thomas B, Borghuis T, Jongman RM, Pillay J, Richards EA, Melgert BN, Burgess JK, Bourke JE
American journal of physiology. Cell physiology 2025 Aug 1;329(2):C611-C623

Spatially resolved transcriptomic analysis of the adult human prostate.

Hu J, Liu F, Zhang J, Yin L, Cao W, Xu W, Chang Y, Wang Y, Wang J, Hou Y, Liu L, Chen S, Zhu G, Jiang J, Wang Z, Wei GH, He HH, Gu D, Chen K, Ren S
Nature genetics 2025 Apr;57(4):922-933

FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release.

Chen X, Liu H, Huang Y, Li L, Jiang X, Liu B, Li N, Zhu L, Liu C, Xiao J
International journal of molecular sciences 2025 Apr 24;26(9)

The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer.

Hu S, Hu C, Xu J, Yu P, Yuan L, Li Z, Liang H, Zhang Y, Chen J, Wei Q, Zhang S, Yang L, Su D, Du Y, Xu Z, Bai F, Cheng X
Nature communications 2024 Sep 30;15(1):8447

Qizhu anticancer prescription enhances immunosurveillance of liver cancer cells by regulating p21-dependent secretory phenotypes.

Hu R, Li J, Huang Q, Zhong X, Sun J, Yi J, Peng L, Liu X, Yang Y, Yang W, Wang Y, Ma W, Feng W, Xu Y, Zhou X
Journal of ethnopharmacology 2024 Oct 28;333:118400

Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice.

Zhong Y, Zhou L, Guo Y, Wang F, He F, Cheng Y, Meng X, Xie H, Zhang Y, Li J
Clinical and translational medicine 2024 May;14(5):e1660

Texture maintenance and degradation mechanism of ice-stored grass carp (Ctenopharyngodon idella): A scope of intramuscular connective tissue.

Yang F, Teng J, Liu J, Yu D, Gao P, Yu P, Jiang Q, Xu Y, Xia W
Food chemistry 2024 Jan 30;432:137256

Single-Nucleus RNA Sequencing Unravels Early Mechanisms of Human Becker Muscular Dystrophy.

Xie Z, Liu C, Sun C, Liu Y, Peng J, Meng L, Deng J, Wang Z, Yang C, Yuan Y, Xie Z
Annals of neurology 2024 Dec;96(6):1070-1085

Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate.

Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM, Pearce OMT
Cancer research communications 2024 Apr 3;4(4):970-985

Epithelial cells activate fibroblasts to promote esophageal cancer development.

Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X, Xi Y, Ma Y, Cheng G, Lin D, Wu C
Cancer cell 2023 May 8;41(5):903-918.e8

Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors.

Yang W, Xu M, Xu S, Guan Q, Geng S, Wang J, Wei W, Xu H, Liu Y, Meng Y, Gao MQ
Breast cancer research : BCR 2023 Aug 29;25(1):100

Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1.

Lu J, Yang X, He C, Chen Y, Li C, Li S, Chen Y, Wu Y, Xiang Z, Kang J, Jiang G, Wang C, Diarra MD, He R, Feng G, Yan R
Acta biomaterialia 2023 Apr 15;161:80-99

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts.

Blokland KEC, Nizamoglu M, Habibie H, Borghuis T, Schuliga M, Melgert BN, Knight DA, Brandsma CA, Pouwels SD, Burgess JK
Frontiers in pharmacology 2022;13:989169

Decorin Promotes Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells.

Adachi O, Sugii H, Itoyama T, Fujino S, Kaneko H, Tomokiyo A, Hamano S, Hasegawa D, Obata J, Yoshida S, Kadowaki M, Sugiura R, Albougha MS, Maeda H
Molecules (Basel, Switzerland) 2022 Nov 25;27(23)

Temporal changes in the muscle extracellular matrix due to volumetric muscle loss injury.

Hoffman DB, Raymond-Pope CJ, Sorensen JR, Corona BT, Greising SM
Connective tissue research 2022 Mar;63(2):124-137

An integrated map of fibroblastic populations in human colon mucosa and cancer tissues.

Li S, Lu R, Shu L, Chen Y, Zhao J, Dai J, Huang Q, Li X, Meng W, Long F, Li Y, Fan C, Zhou Z, Mo X
Communications biology 2022 Dec 3;5(1):1326

Single-cell RNA sequencing analysis to characterize cells and gene expression landscapes in atrial septal defect.

Wang Z, Wang H, Zhang Y, Yu F, Yu L, Zhang C
Journal of cellular and molecular medicine 2021 Oct;25(20):9660-9673

Gut-Lung Dysbiosis Accompanied by Diabetes Mellitus Leads to Pulmonary Fibrotic Change through the NF-κB Signaling Pathway.

Wang G, Hu YX, He MY, Xie YH, Su W, Long D, Zhao R, Wang J, Dai C, Li H, Si ZP, Cheng X, Li RM, Li Z, Yang X
The American journal of pathology 2021 May;191(5):838-856

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes.

Wang M, Li Z, Zhang M, Wang H, Zhang Y, Feng Y, Liu Y, Chen J
PloS one 2020;15(4):e0232321

Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model.

Shi Z, Wang Q, Zhang Y, Jiang D
Stem cell research & therapy 2020 Jun 26;11(1):253

Quantitative proteomics reveal the alterations in the spinal cord after myocardial ischemia‑reperfusion injury in rats.

Li SY, Li ZX, He ZG, Wang Q, Li YJ, Yang Q, Wu DZ, Zeng HL, Xiang HB
International journal of molecular medicine 2019 Nov;44(5):1877-1887

Hypomorphic mutations of TRIP11 cause odontochondrodysplasia.

Wehrle A, Witkos TM, Unger S, Schneider J, Follit JA, Hermann J, Welting T, Fano V, Hietala M, Vatanavicharn N, Schoner K, Spranger J, Schmidts M, Zabel B, Pazour GJ, Bloch-Zupan A, Nishimura G, Superti-Furga A, Lowe M, Lausch E
JCI insight 2019 Feb 7;4(3)

Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency.

Wang M, Xue S, Fang Q, Zhang M, He Y, Zhang Y, Lammi MJ, Cao J, Chen J
Glycoconjugate journal 2019 Dec;36(6):451-459

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Wang H, Ning T, Song C, Luo X, Xu S, Zhang X, Deng Z, Ma D, Wu B
Journal of cellular physiology 2019 Aug;234(8):12897-12909

Identification of CAV1 and DCN as potential predictive biomarkers for lung adenocarcinoma.

Yan Y, Xu Z, Qian L, Zeng S, Zhou Y, Chen X, Wei J, Gong Z
American journal of physiology. Lung cellular and molecular physiology 2019 Apr 1;316(4):L630-L643

Negative impact of hyperglycaemia on mouse alveolar development.

He MY, Wang G, Han SS, Li K, Jin Y, Liu M, Si ZP, Wang J, Liu GS, Yang X
Cell cycle (Georgetown, Tex.) 2018;17(1):80-91

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U
PLoS genetics 2018 Mar;14(3):e1007242

Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome.

Han L, Xin X, Wang H, Li J, Hao Y, Wang M, Zheng C, Shen C
Scientific reports 2018 Mar 22;8(1):5074

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice.

Wang Y, Guan M, Zhao X, Li X
Pharmaceutical biology 2018 Dec;56(1):325-332

Effects of polysaccharide from Physalis alkekengi var. francheti on liver injury and intestinal microflora in type-2 diabetic mice.

Zhao X, Chen Z, Yin Y, Li X
Pharmaceutical biology 2017 Dec;55(1):2020-2025

Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY, Liu F
Journal of proteomics 2014 Oct 14;110:155-71

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 14667-1-AP(DCN antibody) at dilution of 1:1500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Decorin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Decorin. This antibody recognizes human,mouse,rat antigen. The Decorin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14667-1-AP.pdf

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