Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS8353 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PCMT1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human PCMT1.
- Description
- PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase), also known as PIMT, is a member of the L-isoaspartyl/D-aspartyl protein methyltransferase family and is highly expressed in brain. Functioning as a monomer, PCMT localizes to the cytoplasm and participates in the degradation and/or repair of damaged proteins. More specifically, PCMT1 recognizes isomerized Asp or Asn residues in peptides and proteins and catalyzes the conversion of abnormal L-isoaspartyl and D-aspartyl residues to methyl esters that may then spontaneously hydrolyze to re-form normal aspartyl residues. In congruence with this reaction, PCMT1 converts the methyl donor S-adenosylmethionine (AdoMet) to S-andenosylhomocysteine (AdoHcy). In mice lacking PCMT1, damaged proteins accumulate in a variety of tissues and the ratio between AdoMet and AdoHcy is increased in brain tissue. The phenotypic result is progressive epilepsy and death at an early age.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of PCMT1 polyclonal antibody