SIGLEC1

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Description

Sialic acid binding Ig like lectin 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (3686970 - 3712600)

Ensembl ID

ENSG00000088827  (ver. 103.38)

Orthologs

Mouse Siglec1: ENSMUSG00000027322

UniProt

Q9BZZ2

neXtProt

NX_Q9BZZ2

Human splice variants
Mouse splice variants

Protein structure