PCMT1

This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Description

Protein-L-isoaspartate (D-aspartate) O-methyltransferase

Tissue specificity

Low tissue specificity

Subcell location

Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (149749443 - 149811420)

Ensembl ID

ENSG00000120265  (ver. 103.38)

Orthologs

Mouse Pcmt1: ENSMUSG00000019795

UniProt

P22061

neXtProt

NX_P22061

Human splice variants
Mouse splice variants

Protein structure