66184-1-Ig

antibody from Proteintech Group

Targeting: SQSTM1 A170, OSIL, p60, p62, p62B, PDB3

Provider product page for 66184-1-Ig

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Antibody Data
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References [38]
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Product number: 66184-1-Ig - Provider product page
Provider: Proteintech Group
Product name: P62,SQSTM1 antibody
Antibody type: Monoclonal
Description: KD/KO validated P62,SQSTM1 antibody (Cat. #66184-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1H5C1
Vial size: 20ul, 150ul

SQSTM1 protein structure - 66184-1-Ig shown in red.

Submitted references CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.

Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A, Fang Y
The Journal of cell biology 2022 Jan 3;221(1)

GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy.

Guo W, Li W, Su Y, Liu S, Kan X, Ran X, Cao Y, Fu S, Liu J
International journal of biological sciences 2021;17(15):4271-4284

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.

Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.

Lloyd GM, Dhillon JS, Gorion KM, Riffe C, Fromholt SE, Xia Y, Giasson BI, Borchelt DR
Molecular neurodegeneration 2021 Sep 9;16(1):63

Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells.

Deng L, Zhao M, Cui Y, Xia Q, Jiang L, Yin H, Zhao L
Drug and chemical toxicology 2021 Sep 22;:1-12

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.

Li XJ, Zhang YY, Fu YH, Zhang H, Li HX, Li QF, Li HL, Tan RK, Jiang CX, Jiang W, Li ZX, Luo C, Lu BX, Dang YJ
Acta pharmacologica Sinica 2021 Oct;42(10):1556-1566

Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.

Zeng L, Zou Q, Huang P, Xiong L, Cheng Y, Chen Q, Li Y, He H, Yi W, Wei W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994

Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells.

Wang P, Li CG, Zhou X, Ding S
Clinical and experimental pharmacology & physiology 2021 Oct 6;

Pathogenic mechanism of congenital cataract caused by the CRYBA1/A3-G91del variant and related intervention strategies.

Xu J, Wang H, Wu C, Wang A, Wu W, Xu J, Luo C, Ni S, Yao K, Chen X
International journal of biological macromolecules 2021 Oct 31;189:44-52

UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer.

Wang D, He J, Dong J, Wu S, Liu S, Zhu H, Xu T
Cancer letters 2021 Oct 28;519:2-19

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036

Bidirectional role of reactive oxygen species during inflammasome activation in acrolein-induced human EAhy926 cells pyroptosis.

Jiang L, Luo S, Qiu T, Li Q, Jiang C, Sun X, Yang G, Zhang C, Liu X, Jiang L
Toxicology mechanisms and methods 2021 Nov;31(9):680-689

Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.

Zhao L, Zhou N, Zhang H, Pan F, Ai X, Wang Y, Hao S, Wang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582

SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.

Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2021 Nov 29;

Downregulation of FAPP2 gene induces cell autophagy and inhibits PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic leukemia.

Yuan T, Wang J, Shi C, Wang Y, Xia B, Xu W, Yang H, Yang Y, Ye MT, Khalid S, Liang Y, Tian C, You MJ, Wang Y
Hematological oncology 2021 Nov 18;

Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca²⁺/CaMKII signal pathway.

Chen TT, Zhou X, Xu YN, Li Y, Wu XY, Xiang Q, Fu LY, Hu XX, Tao L, Shen XC
Aging 2021 Mar 10;13(7):9542-9565

IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.

Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S, Hu J, Wang G
Nature communications 2021 Jun 15;12(1):3651

HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.

Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S
Oncology reports 2021 Jul;46(1)

RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.

Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571

Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.

Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209

Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.

Lu J, Lu J, Bu X, Li Y, Ge G, Guan S
Journal of food science 2021 Dec;86(12):5503-5515

Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.

Zhong S, Lian Y, Luo W, Luo R, Wu X, Ji J, Ji Y, Ding J, Wang X
Acta neuropathologica 2021 Dec;142(6):1003-1023

XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner.

Deng Y, Chen QS, Huang WF, Dai JW, Wu ZJ
Journal of gastrointestinal oncology 2021 Aug;12(4):1797-1810

Autocrined leptin promotes proliferation of non-small cell lung cancer (NSCLC) via PI3K/AKT and p53 pathways.

Wang J, Zhou F, Li F, Wang B, Hu Y, Li X
Annals of translational medicine 2021 Apr;9(7):568

Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury.

Quan X, Song L, Zheng X, Liu S, Ding H, Li S, Xu G, Li X, Liu L
Neuroscience 2021 Apr 15;460:107-119

TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis.

Wang D, Qi H, Zhang H, Zhou W, Li Y, Li A, Liu Q, Wang Y
International journal of biological sciences 2020;16(7):1180-1193

Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.

Mou Z, Yang C, Zhang Z, Wu S, Xu C, Cheng Z, Dai X, Chen X, Ou Y, Jiang H
Frontiers in genetics 2020;11:566918

The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer.

Sun W, Li J, Zhou L, Han J, Liu R, Zhang H, Ning T, Gao Z, Liu B, Chen X, Ba Y
Theranostics 2020;10(5):1981-1996

In vivo and in vitro studies using Clonorchis sinensis adult-derived total protein (CsTP) on cellular function and inflammatory effect in mouse and cell model.

Shang M, Sun H, Wu Y, Gong Y, Tang Z, Meng F, He L, Yu X, Huang Y, Li X
Parasitology research 2020 May;119(5):1641-1652

Niacin Alleviates Dairy Cow Mastitis by Regulating the GPR109A/AMPK/NRF2 Signaling Pathway.

Guo W, Liu J, Li W, Ma H, Gong Q, Kan X, Cao Y, Wang J, Fu S
International journal of molecular sciences 2020 May 8;21(9)

Phenotypic Drug Screening for Dysferlinopathy Using Patient-Derived Induced Pluripotent Stem Cells.

Kokubu Y, Nagino T, Sasa K, Oikawa T, Miyake K, Kume A, Fukuda M, Fuse H, Tozawa R, Sakurai H
Stem cells translational medicine 2019 Oct;8(10):1017-1029

Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF/6A cells.

Li R, Du J, Yao Y, Yao G, Wang X
Journal of cellular physiology 2019 Nov;234(11):20566-20576

Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin.

Han LL, Jia L, Wu F, Huang C
Molecular cancer research : MCR 2019 Nov;17(11):2267-2280

Parkin truncating variants result in a loss-of-function phenotype.

Santos M, Morais S, Pereira C, Sequeiros J, Alonso I
Scientific reports 2019 Nov 6;9(1):16150

Rab11a is required for porcine reproductive and respiratory syndrome virus induced autophagy to promote viral replication.

Wang K, Li S, Worku T, Hao X, Yang L, Zhang S
Biochemical and biophysical research communications 2017 Oct 14;492(2):236-242

Autophagy is essential for flavopiridol‑induced cytotoxicity against MCF‑7 breast cancer cells.

Wang S, Wang K, Wang H, Han J, Sun H
Molecular medicine reports 2017 Dec;16(6):9715-9720

Clinicopathological description of two cases with SQSTM1 gene mutation associated with frontotemporal dementia.

Kovacs GG, van der Zee J, Hort J, Kristoferitsch W, Leitha T, Höftberger R, Ströbel T, Van Broeckhoven C, Matej R
Neuropathology : official journal of the Japanese Society of Neuropathology 2016 Feb;36(1):27-38

Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.

Gao J, Qin S, Jiang C
Acta biochimica et biophysica Sinica 2015 Jul;47(7):522-9

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