Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- CABT-L827 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Human Il1b monoclonal antibody, clone KK198-4
- Antibody type
- Monoclonal
- Description
- Two forms of interleukin-1, designated IL-1Ï« and IL-1ÉÇ, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1Ï« and IL-1ÉÇ bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1ÉÇ for production of the anti- pathogen IFN-ÎÛ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- KK198-4
- Vial size
- 100 _l
- Storage
- Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
No comments: Submit comment
No validations: Submit validation data