The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]
Bone marrow & Lymphoid tissuesBrainBreast and female reproductive systemConnective & Soft tissueEndocrine tissuesEyeGastrointestinal tractKidney & Urinary bladderLiver & GallbladderLymphoidMale reproductive systemMuscle tissuesMyeloidPancreasProximal digestive tractRespiratory systemSkin
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more RNA data sourced from Human Protein Atlas.