CABT-B9278

antibody from Creative Diagnostics

Targeting: SQSTM1 A170, OSIL, p60, p62, p62B, PDB3

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9278

Provider

Creative Diagnostics

Product name

Mouse anti-Human p62 Ick ligand monoclonal antibody, clone 4/Q73

Antibody type

Monoclonal

Description

p62 lck ligand (zeta-interacting protein (ZIP)) is a cytoplasmic protein that binds to the SH2 domain of lck (a T cell src tyrosine kinase) in the absence of a phosphotyrosine in either protein. The ubiquitously expressed p62 lck ligand contains a cysteine rich region that is similar to a zinc finger domain, a G protein binding region, a PEST sequence, and several phosphorylation sites. Deletion of the p62 lck ligand N-terminal domain has been reported to abrogate its binding to lck. However, mutation of the tyrosine did not have an effect. In addition, p62 lck ligand binds to the pseudosubstrate region of the PKCšø catalytic domain. In turn, PKCšø phosphorylates p62. p62 lck ligand binds to the dimerization region of PKCšø, thereby inhibiting PKCšø-PKCšø interaction. This suggests that p62 lck ligand may compete with PKCšø. However, it requires PKCšø for proper subcellular localization. These data suggest that p62 lck ligand may be part of the protein bridge that links PKCšø to the tyrosine kinases involved in signaling pathways.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG