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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [129]
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- Validations
- Western blot [2]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
- Blocking/Neutralizing [1]
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- Product number
- AF-401-NA - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-1 beta/IL-1F2 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse IL-1 beta/IL-1F2 in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant porcine IL-1 beta is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
NP_032387- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Injury induces endothelial to mesenchymal transition in the mouse corneal endothelium in vivo via FGF2.
Dicer regulates activation of the NLRP3 inflammasome.
High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice.
Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.
MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.
Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer.
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.
A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome.
Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance.
Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.
RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux.
The lncRNA Neat1 promotes activation of inflammasomes in macrophages.
Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation.
Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation.
NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ.
HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.
Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling.
Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality.
AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner.
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss.
Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis.
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis.
Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury.
The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia.
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.
NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation.
The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.
Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina.
The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Interleukin-1 and estrogen protect against disseminating dentoalveolar infections.
Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling.
Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes.
Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.
The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome.
A new approach for ratiometric in vivo calcium imaging of microglia.
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.
Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα.
CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.
SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation.
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.
Targeting IRE1 with small molecules counteracts progression of atherosclerosis.
Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.
MTG16 is a tumor suppressor in colitis-associated carcinoma.
Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice.
Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression.
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages.
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.
Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection.
Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants.
Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation.
Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis.
TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division.
HIF-1α Is an Essential Mediator of IFN-γ-Dependent Immunity to Mycobacterium tuberculosis.
Local immunosuppressive microenvironment enhances migration of melanoma cells to lungs in DJ-1 knockout mice.
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.
IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.
Methylsulfonylmethane inhibits NLRP3 inflammasome activation.
Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.
Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules.
Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.
Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.
Critical role of aquaporins in interleukin 1β (IL-1β)-induced inflammation.
RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages.
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.
A critical role for human caspase-4 in endotoxin sensitivity.
Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin.
Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.
3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.
Critical role for IL-1β in DNA damage-induced mucositis.
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.
Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice.
The role of IL-1β in the early tumor cell-induced angiogenic response.
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury.
Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation.
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.
Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.
Tyrosine kinase 2 controls IL-1ß production at the translational level.
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.
Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.
Lee J, Jung E, Heur M
Molecular vision 2019;25:22-34
Molecular vision 2019;25:22-34
Dicer regulates activation of the NLRP3 inflammasome.
Ojcius DM, Jafari A, Yeruva L, Schindler CW, Abdul-Sater AA
PloS one 2019;14(4):e0215689
PloS one 2019;14(4):e0215689
High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice.
Meng R, Gu L, Lu Y, Zhao K, Wu J, Wang H, Han J, Tang Y, Lu B
The Journal of biological chemistry 2019 May 31;294(22):8872-8884
The Journal of biological chemistry 2019 May 31;294(22):8872-8884
Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.
Spalinger MR, Schmidt TS, Schwarzfischer M, Hering L, Atrott K, Lang S, Gottier C, Geirnaert A, Lacroix C, Dai X, Rawlings DJ, Chan AC, von Mering C, Rogler G, Scharl M
The Journal of clinical investigation 2019 May 20;129(6):2527-2541
The Journal of clinical investigation 2019 May 20;129(6):2527-2541
MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.
Lee E, Hwang I, Park S, Hong S, Hwang B, Cho Y, Son J, Yu JW
Cell death and differentiation 2019 Jan;26(2):213-228
Cell death and differentiation 2019 Jan;26(2):213-228
Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer.
Hwang WL, Lan HY, Cheng WC, Huang SC, Yang MH
Journal of hematology & oncology 2019 Jan 25;12(1):10
Journal of hematology & oncology 2019 Jan 25;12(1):10
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.
Sharma D, Malik A, Guy C, Vogel P, Kanneganti TD
The Journal of clinical investigation 2019 Jan 2;129(1):150-162
The Journal of clinical investigation 2019 Jan 2;129(1):150-162
A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome.
Mathur A, Feng S, Hayward JA, Ngo C, Fox D, Atmosukarto II, Price JD, Schauer K, Märtlbauer E, Robertson AAB, Burgio G, Fox EM, Leppla SH, Kaakoush NO, Man SM
Nature microbiology 2019 Feb;4(2):362-374
Nature microbiology 2019 Feb;4(2):362-374
Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance.
Morita-Takemura S, Nakahara K, Hasegawa-Ishii S, Isonishi A, Tatsumi K, Okuda H, Tanaka T, Kitabatake M, Ito T, Wanaka A
Journal of neuroinflammation 2019 Feb 14;16(1):39
Journal of neuroinflammation 2019 Feb 14;16(1):39
Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.
Erlich Z, Shlomovitz I, Edry-Botzer L, Cohen H, Frank D, Wang H, Lew AM, Lawlor KE, Zhan Y, Vince JE, Gerlic M
Nature immunology 2019 Apr;20(4):397-406
Nature immunology 2019 Apr;20(4):397-406
RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux.
da Costa LS, Outlioua A, Anginot A, Akarid K, Arnoult D
Cell death & disease 2019 Apr 25;10(5):346
Cell death & disease 2019 Apr 25;10(5):346
The lncRNA Neat1 promotes activation of inflammasomes in macrophages.
Zhang P, Cao L, Zhou R, Yang X, Wu M
Nature communications 2019 Apr 2;10(1):1495
Nature communications 2019 Apr 2;10(1):1495
Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation.
Kim YK, Koppula S, Shim DW, In EJ, Kwak SB, Kim MK, Yu SH, Lee KH, Kang TB
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6346734
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6346734
Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation.
Kwak SB, Koppula S, In EJ, Sun X, Kim YK, Kim MK, Lee KH, Kang TB
Mediators of inflammation 2018;2018:6054069
Mediators of inflammation 2018;2018:6054069
NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ.
Chen Y, He X, Yuan X, Hong J, Bhat O, Li G, Li PL, Guo J
Oxidative medicine and cellular longevity 2018;2018:2901871
Oxidative medicine and cellular longevity 2018;2018:2901871
HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.
Coleman LG Jr, Maile R, Jones SW, Cairns BA, Crews FT
PloS one 2018;13(3):e0195335
PloS one 2018;13(3):e0195335
Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, Lin Q, He Y, Zhang M, Zhou W, Ni Z
Cell death & disease 2018 Sep 24;9(10):983
Cell death & disease 2018 Sep 24;9(10):983
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.
Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B
Nature communications 2018 Oct 15;9(1):4260
Nature communications 2018 Oct 15;9(1):4260
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B
Nature communications 2018 Oct 12;9(1):4246
Nature communications 2018 Oct 12;9(1):4246
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE
Cell reports 2018 Nov 27;25(9):2339-2353.e4
Cell reports 2018 Nov 27;25(9):2339-2353.e4
A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling.
Koch B, Barugahare AA, Lo TL, Huang C, Schittenhelm RB, Powell DR, Beilharz TH, Traven A
Cell reports 2018 Nov 20;25(8):2244-2258.e7
Cell reports 2018 Nov 20;25(8):2244-2258.e7
Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality.
Benjamin JT, Moore DJ, Bennett C, van der Meer R, Royce A, Loveland R, Wynn JL
Journal of immunology (Baltimore, Md. : 1950) 2018 Nov 15;201(10):2873-2878
Journal of immunology (Baltimore, Md. : 1950) 2018 Nov 15;201(10):2873-2878
AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner.
Zenke K, Muroi M, Tanamoto KI
Cellular signalling 2018 Mar;43:32-39
Cellular signalling 2018 Mar;43:32-39
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.
Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C
Nature communications 2018 Mar 8;9(1):996
Nature communications 2018 Mar 8;9(1):996
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.
Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K
The Journal of experimental medicine 2018 Mar 5;215(3):827-840
The Journal of experimental medicine 2018 Mar 5;215(3):827-840
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P
The EMBO journal 2018 Mar 15;37(6)
The EMBO journal 2018 Mar 15;37(6)
MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss.
Zhuang W, Wang C, Shi X, Qiu S, Zhang S, Xu B, Chen M, Jiang W, Dong H, Qiao Y
International journal of molecular medicine 2018 Jun;41(6):3448-3456
International journal of molecular medicine 2018 Jun;41(6):3448-3456
Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis.
Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, Wolf D, Saliba AE, Zernecke A
Circulation research 2018 Jun 8;122(12):1661-1674
Circulation research 2018 Jun 8;122(12):1661-1674
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X, Jiang W, Zhou R
Nature communications 2018 Jun 29;9(1):2550
Nature communications 2018 Jun 29;9(1):2550
Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis.
Shahid M, Lee MY, Yeon A, Cho E, Sairam V, Valdiviez L, You S, Kim J
Scientific reports 2018 Jul 18;8(1):10859
Scientific reports 2018 Jul 18;8(1):10859
Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury.
Ross JL, Queme LF, Lamb JE, Green KJ, Jankowski MP
Biology of sex differences 2018 Jan 3;9(1):2
Biology of sex differences 2018 Jan 3;9(1):2
The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia.
Widmann C, Gandin C, Petit-Paitel A, Lazdunski M, Heurteaux C
Scientific reports 2018 Dec 24;8(1):18062
Scientific reports 2018 Dec 24;8(1):18062
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.
Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K
Cell reports 2018 Aug 7;24(6):1425-1433
Cell reports 2018 Aug 7;24(6):1425-1433
NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Marchetti C, Swartzwelter B, Koenders MI, Azam T, Tengesdal IW, Powers N, de Graaf DM, Dinarello CA, Joosten LAB
Arthritis research & therapy 2018 Aug 3;20(1):169
Arthritis research & therapy 2018 Aug 3;20(1):169
Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, Deng X, Liang G, Zhang H, Jiang W, Zhou R
EMBO molecular medicine 2018 Apr;10(4)
EMBO molecular medicine 2018 Apr;10(4)
An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation.
Carroll RG, Zasłona Z, Galván-Peña S, Koppe EL, Sévin DC, Angiari S, Triantafilou M, Triantafilou K, Modis LK, O'Neill LA
The Journal of biological chemistry 2018 Apr 13;293(15):5509-5521
The Journal of biological chemistry 2018 Apr 13;293(15):5509-5521
The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.
Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH
Frontiers in cellular neuroscience 2017;11:227
Frontiers in cellular neuroscience 2017;11:227
Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina.
Rivera JC, Noueihed B, Madaan A, Lahaie I, Pan J, Belik J, Chemtob S
Journal of neuroinflammation 2017 Sep 6;14(1):181
Journal of neuroinflammation 2017 Sep 6;14(1):181
The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald KA
Journal of immunology (Baltimore, Md. : 1950) 2017 Nov 1;199(9):3249-3260
Journal of immunology (Baltimore, Md. : 1950) 2017 Nov 1;199(9):3249-3260
Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.
Ahn H, Jeon E, Kim JC, Kang SG, Yoon SI, Ko HJ, Kim PH, Lee GS
Scientific reports 2017 May 2;7(1):1314
Scientific reports 2017 May 2;7(1):1314
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP
The Journal of experimental medicine 2017 May 1;214(5):1351-1370
The Journal of experimental medicine 2017 May 1;214(5):1351-1370
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM
The Journal of experimental medicine 2017 May 1;214(5):1297-1311
The Journal of experimental medicine 2017 May 1;214(5):1297-1311
Interleukin-1 and estrogen protect against disseminating dentoalveolar infections.
Youssef H, Stashenko P
International journal of oral science 2017 Mar;9(1):16-23
International journal of oral science 2017 Mar;9(1):16-23
Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.
Moriwaki K, Balaji S, Bertin J, Gough PJ, Chan FK
Cell reports 2017 Mar 7;18(10):2441-2451
Cell reports 2017 Mar 7;18(10):2441-2451
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.
Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN
The Journal of experimental medicine 2017 Jun 5;214(6):1737-1752
The Journal of experimental medicine 2017 Jun 5;214(6):1737-1752
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling.
Wu T, Zhang J, Geng M, Tang SJ, Zhang W, Shu J
Scientific reports 2017 Jun 23;7(1):4117
Scientific reports 2017 Jun 23;7(1):4117
Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes.
Kanamori Y, Murakami M, Sugiyama M, Hashimoto O, Matsui T, Funaba M
The Journal of biological chemistry 2017 Jun 16;292(24):10275-10287
The Journal of biological chemistry 2017 Jun 16;292(24):10275-10287
Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.
Zhu Q, Kanneganti TD
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 1;198(11):4210-4215
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 1;198(11):4210-4215
The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome.
Domingo-Fernández R, Coll RC, Kearney J, Breit S, O'Neill LAJ
The Journal of biological chemistry 2017 Jul 21;292(29):12077-12087
The Journal of biological chemistry 2017 Jul 21;292(29):12077-12087
A new approach for ratiometric in vivo calcium imaging of microglia.
Brawek B, Liang Y, Savitska D, Li K, Fomin-Thunemann N, Kovalchuk Y, Zirdum E, Jakobsson J, Garaschuk O
Scientific reports 2017 Jul 20;7(1):6030
Scientific reports 2017 Jul 20;7(1):6030
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.
Yoon S, Kovalenko A, Bogdanov K, Wallach D
Immunity 2017 Jul 18;47(1):51-65.e7
Immunity 2017 Jul 18;47(1):51-65.e7
Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα.
Koh HJ, Kim YR, Kim JS, Yun JS, Jang K, Yang CS
PLoS pathogens 2017 Jan;13(1):e1006126
PLoS pathogens 2017 Jan;13(1):e1006126
CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.
Myles IA, Zhao M, Nardone G, Olano LR, Reckhow JD, Saleem D, Break TJ, Lionakis MS, Myers TG, Gardina PJ, Kirkpatrick CH, Holland SM, Datta SK
Journal of leukocyte biology 2017 Jan;101(1):307-320
Journal of leukocyte biology 2017 Jan;101(1):307-320
SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation.
Tsugita M, Morimoto N, Tashiro M, Kinoshita K, Nakayama M
Cell reports 2017 Jan 31;18(5):1298-1311
Cell reports 2017 Jan 31;18(5):1298-1311
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.
Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS
The Journal of clinical investigation 2017 Jan 3;127(1):321-334
The Journal of clinical investigation 2017 Jan 3;127(1):321-334
Targeting IRE1 with small molecules counteracts progression of atherosclerosis.
Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, Hamid SM, Çimen I, Walter P, Weber C, Erbay E
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 21;114(8):E1395-E1404
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 21;114(8):E1395-E1404
Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.
Domiciano TP, Wakita D, Jones HD, Crother TR, Verri WA Jr, Arditi M, Shimada K
Scientific reports 2017 Feb 2;7:41539
Scientific reports 2017 Feb 2;7:41539
MTG16 is a tumor suppressor in colitis-associated carcinoma.
McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS
JCI insight 2017 Aug 17;2(16)
JCI insight 2017 Aug 17;2(16)
Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice.
Zhong Z, Zhai Y, Bu P, Shah S, Qiao L
Nature communications 2017 Apr 11;8:15004
Nature communications 2017 Apr 11;8:15004
Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression.
Du RH, Tan J, Sun XY, Lu M, Ding JH, Hu G
The international journal of neuropsychopharmacology 2016 Sep;19(9)
The international journal of neuropsychopharmacology 2016 Sep;19(9)
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL, Sewell GW, Saveljeva S, Ashcroft JW, Clare S, Mukhopadhyay S, Brown KP, Tschurtschenthaler M, Raine T, Doe B, Chilvers ER, Griffin JL, Kaneider NC, Floto RA, D'Amato M, Bradley A, Wakelam MJ, Dougan G, Kaser A
Nature immunology 2016 Sep;17(9):1046-56
Nature immunology 2016 Sep;17(9):1046-56
CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages.
Pereira M, Tourlomousis P, Wright J, P Monie T, Bryant CE
Nature communications 2016 Sep 27;7:12874
Nature communications 2016 Sep 27;7:12874
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA
The Journal of clinical investigation 2016 Sep 1;126(9):3389-402
The Journal of clinical investigation 2016 Sep 1;126(9):3389-402
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.
Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JHF
Infection and immunity 2016 Jun;84(6):1796-1805
Infection and immunity 2016 Jun;84(6):1796-1805
Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection.
Meng N, Xia M, Lu YQ, Wang M, Boini KM, Li PL, Tang WX
Oncotarget 2016 Jun 28;7(26):39316-39331
Oncotarget 2016 Jun 28;7(26):39316-39331
Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants.
Marty-Roix R, Vladimer GI, Pouliot K, Weng D, Buglione-Corbett R, West K, MacMicking JD, Chee JD, Wang S, Lu S, Lien E
The Journal of biological chemistry 2016 Jan 15;291(3):1123-36
The Journal of biological chemistry 2016 Jan 15;291(3):1123-36
Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation.
Chavarría-Smith J, Mitchell PS, Ho AM, Daugherty MD, Vance RE
PLoS pathogens 2016 Dec;12(12):e1006052
PLoS pathogens 2016 Dec;12(12):e1006052
Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis.
Haldar S, Dru C, Mishra R, Tripathi M, Duong F, Angara B, Fernandez A, Arditi M, Bhowmick NA
Scientific reports 2016 Dec 20;6:39257
Scientific reports 2016 Dec 20;6:39257
TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.
Mittal M, Tiruppathi C, Nepal S, Zhao YY, Grzych D, Soni D, Prockop DJ, Malik AB
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 13;113(50):E8151-E8158
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 13;113(50):E8151-E8158
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Park YH, Wood G, Kastner DL, Chae JJ
Nature immunology 2016 Aug;17(8):914-21
Nature immunology 2016 Aug;17(8):914-21
Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division.
Stein R, Kapplusch F, Heymann MC, Russ S, Staroske W, Hedrich CM, Rösen-Wolff A, Hofmann SR
The Journal of biological chemistry 2016 Aug 26;291(35):18419-29
The Journal of biological chemistry 2016 Aug 26;291(35):18419-29
HIF-1α Is an Essential Mediator of IFN-γ-Dependent Immunity to Mycobacterium tuberculosis.
Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1287-97
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1287-97
Local immunosuppressive microenvironment enhances migration of melanoma cells to lungs in DJ-1 knockout mice.
Chien CH, Lee MJ, Liou HC, Liou HH, Fu WM
PloS one 2015;10(2):e0115827
PloS one 2015;10(2):e0115827
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Meunier E, Wallet P, Dreier RF, Costanzo S, Anton L, Rühl S, Dussurgey S, Dick MS, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P
Nature immunology 2015 May;16(5):476-484
Nature immunology 2015 May;16(5):476-484
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Denes A, Coutts G, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 31;112(13):4050-5
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 31;112(13):4050-5
The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.
Maier NK, Leppla SH, Moayeri M
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2776-85
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2776-85
IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.
Li B, Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL
Nature communications 2015 Jan 21;6:6131
Nature communications 2015 Jan 21;6:6131
Methylsulfonylmethane inhibits NLRP3 inflammasome activation.
Ahn H, Kim J, Lee MJ, Kim YJ, Cho YW, Lee GS
Cytokine 2015 Feb;71(2):223-31
Cytokine 2015 Feb;71(2):223-31
Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.
Sitaras N, Rivera JC, Noueihed B, Bien-Aimé M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal JS, Chemtob S
The American journal of pathology 2015 Feb;185(2):581-95
The American journal of pathology 2015 Feb;185(2):581-95
Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Yang CS, Kim JJ, Kim TS, Lee PY, Kim SY, Lee HM, Shin DM, Nguyen LT, Lee MS, Jin HS, Kim KK, Lee CH, Kim MH, Park SG, Kim JM, Choi HS, Jo EK
Nature communications 2015 Feb 6;6:6115
Nature communications 2015 Feb 6;6:6115
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
Nature communications 2015 Feb 18;6:6282
Nature communications 2015 Feb 18;6:6282
Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, Masters SL, Genske U, Hornung V, Andoniou CE, Sweet MJ, Degli-Esposti MA, Schroder K, Stacey KJ
Journal of immunology (Baltimore, Md. : 1950) 2015 Aug 1;195(3):1233-41
Journal of immunology (Baltimore, Md. : 1950) 2015 Aug 1;195(3):1233-41
Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules.
Sadeghi H, Lockmann A, Hund AC, Samavedam UK, Pipi E, Vafia K, Hauenschild E, Kalies K, Pas HH, Jonkman MF, Iwata H, Recke A, Schön MP, Zillikens D, Schmidt E, Ludwig RJ
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 15;194(8):3656-63
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 15;194(8):3656-63
Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
Lim YM, Lim H, Hur KY, Quan W, Lee HY, Cheon H, Ryu D, Koo SH, Kim HL, Kim J, Komatsu M, Lee MS
Nature communications 2014 Sep 26;5:4934
Nature communications 2014 Sep 26;5:4934
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.
Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 1;193(5):2519-2530
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 1;193(5):2519-2530
Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
Xia M, Boini KM, Abais JM, Xu M, Zhang Y, Li PL
The American journal of pathology 2014 May;184(5):1617-28
The American journal of pathology 2014 May;184(5):1617-28
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.
Nieto-Torres JL, DeDiego ML, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Alcaraz A, Torres J, Aguilella VM, Enjuanes L
PLoS pathogens 2014 May;10(5):e1004077
PLoS pathogens 2014 May;10(5):e1004077
Critical role of aquaporins in interleukin 1β (IL-1β)-induced inflammation.
Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave JN, Marbaix E, Lison D, Devuyst O, Huaux F
The Journal of biological chemistry 2014 May 16;289(20):13937-47
The Journal of biological chemistry 2014 May 16;289(20):13937-47
RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages.
Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT
The Journal of biological chemistry 2014 May 16;289(20):13701-5
The Journal of biological chemistry 2014 May 16;289(20):13701-5
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Meunier E, Dick MS, Dreier RF, Schürmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P
Nature 2014 May 15;509(7500):366-70
Nature 2014 May 15;509(7500):366-70
Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
Zhao C, Gillette DD, Li X, Zhang Z, Wen H
The Journal of biological chemistry 2014 Jun 13;289(24):17020-9
The Journal of biological chemistry 2014 Jun 13;289(24):17020-9
The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.
Asrat S, Dugan AS, Isberg RR
PLoS pathogens 2014 Jul;10(7):e1004229
PLoS pathogens 2014 Jul;10(7):e1004229
A critical role for human caspase-4 in endotoxin sensitivity.
Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa MA, Elder G, Bozdagi O, Buxbaum JD
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):335-43
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):335-43
Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin.
Smedberg JR, Westcott MM, Ahmed M, Lyles DS
Journal of virology 2014 Jan;88(2):777-85
Journal of virology 2014 Jan;88(2):777-85
Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.
Maier NK, Crown D, Liu J, Leppla SH, Moayeri M
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):763-70
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):763-70
3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.
He Y, Varadarajan S, Muñoz-Planillo R, Burberry A, Nakamura Y, Núñez G
The Journal of biological chemistry 2014 Jan 10;289(2):1142-50
The Journal of biological chemistry 2014 Jan 10;289(2):1142-50
Critical role for IL-1β in DNA damage-induced mucositis.
Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):E702-11
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):E702-11
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y
Scientific reports 2014 Dec 2;4:7281
Scientific reports 2014 Dec 2;4:7281
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
El-Zaatari M, Kao JY, Tessier A, Bai L, Hayes MM, Fontaine C, Eaton KA, Merchant JL
PloS one 2013;8(3):e58935
PloS one 2013;8(3):e58935
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.
Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S
Nature immunology 2013 May;14(5):454-60
Nature immunology 2013 May;14(5):454-60
Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
Li B, Shi Y, Shu J, Gao J, Wu P, Tang SJ
The Journal of biological chemistry 2013 May 10;288(19):13610-9
The Journal of biological chemistry 2013 May 10;288(19):13610-9
Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice.
Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T, Numazawa S
Journal of neuroinflammation 2013 Dec 1;10:143
Journal of neuroinflammation 2013 Dec 1;10:143
The role of IL-1β in the early tumor cell-induced angiogenic response.
Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3500-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3500-9
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM
Nature 2012 Oct 11;490(7419):288-91
Nature 2012 Oct 11;490(7419):288-91
Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C
Infection and immunity 2012 Jan;80(1):410-7
Infection and immunity 2012 Jan;80(1):410-7
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ
Nature 2012 Dec 6;492(7427):123-7
Nature 2012 Dec 6;492(7427):123-7
Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury.
Kim D, You B, Lim H, Lee SJ
Molecular pain 2011 Sep 28;7:74
Molecular pain 2011 Sep 28;7:74
Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation.
Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, Cookson BT
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2748-54
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2748-54
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
The Journal of clinical investigation 2011 Oct;121(10):3846-59
The Journal of clinical investigation 2011 Oct;121(10):3846-59
IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation.
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 1;187(9):4835-43
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 1;187(9):4835-43
Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.
Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN
Journal of immunology (Baltimore, Md. : 1950) 2011 Mar 15;186(6):3462-71
Journal of immunology (Baltimore, Md. : 1950) 2011 Mar 15;186(6):3462-71
Tyrosine kinase 2 controls IL-1ß production at the translational level.
Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Müller M, Strobl B
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3544-53
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3544-53
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T
European journal of immunology 2010 Oct;40(10):2797-803
European journal of immunology 2010 Oct;40(10):2797-803
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
Nature immunology 2010 Oct;11(10):897-904
Nature immunology 2010 Oct;11(10):897-904
Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.
Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN
The American journal of pathology 2010 Dec;177(6):2774-81
The American journal of pathology 2010 Dec;177(6):2774-81
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Gröne HJ, Schaefer L
The Journal of biological chemistry 2009 Sep 4;284(36):24035-48
The Journal of biological chemistry 2009 Sep 4;284(36):24035-48
Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
Journal of immunology (Baltimore, Md. : 1950) 2009 Sep 15;183(6):4021-30
Journal of immunology (Baltimore, Md. : 1950) 2009 Sep 15;183(6):4021-30
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Génin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, André F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
Nature medicine 2009 Oct;15(10):1170-8
Nature medicine 2009 Oct;15(10):1170-8
Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.
Hyvärinen K, Tuomainen AM, Laitinen S, Bykov IL, Törmäkangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ
Infection and immunity 2009 Aug;77(8):3442-9
Infection and immunity 2009 Aug;77(8):3442-9
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R
The Journal of experimental medicine 2008 Sep 1;205(9):1967-73
The Journal of experimental medicine 2008 Sep 1;205(9):1967-73
Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.
Das S, Mishra MK, Ghosh J, Basu A
Journal of neuroimmunology 2008 Mar;195(1-2):60-72
Journal of neuroimmunology 2008 Mar;195(1-2):60-72
Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonça-Previato L, Nobrega A, Bellio M
Journal of leukocyte biology 2007 Sep;82(3):488-96
Journal of leukocyte biology 2007 Sep;82(3):488-96
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Pozsgai G, Sándor K, Perkecz A, Szolcsányi J, Helyes Z, Brain SD, Pintér E
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2007 Nov;56(11):459-67
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2007 Nov;56(11):459-67
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):6933-42
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):6933-42
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):6933-42
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):6933-42
Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.
Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H
Journal of hepatology 2007 Dec;47(6):816-25
Journal of hepatology 2007 Dec;47(6):816-25
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
Genes & development 2006 Sep 15;20(18):2527-38
Genes & development 2006 Sep 15;20(18):2527-38
Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
Perrin FE, Lacroix S, Avilés-Trigueros M, David S
Brain : a journal of neurology 2005 Apr;128(Pt 4):854-66
Brain : a journal of neurology 2005 Apr;128(Pt 4):854-66
Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.
Banks WA, Farr SA, La Scola ME, Morley JE
The Journal of pharmacology and experimental therapeutics 2001 Nov;299(2):536-41
The Journal of pharmacology and experimental therapeutics 2001 Nov;299(2):536-41
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Supportive validation
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- Detection of Human and Mouse IL-1 beta/IL-1F2 by Western Blot. Western blot shows lysates of THP-1 human acute monocytic leukemia cell line untreated (-) or treated (+) with 200 nM PMA for 24 hours and 10 μg/mL LPS for 4 hours and RAW 264.7 mouse monocyte/macrophage cell line untreated (-) or treated (+) with 10 μg/mL LPS for 24 hours. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse IL-1 beta/IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for IL-1 beta/IL-1F2 at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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- Detection of Mouse IL-1 beta/IL-1F2 by Simple Western<SUP abp="266">TM. Simple Western lane view shows lysates of RAW 264.7 mouse monocyte/macrophage cell line untreated (-) or treated (+) with 10 µg/mL LPS for 24 hours, loaded at 0.5 mg/mL. A specific band was detected for IL-1 beta/IL-1F2 at approximately 40 kDa (as indicated) using 2.5 µg/mL of Goat Anti-Mouse IL-1 beta/IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Supportive validation
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- IL-1 beta/IL-1F2 in MCF-7 Human Cell Line. IL-1 beta/IL-1F2 was detected in immersion fixed MCF-7 human breast cancer cell line using Goat Anti-Mouse IL-1 beta/IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Supportive validation
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- IL-1 beta/IL-1F2 in Mouse Thymus. IL-1 beta/IL-1F2 was detected in perfusion fixed frozen sections of mouse thymus using Goat Anti-Mouse IL-1 beta/IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Supportive validation
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- Cell Proliferation Induced by IL-1 beta/IL-1F2 and Neutralization by Mouse IL-1 beta/IL-1F2 Antibody. Recombinant Mouse IL-1 beta/IL-1F2 (Catalog # 401-ML) stimulates proliferation in the the D10.G4.1 mouse helper T cell line in a dose-dependent manner (orange line) as measured by Resazurin (Catalog # AR002). Proliferation elicited by Recombinant Mouse IL-1 beta/IL-1F2 (50 pg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL-1 beta/IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA). The ND50 is typically
