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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
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- Product number
- ABIN1881829 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sequestosome 1 (SQSTM1) (C-Term), (Ser403), (AA 383-409) antibody
- Antibody type
- Polyclonal
- Antigen
- This SQSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-409 amino acids from the C-terminal region of human SQSTM1.
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- C-Term,Ser403,AA 383-409
- Antibody clone number
- RB41445
- Vial size
- 400 μL
- Concentration
- 0.5 mg/mL
Submitted references Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming.
Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone.
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW 2nd, Yin XM
The Journal of biological chemistry 2010 Sep 3;285(36):27879-90
The Journal of biological chemistry 2010 Sep 3;285(36):27879-90
Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone.
Visconti MR, Langston AL, Alonso N, Goodman K, Selby PL, Fraser WD, Ralston SH
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 Nov;25(11):2368-73
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 Nov;25(11):2368-73
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD
Molecular and cellular biology 2010 Jul;30(13):3275-85
Molecular and cellular biology 2010 Jul;30(13):3275-85
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T
The Journal of biological chemistry 2010 Jul 16;285(29):22576-91
The Journal of biological chemistry 2010 Jul 16;285(29):22576-91
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Supportive validation
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- antibodies-online (provider)
- Main image
- Experimental details
- SQSTM1 Antibody (C-term S403) (ABIN1881829) western blot analysis in Hela cell line lysates (35 μg/lane). This demonstrates the SQSTM1 antibody detected the SQSTM1 protein (arrow).
