346007
antibody from BioLegend
Targeting: SIGLEC1
CD169, dJ1009E24.1, FLJ00051, FLJ00055, FLJ00073, FLJ32150, sialoadhesin, SIGLEC-1, SN
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 346007 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#346007, RRID:AB_11150773
- Product name
- APC anti-human CD169 (Sialoadhesin, Siglec-1)
- Antibody type
- Monoclonal
- Antigen
- Human Rhinovirus (HRV14) infected, monocyte derived-DCs
- Description
- CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a 210 kD type I single membrane-spanning glycoprotein. It is the largest member of the Siglec family, consisting of 1709 amino acids and belonging to the immunoglobulin superfamily. CD169 is expressed by macrophages and dendritic cells. By its affinity to α2,3-linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes, monocytes, NK, B and T cells. Several CD169 counter receptors, such as CD227 on human breast cancer cells, CD43 on T cells and CD206 on macrophages, have been reported.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- IFN-γ + TNF-α-stimulated human monocytes (day-3) were stained with CD169 (clone 7-239) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
- Conjugate
- Red dye