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Learn16382-1-AP
antibody from Proteintech Group
Targeting: SERPINA1
A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, PI, PI1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16382-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16382-1-AP, RRID:AB_10641185
- Product name
- Alpha 1 Antitrypsin antibody
- Antibody type
- Polyclonal
- Description
- Alpha 1 Antitrypsin antibody (Cat. #16382-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling.
Characterization of dietary and herbal sourced natural compounds that modulate SEL1L-HRD1 ERAD activity and alleviate protein misfolding in the ER.
Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells.
Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility.
New Mechanisms of Bromelain in Alleviating Non-Alcoholic Fatty Liver Disease-Induced Deregulation of Blood Coagulation.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.
Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury.
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Targeting the Apoa1 locus for liver-directed gene therapy.
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Discovery of bladder cancer biomarkers in paired pre- and postoperative urine samples.
Alpha-1 Antitrypsin Induces Epithelial-to-Mesenchymal Transition, Endothelial-to-Mesenchymal Transition, and Drug Resistance in Lung Cancer Cells.
Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression.
Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity.
Comparative analysis of proteomes between diabetic and normal human sperm: Insights into the effects of diabetes on male reproduction based on the regulation of mitochondria-related proteins.
Free circulating active elastase contributes to chronic inflammation in patients on hemodialysis.
Label-free proteomic analysis of placental proteins during Toxoplasma gondii infection.
The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.
Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancer.
Identification of differentially expressed serum proteins in infectious purpura fulminans.
High-throughput screening of tumor metastatic-related differential glycoprotein in hepatocellular carcinoma by iTRAQ combines lectin-related techniques.
Ma Y, Chen Y, Zhan L, Dong Q, Wang Y, Li X, He L, Zhang J
Cell death discovery 2024 May 6;10(1):219
Cell death discovery 2024 May 6;10(1):219
Characterization of dietary and herbal sourced natural compounds that modulate SEL1L-HRD1 ERAD activity and alleviate protein misfolding in the ER.
Yang J, Zhi Y, Wen S, Pan X, Wang H, He X, Lu Y, Zhu Y, Chen Y, Shi G
The Journal of nutritional biochemistry 2023 Jan;111:109178
The Journal of nutritional biochemistry 2023 Jan;111:109178
Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells.
Muranaka M, Takamatsu S, Ouchida T, Kanazawa Y, Kondo J, Nakagawa T, Egashira Y, Fukagawa K, Gu J, Okamoto T, Kamada Y, Miyoshi E
International journal of molecular sciences 2023 Apr 11;24(8)
International journal of molecular sciences 2023 Apr 11;24(8)
Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility.
Ouni E, Nedbal V, Da Pian M, Cao H, Haas KT, Peaucelle A, Van Kerk O, Herinckx G, Marbaix E, Dolmans MM, Tuuri T, Otala M, Amorim CA, Vertommen D
Matrix biology : journal of the International Society for Matrix Biology 2022 May;109:91-120
Matrix biology : journal of the International Society for Matrix Biology 2022 May;109:91-120
New Mechanisms of Bromelain in Alleviating Non-Alcoholic Fatty Liver Disease-Induced Deregulation of Blood Coagulation.
Hu PA, Wang SH, Chen CH, Guo BC, Huang JW, Lee TS
Nutrients 2022 Jun 1;14(11)
Nutrients 2022 Jun 1;14(11)
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Wilkinson DJ, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, Arques MDC, Janciauskiene S, Refaie R, Rankin KS, Young DA, Rowan AD
The FEBS journal 2022 Jan;289(1):121-139
The FEBS journal 2022 Jan;289(1):121-139
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.
Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA
Cell reports 2022 Dec 6;41(10):111775
Cell reports 2022 Dec 6;41(10):111775
Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury.
Stearns K, Goldklang M, Xiao R, Zelonina T, Blomenkamp K, Teckman J, D'Armiento JM
PloS one 2021;16(2):e0246040
PloS one 2021;16(2):e0246040
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J
Nature communications 2021 Mar 19;12(1):1726
Nature communications 2021 Mar 19;12(1):1726
Targeting the Apoa1 locus for liver-directed gene therapy.
De Giorgi M, Li A, Hurley A, Barzi M, Doerfler AM, Cherayil NA, Smith HE, Brown JD, Lin CY, Bissig KD, Bao G, Lagor WR
Molecular therapy. Methods & clinical development 2021 Jun 11;21:656-669
Molecular therapy. Methods & clinical development 2021 Jun 11;21:656-669
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Cui C, Chakraborty K, Tang XA, Zhou G, Schoenfelt KQ, Becker KM, Hoffman A, Chang YF, Blank A, Reardon CA, Kenny HA, Vaisar T, Lengyel E, Greene G, Becker L
Cell 2021 Jun 10;184(12):3163-3177.e21
Cell 2021 Jun 10;184(12):3163-3177.e21
Discovery of bladder cancer biomarkers in paired pre- and postoperative urine samples.
Li X, Huang C, Zhang X, Yang T, Zuo S, Fu C, Zhang Y, Yang C, Chen L
Translational andrology and urology 2021 Aug;10(8):3402-3414
Translational andrology and urology 2021 Aug;10(8):3402-3414
Alpha-1 Antitrypsin Induces Epithelial-to-Mesenchymal Transition, Endothelial-to-Mesenchymal Transition, and Drug Resistance in Lung Cancer Cells.
Wu DM, Liu T, Deng SH, Han R, Zhang T, Li J, Xu Y
OncoTargets and therapy 2020;13:3751-3763
OncoTargets and therapy 2020;13:3751-3763
Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression.
Everett LA, Khoriaty RN, Zhang B, Ginsburg D
Blood advances 2020 Nov 24;4(22):5635-5643
Blood advances 2020 Nov 24;4(22):5635-5643
Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity.
Xu C, Zhang J, Liu J, Li Z, Liu Z, Luo Y, Xu Q, Wang M, Zhang G, Wang F, Chen H
Journal of proteomics 2020 May 30;220:103760
Journal of proteomics 2020 May 30;220:103760
Comparative analysis of proteomes between diabetic and normal human sperm: Insights into the effects of diabetes on male reproduction based on the regulation of mitochondria-related proteins.
An T, Wang YF, Liu JX, Pan YY, Liu YF, He ZC, Mo FF, Li J, Kang LH, Gu YJ, Lv BH, Gao SH, Jiang GJ
Molecular reproduction and development 2018 Jan;85(1):7-16
Molecular reproduction and development 2018 Jan;85(1):7-16
Free circulating active elastase contributes to chronic inflammation in patients on hemodialysis.
Khatib-Massalha E, Michelis R, Trabelcy B, Gerchman Y, Kristal B, Ariel A, Sela S
American journal of physiology. Renal physiology 2018 Feb 1;314(2):F203-F209
American journal of physiology. Renal physiology 2018 Feb 1;314(2):F203-F209
Label-free proteomic analysis of placental proteins during Toxoplasma gondii infection.
Jiao F, Zhang D, Jiang M, Mi J, Liu X, Zhang H, Hu Z, Xu X, Hu X
Journal of proteomics 2017 Jan 6;150:31-39
Journal of proteomics 2017 Jan 6;150:31-39
The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.
Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschl T, Stoffel M
Nature communications 2016 Sep 26;7:12848
Nature communications 2016 Sep 26;7:12848
Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancer.
Ludwig MR, Kojima K, Bowersock GJ, Chen D, Jhala NC, Buchsbaum DJ, Grizzle WE, Klug CA, Mobley JA
Proteomics 2016 Feb;16(3):516-31
Proteomics 2016 Feb;16(3):516-31
Identification of differentially expressed serum proteins in infectious purpura fulminans.
He T, Hu JY, Han J, Zhang DX, Jiang XP, Chen B, Huang YS
Disease markers 2014;2014:698383
Disease markers 2014;2014:698383
High-throughput screening of tumor metastatic-related differential glycoprotein in hepatocellular carcinoma by iTRAQ combines lectin-related techniques.
Qin X, Chen Q, Sun C, Wang C, Peng Q, Xie L, Liu Y, Li S
Medical oncology (Northwood, London, England) 2013 Mar;30(1):420
Medical oncology (Northwood, London, England) 2013 Mar;30(1):420
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 16382-1-AP(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Alpha-1-Antitrypsin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Alpha-1-Antitrypsin. This antibody recognizes human,mouse,rat antigen. The Alpha-1-Antitrypsin antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16382-1-AP(Alpha-1-Antitrypsin antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
