Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [1071]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 16806-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16806-1-AP, RRID:AB_10646432
- Product name
- IL-1 Beta antibody
- Antibody type
- Polyclonal
- Description
- IL-1 Beta antibody (Cat. #16806-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model.
Sirtuin 4 Knockout Aggravates Sepsis-Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes.
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Intracavernous Injection of Mechanically Extracted Stromal Vascular Fragments Suppresses Endothelial-Mesenchymal Transformation to Mitigate Erectile Dysfunction in Hypertensive Rats.
Transcriptomics and Network Pharmacology Reveal Anti-Inflammatory and Anti-Oxidative Stress Mechanisms of Qingxuan Runmu Yin in Dry Eye Disease.
Enterotoxigenic Escherichia coli-induced intestinal epithelial necroptosis drives lamina propria immune cell pyroptosis and mucosal injury in piglets.
Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.
Potential molecular communication of blood and synovium through ligand-receptor interactions in osteoarthritis.
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Cell membrane-encased thylakoid as white light triggered PDT therapy for facile and targeted choroidal melanoma treatment.
Embryonic exposure to bisphenol A glycidyl methacrylate induces craniofacial cartilage malformation via NLR signaling pathway in zebrafish.
Xiayuxue decoction alleviates MASH by regulating gut microbiota, bile acid metabolism, and m(6)A modification.
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Exosomes derived from Bcl-2-engineered iPSC-cardiomyocytes mitigate aortic valve calcification and inhibit cardiomyocyte apoptosis.
Self-Assembled Quercetin-Mecobalamin Nanoparticles Mitigate Ischemic Stroke Injury via Enhanced Neuroprotection and Microglial Modulation.
LncRNA RMST knockout inhibits fibrosis by down-regulating Smad3 during mouse skin wound healing.
Thymic stromal lymphopoietin modification gates chronic pain via regulation of transient receptor potential vanilloid type 1-caspase1.
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Lactobacillus paragasseri LPG-9 reduces placental inflammation in intrahepatic cholestasis of pregnancy by regulating TGR5 in mice.
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy.
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
Drug Repurposing of Verapamil for H1N1 Influenza Virus Infection: A Multi-Target Strategy Revealed by Network Pharmacology and Experimental Validation.
Microglial GLUL loss worsens TBI outcomes by amplifying the arginine-citrulline pathway.
SiO(2) dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway.
Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming.
Eleutheroside B alleviates LPS-induced depressive-like behaviors by suppressing the TLR4/MyD88/NF-κB signaling pathway in the dentate gyrus.
New antidepressant diterpenoid alkaloids from Aconitum carmichaelii Debeaux: Potential inhibitors of NLRP3 activation.
Sanmiao pill ameliorates rheumatoid arthritis via PPARγ-mediated lipid accumulation in macrophage: A multi-omics and experimental validation.
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis.
Polydopamine-encapsulated modified Pulsatilla decoction: a strategy to enhance ulcerative colitis therapy.
SanHuang decoction may suppress breast cancer by regulating M1 macrophage polarization via NF-κB signaling pathway: in vitro and in vivo studies.
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity.
S100A4 triggeres the pyroptosis of vsmcs: association with mitochondrial damage, impaired mitophagy, and Ca(2+) dysregulation.
Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network.
Association Between Genetically Proxied SLC12A2 Inhibition and Inflammatory Bowel Disease: A Mendelian Randomization Study.
Systematic Identification and Functional Validation of CASP10 as a DNA-Damage-Responsive Driver of Endothelial Pyroptosis in Atherosclerosis.
Macrophage USP14 suppresses Wnt/β-catenin signaling via NLK deubiquitination to enhance immune response.
Sulfated Pelvetia siliquosa Polysaccharides Attenuate Pyroptosis via NF-κB Pathway Inhibition Against Calcium Oxalate Stone Formation.
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
The regulation of lymphatic valve formation promotes lymphatic drainage to reduce atherosclerotic plaques: A novel mechanism of anti-atherosclerosis by Gualou-Xiebai.
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Ophiopogon japonicus-derived plant exosomes: a promising strategy for blocking the progression of diabetic vasculopathy to myocardial infarction.
AMPK Deficiency Induces Corneal Epithelial Barrier Dysfunction by Modulating Energy Homeostasis.
Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.
Coptis chinensis extracellular vesicles loaded with CA1-siRNA promote endothelial repair and stent restenosis therapy by regulating the PADI2 and NF-κB pathway.
Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats.
Fisetin alleviates lipopolysaccharide-induced mastitis by inhibiting ferroptosis and modulating the gut microbiota.
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice.
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
MicroRNA-493-5p engineered exosomes delivered via piezoelectric microneedles for epigenetic modulation of macrophages in diabetic wound healing.
Emodin modulates the NLRP3/GSDMD pathway to alleviate Fusobacterium necrophorum-induced pyroptosis in the interdigital skin fibroblasts of dairy Cows.
Hypoxia-activated dual donors of H(2)S and NO alleviate myocardial injury in coronary heart disease via synergistic mechanisms.
Overexpression of miR-7641 activates ox-LDL-induced autophagy in macrophages by regulating USP7.
Aerobic Exercise Alleviates Oxidative Stress and Inflammation to Attenuate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in ApoE(-/-) Mice.
NOTCH3-R544C mutation drives endothelial dysfunction through inflammation, migration impairment, and lipid dysregulation.
GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation.
hsa_circ_0095812 accelerates periodontitis progression by adsorbing miR-485-3p-mediated THBS1 expression.
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
The alteration of uterine microbiota participated in the activation of the decidual inflammatory response in early spontaneous abortion.
High-temperature requirement serine protease A2 inhibitor UCF-101 ameliorates damaged neurons in traumatic brain-injured rats by the AMPK/NF-κB pathway.
HDAC7 knockout mitigates astrocyte reactivity and neuroinflammation via the IRF3/cGAS/STING signaling pathway.
Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis.
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Unveiling the IL-1β/CXCL2 axis: a shared therapeutic target in periodontitis and inflammatory bowel disease.
Berberine-taxifolin co-administration attenuates inflammatory response and intestinal barrier injury via nf-κB/NLRP3 suppression in colitis.
Administration of 2-deoxy-D-glucose induces pyroptosis in murine breast cancer cells via cAMP/PKA/HK2 to impair tumor survival.
Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223-associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure.
Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.
Unlocking amyotrophic lateral sclerosis: the role of adiponectin in inflammation and disease progression.
Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle.
Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice.
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.
Yersiniabactin produced by Escherichia coli promotes intestinal inflammation through lipid peroxidation and ferroptosis.
An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice.
Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling.
Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways.
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Aqueous extract of Saposhnikovia divaricata root alleviates rheumatoid arthritis by acting on TNF-α and RAGE signaling pathways.
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Ursolic acid attenuates sarcopenia through IL-17a-related gut-muscle axis in senile diabetic mice and myotube model.
A Novel Mechanism of Chlorogenic Acid in Cardioprotection: Blocking NLRP3 Inflammasome via Ca(2+)/CaMKIIα Signaling in Sepsis-Induced Cardiomyopathy.
Comprehensive multiomic analysis of extracellular vesicles from Mycoplasma bovis-infected bovine mammary epithelial cells identifies proteins and miRNAs that induce inflammatory responses in macrophages.
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Vitamin D against diabetic adipose tissue inflammation through SHP-1/STAT3 pathway.
Sinomenine Modifies Parkinson's Disease Through Nrf2 Activation.
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.
Exposure to Bovine Viral Diarrhea Virus Disrupts Intestinal Barrier Function via NLRP3/Caspase-1-Mediated Pyroptosis and Gut Microbiota Dysbiosis.
A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease.
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.
Yogurt alleviates alcohol-induced hepatocyte pyroptosis and inflammation via autophagy/P62/Nrf2/ROS/NLRP3 pathway.
Potential Mechanism of Qiju Dihuang Pill in Treating Primary Sjogren's Syndrome Revealed by Network Pharmacology and Experimental Verification.
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
M2-exo promote orthodontic bone remodeling via the MeCP2-TCF20-HDAC1 axis.
Microneedles combining delivery of hUMSC-derived exosomes and EGCG mitigate UV-induced skin damage.
The effect of puerarin on the NLRP3 Inflammasome pathway and MMP-9 in aortic dissection of ApoE(-/-) mice.
Corilagin alleviates radiation enteritis through caspase-1/gasdermin D-dependent pyroptosis by targeting aldo-keto reductase family 1 member C2 via glutathione metabolism.
Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.
Empagliflozin attenuates sorafenib-promoted renal ferroptosis and inflammation by targeting cyclooxygenase-2/prostaglandin E(2) axis.
Structural characterization and medium-chain acyl-coenzyme a dehydrogenase-mediated anti-inflammatory mechanism of a Hulless barley Monascus polysaccharide in ulcerative colitis.
Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Integrated bioinformatics decoding of the MASLD ceRNA network reveals novel therapeutic targets.
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome.
The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus.
Remote ischemic conditioning as a potential therapy for Parkinson's Disease: Inhibiting TLR4-Driven neuroinflammation and oxidative damage.
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.
Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice.
Fusobacterium necrophorum mediates the inflammatory response in the interdigital skin and fibroblasts of dairy cows via the TNF-α/TNFR1/NF-κB pathway.
Decoding ozone's impact on the cornea: disruption of barrier integrity and its molecular drivers.
FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors.
Astragaloside III inhibits MAPK-mediated M2 tumor-associated macrophages to suppress the progression of lung Cancer cells via Akt/mTOR signaling pathway.
Scorpion Venom Heat-Resistant Synthetic Peptide Alleviates Neuronal Necroptosis in Alzheimer's Disease Model by Regulating Lnc Gm6410 Under PM(2.5) Exposure.
Drinking Water Temperature Impacts the Pathogenesis of DSS-Induced Ulcerative Colitis by Regulating Intestinal Barrier Function and Remodeling the Gut Microbiota Composition.
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle.
Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS.
IL-17 enhanced the susceptibility to fluoxetine resistance in depression via the JAK1-STAT6 signaling pathway.
Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2.
Esterase-responsive kartogenin composite hydrogel microspheres boost nucleus pulposus regeneration in intervertebral disc degeneration.
HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation.
The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2.
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis.
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.
Targeting the NF-κB p65-MMP28 axis: Wogonoside as a novel therapeutic agent for attenuating podocyte injury in diabetic nephropathy.
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression.
Akkermansia muciniphila-derived extracellular vesicles mitigate smoking-induced prostate inflammation and fibrosis.
Erianin alleviates autoimmune myocarditis by suppressing the M1 polarization of macrophages via the NF-κB/NLRP3 signaling pathway.
Artesunate alleviated hippocampal neuron pyroptosis by down-regulating NLRP3 in rats with cerebral small vessel disease.
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
Single-cell RNA sequencing reveals an IL1R2+Treg subset driving immunosuppressive microenvironment in HNSCC.
Role of Adiponectin in Regulating Cytokines and Its Contribution to the Occurrence and Progression of Clinical Mastitis in Holstein Cows.
Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.
High energy diet-induced prediabetic neuropathic pain is mediated by reduction of SIRT6 negative control of both spinal and peripheral neuroinflammation.
Arsenic exposure induces neural cells senescence and abnormal lipid droplet accumulation leading to social memory impairment in mice.
Myelination Trajectory and Microglial Dynamics Following Repeated Sevoflurane Exposure in Developing Brain.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.
GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment.
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Curcumin-loaded platelets with hydroxypropyl chitin hydrogel composite system through photo-activation for effective hemostasis management and wound healing.
miR-301a-5p regulated IKKβ/NF-κB axis and macrophage polarization to accelerate skin wound healing.
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Hydrogen sulfide preserves the function of senescent endothelium through SIRT2 mediated inflammatory inhibition.
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway.
Biochanin A mitigates colitis by inhibiting ferroptosis-mediated intestinal barrier dysfunction, oxidative stress, and inflammation via the JAK2/STAT3 signaling pathway.
Integrated network pharmacology and experimental validation to elucidate the mechanism of celastrol in mitigating sepsis-induced acute lung injury in mice.
Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.
Pelargonidin-3-O-galactoside Alleviates Acute Lung Injury Induced by Klebsiella pneumoniae by Targeting CD38-Mediated Pyroptosis.
Cerium-Organic Framework and Resveratrol Composite Hydrogel Scaffold with Dual Antioxidant Activity for Enhanced Bone Regeneration.
Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis.
Cyanidin-3-O-glucoside mitigates Staphylococcus aureus-induced mastitis by suppressing inflammatory responses and Ferroptosis mediated by SESN2/Nrf2.
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation.
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model.
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway.
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis.
Sex-dependent effects of heat exposure on the middle ear health in mice.
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction.
Rhein Inhibits Microglia-Mediated Neuroinflammation and Neuronal Damage of Alzheimer's Disease via Regulating the Glutamine-Aspartate-Arginine-NO Metabolic Pathway.
The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation.
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
High-fat diet activates pyroptosis of retinal pigment epithelial cells in aged TgAPPswePS1 transgenic mice.
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals.
Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway.
AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex.
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses.
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.
CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice.
Luteolin Alleviates Ulcerative Colitis in Mice by Modulating Gut Microbiota and Plasma Metabolism.
Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R /NLRP3 signaling pathway.
IL-17A exacerbates synovial inflammation in osteoarthritis via activation of endoplasmic reticulum stress.
Novel Nanoliposomes Synergistically Modulated by Sitogluside and Dioscin: Stability, Bioavailability, and Capacity To Alleviate Hyperuricaemia.
The injury effect of osteopontin in sepsis-associated lung injury.
Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages.
Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway.
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy.
Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
CAVIN2 attenuates ventilator-induced lung injury in rats by MAPK/ERK1/2 signaling pathway.
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Chairside live biotherapeutic hydrogel for comprehensive periodontitis therapy.
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Neohesperidin protects against colitis-associated colorectal cancer in mice via suppression of the NF-κB/p65 and MAPK pathways.
Beclin1 regulates yak endometrial inflammation and TLR4/NF-κB signaling pathway through autophagy/non-autophagy function.
Autophagy-dependent splicing control directs translation toward inflammation during senescence.
Enhancing the Therapeutic Efficacy of Berberine and Quercetin Through Salt Formulation for Liver Fibrosis Treatment.
Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration.
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway.
Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model.
Carboxymethyl chitosan and sodium alginate oxide pH-sensitive dual-release hydrogel for diabetes wound healing: The combination of astilbin liposomes and diclofenac sodium.
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds.
RUNX1 Induces Central Neuropathic Pain by Activating Microglia and Triggering the Inflammatory Response in Spinal Cord Injury.
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Effect of hesperidin on nanocopper induced PANoptosis in chicken kidney through RIPK1/ZBP1 pathway.
Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus.
Pyridostigmine attenuates placental-ischemia-upregulated placental angiotensin II type 1 receptor in rats.
Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic target.
E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation.
Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma.
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Brevilin A reverses colitis of inflammatory bowel disease via modulation of TNF-α signaling and microbiome dysregulation.
Interleukin-27 is a multitarget regulator of fibroblast remodeling in thyroid-associated ophthalmopathy.
Apoptotic extracellular vesicles from peripancreatic adipose-derived mesenchymal stem cells ameliorate severe acute pancreatitis through the transcription factor EB-mediated autophagy-lysosomal pathway: an experimental study.
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice.
The Toxoplasma surface SRS14A promotes ASC ubiquitination to suppress AIM2 inflammasome and tumor immunity.
The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons.
Exploration of the Therapeutic Time Window for Thrombectomy in Rat Models of Middle Cerebral Artery Ischemia-Reperfusion.
Targeting CDK1 inhibits Golgi apparatus stress-mediated neuroinflammation and neuronal apoptosis after intracerebral hemorrhage by modulating GRASP55 phosphorylation.
Carbon Monoxide Alleviates Cardiomyocyte Pyroptosis in Diabetic Cardiomyopathy by Downregulating the IL-33/ST2L Axis.
Decreased excitatory and increased inhibitory transmission in the hippocampal CA1 drive neuroinflammation-induced cognitive impairments in mice.
Stimulation of microglia leads to a rapid antidepressant effect by triggering astrocytic P2Y1Rs and promoting BDNF-mediated neurogenesis in the hippocampus.
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
Glucuronolactone improves lung injury caused by PRRSV and DON co-challenge by enhancing the Nrf2-mediated antioxidant capacity in weaning piglets.
Apigenin mitigates intestinal barrier dysfunction in sepsis by modulating the AKT signaling pathway.
ADAMTS2 mediates epithelial‒mesenchymal transition and inflammation in high-grade serous ovarian cancer: a study based on bioinformatic analyses and experiments.
Inhibition of ADAM17: A New Therapeutic Strategy to Alleviate Zearalenone Toxin-Induced Liver Injury by Endoplasmic Reticulum Stress and Inflammation.
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood-Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy.
Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways.
A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury.
Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies.
Targeted Regulation of HSP70 by the ARP2/3 Complex in Mammary Epithelial Cells and Its Impact on Host Cell Apoptosis.
The LTB4-BLT1 axis attenuates influenza-induced lung inflammation by suppressing NLRP3 activation.
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage.
Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis.
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus.
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury.
NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation.
miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.
NLRP3 Inflammasome Deficiency Alleviates Inflammation and Oxidative Stress by Promoting PINK1/Parkin-Mediated Mitophagy in Allergic Rhinitis Mice and Nasal Epithelial Cells.
Nrf2 Deficiency Exacerbates Parkinson's Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells.
VX-702 Ameliorates the Severity of Sepsis-Associated Acute Kidney Injury by Downregulating Inflammatory Factors in Macrophages.
Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.
Identification and Validation of Genes Related to Macrophage Polarization and Cell Death Modes Under Mycobacterium tuberculosis Infection.
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
(+)-catechin protects PC12 cells against CORT-induced oxidative stress and pyroptosis through the pathways of PI3K/AKT and Nrf2/HO-1/NF-κB.
Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway.
Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities.
Transcriptome profiling of immune rejection mechanisms in a porcine vascularized composite allotransplantation model.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.
Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis.
Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaustion.
Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma.
Taraxasterol exhibits dual biological effects on anti-aging and anti-cancer in lung cells.
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Antibacterial and antioxidant phlorizin-loaded nanofiber film effectively promotes the healing of burn wounds.
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway.
Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.
Targeted-lung delivery of bardoxolone methyl using PECAM-1 antibody-conjugated nanostructure lipid carriers for the treatment of lung inflammation.
Geniposide dosage and administration time: Balancing therapeutic benefits and adverse reactions in liver disease treatment.
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Integrated analyses of the intestinal microbiome and transcriptome in Ningxiang piglets.
Eudragit S100 coated iron oxide-chitosan nanocomposites for colon targeting of 5-aminosalicylic acid ameliorate ulcerative colitis by improving intestinal barrier function and inhibiting NLRP3 inflammasome.
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment.
BV2 Microglial Cell Activation/Polarization Is Influenced by Extracellular Vesicles Released from Mutated SOD1 NSC-34 Motoneuron-like Cells.
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Immune Rejection of Cartilage in a Swine Vascularized Composite Allotransplantation Model.
Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs.
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Identification of a novel caspase cleavage motif AEAD.
Mechanisms of Shufeng Jiedu Capsule in treating bacterial pneumonia based on network pharmacology and experimental verification.
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway.
Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.
ACOD1 mediates Staphylococcus aureus-induced inflammatory response via the TLR4/NF-κB signaling pathway.
The ASB@HNTs-PVA nanofiber membrane, possessing both anti-inflammatory and hemostatic activities, promotes the healing of T2D skin wounds.
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression.
Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP/TSLPR/pSTAT5 signals.
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Oxytocin attenuates neuroinflammation-induced anxiety through restoration of excitation and inhibition balance in the anterior cingulate cortex in mice.
Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis.
Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat.
Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin Attenuates Sorafenib-Induced Myocardial Inflammation and Toxicity.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS-induced acute kidney injury.
The role of phlorizin liposome-embedded oxidized sodium alginate/carboxymethyl chitosan in diabetic wound healing.
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
SIRT2 regulates high mobility group protein B1 nucleoplasmic shuttle and degradation via deacetylation in microglia.
Targeted Therapy of Osteoarthritis via Intra-Articular Delivery of Lipid-Nanoparticle-Encapsulated Recombinant Human FGF18 mRNA.
Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway.
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles.
Dexmedetomidine Attenuates Neuroinflammation-Mediated Hippocampal Neurogenesis Impairment in Sepsis-Associated Encephalopathy Mice through Central α2A-Adrenoceptor.
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.
Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing.
NLRX1 and STING alleviate renal ischemia-reperfusion injury by regulating LC3 lipidation during mitophagy.
TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response.
Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury.
Mogroside Ⅴ Inhibits M1 Polarization and Inflammation of Diabetic Mouse Macrophages via p38 MAPK/NF-Κb Signaling Pathway.
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
Supercritical CO(2) fluid extract from Stellariae Radix ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation.
Palmitic acid induces GSDMD-mediated pyroptosis in periodontal ligament cells via the NF-κB pathway.
SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia.
Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing.
Emodin Blocks mPTP Opening and Improves LPS-Induced HMEC-1 Cell Injury by Upregulation of ATP5A1.
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2.
Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury.
Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes.
Uterine Immunoprivileged Cells Restore Cardiac Function of Male Recipients After Myocardial Infarction.
The role of FGF-21 in promoting diabetic wound healing by modulating high glucose-induced inflammation.
Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis.
Glycosides of Buyang Huanwu decoction inhibits inflammation associated with cerebral ischemia-reperfusion via the PINK1/Parkin mitophagy pathway.
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3.
Kaempferol alleviates adipose tissue inflammation and insulin resistance in db/db mice by inhibiting the STING/NLRP3 signaling pathway.
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity.
Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway.
Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/IκB-α/NF-κB p65 pathway after spinal cord injury.
Knee Osteotomy Decreases Joint Inflammation Based on Synovial Histology and Synovial Fluid Analysis.
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway.
M1 Macrophage-Derived Exosome LncRNA PVT1 Promotes Inflammation and Pyroptosis of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Inhibiting miR-186-5p and Regulating HMGB1.
Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway.
S100A9(-/-) alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFκB signaling axis.
Rescuing Nucleus Pulposus Cells from ROS Toxic Microenvironment via Mitochondria-Targeted Carbon Dot-Supported Prussian Blue to Alleviate Intervertebral Disc Degeneration.
Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy.
REXO2 up-regulation is positively correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma.
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Lactococcus garvieae exerts a critical role in inducing inflammation in dairy mastitis by triggering NLRP3 inflammasome-mediated pyroptosis in MAC-T cells.
Inhibition of PKM2 suppresses osteoclastogenesis and alleviates bone loss in mouse periodontitis.
Caffeine Ameliorates Age-Related Hearing Loss by Downregulating the Inflammatory Pathway in Mice.
C5a stimulation induces caspase-1 activation and mature IL-1β production in human peripheral blood mononuclear cells.
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.
Identification of subclusters and prognostic genes based on GLS-associated molecular signature in ulcerative colitis.
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation.
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice.
[Aqueous extract of Chuan Xiong Rhizoma enhances inhibitory effect of temozolomide against brain metastasis of melanoma in mice].
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.
ATF4 Contributes to Abdominal Aortic Aneurysm Formation via Modulating M1 Macrophage Polarization and Inflammation.
Forsythiaside A attenuates lipopolysaccharide-induced mouse mastitis by activating autophagy and regulating gut microbiota and metabolism.
Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer's Disease.
Type 2 diabetes aggravates periodontitis-induced pathological changes in the dental pulp.
Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus.
Artificial aging conditions for Artemisia argyi leaves based on quality-inflammation-quality marker transformation.
Adiponectin inhibits ROS/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis.
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens.
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study.
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model.
Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway.
Novel insights into gut health: Cilostazol strengthens gut integrity by adjusting TLR-2/NF-κB/IL-23 and CD44/AKT/GSK-3β/cyclin-D1 trajectories in methotrexate-induced mucositis model.
Toll-like receptor 4-dependent innate immune responses are mediated by intracrine corticosteroids and activation of glycogen synthase kinase-3β in astrocytes.
Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain.
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.
NADase CD38 is a key determinant of ovarian aging.
MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation.
Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization.
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
The improvement of homocysteine-induced myocardial inflammation by vitamin D depends on activation of NFE2L2 mediated MTHFR.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway.
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells.
Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.
2-Deoxy-D-glucose ameliorates inflammation and fibrosis in a silicosis mouse model by inhibiting hypoxia-inducible factor-1α in alveolar macrophages.
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
METTL3 promotes microglial inflammation via MEF2C in spinal cord injury.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Liver toxicity in rats after subchronic exposure to HTP aerosol and cigarette smoke.
ENST00000534735 inhibits proliferation and migration, promotes apoptosis and pyroptosis of endometrial cancer via OSBPL3 through APMK/SIRT1/NF-κB pathway.
Protective effect of Tetrandrine on optic nerve by inhibiting glial activation through NF-κB pathway.
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury.
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
MKK3 K329 Mutation Attenuates Diabetes-Associated Cognitive Dysfunction by Blocking the MKK3-RAGE Interaction and Inhibiting Neuroinflammation.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease.
Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.
Protective Effect and Mechanism of L-Theanine on Acute Alcoholic Liver Injury in Mice.
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells.
Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Biocooperative Regenerative Materials by Harnessing Blood-Clotting and Peptide Self-Assembly.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Dietary sanguinarine supplementation improves the growth performance and intestinal immunity of broilers.
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Praelolide alleviates collagen-induced arthritis through increasing catalase activity and activating Nrf2 pathway.
Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy.
Lipopolysaccharide-regulated RNF31/NRF2 axis in colonic epithelial cells mediates homeostasis of the intestinal barrier in ulcerative colitis.
Protective Effects of Exogenous Melatonin Administration on White Fat Metabolism Disruption Induced by Aging and a High-Fat Diet in Mice.
FGF20 modulates gut microbiota to mitigate dextran sodium sulfate-induced ulcerative colitis in mouse models.
Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway.
Pinocembrin alleviates LPS-induced depressive-like behavior in mice via the NLRP3/DCC signaling pathway.
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
METTL3-mediated m(6)A modification of CD36: Implications for glucose metabolism and inflammatory dysregulation in follicles of polycystic ovary syndrome.
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Empagliflozin reduces renal calcium oxalate deposition in hyperoxaluria rats induced with ethylene glycol-ammonium chloride.
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice.
Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension.
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury.
Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
Homoplantaginin alleviates intervertebral disc degeneration by blocking the NF-κB/MAPK pathways via binding to TAK1.
PL-Relief(TM)plus Alleviates Atopic Dermatitis and Regulates Inflammatory Responses via Inhibiting NF-κB Signaling Pathway.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Matrine Suppresses Arsenic-Induced Malignant Transformation of SV-HUC-1 Cells via NOX2.
Capsaicin alleviates acute alcohol-induced pyroptosis by activating ESCRT-III-dependent cell membrane repair in hepatocytes.
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential.
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway.
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Naringenin Inhibits Acid Sphingomyelinase-Mediated Membrane Raft Clustering to Reduce NADPH Oxidase Activation and Vascular Inflammation.
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.
Investigating the Mechanistic of Danhong Injection in Brain Damage Caused by Cardiac I/R Injury via Bioinformatics, Computer Simulation, and Experimental Validation.
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
Biomimetic nanoparticles for effective Celastrol delivery to targeted treatment of rheumatoid arthritis through the ROS-NF-κB inflammasome axis.
The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment.
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF-κB/NLRP3 signaling pathway via H(2)S generation.
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
LncRNA HCG18 loaded by polymorphonuclear neutrophil-secreted exosomes aggravates sepsis acute lung injury by regulating macrophage polarization.
Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.
C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.
Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle.
Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.
Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy.
Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis.
Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts.
Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro.
Exosome Derived from Mesenchymal Stem Cells Alleviates Hypertrophic Scar by Inhibiting the Fibroblasts via TNFSF-13/HSPG2 Signaling Pathway.
Synergistic and Long-Lasting Wound Dressings Promote Multidrug-Resistant Staphylococcus Aureus-Infected Wound Healing.
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Investigation of He's Yang Chao recipe against oxidative stress-related mitophagy and pyroptosis to improve ovarian function.
Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction.
Role of NLRP3 inflammasome activation in HCC cell progression.
Sophoricoside attenuates autoimmune‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway.
Kartogenin-enhanced dynamic hydrogel ameliorates intervertebral disc degeneration via restoration of local redox homeostasis.
Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage.
Astragaloside IV attenuates high glucose-induced NF-κB-mediated inflammation through activation of PI3K/AKT-ERK-dependent Nrf2/ARE signaling pathway in glomerular mesangial cells.
PM(2.5) induces the inflammatory response in rat spleen lymphocytes through autophagy activation of NLRP3 inflammasome.
Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model.
MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.
A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing.
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis.
Glymphatic Dysfunction in Migraine Mice Model.
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.
Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway.
Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Role of SIRT2 in intestinal barrier under cold exposure.
Complement C1q drives microglia-dependent synaptic loss and cognitive impairments in a mouse model of lipopolysaccharide-induced neuroinflammation.
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Lidocaine ameliorates intestinal barrier dysfunction in irritable bowel syndrome by modulating corticotropin-releasing hormone receptor 2.
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis.
Carnosine alleviates cisplatin-induced acute kidney injury by targeting Caspase-1 regulated pyroptosis.
GBP2 upregulated in LPS-stimulated macrophages-derived exosomes accelerates septic lung injury by activating epithelial cell NLRP3 signaling.
Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity.
The STING inhibitor C-176 attenuates MPTP-induced neuroinflammation and neurodegeneration in mouse parkinsonian models.
Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway.
Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Application of Dominant Gut Microbiota Promises to Replace Fecal Microbiota Transplantation as a New Treatment for Alzheimer's Disease.
Injectable kaempferol-loaded fibrin glue regulates the metabolic balance and inhibits inflammation in intervertebral disc degeneration.
Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response.
Sleep deprivation alleviates depression-like behaviors in mice via inhibiting immune and inflammatory pathways and improving neuroplasticity.
Activation of LXRα attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction.
Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid.
Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration.
Selenium Deficiency Promotes the Expression of LncRNA-MORC3, Activating NLRP3-Caspase-1/IL-1β Signaling to Induce Inflammatory Damage and Disrupt Tight Junctions in Piglets.
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages.
Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility.
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Role of nuclear factor of activated T Cells-1 in Sepsis-induced behavioral deficits in mice.
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Lysosomal control of senescence and inflammation through cholesterol partitioning.
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia.
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-κB/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages.
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.
Metformin Attenuates the Inflammatory Response via the Regulation of Synovial M1 Macrophage in Osteoarthritis.
Novel long non-coding RNAs associated with inflammation and macrophage activation in human.
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.
The expression of cyclic GMP-AMP synthase in human apical periodontitis: A laboratory investigation.
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
microRNA-149-5p mediates the PM(2.5)-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.
Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Gastroprotective Effects of the Aqueous Extract of Finger Citron Pickled Products against Ethanol-Induced Gastric Damage: In Vitro and In Vivo Studies.
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Stigmasterol Protects Against Steatohepatitis Induced by High-Fat and High-Cholesterol Diet in Mice by Enhancing the Alternative Bile Acid Synthesis Pathway.
Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis.
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway.
NF-κB pathway affects silica nanoparticle-induced fibrosis via inhibited inflammatory response and epithelial-mesenchymal transition in 3D co-culture.
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model.
Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation.
Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.
Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Role of NF-κB in lead exposure-induced activation of astrocytes based on bioinformatics analysis of hippocampal proteomics.
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
The combined effect of deoxynivalenol and Fumonisin B(1) on small intestinal inflammation mediated by pyroptosis in vivo and in vitro.
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway.
Taurine alleviates ochratoxin A-induced pyroptosis in PK-15 cells by inhibiting oxidative stress.
Atractylodin targets GLA to regulate D-mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification.
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury.
A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis.
Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro.
Extracellular vesicles released from macrophages modulates interleukin-1β in astrocytic and neuronal cells.
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Adrenomedullin Improves Hypertension and Vascular Remodeling partly through the Receptor-Mediated AMPK Pathway in Rats with Obesity-Related Hypertension.
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
Exosomal RBP4 potentiated hepatic lipid accumulation and inflammation in high-fat-diet-fed mice by promoting M1 polarization of Kupffer cells.
Multilayer amnion-PCL nanofibrous membrane loaded with celecoxib exerts a therapeutic effect against tendon adhesion by improving the inflammatory microenvironment.
LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3/AMPKα.
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Vitamin D/Vitamin D receptor mitigates cisplatin-induced acute kidney injury by down-regulating C5aR.
Resveratrol and its analogs suppress HIV replication, oxidative stress, and inflammation in macrophages.
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition.
The E3 ubiquitin ligase RNF31 mediates the development of ulcerative colitis by regulating NLRP3 inflammasome activation.
Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice.
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.
MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia.
Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.
Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response.
Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine.
Berberine-loaded MSC-derived sEVs encapsulated in injectable GelMA hydrogel for spinal cord injury repair.
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
Transcriptomics Reveals Molecular Features of the Bilateral Pelvic Nerve Injury Rat Model of Detrusor Underactivity.
Purple Yam Polyphenol Extracts Exert Anticolitis and Anticolitis-Associated Colorectal Cancer Effects through Inactivation of NF-κB/p65 and STAT3 Signaling Pathways.
Repairing gastric ulcer with hyaluronic acid/extracellular matrix composite through promoting M2-type polarization of macrophages.
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Amelioration of nerve demyelination by hydrogen-producing silicon-based agent in neuropathic pain rats.
Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis.
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway.
Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability.
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
PM(2.5) induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway.
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking.
Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing.
Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease.
Transfer of Tumor-Bearing Mice Intestinal Flora Can Ameliorate Cognition in Alzheimer's Disease Mice.
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-[Formula: see text]B Signaling Pathway.
Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites.
HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
ETC-1002 Attenuates Porphyromonas gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-κB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice.
OPN Promotes Cell Proliferation and Invasion through NF-κB in Human Esophageal Squamous Cell Carcinoma.
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Enriched Environment-Induced Neuroprotection against Cerebral Ischemia-Reperfusion Injury Might Be Mediated via Enhancing Autophagy Flux and Mitophagy Flux.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats.
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Supplementation with dietary omega-3 PUFA mitigates fetal brain inflammation and mitochondrial damage caused by high doses of sodium nitrite in maternal rats.
Effect of benzo(a)pyrene on oxidative stress and inflammatory mediators in astrocytes and HIV-infected macrophages.
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis.
Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α-Syn and tau fragments.
The role of APTX4870 peptide in reducing cellular inflammatory responses by inhibiting Mycobacterium tuberculosis-derived mycolic acid-induced cytotoxicity.
The Assessment on Synergistic Activity of Ebselen and Silver Ion Against Yersinia pseudotuberculosis.
Tongluo Yishen Decoction Ameliorates Renal Fibrosis via NLRP3-Mediated Pyroptosis In Vivo and In Vitro.
Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β.
Oridonin Delays Aging Through the AKT Signaling Pathway.
AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFκB-p65 Pathway Following Intracerebral Hemorrhage.
Neutrophil Extracellular Traps Regulate HMGB1 Translocation and Kupffer Cell M1 Polarization During Acute Liver Transplantation Rejection.
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p.
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases.
NLRP3 inflammasome contributes to endothelial dysfunction in angiotensin II-induced hypertension in mice.
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation.
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury.
Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation.
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Effects of intraperitoneal injection of lipopolysaccharide-induced peripheral inflammation on dopamine neuron damage in rat midbrain.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.
Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia.
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis.
Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling.
Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice.
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury.
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2-Signal Transducer and Activator of Transcription 6 Pathway.
Effect of Lactobacillus with Feruloyl Esterase-Producing Ability on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity.
linc00174 deteriorates the pathogenesis of diabetic retinopathy via miR-26a-5p/PTEN/Akt signalling cascade-mediated pyroptosis.
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration.
Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway.
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Interleukin-4 activates the PI3K/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells.
Rescuing ischemic stroke by biomimetic nanovesicles through accelerated thrombolysis and sequential ischemia-reperfusion protection.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.
Mild inflammation persists in the glenohumeral joint of patients with shoulder instability: Cross-sectional study.
Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets.
Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4(+) T cells in chronic liver injury.
Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension.
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).
Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling.
L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis.
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice.
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Role of salivary glycopatterns for oral microbiota associated with gastric cancer.
Construction and comprehensive analysis of a lncRNA-mRNA interactive network to reveal a potential lncRNA for hepatic encephalopathy development.
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus.
Reduced inhibition underlies early life LPS exposure induced-cognitive impairment: Prevention by environmental enrichment.
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2.
Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.
Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells.
Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter.
Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response.
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms.
Mutant C/EBPα p30 alleviates immunosuppression of CD8(+) T cells by inhibiting autophagy-associated secretion of IL-1β in AML.
Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics.
Morin Inhibits Dox-Induced Vascular Inflammation By Regulating PTEN/AKT/NF-κB Pathway.
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
A novel Atlantic salmon (Salmo salar) bone collagen peptide delays osteoarthritis development by inhibiting cartilage matrix degradation and anti-inflammatory.
Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas.
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
Inhibition of glutamine transporter ASCT2 mitigates bleomycin-induced pulmonary fibrosis in mice.
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Calcium phosphate cement with icariin-loaded gelatin microspheres as a local drug delivery system for bone regeneration.
Treadmill training mitigates bone deterioration via inhibiting NLRP3/Caspase1/IL-1β signaling in aged rats.
Betaine supplementation alleviates dextran sulfate sodium-induced colitis via regulating the inflammatory response, enhancing the intestinal barrier, and altering gut microbiota.
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Pyroptosis participates in PM(2.5)-induced air-blood barrier dysfunction.
Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway.
Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy.
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice.
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1.
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis.
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain.
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury.
Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model.
F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis.
Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction.
Benefit Effect of Dendrobium officinale Ultrafine Powder on DSS-Induced Ulcerative Colitis Rats by Improving Colon Mucosal Barrier.
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.
Berberine Protects against TNF-α-Induced Injury of Human Umbilical Vein Endothelial Cells via the AMPK/NF-κB/YY1 Signaling Pathway.
Dihydroartemisinin inhibits activation of the AIM2 inflammasome pathway and NF-κB/HIF-1α/VEGF pathway by inducing autophagy in A431 human cutaneous squamous cell carcinoma cells.
Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
KCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease.
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
The cardioprotective effect of the sodium-glucose cotransporter 2 inhibitor dapagliflozin in rats with isoproterenol-induced cardiomyopathy.
A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway.
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells.
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Extracellular CIRP Induces Macrophage Extracellular Trap Formation Via Gasdermin D Activation.
The Protective Effects of Zornia diphylla (L.) Pers. Against Acute Liver Injury Induced by Carbon Tetrachloride in Mice.
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway.
CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis.
Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury.
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.
Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering.
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Magnesium-L-threonate alleviate colonic inflammation and memory impairment in chronic-plus-binge alcohol feeding mice.
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Anti-NAFLD Effect of Djulis Hull and Its Major Compound, Rutin, in Mice with High-Fat Diet (HFD)-Induced Obesity.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway.
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway.
Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.
miR‑4792 regulates inflammatory responses in Cryptococcus neoformans‑infected microglia.
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction.
Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation.
c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.
Maternal immune activation alters adult behavior, intestinal integrity, gut microbiota and the gut inflammation.
Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.
Anti-HIV Activity of Cucurbitacin-D against Cigarette Smoke Condensate-Induced HIV Replication in the U1 Macrophages.
Resveratrol attenuates radiation enteritis through the SIRT1/FOXO3a and PI3K/AKT signaling pathways.
Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6.
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis.
Cordyceps acid alleviates lung cancer in nude mice.
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis.
Therapeutic targets of rosuvastatin on heart failure and associated biological mechanisms: A study of network pharmacology and experimental validation.
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.
Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease.
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor-Mediated PKA Pathway.
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Microcystin-LR Induces NLRP3 Inflammasome Activation via FOXO1 Phosphorylation, Resulting in Interleukin-1β Secretion and Pyroptosis in Hepatocytes.
Circ_0001438 participates in the pathogenesis of preeclampsia via the circ_0001438/miR-942/NLRP3 regulatory network.
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Adrenomedullin 2 attenuates LPS-induced inflammation in microglia cells by receptor-mediated cAMP-PKA pathway.
Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.
Long-term ketamine administration induces bladder damage and upregulates autophagy-associated proteins in bladder smooth muscle tissue.
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Loss of Arf Guanine Nucleotide Exchange Factor GBF1 Activity Disturbs Organelle Dynamics in Mouse Oocytes.
CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes.
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.
Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
17-Allylamino-Demethoxygeldanamycin Ameliorate Microthrombosis Via HSP90/RIP3/NLRP3 Pathway After Subarachnoid Hemorrhage in Rats.
Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease.
Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation.
Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer's disease.
Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia.
Role of Endoplasmic Reticulum Stress in Otitis Media.
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.
Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome.
Fucoidan inhibits tooth movement by promoting restorative macrophage polarization through the STAT3 pathway.
Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants.
Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-κB signaling and NLRP3 inflammasome.
Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats.
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response.
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.
The Differential Expression of Cytokines and Growth Factors After SMILE Compared With FS-LASIK in Rabbits.
LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell.
Aging alters Hv1-mediated microglial polarization and enhances neuroinflammation after peripheral surgery.
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.
The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis.
Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats.
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Anti-human serum albumin autoantibody may be involved in the pathogenesis of autoimmune bullous skin diseases.
Corneal epithelial injury-induced norepinephrine promotes Pseudomonas aeruginosa keratitis.
CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats.
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation.
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway.
A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice.
Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation.
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis.
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
COMP in the Infrapatellar Fat Pad-Results of a Prospective Histological, Immunohistological, and Biochemical Case-Control Study.
High- and low-virulent bovine Pasteurella multocida induced differential NLRP3 inflammasome activation and subsequent IL-1β secretion.
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release.
NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs.
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Vaccaria n-Butanol Extract Lower the Production of Proinflammatory Cytokines and the Infection Risk of T. spiralis In Vivo.
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation.
Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System.
Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection.
LncRNA HIF1A-AS1 contributes to ventricular remodeling after myocardial ischemia/reperfusion injury by adsorption of microRNA-204 to regulating SOCS2 expression.
Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling.
SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.
Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis.
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension.
OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.
Purple sweet potato color attenuated NLRP3 inflammasome by inducing autophagy to delay endothelial senescence.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling.
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.
Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1.
Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB.
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).
Chitosan Hydrogel Delivery System Containing Herbal Compound Functions as a Potential Antineuroinflammatory Agent.
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Helicobacter pylori-induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL-1β expression.
Pioglitazone decreased renal calcium oxalate crystal formation by suppressing M1 macrophage polarization via the PPAR-γ-miR-23 axis.
The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Relationship between serum IL-1β and insomnia and liver depression in patients with perimenopausal non-organic sleep disorder.
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.
Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset Still's disease.
Differential immune responses of C57BL/6 mice to infection by Salmonella enterica serovar Typhimurium strain SL1344, CVCC541 and CMCC50115.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Schwann cell transplantation exerts neuroprotective roles in rat model of spinal cord injury by combating inflammasome activation and improving motor recovery and remyelination.
Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell.
Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1β secretion in macrophages infected with Pasteurella multocida.
Protective effects of ginsenoside Rk3 against chronic alcohol-induced liver injury in mice through inhibition of inflammation, oxidative stress, and apoptosis.
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.
Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress.
Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus.
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
NADH protect against radiation enteritis by enhancing autophagy and inhibiting inflammation through PI3K/AKT pathway.
Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.
Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.
Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome.
Autocrine IL-1β mediates the promotion of corneal neovascularization by senescent fibroblasts.
Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats.
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption.
Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain.
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Effects of Dandelion Extract on the Proliferation of Rat Skeletal Muscle Cells and the Inhibition of a Lipopolysaccharide-Induced Inflammatory Reaction.
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala.
Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury.
NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-β1/SMADs Pathway.
Telbivudine attenuates UUO-induced renal fibrosis via TGF-β/Smad and NF-κB signaling.
Fungal β-Glucan Activates the NLRP3 Inflammasome in Human Bronchial Epithelial Cells Through ROS Production.
Effects of platelet-rich plasma on the activity of human menstrual blood-derived stromal cells in vitro.
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Influence of vitamin D deficiency on T cell subsets and related indices during spinal tuberculosis.
Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection.
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Establishment of experimental autoimmune prostatitis model by T(2) peptide in aluminium hydroxide adjuvant.
Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer.
Aliskiren Improves Ischemia- and Oxygen Glucose Deprivation-Induced Cardiac Injury through Activation of Autophagy and AMP-Activated Protein Kinase.
NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling.
Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.
Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.
NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.
Role of NF-κB/GATA3 in the inhibition of lysyl oxidase by IL-1β in human amnion fibroblasts.
LOX-1 is involved in IL-1β production and extracellular matrix breakdown in dental peri-implantitis.
Neuroprotective Effect of Chitosan Oligosaccharide on Hypoxic-Ischemic Brain Damage in Neonatal Rats.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat.
Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer's disease.
Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.
Rapamycin suppresses Aβ(25-35)- or LPS-induced neuronal inflammation via modulation of NF-κB signaling.
Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.
Dopamine D(2) receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation.
Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8(+) T cells.
Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice.
A recombinant TGF-β1 vaccine ameliorates diabetic nephropathy in OLETF rats.
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Dendrobium officinale Kimura et Migo attenuates diabetic cardiomyopathy through inhibiting oxidative stress, inflammation and fibrosis in streptozotocin-induced mice.
Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit.
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction.
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation.
Aging increases the susceptibility of cisplatin-induced nephrotoxicity.
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α.
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
NDGA reduces secondary damage after spinal cord injury in rats via anti-inflammatory effects.
Song Q, Li D, Yuan Z, Zhang C, Wang J, Liao F, Xu P, Xiao Q
PloS one 2026;21(3):e0344474
PloS one 2026;21(3):e0344474
Sirtuin 4 Knockout Aggravates Sepsis-Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes.
Li N, Ma D, Luo S, He A, Chang S
Mediators of inflammation 2026;2026:7600668
Mediators of inflammation 2026;2026:7600668
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Xie F, Feng J, Li K, Chen Y, Han L, Wu Y
Mediators of inflammation 2026;2026:5524066
Mediators of inflammation 2026;2026:5524066
Intracavernous Injection of Mechanically Extracted Stromal Vascular Fragments Suppresses Endothelial-Mesenchymal Transformation to Mitigate Erectile Dysfunction in Hypertensive Rats.
Shao C, Sun Y, Zhao J, Ju C, Yang T, Liu J, Zhou L, Jia R, Zhao F
Stem cells international 2026;2026:3343152
Stem cells international 2026;2026:3343152
Transcriptomics and Network Pharmacology Reveal Anti-Inflammatory and Anti-Oxidative Stress Mechanisms of Qingxuan Runmu Yin in Dry Eye Disease.
Zhao S, Wang J, Liu Y, Hu X, Gu C, Yao J
Journal of inflammation research 2026;19:516780
Journal of inflammation research 2026;19:516780
Enterotoxigenic Escherichia coli-induced intestinal epithelial necroptosis drives lamina propria immune cell pyroptosis and mucosal injury in piglets.
Wu X, Liu Y, Wu S, Wei H, Peng J
Frontiers in immunology 2026;17:1778258
Frontiers in immunology 2026;17:1778258
Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.
Xiao Y, Zhang T, Chen Q, Zhang Y, Chen B, Wang M, Zhang Y, Huang M, Su Y, Guo J
Frontiers in immunology 2026;17:1761558
Frontiers in immunology 2026;17:1761558
Potential molecular communication of blood and synovium through ligand-receptor interactions in osteoarthritis.
Wang M, Tan G, Wang S, Lv W
Frontiers in medicine 2026;13:1719995
Frontiers in medicine 2026;13:1719995
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Zhang W, Wang Y, Meng Q, Liu Z, Qu S, Zhou J
Frontiers in molecular biosciences 2026;13:1714966
Frontiers in molecular biosciences 2026;13:1714966
Cell membrane-encased thylakoid as white light triggered PDT therapy for facile and targeted choroidal melanoma treatment.
Wang J, Chen Z, Yang Y, Wang Y, Xie H, Hong W, Lin Q
Bioactive materials 2026 Sep;63:31-55
Bioactive materials 2026 Sep;63:31-55
Embryonic exposure to bisphenol A glycidyl methacrylate induces craniofacial cartilage malformation via NLR signaling pathway in zebrafish.
Luo W, Zhang J, Wu S, Liao X, Xi W
Ecotoxicology and environmental safety 2026 May;316:120121
Ecotoxicology and environmental safety 2026 May;316:120121
Xiayuxue decoction alleviates MASH by regulating gut microbiota, bile acid metabolism, and m(6)A modification.
Shi J, Zhao C, Zhang D, Zhang L, Feng Q, Qi S, He X, Liu P, Mu Y, Chen G, Ma W, Peng D, Li R, Wang Y, Cheng Y, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158023
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158023
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Li J, Zhou J, Zhang G, Ding N, Kuang Z, Wang J, Liu N, Jia G, Jiang M, Wu S, Yang J, Ding X, Lei Z, Nie Y, Zhang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Qiu M, Yi Q, Luo M, Duan S, Zhang Z, Wu X, Chen T, Ma C, Cui T, Zhang B, Zhang Y, Li J, Guo S, Gao Y, Zhang D
Journal of ethnopharmacology 2026 May 23;363:121373
Journal of ethnopharmacology 2026 May 23;363:121373
Exosomes derived from Bcl-2-engineered iPSC-cardiomyocytes mitigate aortic valve calcification and inhibit cardiomyocyte apoptosis.
Li N, Xiao R, Zhu L, Cai L, Zhang Z, Sun L, Shi H, Ye H, Shao G, Gao J
International journal of pharmaceutics 2026 May 20;697:126877
International journal of pharmaceutics 2026 May 20;697:126877
Self-Assembled Quercetin-Mecobalamin Nanoparticles Mitigate Ischemic Stroke Injury via Enhanced Neuroprotection and Microglial Modulation.
Zhang T, Fan S, Ji H, Liu W, Chen X, Fu D
ACS biomaterials science & engineering 2026 May 11;12(5):2606-2618
ACS biomaterials science & engineering 2026 May 11;12(5):2606-2618
LncRNA RMST knockout inhibits fibrosis by down-regulating Smad3 during mouse skin wound healing.
Zhou Z, Huang X, Chen C, Zou T, Hai Y, Dong G, Li S
Biochemistry and biophysics reports 2026 Mar;45:102386
Biochemistry and biophysics reports 2026 Mar;45:102386
Thymic stromal lymphopoietin modification gates chronic pain via regulation of transient receptor potential vanilloid type 1-caspase1.
Lu YY, Lu CC, Tsai HP, Wu CH
The International journal of neuroscience 2026 Mar;136(3):309-317
The International journal of neuroscience 2026 Mar;136(3):309-317
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Zhang S, Li X, Gao Y, Dong Q, Jin X, Shi P, Dong J
Fish physiology and biochemistry 2026 Mar 5;52(2)
Fish physiology and biochemistry 2026 Mar 5;52(2)
Lactobacillus paragasseri LPG-9 reduces placental inflammation in intrahepatic cholestasis of pregnancy by regulating TGR5 in mice.
Huang W, Zhang J, Shan J, Shen W, Du P, Liu J, Guo X, Chen Z, Zeng W, Lin Q, Fan H
Communications biology 2026 Mar 26;9(1)
Communications biology 2026 Mar 26;9(1)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression.
Yan K, Jiang Y, Yong Y, Zhang T, Zhang N, Zeng Q, Gong X, Meng L, Bi F, Liu Y
Annals of clinical and translational neurology 2026 Mar 24;
Annals of clinical and translational neurology 2026 Mar 24;
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy.
Zhou Q, Tang M, Wang Y, Lv H, Yang G, Wang F, Ye H
Chinese medicine 2026 Mar 16;21(1)
Chinese medicine 2026 Mar 16;21(1)
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Chen SX, Qi X, Zheng XT, Bi ZM, Zhang Y, Wang YM
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
Hao R, Sun Y, Wang C, Wang Y, Li L, Sun H, Chen L
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
Drug Repurposing of Verapamil for H1N1 Influenza Virus Infection: A Multi-Target Strategy Revealed by Network Pharmacology and Experimental Validation.
Cao Y, Wu J, Li X, Qiu F, Wang S, Qian B, Fan L, Wang Y, Xue K, Zhang J, Shen B, Gao Y
International journal of molecular sciences 2026 Mar 10;27(6)
International journal of molecular sciences 2026 Mar 10;27(6)
Microglial GLUL loss worsens TBI outcomes by amplifying the arginine-citrulline pathway.
Li J, Zhao Y, Yang Y, Dai Q, Tian R, Wang J, Ye J, Zhang L, Li L
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168230
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168230
SiO(2) dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway.
Zhang H, Huang F, Guan L, Zeng M
Toxicology in vitro : an international journal published in association with BIBRA 2026 Jun;114:106229
Toxicology in vitro : an international journal published in association with BIBRA 2026 Jun;114:106229
Ailanthone ameliorates CCl(4)-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming.
Wan Y, Wang T, Wang K, Huo Q, Cheng X
International immunopharmacology 2026 Jun 15;179:116640
International immunopharmacology 2026 Jun 15;179:116640
Eleutheroside B alleviates LPS-induced depressive-like behaviors by suppressing the TLR4/MyD88/NF-κB signaling pathway in the dentate gyrus.
Wu S, Jiang Y, Zhai C, Li P, Yang H, Xu C, Wang Y, Liu JG, Zhang L
International immunopharmacology 2026 Jul 1;180:116727
International immunopharmacology 2026 Jul 1;180:116727
New antidepressant diterpenoid alkaloids from Aconitum carmichaelii Debeaux: Potential inhibitors of NLRP3 activation.
Yin WF, Pan XG, Bai ML, Tong ZH, Li DX, Ding K, He J, Zhang WK, Xu JK
Bioorganic chemistry 2026 Jan;168:109317
Bioorganic chemistry 2026 Jan;168:109317
Sanmiao pill ameliorates rheumatoid arthritis via PPARγ-mediated lipid accumulation in macrophage: A multi-omics and experimental validation.
Jiang Q, Jiang X, Xia SL, Bu Y, Wang Y, Wu H, Deng R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157697
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Huang K, Xiao JL, Tang JY, Pu HY, Li FH, Gao K, Yu X, Guo SZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Zhang S, Xie Y, Zhang L, Qi Y, Liao Q, Xu C, Yang S, Zhou H, Tan Q, Qi S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis.
Jiang Y, Zhang S, Guan H, Lv K, Yu J, Li S, Jia R, Zhang X, Ma S, Qu J, Lin J
Chinese medicine 2026 Jan 8;21(1):18
Chinese medicine 2026 Jan 8;21(1):18
Polydopamine-encapsulated modified Pulsatilla decoction: a strategy to enhance ulcerative colitis therapy.
Chen YJ, Li CQ, Liu C, Zhu YJ, Wu JJ, Wu TT, Zhu HP, Hua DB, Sun HW
Chinese medicine 2026 Jan 5;21(1):2
Chinese medicine 2026 Jan 5;21(1):2
SanHuang decoction may suppress breast cancer by regulating M1 macrophage polarization via NF-κB signaling pathway: in vitro and in vivo studies.
Ying Y, Guo M, Ning Q, Wei Y, Qian J, Cai R
Translational cancer research 2026 Jan 31;15(1):33
Translational cancer research 2026 Jan 31;15(1):33
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Li C, Liu C, Xia Y, Liu X, Wang F, Zhuo G, Ren Q
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Chen C, Ma L, Dawuti A, Feng X, Chen S, An X, Bai Y, Zhang T, Aydin M, Kashmiri K, Ma Z, Zhang W, Yaermaimaiti S, Abulizi A
NPJ science of food 2026 Jan 23;10(1):73
NPJ science of food 2026 Jan 23;10(1):73
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
Chen XW, Tong XY, Tan RM, Ouyang JM
iScience 2026 Jan 16;29(1):114459
iScience 2026 Jan 16;29(1):114459
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity.
Liu D, Zhou C, Wang X, Luo Z, Xu R, Huo S, Guo L, Luo X, Yang S, Click A, Vancil J, Barajas P, Mijares V, Baniasadi H, Yan N, Rehwinkel J, Hancks DC, Chen EH, Liang S, Zhong Z
Science (New York, N.Y.) 2026 Jan 15;391(6782):eadq9006
Science (New York, N.Y.) 2026 Jan 15;391(6782):eadq9006
S100A4 triggeres the pyroptosis of vsmcs: association with mitochondrial damage, impaired mitophagy, and Ca(2+) dysregulation.
Huang J, Zhou B, Wang L, Huang Q, Lin X, Zhao H, Xia Y
Biology direct 2026 Jan 12;21(1):18
Biology direct 2026 Jan 12;21(1):18
Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network.
Li Y, Zheng K, Chen C, Wu Y, Li S, Zhou W, Liu X
Biochimica et biophysica acta. Proteins and proteomics 2026 Jan 1;1874(1):141101
Biochimica et biophysica acta. Proteins and proteomics 2026 Jan 1;1874(1):141101
Association Between Genetically Proxied SLC12A2 Inhibition and Inflammatory Bowel Disease: A Mendelian Randomization Study.
Yu X, Cao Y, Mao C, Tao C, Chen W
Biochemical genetics 2026 Feb;64(1):487-503
Biochemical genetics 2026 Feb;64(1):487-503
Systematic Identification and Functional Validation of CASP10 as a DNA-Damage-Responsive Driver of Endothelial Pyroptosis in Atherosclerosis.
Meng X, Zhang K, Xi Y, Wang Z, Zhu X, Zhang W
Journal of cellular and molecular medicine 2026 Feb;30(4):e71060
Journal of cellular and molecular medicine 2026 Feb;30(4):e71060
Macrophage USP14 suppresses Wnt/β-catenin signaling via NLK deubiquitination to enhance immune response.
Zhao M, Shi J, Wei X, Tian W, Chen Y
Cytokine 2026 Feb;198:157079
Cytokine 2026 Feb;198:157079
Sulfated Pelvetia siliquosa Polysaccharides Attenuate Pyroptosis via NF-κB Pathway Inhibition Against Calcium Oxalate Stone Formation.
Tong XY, Chen XW, Zhang JY, Ouyang JM
Marine drugs 2026 Feb 8;24(2)
Marine drugs 2026 Feb 8;24(2)
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Ma CS, Han B, Guo JR, Guo JF, Shi CK, Liu YX, Yi WJ, Zhang LY, Deng AJ, Wang YS, He MT
Journal of translational medicine 2026 Feb 7;24(1)
Journal of translational medicine 2026 Feb 7;24(1)
The regulation of lymphatic valve formation promotes lymphatic drainage to reduce atherosclerotic plaques: A novel mechanism of anti-atherosclerosis by Gualou-Xiebai.
Liu J, Li Z, Sun X, Zhu L, Bao Y, Liu Z, Xu Y, Xia X, Zhao W, Zhang Y, Zhou A, Wu H
Journal of ethnopharmacology 2026 Feb 28;357:120937
Journal of ethnopharmacology 2026 Feb 28;357:120937
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Ni J, Zhou H, Shen K, Xu H, Wang J, Liu J, Liu F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W
Biology direct 2026 Feb 26;21(1)
Biology direct 2026 Feb 26;21(1)
Ophiopogon japonicus-derived plant exosomes: a promising strategy for blocking the progression of diabetic vasculopathy to myocardial infarction.
Pan Y, Tan M, Li X, Chen Q, Tao J, Lin X, Zeng Z, Song Y, Jiang F
BMC complementary medicine and therapies 2026 Feb 21;26(1)
BMC complementary medicine and therapies 2026 Feb 21;26(1)
AMPK Deficiency Induces Corneal Epithelial Barrier Dysfunction by Modulating Energy Homeostasis.
Yang Y, Yan K, Tang Y, Liu Z, Zhu L, Wei M, Huang C, Liu Z, Zhao D, Ren S
Investigative ophthalmology & visual science 2026 Feb 2;67(2):47
Investigative ophthalmology & visual science 2026 Feb 2;67(2):47
Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.
Hu R, Li R, Wang L, Li S, Chu H, Zhang L, Qin L, Sun Q, Liu C
ACS nano 2026 Feb 17;20(6):5054-5071
ACS nano 2026 Feb 17;20(6):5054-5071
Coptis chinensis extracellular vesicles loaded with CA1-siRNA promote endothelial repair and stent restenosis therapy by regulating the PADI2 and NF-κB pathway.
Wang X, Liu Y, Li W, Hao J, Zhao Z, Fan H, Wu X, Liu X, Xu H, Yu T, Liu M, Guo M, Li Y
Journal of nanobiotechnology 2026 Feb 11;24(1):157
Journal of nanobiotechnology 2026 Feb 11;24(1):157
Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats.
Zhao WP, Zhu SQ, Yin ZH, Ommati MM, Zhang YW, Zhao J, Zhou BH, Wang HW
Environmental pollution (Barking, Essex : 1987) 2026 Feb 1;390:127503
Environmental pollution (Barking, Essex : 1987) 2026 Feb 1;390:127503
Fisetin alleviates lipopolysaccharide-induced mastitis by inhibiting ferroptosis and modulating the gut microbiota.
Tong C, Wang L, Wen H, Yao X, Tong J, Zhang R, Li X, Xiang Y, Wang X
The veterinary quarterly 2026 Dec;46(1):2642789
The veterinary quarterly 2026 Dec;46(1):2642789
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice.
Che J, Wu Y, Dong J, Shi C, Chen Y, He Z, Zhang X, Zhang J
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2026 Apr;86(2):e70123
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2026 Apr;86(2):e70123
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.
Xu LT, Han QT, Xu ZP, Wang XN, Zhang H, Shen T
Journal of advanced research 2026 Apr;82:1149-1162
Journal of advanced research 2026 Apr;82:1149-1162
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
Li S, Zhang X, Zhang P, Wang X, Yang Y, Qin D, Law BY, Pan Y, Tang Y
Molecular nutrition & food research 2026 Apr;70(7):e70452
Molecular nutrition & food research 2026 Apr;70(7):e70452
MicroRNA-493-5p engineered exosomes delivered via piezoelectric microneedles for epigenetic modulation of macrophages in diabetic wound healing.
Chen T, Ouyang L, Mi B, Sheng Y, Al-Smadi F, Xu H, Wu Y, Zhang X, Zhou K, Wu A, Wang X, Liu G, Zhang W
Materials today. Bio 2026 Apr;37:102931
Materials today. Bio 2026 Apr;37:102931
Emodin modulates the NLRP3/GSDMD pathway to alleviate Fusobacterium necrophorum-induced pyroptosis in the interdigital skin fibroblasts of dairy Cows.
Zhang A, Liu M, Tang Y, Wang R, Ruan H, Zhu T, Ge Y, Xu E, Zheng J
International journal of biological macromolecules 2026 Apr;353:151331
International journal of biological macromolecules 2026 Apr;353:151331
Hypoxia-activated dual donors of H(2)S and NO alleviate myocardial injury in coronary heart disease via synergistic mechanisms.
Zhou W, Ma C, Wang Y, Yang W, Gou S
European journal of medicinal chemistry 2026 Apr 5;307:118671
European journal of medicinal chemistry 2026 Apr 5;307:118671
Overexpression of miR-7641 activates ox-LDL-induced autophagy in macrophages by regulating USP7.
Tian P, Du Q, Zeng F, Chen J, Wang P, Zhang L, Li Y
Molecular biology reports 2026 Apr 22;53(1)
Molecular biology reports 2026 Apr 22;53(1)
Aerobic Exercise Alleviates Oxidative Stress and Inflammation to Attenuate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in ApoE(-/-) Mice.
Zhang L, Wang W, Zheng F, Weng J, Lu Y, Li Q, Li T, Li W, Wang L
Metabolites 2026 Apr 21;16(4)
Metabolites 2026 Apr 21;16(4)
NOTCH3-R544C mutation drives endothelial dysfunction through inflammation, migration impairment, and lipid dysregulation.
Sun R, Li W, Liu N, Ji X, Zhao Z, Che N, Li A, Hu W, Zhang J
Journal of Alzheimer's disease : JAD 2026 Apr 21;:13872877261444309
Journal of Alzheimer's disease : JAD 2026 Apr 21;:13872877261444309
GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation.
Jiang R, Li L, Luo Y, Wang W, Zeng X, Qian C, Gong C, Sheng J
International immunopharmacology 2026 Apr 1;174:116394
International immunopharmacology 2026 Apr 1;174:116394
hsa_circ_0095812 accelerates periodontitis progression by adsorbing miR-485-3p-mediated THBS1 expression.
Xie X, Li R, Mi F
Clinics (Sao Paulo, Brazil) 2025;80:100631
Clinics (Sao Paulo, Brazil) 2025;80:100631
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
Wu Y, Mao J, Zhou Y, Hong G, Wu H, Hu Z, Huang X, Shi J, Xie Z, Lan Y
Research (Washington, D.C.) 2025;8:0644
Research (Washington, D.C.) 2025;8:0644
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
Zhou F, Tian Y, Liao W, Ma Q, Bao H, Meng F, Jiang J
Anesthesiology research and practice 2025;2025:6624776
Anesthesiology research and practice 2025;2025:6624776
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Peng J, Hu X, He J, Xia Y
Mediators of inflammation 2025;2025:3585885
Mediators of inflammation 2025;2025:3585885
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Wang Y, Liao Q, Mei X, Xu H, Luo L, Huang R, Tang Y, Zhou C
PloS one 2025;20(6):e0326687
PloS one 2025;20(6):e0326687
The alteration of uterine microbiota participated in the activation of the decidual inflammatory response in early spontaneous abortion.
Liu P, Chen G, Zhao S, Kong L, Liao X, Cheng M
PloS one 2025;20(2):e0317595
PloS one 2025;20(2):e0317595
High-temperature requirement serine protease A2 inhibitor UCF-101 ameliorates damaged neurons in traumatic brain-injured rats by the AMPK/NF-κB pathway.
Qiu TW, Jin Z, Fu ZZ, Yan XJ, Zhan CP, Zheng HW, Li MY, Yu GF
Open life sciences 2025;20(1):20220971
Open life sciences 2025;20(1):20220971
HDAC7 knockout mitigates astrocyte reactivity and neuroinflammation via the IRF3/cGAS/STING signaling pathway.
Yue RZ, Guo X, Li W, Li C, Shan L
Frontiers in cellular neuroscience 2025;19:1683595
Frontiers in cellular neuroscience 2025;19:1683595
Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis.
Mei Y, Zheng Y, Zhang X, Hu T, Zheng X, Zhang C, Deng Q
Journal of inflammation research 2025;18:8243-8262
Journal of inflammation research 2025;18:8243-8262
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Kang M, Cai J, Yi W, Zhang B, Ai L, Ning B, Dong J, Chen L, Fu W
American journal of translational research 2025;17(5):3619-3629
American journal of translational research 2025;17(5):3619-3629
Unveiling the IL-1β/CXCL2 axis: a shared therapeutic target in periodontitis and inflammatory bowel disease.
Gu Z, Gao A, Ma X, Wang X, Zhang Y, Wang Y, Qiu C
Frontiers in immunology 2025;16:1728773
Frontiers in immunology 2025;16:1728773
Berberine-taxifolin co-administration attenuates inflammatory response and intestinal barrier injury via nf-κB/NLRP3 suppression in colitis.
Miao G, Zhang D, Sui Z, Leng J, Deng Y, Gu X, Cao H
Frontiers in immunology 2025;16:1725084
Frontiers in immunology 2025;16:1725084
Administration of 2-deoxy-D-glucose induces pyroptosis in murine breast cancer cells via cAMP/PKA/HK2 to impair tumor survival.
Pan T, Jin S, Gao W, Eom K, Dong J, Li L
Frontiers in immunology 2025;16:1724476
Frontiers in immunology 2025;16:1724476
Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223-associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure.
Ye Z, Liu M, Zhang X, Wu H, Qiu Z, Chai R, Hu Y
Frontiers in pharmacology 2025;16:1697422
Frontiers in pharmacology 2025;16:1697422
Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.
Zeng JW, Han ZJ, He XT, Liu XJ, Wang HY, Yang SS, Bai J, Duan YJ, Lin L
Frontiers in psychiatry 2025;16:1628634
Frontiers in psychiatry 2025;16:1628634
Unlocking amyotrophic lateral sclerosis: the role of adiponectin in inflammation and disease progression.
Tian M, Xin C, Huo J, Liu Q, Dong H, Bai L, Wang Y, Li R, Liu Y
Frontiers in neurology 2025;16:1605822
Frontiers in neurology 2025;16:1605822
Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle.
Cao Y, Zhou J, Quan H, Li W, Li T, Wang L
Frontiers in immunology 2025;16:1597222
Frontiers in immunology 2025;16:1597222
Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice.
Yang Z, Zhang FR, Ren L, Bai JM, Wang SC, Li XY, Yang HJ, Xiao HH
Frontiers in pharmacology 2025;16:1596728
Frontiers in pharmacology 2025;16:1596728
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Yang X, Wang X, Li K, Deng Q, Hou Y, Xi G, Lu K, Liu Z, Bai Y, Wu J, Yu J, Zhang P
Frontiers in immunology 2025;16:1569210
Frontiers in immunology 2025;16:1569210
Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.
Zhao J, Fu Y, Qiu H
Frontiers in microbiology 2025;16:1555734
Frontiers in microbiology 2025;16:1555734
Yersiniabactin produced by Escherichia coli promotes intestinal inflammation through lipid peroxidation and ferroptosis.
Wang H, Chen B, Xiao P, Han D, Gao B, Yan Y, Zhao R, Pan T, Zhang J, Zhou M, Lv L, Gao H
Frontiers in microbiology 2025;16:1542801
Frontiers in microbiology 2025;16:1542801
An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.
Liang S, Dong Y, Chang Z, Guo P, Jia J, Yang G, Chen Y, Dong L, Xu X, Cai T, Li T, Fang Y, Sun W, Li L, Wang C, Song X
Frontiers in pharmacology 2025;16:1521111
Frontiers in pharmacology 2025;16:1521111
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice.
Wang X, Wang Q, Cai Z, Ni C, Wang H, Liu H, Zhao Y, Wang J, Liu S, Wang X
Frontiers in immunology 2025;16:1503807
Frontiers in immunology 2025;16:1503807
Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling.
Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X
ImmunoTargets and therapy 2025;14:259-278
ImmunoTargets and therapy 2025;14:259-278
Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways.
Wang H, Ma R, Qi R, Liu Z, Li Y, Wu X, Zhao C, Ma Q, Zhan K
Frontiers in nutrition 2025;12:1704168
Frontiers in nutrition 2025;12:1704168
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Chen R, Zhou Z, Song Z, Feng W, Ding X, Zhang H, Wang Y
Cell biology international 2025 Sep;49(9):1173-1183
Cell biology international 2025 Sep;49(9):1173-1183
Aqueous extract of Saposhnikovia divaricata root alleviates rheumatoid arthritis by acting on TNF-α and RAGE signaling pathways.
Xu A, Wen Y, Hou B, Zhang S, Nhamdriel T, Ma X, Cui L, Zhu X, Cai W, Qiu L, Sun H
Biochemistry and biophysics reports 2025 Sep;43:102153
Biochemistry and biophysics reports 2025 Sep;43:102153
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Li X, Ye T, Zhu W, Gu J, Zheng Z, Wang C, Zhang X, Geng H, Zhou W, Tan X, Ma Y, Zhang H, Wang X
Biochemical pharmacology 2025 Sep;239:117083
Biochemical pharmacology 2025 Sep;239:117083
Ursolic acid attenuates sarcopenia through IL-17a-related gut-muscle axis in senile diabetic mice and myotube model.
She M, Li T, Zhou L, Deng Z, Huang M, Yan Y, Zhang M, Yang Y, Wang D
The Journal of nutritional biochemistry 2025 Sep;143:109940
The Journal of nutritional biochemistry 2025 Sep;143:109940
A Novel Mechanism of Chlorogenic Acid in Cardioprotection: Blocking NLRP3 Inflammasome via Ca(2+)/CaMKIIα Signaling in Sepsis-Induced Cardiomyopathy.
Meng H, Chen K, Lu Z, Yu W, Hu X, Xu H, Zhou S, Peng S, Guo X, Sun Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71046
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71046
Comprehensive multiomic analysis of extracellular vesicles from Mycoplasma bovis-infected bovine mammary epithelial cells identifies proteins and miRNAs that induce inflammatory responses in macrophages.
Wu Y, Yuan X, Ma J, Xu L, Li M, Zhao G, Wang Y
Veterinary research 2025 Sep 25;56(1):185
Veterinary research 2025 Sep 25;56(1):185
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Duan H, Zhang Y, Shen A, Ren J, Zhang F, Lu Y, Wei X, Yang C, Gong J, Wang X, Du Y, Pei Q, Zhang A
Veterinary research 2025 Sep 25;56(1):182
Veterinary research 2025 Sep 25;56(1):182
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Chen X, Pang Y, Amona FM, Liu Z, Wang F, Liang Y, Yang J, Zhang W, Fang X, Chen X
Journal of virology 2025 Sep 23;99(9):e0095425
Journal of virology 2025 Sep 23;99(9):e0095425
Vitamin D against diabetic adipose tissue inflammation through SHP-1/STAT3 pathway.
Wei X, Wang Y, Liu W, Zhang D, Zhou C, Jiang Z, Li W, Li X, Miao Y
International immunopharmacology 2025 Sep 23;162:115131
International immunopharmacology 2025 Sep 23;162:115131
Sinomenine Modifies Parkinson's Disease Through Nrf2 Activation.
Zhu L, Lin L, Yang Z, Tang H, Wu J, Kang Z, Feng Y, Zheng B, Hu Q, Wang S, Liu C, Jiang Z, Liu S, Wu G
Neurochemical research 2025 Sep 18;50(5):302
Neurochemical research 2025 Sep 18;50(5):302
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Sun T, Wu Y, Liu G, Xue Z, Yu M, Mao B, Han M, Liang X, Ling L, You N, Ji L, Liu H, Xu C, Qin Z, Zhao P, Wang D
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.
Liu G, Kuang S, Zhong W, Yang A, Huang X, Xie Y, Zhang X, Li Y, Qin Q, Liu G
Journal of pharmaceutical and biomedical analysis 2025 Sep 15;263:116899
Journal of pharmaceutical and biomedical analysis 2025 Sep 15;263:116899
Exposure to Bovine Viral Diarrhea Virus Disrupts Intestinal Barrier Function via NLRP3/Caspase-1-Mediated Pyroptosis and Gut Microbiota Dysbiosis.
Chen S, Liu F, Han X, Jia D, Chen J, Wei Y, Yu Z, He L, Liao C, Ding K
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22384-22396
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22384-22396
A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.
Yin H, Jiang H, Zhao R, Zhang Y, Fan X, Zhai X, Yang X, Zhang Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118752
Ecotoxicology and environmental safety 2025 Sep 1;302:118752
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Liu JR, Wu FN, Lin S, Chen C, Liu Y, Fan JW, Hong Q, Chen YH
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease.
Shen J, Wang Y, Qin Y, Chen G, Xu J, Li Y, Hou Y, Liu Y, Liu W
Molecular neurobiology 2025 Oct;62(10):12938-12950
Molecular neurobiology 2025 Oct;62(10):12938-12950
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
Song Y, Luo JL, Zhang F, Shi J, Du S, Jiang HB, Zhang WD, Chen SY, Zhang DD, Kong P, Gao Y, Han M, Li H
MedComm 2025 Oct;6(10):e70405
MedComm 2025 Oct;6(10):e70405
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Li S, Wang J, Chen Y, Cheng Y, Wang Y, Xu N, Wang H, Wang L, Chi Y, Ye X, Shi Y, Fang J, Yao X, Huang J, Xia Q, Bai T, Zhu B
Inflammation 2025 Oct;48(5):3180-3193
Inflammation 2025 Oct;48(5):3180-3193
Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
He SY, Bu YR, Xu J, Wang YM, Feng TX, Li PJ, Zhao YX, Ge YL, Xie MJ
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2225-2237
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2225-2237
Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways.
Wang A, An Y, Wang X, Gou W, Xu F, Li Y, Wang C, Tu Z, Hou W, Cui Y
Stem cell reviews and reports 2025 Oct;21(7):2200-2217
Stem cell reviews and reports 2025 Oct;21(7):2200-2217
Yogurt alleviates alcohol-induced hepatocyte pyroptosis and inflammation via autophagy/P62/Nrf2/ROS/NLRP3 pathway.
Guan S, Wang Y, Zhang R, Yao X, Lu S, Deng X, Lu J
Journal of dairy science 2025 Oct;108(10):10489-10503
Journal of dairy science 2025 Oct;108(10):10489-10503
Potential Mechanism of Qiju Dihuang Pill in Treating Primary Sjogren's Syndrome Revealed by Network Pharmacology and Experimental Verification.
Wang H, Cheng H, Li M, Zhu X, Wang X
Chemical biology & drug design 2025 Oct;106(4):e70186
Chemical biology & drug design 2025 Oct;106(4):e70186
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
Ding Y, Luo J, Deng YJ, Liu JL, Wang MQ, Hu Y
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Zhu XX, Meng XY, Zhang AY, Zhao CY, Wei YT, Wen YY, Su JB, Fu X, Chen G, Xu AJ, Wang MY, Ji LM, Bao N, Bao ZY, Li N, Lu QB, Sun HJ
Nature communications 2025 Oct 24;16(1):9436
Nature communications 2025 Oct 24;16(1):9436
M2-exo promote orthodontic bone remodeling via the MeCP2-TCF20-HDAC1 axis.
Chen M, Li Y, Yang Z, Chen M, Li J, Bao G, Ma L, Hu J
Stem cell research & therapy 2025 Oct 15;16(1):569
Stem cell research & therapy 2025 Oct 15;16(1):569
Microneedles combining delivery of hUMSC-derived exosomes and EGCG mitigate UV-induced skin damage.
He C, Wang Z, Jiang Z, Zhou Y, Chen X, Zhang J, Wang B, Wang Q, Wu T, Li C, Jian Z
Journal of nanobiotechnology 2025 Oct 10;23(1):643
Journal of nanobiotechnology 2025 Oct 10;23(1):643
The effect of puerarin on the NLRP3 Inflammasome pathway and MMP-9 in aortic dissection of ApoE(-/-) mice.
Cai Z, Yan T, Zhang B, Cao X, Feng M, Zhang W, Zhang H, Wang X
International immunopharmacology 2025 Oct 10;163:115286
International immunopharmacology 2025 Oct 10;163:115286
Corilagin alleviates radiation enteritis through caspase-1/gasdermin D-dependent pyroptosis by targeting aldo-keto reductase family 1 member C2 via glutathione metabolism.
Zhang SH, Zhang T, Wang XB, Yang YY, Chen ZX, Liu T, Deng SH, Liu YB, He X, Wu DM, Xu Y
International immunopharmacology 2025 Oct 10;163:115245
International immunopharmacology 2025 Oct 10;163:115245
Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.
Chen Z, Hu L, Yang Y, Wang Y, Li Y, Su J, Wang G, Gong S
Molecular nutrition & food research 2025 Nov;69(21):e70194
Molecular nutrition & food research 2025 Nov;69(21):e70194
Empagliflozin attenuates sorafenib-promoted renal ferroptosis and inflammation by targeting cyclooxygenase-2/prostaglandin E(2) axis.
Tsai MK, Lee WC, Huang SC, Huang CC, Wang YC, Yuan CH, Wang CC, Liu CH, Huang NC, Chang YC, Fang CC, Yeh BW, Yang JH, Ho YC, Lee YK, Wu CC, Hsiao KY, Liu WL, Yang SM, Huang CY, Chu TH
Toxicology and applied pharmacology 2025 Nov;504:117512
Toxicology and applied pharmacology 2025 Nov;504:117512
Structural characterization and medium-chain acyl-coenzyme a dehydrogenase-mediated anti-inflammatory mechanism of a Hulless barley Monascus polysaccharide in ulcerative colitis.
Xiong H, Bai S, Ouyang H, Xie L, Feng Y, Cheng J, Luo Y
International journal of biological macromolecules 2025 Nov;330(Pt 3):148033
International journal of biological macromolecules 2025 Nov;330(Pt 3):148033
Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.
Yao X, Li Y, Wang J, Liu Z, Chen J, Feng Z, Wang Z, Xiang J, Xu R, Jia S, Qi Z, Xu Y
Veterinary microbiology 2025 Nov;310:110736
Veterinary microbiology 2025 Nov;310:110736
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Integrated bioinformatics decoding of the MASLD ceRNA network reveals novel therapeutic targets.
Yu S, Jiang X, Peng L, Zeng X, Wen S, Xiong H, Guo S, Huang F, Liu H, Luo Q
Clinical and experimental medicine 2025 Nov 6;25(1):354
Clinical and experimental medicine 2025 Nov 6;25(1):354
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Wang Z, Liu J, Xu H, Sun Y, Xu S, He X
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome.
Duan H, Yang S, Xiao L, Yang S, Jiang B, Fang Z, Yan Z, Zeng J, Ma X, Dong W, Liu Y
Journal of agricultural and food chemistry 2025 Nov 19;73(46):29874-29885
Journal of agricultural and food chemistry 2025 Nov 19;73(46):29874-29885
The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus.
Song R, Yang R, Lu X, Gu Y, Li F, Hu W, Chen Z, Zhang L, Huang C, Liu L
International immunopharmacology 2025 Nov 14;165:115494
International immunopharmacology 2025 Nov 14;165:115494
Remote ischemic conditioning as a potential therapy for Parkinson's Disease: Inhibiting TLR4-Driven neuroinflammation and oxidative damage.
Cai L, Ding Y, Tekreeti AA, Li F, Zhu Y, Geng X, Ji X
Brain research 2025 Nov 1;1866:149920
Brain research 2025 Nov 1;1866:149920
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Li ZD, Kang S, Li H, Yu P, Xie R, Li C, Jing Q, Gong Z, Li L, Li Z, Geng M, Zhang Z, Li Y, Chang YZ
Redox biology 2025 May;82:103611
Redox biology 2025 May;82:103611
Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.
Yu SX, Yu HD, Wang YF, Yao TF, Lv SZ, Wang YC, Li JQ, Liu WQ, Ding JY, Liu XZ, Zuo ZF, Liu WP
Acta diabetologica 2025 May;62(5):633-650
Acta diabetologica 2025 May;62(5):633-650
Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice.
Zhao Y, Ding Q, He Q, Zu T, Rong Z, Wu Y, Shmanai VV, Jiao J, Zheng R
International journal of biological macromolecules 2025 May;306(Pt 2):141464
International journal of biological macromolecules 2025 May;306(Pt 2):141464
Fusobacterium necrophorum mediates the inflammatory response in the interdigital skin and fibroblasts of dairy cows via the TNF-α/TNFR1/NF-κB pathway.
Yue Y, Zhang A, Liu M, Ge Y, Xu E, Zheng J
Veterinary microbiology 2025 May;304:110483
Veterinary microbiology 2025 May;304:110483
Decoding ozone's impact on the cornea: disruption of barrier integrity and its molecular drivers.
Tian Y, Li L, Sun Z, Liu J, Qiu C, Zhou J, Sun X, Lei Y
Ecotoxicology and environmental safety 2025 May;296:118213
Ecotoxicology and environmental safety 2025 May;296:118213
FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors.
Bastian K, Orozco-Moreno M, Thomas H, Hodgson K, Visser EA, Rossing E, Pijnenborg JFA, Eerden N, Wilson L, Saravannan H, Hanley O, Grimsley G, Frame F, Peng Z, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Maitland NJ, Heer R, Wang N, Goddard-Borger ED, Guerrero RH, Boltje TJ, Drake RR, Scott E, Elliott DJ, Munkley J
Cancer medicine 2025 May;14(10):e70959
Cancer medicine 2025 May;14(10):e70959
Astragaloside III inhibits MAPK-mediated M2 tumor-associated macrophages to suppress the progression of lung Cancer cells via Akt/mTOR signaling pathway.
Sun Y, Liu JQ, Chen WJ, Tang WF, Zhou YL, Liu BJ, Wei Y, Dong JC
International immunopharmacology 2025 May 8;154:114546
International immunopharmacology 2025 May 8;154:114546
Scorpion Venom Heat-Resistant Synthetic Peptide Alleviates Neuronal Necroptosis in Alzheimer's Disease Model by Regulating Lnc Gm6410 Under PM(2.5) Exposure.
Qin C, Li D, Zhang J, Yin Z, Li F
International journal of molecular sciences 2025 May 4;26(9)
International journal of molecular sciences 2025 May 4;26(9)
Drinking Water Temperature Impacts the Pathogenesis of DSS-Induced Ulcerative Colitis by Regulating Intestinal Barrier Function and Remodeling the Gut Microbiota Composition.
Wang H, Yang Y, Li T, Chang S, Zhu Y, Liu C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70645
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70645
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Meng Y, Jia Y, He Z, Li J, Yuan L
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.
Wang J, Ji L, Gao Y, Sun J, Zhou X, Ding Y, Zhou Z, Guo X, Liu C, Wang Y, Zhang Q, Lv Z, Ma D
Scientific reports 2025 May 27;15(1):18509
Scientific reports 2025 May 27;15(1):18509
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle.
Tang X, Zou Y, Yang S, Chen Z, Zhou Z, Peng X, Tang C
Nutrients 2025 May 18;17(10)
Nutrients 2025 May 18;17(10)
Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS.
Cai J, Zhu Q, Xiang Y, Weng L, Liang N, Hong X, Xue M, Ge H
iScience 2025 May 16;28(5):112391
iScience 2025 May 16;28(5):112391
IL-17 enhanced the susceptibility to fluoxetine resistance in depression via the JAK1-STAT6 signaling pathway.
Zhang M, Hong Y, Yu W, Zhang Y, Shen Y, Cai Z, Jia R, Pang Z, Huang X, Huang Y, Gao X, Liu Y, Qu Y, Yang Q, Zhang X, Zhu A, Ao H
International immunopharmacology 2025 May 16;155:114513
International immunopharmacology 2025 May 16;155:114513
Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2.
Zhao Y, Tian X, Yan Y, Tian S, Liu D, Xu J
European journal of pharmacology 2025 May 15;995:177390
European journal of pharmacology 2025 May 15;995:177390
Esterase-responsive kartogenin composite hydrogel microspheres boost nucleus pulposus regeneration in intervertebral disc degeneration.
Dai J, Ni L, Jin C, Tian X, Shen Y, Miao Y, Xu Y, He F, Yang H
Acta biomaterialia 2025 May 15;198:131-150
Acta biomaterialia 2025 May 15;198:131-150
HDLR-SR-BI Expression and Cholesterol Uptake are Regulated via Indoleamine-2,3-dioxygenase 1 in Macrophages under Inflammation.
Chini A, Guha P, Rishi A, Bhat N, Covarrubias A, Martinez V, Devejian L, Nguyen BN, Mandal SS
Langmuir : the ACS journal of surfaces and colloids 2025 May 13;41(18):11253-11271
Langmuir : the ACS journal of surfaces and colloids 2025 May 13;41(18):11253-11271
The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2.
Nuovo GJ, Rice M, Zanesi N, Sawant D, Crilly C, Tili E
Applied immunohistochemistry & molecular morphology : AIMM 2025 May 1;33(3):142-151
Applied immunohistochemistry & molecular morphology : AIMM 2025 May 1;33(3):142-151
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.
Ding J, Zhang S, Li Q, Xia B, Wu J, Lu X, Huang C, Yuan X, You Q
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 May 1;29(3):307-319
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 May 1;29(3):307-319
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Xu H, Pang M, Hu C, Xu T, Chen G, Zhang G, Han X, Hua Y, Wu Y, Zhang J, Bi Y, Liu B, Zhou Y
Journal of ginseng research 2025 Mar;49(2):197-207
Journal of ginseng research 2025 Mar;49(2):197-207
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Xiang Y, Kuang G, Gong X, Xie H, Lin Y, Zhang X, Chen Z, Wan J, Li Z
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis.
Liu H, Ma X, Yang X, Xiao S, Ouyang S, Hu Z, Zhou Z, Jiang Z
International journal of medical microbiology : IJMM 2025 Mar;318:151642
International journal of medical microbiology : IJMM 2025 Mar;318:151642
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Lian X, Guo Z, Liu J, Zeng W
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.
Cui Q, Zhang Z, Qin L, Teng Z, Wang Z, Wu W, Fan L, Su J, Hao Y, Qin J, Zhang L, Wang Q, Zhuang Y, Zheng H, Zhang S, Geng X, Zhu L, Chen Y, Lu B, Li Y, Zhu X
Journal of diabetes investigation 2025 Mar;16(3):405-413
Journal of diabetes investigation 2025 Mar;16(3):405-413
Targeting the NF-κB p65-MMP28 axis: Wogonoside as a novel therapeutic agent for attenuating podocyte injury in diabetic nephropathy.
Li X, Zhao S, Xie J, Li M, Tong S, Ma J, Yang R, Zhao Q, Zhang J, Xu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156406
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156406
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression.
Lei X, Zhao D, Chen T, Li Q, Xue A, Hu Z, Jia F, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156365
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156365
Akkermansia muciniphila-derived extracellular vesicles mitigate smoking-induced prostate inflammation and fibrosis.
Zhu S, Wang YY, Hu XY, Zhou HL, Wang G, Chen HX, Zeng HB, Xie H, Wang ZX, Xu R
International immunopharmacology 2025 Mar 6;149:114195
International immunopharmacology 2025 Mar 6;149:114195
Erianin alleviates autoimmune myocarditis by suppressing the M1 polarization of macrophages via the NF-κB/NLRP3 signaling pathway.
Liu W, Mao Y, Li H, Hu J, Gan T, Wang Y, Wang Y, Wang Z
European journal of pharmacology 2025 Mar 5;990:177292
European journal of pharmacology 2025 Mar 5;990:177292
Artesunate alleviated hippocampal neuron pyroptosis by down-regulating NLRP3 in rats with cerebral small vessel disease.
Wang X, Zhong H, Kong X, Wei H, Li B
Metabolic brain disease 2025 Mar 26;40(4):160
Metabolic brain disease 2025 Mar 26;40(4):160
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
Xu Y, Liang H, Xia K, Yao J, Chen Y, Hou B, Hao Z
International immunopharmacology 2025 Mar 26;150:114250
International immunopharmacology 2025 Mar 26;150:114250
Single-cell RNA sequencing reveals an IL1R2+Treg subset driving immunosuppressive microenvironment in HNSCC.
Guo H, Liu C, Wu K, Li Y, Zhang Z, Chen F
Cancer immunology, immunotherapy : CII 2025 Mar 25;74(5):159
Cancer immunology, immunotherapy : CII 2025 Mar 25;74(5):159
Role of Adiponectin in Regulating Cytokines and Its Contribution to the Occurrence and Progression of Clinical Mastitis in Holstein Cows.
Zhang J, Chen N, Yang Z, Gao Y, Zhang B, Li J, Zhou B, Tang Z, Dong W, Zhao X, Zhang Y, Zhang Q
International journal of molecular sciences 2025 Mar 22;26(7)
International journal of molecular sciences 2025 Mar 22;26(7)
Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.
Bo C, Liu X, Liu Y, Xu L, Huang Q
European journal of medical research 2025 Mar 20;30(1):189
European journal of medical research 2025 Mar 20;30(1):189
High energy diet-induced prediabetic neuropathic pain is mediated by reduction of SIRT6 negative control of both spinal and peripheral neuroinflammation.
Yang Y, Sun W, Yang F, Liang T, Li CL, Wang Y, Wang XL, Wang RR, Wu SC, Chen J
Neuroscience 2025 Mar 17;569:58-66
Neuroscience 2025 Mar 17;569:58-66
Arsenic exposure induces neural cells senescence and abnormal lipid droplet accumulation leading to social memory impairment in mice.
Zhang B, Chen J, Wang J, Pan X
Environmental pollution (Barking, Essex : 1987) 2025 Mar 1;368:125779
Environmental pollution (Barking, Essex : 1987) 2025 Mar 1;368:125779
Myelination Trajectory and Microglial Dynamics Following Repeated Sevoflurane Exposure in Developing Brain.
Che J, Wu Y, Dong J, Jiang X, Yang L, Chen Y, Zhang J
Glia 2025 Jun;73(6):1221-1240
Glia 2025 Jun;73(6):1221-1240
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.
Ozkanlar S, Ozkanlar Y, Kara A, Dalkilinc E
Environmental toxicology 2025 Jun;40(6):924-934
Environmental toxicology 2025 Jun;40(6):924-934
GM@mTG-V microspheres promote NP regeneration by reconstructing IVD biomechanics and inflammatory microenvironment.
Gao R, Zhang Y, Deng B, Zhang J, Liang Z, Wei Z, Xu F, Ding T
Materials today. Bio 2025 Jun;32:101897
Materials today. Bio 2025 Jun;32:101897
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Wu Y, Ma Q, Meng X, Sun Q, Wang Z, Zhang W
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
Curcumin-loaded platelets with hydroxypropyl chitin hydrogel composite system through photo-activation for effective hemostasis management and wound healing.
Zhao XY, Lu JY, Zheng L, Yan M, Zhang SH, Chen S, Zhang Q, Jiang X, Tan Y, Li TF, Leng F
International journal of biological macromolecules 2025 Jun;314:144291
International journal of biological macromolecules 2025 Jun;314:144291
miR-301a-5p regulated IKKβ/NF-κB axis and macrophage polarization to accelerate skin wound healing.
Li Y, Fu Z, Deng C, Qian J, Wang Z, Lu Y, Zhang S, Liu G, Wen J, Chen Y, Jiang J, Liu X, Zheng X, Shen X, Su W, Yang M, Tang J, Wang Y, Meng B, Yang X
International journal of biological macromolecules 2025 Jun;311(Pt 4):143995
International journal of biological macromolecules 2025 Jun;311(Pt 4):143995
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Song J, Luo X, Xiong L, Li S, Chen Y, Liu W, Yuan Y, Ma Y, Bian J, Liu Z, Zou H
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
Hydrogen sulfide preserves the function of senescent endothelium through SIRT2 mediated inflammatory inhibition.
Qin X, Lu F, Wan J, Teng X, Jin S, Xiao L, Xue H, Guo Q, Tian D, Wu Y
Journal of molecular and cellular cardiology 2025 Jun;203:10-21
Journal of molecular and cellular cardiology 2025 Jun;203:10-21
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway.
Wu X, Ding C, Liu X, Ding Q, Zhang S, Wang Y, Zhao T, Liu W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159613
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159613
Biochanin A mitigates colitis by inhibiting ferroptosis-mediated intestinal barrier dysfunction, oxidative stress, and inflammation via the JAK2/STAT3 signaling pathway.
Deng B, Wang K, He H, Xu M, Li J, He P, Liu Y, Ma J, Zhang J, Dong W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156699
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156699
Integrated network pharmacology and experimental validation to elucidate the mechanism of celastrol in mitigating sepsis-induced acute lung injury in mice.
Zhu D, Zhang J, Huang X, Wei N, Jiang J, Li J, Liu L, Liu Y, Zhou J, Jia J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156678
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156678
Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.
Du H, Liu X, Shen J, Yuan H, Zhang H, Xi G, Li Y, Wang Y, Zhang J, Yang C, Xu P, Wang J, Wang F, Liu S, Zhou Y, Gu Q, Lu J, Wei T, Gao Z, Zang J, Wang J, Song M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2417827
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2417827
Pelargonidin-3-O-galactoside Alleviates Acute Lung Injury Induced by Klebsiella pneumoniae by Targeting CD38-Mediated Pyroptosis.
Jiang F, Jiang J, Sun Y, Meng L, Chen J, Liang L, Wang X, Zhang H, Meng M, Yuan B, He S, Li R
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13415-13426
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13415-13426
Cerium-Organic Framework and Resveratrol Composite Hydrogel Scaffold with Dual Antioxidant Activity for Enhanced Bone Regeneration.
Lu Y, Zhang L, Yang B, Hu H, Sun H, Guo D
ACS applied materials & interfaces 2025 Jun 4;17(22):31828-31842
ACS applied materials & interfaces 2025 Jun 4;17(22):31828-31842
Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis.
Kang J, Zhang L, Zhang L, Nan N, Liu Y, Hao H
International immunopharmacology 2025 Jun 26;159:114916
International immunopharmacology 2025 Jun 26;159:114916
Cyanidin-3-O-glucoside mitigates Staphylococcus aureus-induced mastitis by suppressing inflammatory responses and Ferroptosis mediated by SESN2/Nrf2.
Pang Y, Ke Y, Amona FM, Chen X, Liu Z, Chen J, Liang Y, Wang F, Wang Y, Fang X, Chen X, Zhang C
International immunopharmacology 2025 Jun 26;159:114868
International immunopharmacology 2025 Jun 26;159:114868
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation.
Yuan HJ, Han QC, Yu H, Yu YD, Liu XJ, Xue YT, Li Y
European journal of pharmacology 2025 Jun 15;997:177621
European journal of pharmacology 2025 Jun 15;997:177621
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62
Bone research 2025 Jun 12;13(1):62
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model.
Gu J, Liu C, Li Y, Feng L, Geng M, Dong J, Han J, Zhao L, Shao Q, Wang HY, Wang CH
Behavioral and brain functions : BBF 2025 Jun 11;21(1):16
Behavioral and brain functions : BBF 2025 Jun 11;21(1):16
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Wei X, Yu C, Wang J
Connective tissue research 2025 Jul;66(4):298-310
Connective tissue research 2025 Jul;66(4):298-310
Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway.
Qin L, Peng L, Sun Y, Chen G, Du C, Xie R, Ling Y, Xu H, Zhao M, Zhao Y, Zheng Z
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jul;34(7):108314
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jul;34(7):108314
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Tang H, Ning K, Wu B, Wang X, He J, Li P, Pan L, Zhang J, He Y, Bian S, Ma X, Zhang J, Liu C, Qin Z, Hu H
Biochemical pharmacology 2025 Jul;237:116932
Biochemical pharmacology 2025 Jul;237:116932
PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis.
Yue Z, Gong W, Chu H, Li Y
Tissue engineering and regenerative medicine 2025 Jul;22(5):705-718
Tissue engineering and regenerative medicine 2025 Jul;22(5):705-718
Sex-dependent effects of heat exposure on the middle ear health in mice.
Li J, Fan W, Yuan X, Wan T, Qin L, Zhang L, Hou T, Liu C, Li R
Journal of thermal biology 2025 Jul;131:104198
Journal of thermal biology 2025 Jul;131:104198
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction.
Xu T, Xiang Y, Huang Z, Zhu Q, Wu H, Cai J, Weng L, Ge H
Journal of ovarian research 2025 Jul 30;18(1):170
Journal of ovarian research 2025 Jul 30;18(1):170
Rhein Inhibits Microglia-Mediated Neuroinflammation and Neuronal Damage of Alzheimer's Disease via Regulating the Glutamine-Aspartate-Arginine-NO Metabolic Pathway.
Chi B, Zhang Z, Zhang Z, Zhang H, Tian M, Wang Y, Gao X
International journal of molecular sciences 2025 Jul 3;26(13)
International journal of molecular sciences 2025 Jul 3;26(13)
The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation.
Ding R, Zhang S, Meng L, Wang L, Han Z, Gui J, Yang J, Cheng L, Xie L, Jiang L
International journal of molecular sciences 2025 Jul 26;26(15)
International journal of molecular sciences 2025 Jul 26;26(15)
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
Liu Y, Wang C, Hui T, Yuan Y, Chen S, Li Y, Wang G, Kang J, Xue X
Journal of ethnopharmacology 2025 Jul 24;351:120104
Journal of ethnopharmacology 2025 Jul 24;351:120104
High-fat diet activates pyroptosis of retinal pigment epithelial cells in aged TgAPPswePS1 transgenic mice.
Cao J, Li J, Zheng H, Dong Z
European journal of medical research 2025 Jul 16;30(1):635
European journal of medical research 2025 Jul 16;30(1):635
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals.
Tong XY, Nong WJ, Tan RM, Ouyang JM
Journal of nanobiotechnology 2025 Jul 10;23(1):499
Journal of nanobiotechnology 2025 Jul 10;23(1):499
Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway.
Wang N, Sun C, Yang Y, Zhang D, Huang L, Xu C, Wang M, Xu M, Yan T, Wu Y, Xu L, Ju Y, Sun H, Guo W
Journal of neuroinflammation 2025 Jul 10;22(1):179
Journal of neuroinflammation 2025 Jul 10;22(1):179
AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex.
Liu SL, Yuan L, Sun XS, Xiao BB, Lan KQ, Lu ZJ, Lin DF, Li XY, Yan JJ, Yan SM, Chen QY, Tang LQ, Mai HQ
Cell death & disease 2025 Jul 1;16(1):480
Cell death & disease 2025 Jul 1;16(1):480
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
Xiao T, Zhao H, Wang Y, Chen M, Wang C, Qiao C
Diabetes & metabolism journal 2025 Jan;49(1):34-48
Diabetes & metabolism journal 2025 Jan;49(1):34-48
Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses.
Zhao X, Huang H, Jiang X, Zheng S, Qiu C, Cheng Y, Lin Y, Wang Y, Yan Y, Di X, Hu M, Zhu W, Wu F, Shi X, Chen R, Kou L
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114243
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114243
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.
Tang J, Li X, Yu X, Wang D, Huang K, Pu H, Yu J, Li S, Wang W, Liu B, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156326
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156326
CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice.
Zhao Y, He X, Yang X, Hong Z, Xu Y, Xu J, Zheng H, Zhang L, Zuo Z, Hu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2403818
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2403818
Luteolin Alleviates Ulcerative Colitis in Mice by Modulating Gut Microbiota and Plasma Metabolism.
Yang S, Duan H, Yan Z, Xue C, Niu T, Cheng W, Zhang Y, Zhao X, Hu J, Zhang L
Nutrients 2025 Jan 7;17(2)
Nutrients 2025 Jan 7;17(2)
Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R /NLRP3 signaling pathway.
Feng H, Wu T, Chin J, Ding R, Long C, Wang G, Yan D, Ma X, Yue R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118792
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118792
IL-17A exacerbates synovial inflammation in osteoarthritis via activation of endoplasmic reticulum stress.
Sun W, Li X, Zhang L, Zhang Y, Shi Y, Tao H, Zhou J, Hao Y, Chen G, Gu C, Yang X
International immunopharmacology 2025 Jan 3;145:113733
International immunopharmacology 2025 Jan 3;145:113733
Novel Nanoliposomes Synergistically Modulated by Sitogluside and Dioscin: Stability, Bioavailability, and Capacity To Alleviate Hyperuricaemia.
Liu G, Liu J, Shao P, Kai D, Yang L, Sun P, Feng S
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2596-2612
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2596-2612
The injury effect of osteopontin in sepsis-associated lung injury.
Wang Q, Yu Z, Song Z, Lu X, Li Z, Pi D, Li J, Xu F
Journal of inflammation (London, England) 2025 Jan 24;22(1):4
Journal of inflammation (London, England) 2025 Jan 24;22(1):4
Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages.
Hou SM, Yang CM, Huang WC, Cheng SW, Yen TL, Hsia CW, Hsieh CY, Hsia CH
Biomolecules 2025 Jan 24;15(2)
Biomolecules 2025 Jan 24;15(2)
Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway.
Ni W, Zhao Y, Shen J, Yin Q, Wang Y, Li Z, Tang T, Wen Y, Zhang Y, Jiang W, Jiang L, Wei J, Gan W, Zhang A, Zhou X, Wang B, Liu BC
Chinese medical journal 2025 Jan 20;138(2):193-204
Chinese medical journal 2025 Jan 20;138(2):193-204
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Wang H, Zhang H, Miao L, Wang C, Teng H, Li X, Zhang X, Yang G, Wang S, Zeng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy.
Jiang F, Tang J, Wei X, Pan H, Fan X, Zhang P, Guo S
Chinese medicine 2025 Jan 15;20(1):12
Chinese medicine 2025 Jan 15;20(1):12
Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.
Yang S, Duan H, Zeng J, Yan Z, Niu T, Ma X, Zhang Y, Hu J, Zhang L, Zhao X
Journal of ethnopharmacology 2025 Jan 13;339:119157
Journal of ethnopharmacology 2025 Jan 13;339:119157
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Hu Q, Zeng H, Feng C, Tian W, He Y, Li B
Experimental animals 2025 Jan 10;74(1):39-48
Experimental animals 2025 Jan 10;74(1):39-48
CAVIN2 attenuates ventilator-induced lung injury in rats by MAPK/ERK1/2 signaling pathway.
Zhu Q, Wu K, Lv J, Yang R, Li C, Liu W, Zhang J, Lian S, Wang L, Zhang X
International immunopharmacology 2025 Jan 10;144:113669
International immunopharmacology 2025 Jan 10;144:113669
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
Wang L, Xie X, Chen Q, Chen Y, Xu X, Liang T
Molecular and cellular endocrinology 2025 Jan 1;595:112409
Molecular and cellular endocrinology 2025 Jan 1;595:112409
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Liu Y, Wang W, Liang B, Zou Z, Zhang A
Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Chairside live biotherapeutic hydrogel for comprehensive periodontitis therapy.
Li K, Li B, Li J, Wu X, Zhao Y, Yu J, Guo J, Huang C
Trends in biotechnology 2025 Feb;43(2):408-432
Trends in biotechnology 2025 Feb;43(2):408-432
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Cheng Z, Gan W, Xiang Q, Zhao K, Gao H, Chen Y, Shi P, Zhang A, Li G, Song Y, Feng X, Yang C, Zhang Y
Autophagy 2025 Feb;21(2):352-373
Autophagy 2025 Feb;21(2):352-373
Neohesperidin protects against colitis-associated colorectal cancer in mice via suppression of the NF-κB/p65 and MAPK pathways.
Cao X, Li L, Hu J, Zhu S, Song S, Kong S, Zhou L, Huang Y
The Journal of nutritional biochemistry 2025 Feb;136:109804
The Journal of nutritional biochemistry 2025 Feb;136:109804
Beclin1 regulates yak endometrial inflammation and TLR4/NF-κB signaling pathway through autophagy/non-autophagy function.
Ma W, Wang L, Pan Y, Wang M, Wang J, Feng M, Wang J, Zhang H, Zhang R, Jiao Z, Cui Y, Yu S
International immunopharmacology 2025 Feb 6;147:113940
International immunopharmacology 2025 Feb 6;147:113940
Autophagy-dependent splicing control directs translation toward inflammation during senescence.
Kim J, Lee Y, Jeon T, Ju S, Kim JS, Kim MS, Kang C
Developmental cell 2025 Feb 3;60(3):364-378.e7
Developmental cell 2025 Feb 3;60(3):364-378.e7
Enhancing the Therapeutic Efficacy of Berberine and Quercetin Through Salt Formulation for Liver Fibrosis Treatment.
Cheng Y, Yu H, Yang S, Tian X, Zhao M, Ren L, Guo X, Hu C, Jiang J, Wang L
International journal of molecular sciences 2025 Feb 28;26(5)
International journal of molecular sciences 2025 Feb 28;26(5)
Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration.
Gao S, Li H, Li Z, Wang H, Li X, Yang S, Huang L, Zhang B, Zhang K, Tsoi JKH, He J, Dissanayaka WL
ACS nano 2025 Feb 25;19(7):7098-7116
ACS nano 2025 Feb 25;19(7):7098-7116
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Xiang J, Lv M, Luo Y, Ke K, Zhang B, Wang M, Zhang K, Li H
Scientific reports 2025 Feb 24;15(1):6669
Scientific reports 2025 Feb 24;15(1):6669
Anticancer effects of OSW-1 on colorectal cancer cells via the ROS/NLRP3/Caspase-1 pyroptosis signaling pathway.
Yao Y, Chen Y, Yao T, Li C, Li S, Wang N
International immunopharmacology 2025 Feb 20;148:114054
International immunopharmacology 2025 Feb 20;148:114054
Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.
Meng X, Li Y, Meng L, Yang C, Xia C, Wang X, Wang F
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Joung J, Heo Y, Kim Y, Kim J, Choi H, Jeon T, Jang Y, Kim EJ, Lee SH, Suh JM, Elledge SJ, Kim MS, Kang C
Nature communications 2025 Feb 17;16(1):1696
Nature communications 2025 Feb 17;16(1):1696
Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model.
Wu Z, Yin Y, Liu R, Li X, Wang Z, Wu C, Tan J, Fu Z, Song C, Lee Wong N, Peng X, Lai S, Cui J, Han M, Peng Y, Sun Y, Wu L, Adzic M, Zeng L, Zhang H, Yau SY, Chen G
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119031
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119031
Carboxymethyl chitosan and sodium alginate oxide pH-sensitive dual-release hydrogel for diabetes wound healing: The combination of astilbin liposomes and diclofenac sodium.
Wu X, Wang Y, Liu X, Ding Q, Zhang S, Wang Y, Chai G, Tang Y, Yang J, Yu T, Liu W, Ding C
Carbohydrate polymers 2025 Feb 1;349(Pt B):122960
Carbohydrate polymers 2025 Feb 1;349(Pt B):122960
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.
Deng D, Ma L, Shen J, Huang L, Zhang T, Yang X, Huang S, Zhao W, Zhou Y, Fan S, Wang K, Chen X
Molecular neurobiology 2025 Dec;62(12):15478-15493
Molecular neurobiology 2025 Dec;62(12):15478-15493
Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds.
Cui S, Meng S, Liu Y, Chen S, Hu W, Huang Q, Chu Z, Zhong W, Ma L, Li Z, Jiang Y, Liu X, Fu X, Zhang C
Exploration (Beijing, China) 2025 Dec;5(6):20240062
Exploration (Beijing, China) 2025 Dec;5(6):20240062
RUNX1 Induces Central Neuropathic Pain by Activating Microglia and Triggering the Inflammatory Response in Spinal Cord Injury.
Huang M, Yang Y, Tang Y, Li Y, Wang X, Zhou M
Inflammation 2025 Dec;48(6):4443-4460
Inflammation 2025 Dec;48(6):4443-4460
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.
Amona FM, Pang Y, Chen X, Liu Z, Su C, Yang J, Liu K, Wu Q, Liu B, Chen X, Zhang C
Materials today. Bio 2025 Dec;35:102491
Materials today. Bio 2025 Dec;35:102491
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Li X, Li X, Zhou D, Xu Y, Sun B, Hu Y, Zhu Y, Hu J, Pang Z, Zhao C, Gao Y, Long Y, Li P, Zhou Q, Wang Y
Materials today. Bio 2025 Dec;35:102347
Materials today. Bio 2025 Dec;35:102347
Effect of hesperidin on nanocopper induced PANoptosis in chicken kidney through RIPK1/ZBP1 pathway.
Li H, Zhu H, Zhao L, Wu H, Li S, Tang Z, Liao J, Guo J
Veterinary journal (London, England : 1997) 2025 Dec;314:106466
Veterinary journal (London, England : 1997) 2025 Dec;314:106466
Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus.
Hu W, Ye M, Dai Q, Sun M, Song R, Lu X, Huang C, Zhang L, Yang R
Pharmacology, biochemistry, and behavior 2025 Dec;257:174114
Pharmacology, biochemistry, and behavior 2025 Dec;257:174114
Pyridostigmine attenuates placental-ischemia-upregulated placental angiotensin II type 1 receptor in rats.
Issotina Zibrila A, Alkuhali AA, Yuan M, Zeng Z, Ali MA, Zeng M, Elenany AM, Manzoor M, Wang X, Zhao M, Jin L, Liu J
Peptides 2025 Dec;194:171450
Peptides 2025 Dec;194:171450
Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic target.
Ma Y, Wang Y, Zhao P, Cheng L, Li L, Li R, Zhou X
Journal of cell communication and signaling 2025 Dec;19(4):e70055
Journal of cell communication and signaling 2025 Dec;19(4):e70055
E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation.
Chen J, Huang Z, Jing P, Shi H, Liu S, Feng L, Long Y, Ye M, Fu W, Tan P
British journal of pharmacology 2025 Dec;182(24):6100-6119
British journal of pharmacology 2025 Dec;182(24):6100-6119
Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma.
Wu J, Zheng W, Ding X, Jin Q, Ding M
Future science OA 2025 Dec;11(1):2599729
Future science OA 2025 Dec;11(1):2599729
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639
International immunopharmacology 2025 Dec 3;166:115639
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150
Molecular biomedicine 2025 Dec 29;6(1):150
Brevilin A reverses colitis of inflammatory bowel disease via modulation of TNF-α signaling and microbiome dysregulation.
Chen L, Tang C, Hu D, Yu S, Liao P
Gut pathogens 2025 Dec 29;18(1):1
Gut pathogens 2025 Dec 29;18(1):1
Interleukin-27 is a multitarget regulator of fibroblast remodeling in thyroid-associated ophthalmopathy.
Zhang P, Wang X, Lu N, Nie Y, Zhang X, Liu L
iScience 2025 Dec 19;28(12):113982
iScience 2025 Dec 19;28(12):113982
Apoptotic extracellular vesicles from peripancreatic adipose-derived mesenchymal stem cells ameliorate severe acute pancreatitis through the transcription factor EB-mediated autophagy-lysosomal pathway: an experimental study.
Wang A, An Y, Wang X, Gou W, Xu F, Li Y, Wang C, Tu Z, Hou W, Cui Y
International journal of surgery (London, England) 2025 Dec 17;112(4):9262-81
International journal of surgery (London, England) 2025 Dec 17;112(4):9262-81
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Ding R, Hu N, Zhang X, Jiang F, Feng Y, Li Z, Tang S, Li W, Shi H, Si Y
Free radical biology & medicine 2025 Dec 1;240:15-28
Free radical biology & medicine 2025 Dec 1;240:15-28
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Chen H, Duan Z, Jia Q, Zhang X, Xu D, Zheng L, Qi Z, Yang Y, Yang L, Wu C
Molecular neurobiology 2025 Aug;62(8):10834-10855
Molecular neurobiology 2025 Aug;62(8):10834-10855
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Chen X, Zhang F, Zhou Z, Jiang D, Wen L
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice.
Han X, Fu X, Guo W, Liu Y, Sun J, Wang T, Yang W
Inflammation 2025 Aug;48(4):2292-2312
Inflammation 2025 Aug;48(4):2292-2312
The Toxoplasma surface SRS14A promotes ASC ubiquitination to suppress AIM2 inflammasome and tumor immunity.
Yang K, Song Y, Yuan H, Yang Z, He H, Nie L, Mahmmod YS, Zhang XX, Yu M, Yuan ZG
International journal of biological macromolecules 2025 Aug;319(Pt 1):145343
International journal of biological macromolecules 2025 Aug;319(Pt 1):145343
The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons.
Luo D, Sun B, Wang W, Zhang A
Biological trace element research 2025 Aug;203(8):4224-4239
Biological trace element research 2025 Aug;203(8):4224-4239
Exploration of the Therapeutic Time Window for Thrombectomy in Rat Models of Middle Cerebral Artery Ischemia-Reperfusion.
He Y, Huang P, Li S, Lin J, Ren X, Xiong Y, Yang Y, Hong D
Brain and behavior 2025 Aug;15(8):e70713
Brain and behavior 2025 Aug;15(8):e70713
Targeting CDK1 inhibits Golgi apparatus stress-mediated neuroinflammation and neuronal apoptosis after intracerebral hemorrhage by modulating GRASP55 phosphorylation.
Zhang X, Yang M, Jiang F, Wang Y, Zhou Z, Wu Z
Cellular signalling 2025 Aug;132:111835
Cellular signalling 2025 Aug;132:111835
Carbon Monoxide Alleviates Cardiomyocyte Pyroptosis in Diabetic Cardiomyopathy by Downregulating the IL-33/ST2L Axis.
Jiang C, Zhu P, Yao P, Bi X, Gao C
Immunity, inflammation and disease 2025 Aug;13(8):e70231
Immunity, inflammation and disease 2025 Aug;13(8):e70231
Decreased excitatory and increased inhibitory transmission in the hippocampal CA1 drive neuroinflammation-induced cognitive impairments in mice.
Wu XM, Shi CN, Liu K, Hu XY, He QL, Yao H, Fan D, Ma DQ, Yang JJ, Shen JC, Ji MH
Brain, behavior, and immunity 2025 Aug;128:416-428
Brain, behavior, and immunity 2025 Aug;128:416-428
Stimulation of microglia leads to a rapid antidepressant effect by triggering astrocytic P2Y1Rs and promoting BDNF-mediated neurogenesis in the hippocampus.
Wang H, Lu X, Ye Y, Huang C, Fang Y, Yang R, Sun M, Ren J, Song R, Xu F, Su J, Hong H, Huang C
Brain, behavior, and immunity 2025 Aug;128:134-151
Brain, behavior, and immunity 2025 Aug;128:134-151
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
Zhang S, Guo J, Liu M, Chen Y, Shen X, Wang J, Deng X, Guan S
Journal of dairy science 2025 Aug;108(8):7896-7911
Journal of dairy science 2025 Aug;108(8):7896-7911
Glucuronolactone improves lung injury caused by PRRSV and DON co-challenge by enhancing the Nrf2-mediated antioxidant capacity in weaning piglets.
Hou J, Cui C, Wu J, Tian M, Lu Q, Liu S, Ye G, Tian C, Tang J, Gao K, Wang L, Jiang Z, Qiu Y, Yang X
Veterinary research 2025 Aug 5;56(1):161
Veterinary research 2025 Aug 5;56(1):161
Apigenin mitigates intestinal barrier dysfunction in sepsis by modulating the AKT signaling pathway.
Lijun Z, Liping W, Dandan Z, Wenjie Z, Renjie X, Xueyan J, Wenqing C, Chen L, Lu Z
BMC gastroenterology 2025 Aug 30;25(1):626
BMC gastroenterology 2025 Aug 30;25(1):626
ADAMTS2 mediates epithelial‒mesenchymal transition and inflammation in high-grade serous ovarian cancer: a study based on bioinformatic analyses and experiments.
Tian Y, Li J, Dong R, Guan Y, Wang Y, Yan L, Zhang J, Kang S
BMC cancer 2025 Aug 26;25(1):1376
BMC cancer 2025 Aug 26;25(1):1376
Inhibition of ADAM17: A New Therapeutic Strategy to Alleviate Zearalenone Toxin-Induced Liver Injury by Endoplasmic Reticulum Stress and Inflammation.
Liu P, Gu Y, Xu Z, Zou H, Gu J, Yuan Y, Liu Z, Bian J
Journal of agricultural and food chemistry 2025 Aug 20;73(33):21120-21132
Journal of agricultural and food chemistry 2025 Aug 20;73(33):21120-21132
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood-Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation.
Luo L, Hu Q, Yan R, Gao X, Zhang D, Yan Y, Liu Q, Mao S
Molecular neurobiology 2025 Apr;62(4):5252-5272
Molecular neurobiology 2025 Apr;62(4):5252-5272
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.
Zhang Y, Zhang S, Zhao X, Wu P, Ying Y, Wu L, Zhuang J, Chen Z, Chao Y, Dong X, Zhao RC, Wang J
MedComm 2025 Apr;6(4):e70139
MedComm 2025 Apr;6(4):e70139
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
Pekkle Lam HY, Liang TR, Jiang SJ, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy.
Sun W, Wang R, Gong K, Wang L, Li F, Deng J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4571-4582
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4571-4582
Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.
Zhao Y, Ying X, Pang X, Lin Y, Shen J, Zhao Y, Shen W, Yang Y, Hong Z, Wu W, Hu X, Xie Q
Experimental neurology 2025 Apr;386:115174
Experimental neurology 2025 Apr;386:115174
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
Zhang Y, Lou Q, Lian H, Yang R, Cui R, Wang L, Ma B, Hou L, Jin L, Teng W
Materials today. Bio 2025 Apr;31:101589
Materials today. Bio 2025 Apr;31:101589
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Wang G, Li Z, Han W, Tian Q, Liu C, Jiang S, Xiang X, Zhao X, Wang L, Liao J, Li M
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
Zhang BH, Chen H, Yang R, Jiang Z, Huang S, Chen Z, Liu C, Wang L, Liu XH
The FEBS journal 2025 Apr;292(8):2119-2144
The FEBS journal 2025 Apr;292(8):2119-2144
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Luo X, He C, Yang B, Yin S, Li K
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.
Tang CT, Wu Y, Tao Q, Zeng CY, Chen YX
Journal of pharmaceutical analysis 2025 Apr;15(4):101121
Journal of pharmaceutical analysis 2025 Apr;15(4):101121
ErTao decoction alleviates liver fibrosis by suppressing STING-mediated macrophages and NLRP3 inflammasome activation.
Jia H, Li J, Chen X, Liu Z, Wu C, Liu C, Zhang J, Luo M, Huang M, Huang S, Cai M, Gao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156489
Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-κB/NLRP3/Caspase-1 pathways.
An Y, Tu Z, Wang A, Gou W, Yu H, Wang X, Xu F, Li Y, Wang C, Li J, Zhang M, Xiao M, Di Y, Hou W, Cui Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156424
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156424
A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury.
Ling L, Zhou G, Zhang X, Mao B, Wan S, Bao Y
Archives of gerontology and geriatrics 2025 Apr;131:105739
Archives of gerontology and geriatrics 2025 Apr;131:105739
Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies.
Zhang G, Qu Y, Wan X, Fang X, Wu Y, Li T, Sun J, Liu X, Xu Y, Luo H, Meng X, Hu W, Chen R, Wu Z, Jia H, Sun X
Innovation (Cambridge (Mass.)) 2025 Apr 7;6(4):100808
Innovation (Cambridge (Mass.)) 2025 Apr 7;6(4):100808
Targeted Regulation of HSP70 by the ARP2/3 Complex in Mammary Epithelial Cells and Its Impact on Host Cell Apoptosis.
Yang T, Fang B, Chen Y, Bao D, Zhang J, Liu P, Duan Z, He Y, Zhao X, Zhang QW, Dong WT, Zhang Y
Biomolecules 2025 Apr 7;15(4)
Biomolecules 2025 Apr 7;15(4)
The LTB4-BLT1 axis attenuates influenza-induced lung inflammation by suppressing NLRP3 activation.
Wei C, Xu Y, Zheng Y, Hong L, Lyu C, Li H, Cao B
Cell death discovery 2025 Apr 6;11(1):148
Cell death discovery 2025 Apr 6;11(1):148
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Ma L, Sun H, Xiang N, Xu Q
Scientific reports 2025 Apr 25;15(1):14516
Scientific reports 2025 Apr 25;15(1):14516
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage.
Huang H, Li G, Guo S, Li K, Li W, Zhou Q, He Z, Yang X, Liu L, Wei Q
Chemical research in toxicology 2025 Apr 21;38(4):717-732
Chemical research in toxicology 2025 Apr 21;38(4):717-732
Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis.
Li X, Zhao S, Li M, Xing X, Xie J, Wang M, Xu A, Zhao Q, Zhang J
International immunopharmacology 2025 Apr 16;152:114481
International immunopharmacology 2025 Apr 16;152:114481
VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.
Zhang X, Liu T, Ma Z, Li G, Ding N, Wang Z, Guan Y, Zhang Y, Liu L, Chen X
Journal of translational medicine 2025 Apr 12;23(1):437
Journal of translational medicine 2025 Apr 12;23(1):437
Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus.
Liu L, Wang Y, Wang X, Zhang G, Sha S, Zhou R, Du Y, Wu C, Chen L
Acta neuropathologica communications 2025 Apr 10;13(1):73
Acta neuropathologica communications 2025 Apr 10;13(1):73
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Liu X, Zhao W, Hu M, Zhang Y, Wang J, Zhang L
Iranian journal of basic medical sciences 2024;27(5):588-595
Iranian journal of basic medical sciences 2024;27(5):588-595
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
Fang X, Jiang XF, Zhang YP, Zhou CL, Dong YJ, Bo-Li, Lv GY, Chen SH
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury.
Wang C, Jiang C, Yang Y, Xi C, Yin Y, Wu H, Qian C
Iranian journal of basic medical sciences 2024;27(3):375-382
Iranian journal of basic medical sciences 2024;27(3):375-382
NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
Wu YC, Yan Q, Yue SQ, Pan LX, Yang DS, Tao LS, Wei ZY, Rong F, Qian C, Han MQ, Zuo FC, Yang JF, Xu JJ, Shi ZR, Du J, Chen ZL, Xu T
International journal of biological sciences 2024;20(6):2219-2235
International journal of biological sciences 2024;20(6):2219-2235
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation.
Li Q, Zhang C, Sun X, Wang M, Zhang Z, Chen R, Sun X
PloS one 2024;19(6):e0305541
PloS one 2024;19(6):e0305541
miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.
Yao M, Fang C, Wang Z, Guo T, Wu D, Ma J, Wu J, Mo J
PloS one 2024;19(2):e0299382
PloS one 2024;19(2):e0299382
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.
Wu X, Ding S, Wang G, Zhang W, He K
Journal of inflammation research 2024;17:8135-8146
Journal of inflammation research 2024;17:8135-8146
NLRP3 Inflammasome Deficiency Alleviates Inflammation and Oxidative Stress by Promoting PINK1/Parkin-Mediated Mitophagy in Allergic Rhinitis Mice and Nasal Epithelial Cells.
Ding H, Lu X, Wang H, Chen W, Niu B
Journal of asthma and allergy 2024;17:717-731
Journal of asthma and allergy 2024;17:717-731
Nrf2 Deficiency Exacerbates Parkinson's Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells.
Lu R, Zhou X, Zhang L, Hao M, Yang X
Journal of inflammation research 2024;17:6277-6295
Journal of inflammation research 2024;17:6277-6295
VX-702 Ameliorates the Severity of Sepsis-Associated Acute Kidney Injury by Downregulating Inflammatory Factors in Macrophages.
Han Y, Wang J, Zhang J, Zheng X, Jiang Y, Liu W, Li W
Journal of inflammation research 2024;17:4037-4054
Journal of inflammation research 2024;17:4037-4054
Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.
Li Y, Wu T, Li H, Liu M, Xu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:2709-2724
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:2709-2724
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.
Huang L, Sun S, Jiang G, Xie G, Yang Y, Chen S, Luo J, Lv C, Li X, Liao J, Wang Z, Zhang Z, Xiong J
Frontiers in molecular neuroscience 2024;17:1459858
Frontiers in molecular neuroscience 2024;17:1459858
Identification and Validation of Genes Related to Macrophage Polarization and Cell Death Modes Under Mycobacterium tuberculosis Infection.
Yang Z, Wang J, Pi J, Hu D, Xu J, Zhao Y, Wang Y
Journal of inflammation research 2024;17:1397-1411
Journal of inflammation research 2024;17:1397-1411
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Qin Y, Gao Y, Wu D, Liu QQ, Su C, Liu G, Yang L, Zhao MG, Yao JY
Frontiers in pharmacology 2024;15:1509482
Frontiers in pharmacology 2024;15:1509482
"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.
Xu P, Li K, Yuan J, Zhao J, Pan H, Pan C, Xiong W, Tan J, Li T, Huang G, Chen X, Miao X, He D, Cheng X
Frontiers in immunology 2024;15:1465126
Frontiers in immunology 2024;15:1465126
(+)-catechin protects PC12 cells against CORT-induced oxidative stress and pyroptosis through the pathways of PI3K/AKT and Nrf2/HO-1/NF-κB.
Chencen L, Shuo Z, Zhiyu C, Xiaoyu F, Min Z, Pengjiao W, Xiuli G
Frontiers in pharmacology 2024;15:1450211
Frontiers in pharmacology 2024;15:1450211
Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway.
Shang C, Su Y, Ma J, Li Z, Wang P, Ma H, Song J, Zhang Z
Frontiers in pharmacology 2024;15:1434568
Frontiers in pharmacology 2024;15:1434568
Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities.
Fu Z, Wang X, Fan Y, Shang D, Zhang J, Xiao T, Guo J, Wang Y, Wang Z, Zhang Z, Jia Q, Zhu J, Jahromi AB, Meng Y, Gao N, Chang J, Gao Y
Frontiers in pharmacology 2024;15:1428455
Frontiers in pharmacology 2024;15:1428455
Transcriptome profiling of immune rejection mechanisms in a porcine vascularized composite allotransplantation model.
Zhang L, Arenas Hoyos I, Helmer A, Banz Y, Zubler C, Lese I, Hirsiger S, Constantinescu M, Rieben R, Gultom M, Olariu R
Frontiers in immunology 2024;15:1390163
Frontiers in immunology 2024;15:1390163
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson's rats.
Wang J, Li H, Wang C, Li D, Zhang Y, Shen M, Xu X, Wu T
Frontiers in neurology 2024;15:1367973
Frontiers in neurology 2024;15:1367973
Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis.
He XX, Huang YJ, Hu CL, Xu QQ, Wei QJ
Frontiers in immunology 2024;15:1344949
Frontiers in immunology 2024;15:1344949
Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaustion.
Li P, Wang S, Wan H, Huang Y, Yin K, Sun K, Jin H, Wang Z
Frontiers in immunology 2024;15:1258475
Frontiers in immunology 2024;15:1258475
Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma.
Li Y, Li F, Xu L, Shi X, Xue H, Liu J, Bai S, Wu Y, Yang Z, Xue F, Xia Y, Dong H, Shen F, Wang K
Theranostics 2024;14(9):3526-3547
Theranostics 2024;14(9):3526-3547
Taraxasterol exhibits dual biological effects on anti-aging and anti-cancer in lung cells.
Xie J, Ou Y, Fu Q, Ye Z, Chen Y, Yang Z, Lin L, Wu Q, Wu D, Gan R, Wang J, Luo Q, Zeng K, Miao H
American journal of cancer research 2024;14(6):2755-2769
American journal of cancer research 2024;14(6):2755-2769
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Shen S, Zhang M, Wang X, Liu Q, Su H, Sun B, Guo Z, Tian B, Gan H, Gong C, Ma L
Theranostics 2024;14(3):1241-1259
Theranostics 2024;14(3):1241-1259
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C
Burns & trauma 2024;12:tkad062
Burns & trauma 2024;12:tkad062
Antibacterial and antioxidant phlorizin-loaded nanofiber film effectively promotes the healing of burn wounds.
Yang Y, Ma S, Li A, Xia G, Li M, Ding C, Sun X, Yan L, Yang M, Zhao T
Frontiers in bioengineering and biotechnology 2024;12:1428988
Frontiers in bioengineering and biotechnology 2024;12:1428988
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Xie X, Shen X, Liu Y, Zuo Y, Wang S, Zhou Y, Li X, Wang K, Li B, Wang Z
Archives of biochemistry and biophysics 2024 Sep;759:110102
Archives of biochemistry and biophysics 2024 Sep;759:110102
Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway.
Zhan M, Xu H, Yu G, Chen Q, Yang R, Chen Y, Ge J, Wang Z, Yang R, Xu B
Redox biology 2024 Sep;75:103298
Redox biology 2024 Sep;75:103298
Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.
Yang L, Wu J, Zhang F, Zhang L, Zhang X, Zhou J, Pang J, Xie B, Xie H, Jiang Y, Peng J
Experimental neurology 2024 Sep;379:114853
Experimental neurology 2024 Sep;379:114853
Targeted-lung delivery of bardoxolone methyl using PECAM-1 antibody-conjugated nanostructure lipid carriers for the treatment of lung inflammation.
He JX, Zhu CQ, Liang GF, Mao HB, Shen WY, Hu JB
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:116992
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:116992
Geniposide dosage and administration time: Balancing therapeutic benefits and adverse reactions in liver disease treatment.
Qiu J, Lin C, Ren G, Xu F, Hu T, Le Y, Fan X, Yu Z, Liu Q, Wang X, Dou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155799
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155799
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Xu X, Wang Y, Song Q, Zheng H, Lv J, Fu Z, Mao X, Li Y, Wu H, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Integrated analyses of the intestinal microbiome and transcriptome in Ningxiang piglets.
Hu Z, Yao Y, Chen F, Feng L, Yuan Z, Deng J, Huang L, Yin Y, Tang X
Genomics 2024 Sep;116(5):110919
Genomics 2024 Sep;116(5):110919
Eudragit S100 coated iron oxide-chitosan nanocomposites for colon targeting of 5-aminosalicylic acid ameliorate ulcerative colitis by improving intestinal barrier function and inhibiting NLRP3 inflammasome.
Zhang D, Wan H, Zhao R, Zhang Y, Chen H
International immunopharmacology 2024 Sep 30;139:112661
International immunopharmacology 2024 Sep 30;139:112661
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Liu W, Zhong X, Yi Y, Xie L, Zhou W, Cao W, Chen L
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment.
Zou C, Cai R, Li Y, Xue Y, Zhang G, Alitongbieke G, Pan Y, Zhang S
iScience 2024 Sep 20;27(9):110766
iScience 2024 Sep 20;27(9):110766
BV2 Microglial Cell Activation/Polarization Is Influenced by Extracellular Vesicles Released from Mutated SOD1 NSC-34 Motoneuron-like Cells.
Carata E, Muci M, Mariano S, Panzarini E
Biomedicines 2024 Sep 11;12(9)
Biomedicines 2024 Sep 11;12(9)
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Xue J, Jiang C, Chen X, Wang L
International immunopharmacology 2024 Sep 10;138:112591
International immunopharmacology 2024 Sep 10;138:112591
Immune Rejection of Cartilage in a Swine Vascularized Composite Allotransplantation Model.
Zhang L, Arenas Hoyos I, Helmer A, Banz Y, Haenni B, Lese I, Constantinescu M, Rieben R, Olariu R
Transplantation proceedings 2024 Oct;56(8):1896-1903
Transplantation proceedings 2024 Oct;56(8):1896-1903
Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs.
Li X, Yao C, Lan DM, Wang Y, Qi SC
Current medical science 2024 Oct;44(5):932-946
Current medical science 2024 Oct;44(5):932-946
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Chen C, Zhu S, Fu T, Chen Y, Bai L, Chen D
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Identification of a novel caspase cleavage motif AEAD.
Fang Y, Gong Z, You M, Peng K
Virologica Sinica 2024 Oct;39(5):755-766
Virologica Sinica 2024 Oct;39(5):755-766
Mechanisms of Shufeng Jiedu Capsule in treating bacterial pneumonia based on network pharmacology and experimental verification.
Xu Y, Bao L, Zhao R, Geng Z, Li S, Pang B, Sun Q, Guo S, Cui X, Sun J
Chinese herbal medicines 2024 Oct;16(4):656-666
Chinese herbal medicines 2024 Oct;16(4):656-666
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway.
Lv F, Xie L, Li L, Lin J
Scientific reports 2024 Oct 8;14(1):23450
Scientific reports 2024 Oct 8;14(1):23450
Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
Zhang Z, Zheng Y, Zhang B, Wang R, Chen L, Wang Y, Feng W, Zheng X, Li K, Zhou N
Journal of ethnopharmacology 2024 Oct 5;332:118376
Journal of ethnopharmacology 2024 Oct 5;332:118376
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.
Chen T, Zhou X, Zhu M, Chen X, Chang D, Lin Y, Xu W, Zheng Y, Li S, Song J, Huang M
Journal of ethnopharmacology 2024 Oct 28;333:118418
Journal of ethnopharmacology 2024 Oct 28;333:118418
ACOD1 mediates Staphylococcus aureus-induced inflammatory response via the TLR4/NF-κB signaling pathway.
Dai F, Zhang X, Ma G, Li W
International immunopharmacology 2024 Oct 25;140:112924
International immunopharmacology 2024 Oct 25;140:112924
The ASB@HNTs-PVA nanofiber membrane, possessing both anti-inflammatory and hemostatic activities, promotes the healing of T2D skin wounds.
Tang Y, Wang N, Liu W, Ding Q, Yang J, Wu X, Cheng Z, Hong B, Ding C
International immunopharmacology 2024 Oct 25;140:112780
International immunopharmacology 2024 Oct 25;140:112780
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression.
Zhao R, Guo Z, Lu K, Chen Q, Riaz F, Zhou Y, Yang L, Cheng X, Wu L, Cheng K, Feng L, Liu S, Wu X, Zheng M, Yin C, Li D
Cell death & disease 2024 Oct 23;15(10):770
Cell death & disease 2024 Oct 23;15(10):770
Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP/TSLPR/pSTAT5 signals.
Lu YY, Lin CY, Lu CC, Tsai HP, Wang WT, Zhang ZH, Wu CH
Brain research bulletin 2024 Oct 15;217:111081
Brain research bulletin 2024 Oct 15;217:111081
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Zhang Z, Li M, Li X, Feng Z, Luo G, Wang Y, Gao X
Journal of neuroinflammation 2024 Oct 15;21(1):261
Journal of neuroinflammation 2024 Oct 15;21(1):261
Oxytocin attenuates neuroinflammation-induced anxiety through restoration of excitation and inhibition balance in the anterior cingulate cortex in mice.
Shi CN, Wu XM, Gao YZ, Ma DQ, Yang JJ, Ji MH
Journal of affective disorders 2024 Oct 1;362:341-355
Journal of affective disorders 2024 Oct 1;362:341-355
Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis.
Wang X, Wang K, Mao W, Fan Z, Liu T, Hong R, Chen H, Pan C
Environmental research 2024 Oct 1;258:119483
Environmental research 2024 Oct 1;258:119483
Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat.
Issotina Zibrila A, Zhou J, Wang X, Zeng M, Ali MA, Liu X, Alkuhali AA, Zeng Z, Meng Y, Wang Z, Li X, Liu J
Pflugers Archiv : European journal of physiology 2024 Nov;476(11):1677-1691
Pflugers Archiv : European journal of physiology 2024 Nov;476(11):1677-1691
Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin Attenuates Sorafenib-Induced Myocardial Inflammation and Toxicity.
Liu CH, Ho YC, Lee WC, Huang CY, Lee YK, Hsieh CB, Huang NC, Wu CC, Nguyen NUN, Hsu CC, Chen CH, Chen YC, Huang WC, Lu YY, Fang CC, Chang YC, Chang CL, Tsai MK, Wen ZH, Li CZ, Li CC, Chuang PK, Yang SM, Chu TH, Huang SC
Environmental toxicology 2024 Nov;39(11):4844-4858
Environmental toxicology 2024 Nov;39(11):4844-4858
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS-induced acute kidney injury.
Huang L, Wu Y, Sai W, Wang Y, Feng G, Lu Y, Chen F, Huang X, Zhao H, Gu Z, Yang B
Journal of cellular and molecular medicine 2024 Nov;28(22):e70202
Journal of cellular and molecular medicine 2024 Nov;28(22):e70202
The role of phlorizin liposome-embedded oxidized sodium alginate/carboxymethyl chitosan in diabetic wound healing.
Wu X, Ding C, Liu X, Ding Q, Zhang S, Wang Y, Xin C, Wei H, Mao R, Zhang G, Zhao T, Liu W
International journal of biological macromolecules 2024 Nov;279(Pt 3):135324
International journal of biological macromolecules 2024 Nov;279(Pt 3):135324
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
Zeng X, Zhang H, Xu T, Mei X, Wang X, Yang Q, Luo Z, Zeng Q, Xu D, Ren H
Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
SIRT2 regulates high mobility group protein B1 nucleoplasmic shuttle and degradation via deacetylation in microglia.
Xing WQ, Piao XJ, Han Q, Shi HY, Wu WC, Si F, Lu JJ, Zhou TZ, Guo JR, Li SZ, Xu B
Journal of cellular physiology 2024 Nov;239(11):e31364
Journal of cellular physiology 2024 Nov;239(11):e31364
Targeted Therapy of Osteoarthritis via Intra-Articular Delivery of Lipid-Nanoparticle-Encapsulated Recombinant Human FGF18 mRNA.
Sun M, Ma B, Pan Z, Zhao Y, Tian L, Fan Y, Kong W, Wang J, Xu B, Ao Y, Guo Q, Wang X, Peng X, Li X, Cheng J, Miao L, Wang K, Hu X
Advanced healthcare materials 2024 Nov;13(29):e2400804
Advanced healthcare materials 2024 Nov;13(29):e2400804
Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway.
Qu L, Huang Y, Wu Y, He L, Liu Y, Chen Z, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Nov 6;72(44):24387-24399
Journal of agricultural and food chemistry 2024 Nov 6;72(44):24387-24399
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Luo P, Gu Q, Wang J, Li X, Li N, Yang W, Meng X, Zhao M
European journal of medical research 2024 Nov 29;29(1):567
European journal of medical research 2024 Nov 29;29(1):567
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles.
Pei J, Zhang C, Zhang Q, Yu H, Yuan H, Guo Y, Shen H, Liu H, Wang C, Meng F, Yu C, Tie J, Chen X, Wu X, Zhang G, Wang X
Journal of nanobiotechnology 2024 Nov 22;22(1):730
Journal of nanobiotechnology 2024 Nov 22;22(1):730
Dexmedetomidine Attenuates Neuroinflammation-Mediated Hippocampal Neurogenesis Impairment in Sepsis-Associated Encephalopathy Mice through Central α2A-Adrenoceptor.
Zhang X, Feng Y, Zhong Y, Ding R, Guo Y, Jiang F, Xing Y, Shi H, Bao H, Si Y
ACS chemical neuroscience 2024 Nov 20;15(22):4185-4201
ACS chemical neuroscience 2024 Nov 20;15(22):4185-4201
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.
Bai L, Chen Q, Li Y, Wu F, Jin M, Chen Y, Teng X, Jin S, Fan H, Wu Y
Physiological research 2024 Nov 15;73(5):779-789
Physiological research 2024 Nov 15;73(5):779-789
Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing.
Chen C, Amona FM, Chen J, Chen X, Ke Y, Tang S, Xu J, Chen X, Pang Y
ACS applied materials & interfaces 2024 Nov 13;16(45):61751-61764
ACS applied materials & interfaces 2024 Nov 13;16(45):61751-61764
NLRX1 and STING alleviate renal ischemia-reperfusion injury by regulating LC3 lipidation during mitophagy.
Liao Y, Li P, Hang Q, Chong Y, Long W, Wei X, Sun D, Liu Y
Experimental cell research 2024 Nov 1;443(1):114323
Experimental cell research 2024 Nov 1;443(1):114323
TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response.
Xing B, Lan H, Li H
Ecotoxicology and environmental safety 2024 Nov 1;286:117200
Ecotoxicology and environmental safety 2024 Nov 1;286:117200
Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury.
Cao J, Yu X, Liu J, Fu J, Wang B, Wu C, Zhang S, Chen H, Wang Z, Xu Y, Sui T, Chang J, Cao X
Neural regeneration research 2024 Nov 1;19(11):2499-2512
Neural regeneration research 2024 Nov 1;19(11):2499-2512
Mogroside Ⅴ Inhibits M1 Polarization and Inflammation of Diabetic Mouse Macrophages via p38 MAPK/NF-Κb Signaling Pathway.
Dong X, Ye Z, Li C, Li K, Zhong X, Li H
Immunological investigations 2024 May;53(4):604-621
Immunological investigations 2024 May;53(4):604-621
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
Shen SC, Xu J, Cheng C, Xiang XJ, Hong BY, Zhang M, Gong C, Ma LK
Acta pharmacologica Sinica 2024 May;45(5):959-974
Acta pharmacologica Sinica 2024 May;45(5):959-974
Supercritical CO(2) fluid extract from Stellariae Radix ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation.
Wu W, Song L, Wang H, Feng L, Li Z, Li Y, Li L, Peng L
Environmental toxicology 2024 May;39(5):3188-3197
Environmental toxicology 2024 May;39(5):3188-3197
Palmitic acid induces GSDMD-mediated pyroptosis in periodontal ligament cells via the NF-κB pathway.
Sun BJ, Chen MH, Zhang WH, Zhao BJ, Zhang MH, Han XX, Yu LM, Liu YH
Oral diseases 2024 May;30(4):2546-2557
Oral diseases 2024 May;30(4):2546-2557
SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia.
Sun W, Wang J, Liu C, Gao F, Ou Q, Tian H, Xu J, Zhang J, Li J, Xu J, Jia S, Zhang J, Xu G, Huang J, Jin C, Lu L
International journal of biological macromolecules 2024 May;268(Pt 2):131678
International journal of biological macromolecules 2024 May;268(Pt 2):131678
Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing.
Chai G, Wang N, Xu M, Ma L, Liu X, Ding Q, Zhang S, Li A, Xia G, Zhao Y, Liu W, Liang D, Ding C
International journal of biological macromolecules 2024 May;268(Pt 2):131670
International journal of biological macromolecules 2024 May;268(Pt 2):131670
Emodin Blocks mPTP Opening and Improves LPS-Induced HMEC-1 Cell Injury by Upregulation of ATP5A1.
Di T, He L, Shi Q, Chen L, Zhu L, Zhao S, Zhang C
Chemistry & biodiversity 2024 May;21(5):e202301916
Chemistry & biodiversity 2024 May;21(5):e202301916
Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.
Liu T, Ma Z, Liu L, Pei Y, Wu Q, Xu S, Liu Y, Ding N, Guan Y, Zhang Y, Chen X
Neural regeneration research 2024 May;19(5):1105-1111
Neural regeneration research 2024 May;19(5):1105-1111
Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2.
Zhou Z, Li Y, Wu S, Liu T, Jiang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116515
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116515
Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury.
Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J, Song M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307233
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307233
Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes.
Yang Y, Li Y, Yang W, Yang X, Luo M, Qin L, Zhu J
Journal of neuroinflammation 2024 May 17;21(1):132
Journal of neuroinflammation 2024 May 17;21(1):132
Uterine Immunoprivileged Cells Restore Cardiac Function of Male Recipients After Myocardial Infarction.
Peng Z, Ludke A, Wu J, Li S, Alibhai FJ, Zhang Y, Fan Y, Song H, He S, Xie J, Li RK
Stem cells (Dayton, Ohio) 2024 May 15;42(5):430-444
Stem cells (Dayton, Ohio) 2024 May 15;42(5):430-444
The role of FGF-21 in promoting diabetic wound healing by modulating high glucose-induced inflammation.
Li Z, Qiu X, Guan G, Shi K, Chen S, Tang J, Xiao M, Tang S, Yan Y, Zhou J, Xie H
Heliyon 2024 May 15;10(9):e30022
Heliyon 2024 May 15;10(9):e30022
Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis.
Liu M, Huo X, Li C, Hu Y, Lei H, Wang D, Zhu L, Gu Y, Guo D, Huang L, Deng Y
Acta biochimica et biophysica Sinica 2024 May 11;56(12):1789-1801
Acta biochimica et biophysica Sinica 2024 May 11;56(12):1789-1801
Glycosides of Buyang Huanwu decoction inhibits inflammation associated with cerebral ischemia-reperfusion via the PINK1/Parkin mitophagy pathway.
Jiao K, Lai Z, Cheng Q, Yang Z, Liao W, Liao Y, Long H, Sun R, Lang T, Shao L, Deng C, She Y
Journal of ethnopharmacology 2024 May 10;325:117766
Journal of ethnopharmacology 2024 May 10;325:117766
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3.
Wei YF, Li X, Zhao MR, Liu S, Min L, Zhu ST, Zhang ST, Xie SA
Cell communication and signaling : CCS 2024 May 10;22(1):263
Cell communication and signaling : CCS 2024 May 10;22(1):263
Kaempferol alleviates adipose tissue inflammation and insulin resistance in db/db mice by inhibiting the STING/NLRP3 signaling pathway.
Zhai H, Wang D, Wang Y, Gu H, Jv J, Yuan L, Wang C, Chen L
Endocrine connections 2024 May 1;13(5)
Endocrine connections 2024 May 1;13(5)
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity.
Wang Y, Chang J, Qiao S, Yang Y, Yun C, Li Y, Wang F
Canadian journal of physiology and pharmacology 2024 May 1;102(5):318-330
Canadian journal of physiology and pharmacology 2024 May 1;102(5):318-330
Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway.
Luo L, Wang S, Liu W, Zhang Z, Zhao M, Liu A
Neurochemical research 2024 Mar;49(3):692-705
Neurochemical research 2024 Mar;49(3):692-705
Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/IκB-α/NF-κB p65 pathway after spinal cord injury.
Liu G, Huo L, Deng B, Jiang S, Zhao Y, Mo Y, Bai H, Xu L, Hu C, Mu X
Toxicology and applied pharmacology 2024 Mar;484:116872
Toxicology and applied pharmacology 2024 Mar;484:116872
Knee Osteotomy Decreases Joint Inflammation Based on Synovial Histology and Synovial Fluid Analysis.
Watanabe S, Matsushita T, Nishida K, Nagai K, Hoshino Y, Matsumoto T, Kuroda R
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2024 Mar;40(3):830-843
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2024 Mar;40(3):830-843
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway.
Liu MH, Lin XL, Xiao LL
Molecular medicine reports 2024 Mar;29(3)
Molecular medicine reports 2024 Mar;29(3)
M1 Macrophage-Derived Exosome LncRNA PVT1 Promotes Inflammation and Pyroptosis of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Inhibiting miR-186-5p and Regulating HMGB1.
Zhang J, Zhang X, Liu X, Chen H, Wang J, Ji M
Cardiovascular toxicology 2024 Mar;24(3):302-320
Cardiovascular toxicology 2024 Mar;24(3):302-320
Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway.
Li G, Liu X, Sun X, Huang L, Kuang W, Ou J, Zhang J, Zhang Z, Li H, Tang H, Feng C, Gu L, Yang C, Peili W, Wang J
Environment international 2024 Mar;185:108543
Environment international 2024 Mar;185:108543
S100A9(-/-) alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFκB signaling axis.
Gong C, Ma J, Deng Y, Liu Q, Zhan Z, Gan H, Xiang X, Zhang M, Cao K, Shen T, Fang L, Shen B, Shen S, Ding S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116233
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116233
Rescuing Nucleus Pulposus Cells from ROS Toxic Microenvironment via Mitochondria-Targeted Carbon Dot-Supported Prussian Blue to Alleviate Intervertebral Disc Degeneration.
Shi Y, Bu W, Chu D, Lin W, Li K, Huang X, Wang X, Wu Y, Wu S, Li D, Xu Z, Cao Z, Chen H, Wang H
Advanced healthcare materials 2024 Mar;13(8):e2303206
Advanced healthcare materials 2024 Mar;13(8):e2303206
Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy.
Liu J, Gao Y, Zhang H, Hao Z, Zhou G, Wen H, Su Q, Tong C, Yang X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155358
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155358
REXO2 up-regulation is positively correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma.
Zhang T, Zhang R, Zhang Z, Li D, Guo X, Zhang Z, Zhu X, Tan S
International immunopharmacology 2024 Mar 30;130:111740
International immunopharmacology 2024 Mar 30;130:111740
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81
World journal of surgical oncology 2024 Mar 21;22(1):81
Lactococcus garvieae exerts a critical role in inducing inflammation in dairy mastitis by triggering NLRP3 inflammasome-mediated pyroptosis in MAC-T cells.
Wu F, Du T, Jiang X, Liu S, Cheng Y, Zhang Z, Miao W, Wang T
World journal of microbiology & biotechnology 2024 Mar 12;40(4):132
World journal of microbiology & biotechnology 2024 Mar 12;40(4):132
Inhibition of PKM2 suppresses osteoclastogenesis and alleviates bone loss in mouse periodontitis.
Li F, Liu X, Li M, Wu S, Le Y, Tan J, Zhu C, Wan Q
International immunopharmacology 2024 Mar 10;129:111658
International immunopharmacology 2024 Mar 10;129:111658
Caffeine Ameliorates Age-Related Hearing Loss by Downregulating the Inflammatory Pathway in Mice.
Zhang X, Cao R, Li C, Zhao H, Zhang R, Che J, Xie J, Tang N, Wang Y, Liu X, Zheng Q
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2024 Mar 1;45(3):227-237
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2024 Mar 1;45(3):227-237
C5a stimulation induces caspase-1 activation and mature IL-1β production in human peripheral blood mononuclear cells.
Fujita Y, Matsumoto H, Inada K, Onizawa M, Saito K, Sumichika Y, Yoshida S, Temmoku J, Matsuoka N, Asano T, Sato S, Machida T, Migita K
Immunological medicine 2024 Jun;47(2):68-75
Immunological medicine 2024 Jun;47(2):68-75
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Yang R, Li DD, Li XX, Yang XX, Gao HM, Zhang F
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Feng S, Xie X, Li J, Xu X, Chen C, Zou G, Lin G, Huang T, Hu R, Ran T, Han L, Zhang Q, Li Y, Zhao X
Hepatology international 2024 Jun;18(3):1040-1052
Hepatology international 2024 Jun;18(3):1040-1052
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.
Liu M, Zeng C, Zhang Y, Xin Y, Deng S, Hu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613
Identification of subclusters and prognostic genes based on GLS-associated molecular signature in ulcerative colitis.
Xie Y, Li J, Tao Q, Wu Y, Liu Z, Chen Y, Zeng C
Scientific reports 2024 Jun 7;14(1):13102
Scientific reports 2024 Jun 7;14(1):13102
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation.
Zhang P, Yang J, Liu X, Huang C, Tao Y, Shen P, Bai Z, Xiao C, Zhou L, Li G, Zhang L, Zhou W, Gao Y
Cell death & disease 2024 Jun 4;15(6):392
Cell death & disease 2024 Jun 4;15(6):392
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Wang Q, Li A, Yu H, Wang C, Wang T, Zhang J
International journal of molecular sciences 2024 Jun 26;25(13)
International journal of molecular sciences 2024 Jun 26;25(13)
MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice.
Ma H, Ou ZL, Alaeiilkhchi N, Cheng YQ, Chen K, Chen JY, Guo RQ, He MY, Tang SY, Zhang X, Huang ZP, Liu J, Liu J, Zhu QA, Huang ZC, Jiang H
Lipids in health and disease 2024 Jun 22;23(1):194
Lipids in health and disease 2024 Jun 22;23(1):194
[Aqueous extract of Chuan Xiong Rhizoma enhances inhibitory effect of temozolomide against brain metastasis of melanoma in mice].
Zhao Q, Zhang Z, Zhou X, Rong X, Liu X, Zhao X, Wang H, Pang J, Li S, Li X
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Jun 20;44(6):1088-1097
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Jun 20;44(6):1088-1097
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Zou S, Wu Y, Wen M, Liu J, Chen M, Yuan J, Zhou B
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.
Ding M, Wei X, Liu C, Tan X
Journal of ethnopharmacology 2024 Jun 12;327:118041
Journal of ethnopharmacology 2024 Jun 12;327:118041
ATF4 Contributes to Abdominal Aortic Aneurysm Formation via Modulating M1 Macrophage Polarization and Inflammation.
Yu H, Jiao X, Lv Q, Li L, Du Y, Hu C, Du Z, Li F, Wang Y, Gao X, Han L, Sun X, Chen D, Qin Y
Aging and disease 2024 Jun 10;16(3):1691-1708
Aging and disease 2024 Jun 10;16(3):1691-1708
Forsythiaside A attenuates lipopolysaccharide-induced mouse mastitis by activating autophagy and regulating gut microbiota and metabolism.
Gao Y, Hao Z, Zhang H, Liu J, Zhou G, Wen H, Su Q, Tong C, Huang S, Wang X
Chemico-biological interactions 2024 Jun 1;396:111044
Chemico-biological interactions 2024 Jun 1;396:111044
Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer's Disease.
Rice M, Nuovo GJ, Sawant D, Mishra A, Tili E
Molecular neurobiology 2024 Jul;61(7):4589-4601
Molecular neurobiology 2024 Jul;61(7):4589-4601
Type 2 diabetes aggravates periodontitis-induced pathological changes in the dental pulp.
Yang T, Zhou B, Shan Z, Hu L
Oral diseases 2024 Jul;30(5):3250-3260
Oral diseases 2024 Jul;30(5):3250-3260
Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus.
Ding Q, Liu X, Zhang S, Chai G, Ma S, Sun S, Shen L, Gao Y, Ding C, Zhao T, Liu W
International journal of biological macromolecules 2024 Jul;273(Pt 2):133040
International journal of biological macromolecules 2024 Jul;273(Pt 2):133040
Artificial aging conditions for Artemisia argyi leaves based on quality-inflammation-quality marker transformation.
Guo X, Wang D, Xiao Y, Cao H, Yao D, Chen G, Li S, Wang G, Tu J, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155574
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155574
Adiponectin inhibits ROS/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis.
Zeng Y, Luo M, Yao Z, Xiao X
Odontology 2024 Jul;112(3):811-825
Odontology 2024 Jul;112(3):811-825
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
Huang R, Liu L, Shen K, Duan C, Fan Z
Journal of integrative neuroscience 2024 Jul 5;23(7):124
Journal of integrative neuroscience 2024 Jul 5;23(7):124
The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens.
Liu Z, Mou S, Li L, Chen Q, Yang R, Guo S, Jin Y, Liu L, Li T, Chen H, Wang X
Cells 2024 Jul 3;13(13)
Cells 2024 Jul 3;13(13)
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study.
Jo HG, Baek CY, Hwang Y, Baek E, Song HS, Lee D
Nutrients 2024 Jul 26;16(15)
Nutrients 2024 Jul 26;16(15)
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model.
Fang B, Yang T, Chen Y, Duan Z, Hu J, Wang Q, He Y, Zhang Y, Dong W, Zhang Q, Zhao X
Biomolecules 2024 Jul 25;14(8)
Biomolecules 2024 Jul 25;14(8)
Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway.
Yang Q, Chen Q, Li S, Luo J
Diabetology & metabolic syndrome 2024 Jul 2;16(1):146
Diabetology & metabolic syndrome 2024 Jul 2;16(1):146
Novel insights into gut health: Cilostazol strengthens gut integrity by adjusting TLR-2/NF-κB/IL-23 and CD44/AKT/GSK-3β/cyclin-D1 trajectories in methotrexate-induced mucositis model.
Mansour SM, Sabra O, El-Komy F, Ahmed K, El-Abhar H
European journal of pharmacology 2024 Jul 15;975:176669
European journal of pharmacology 2024 Jul 15;975:176669
Toll-like receptor 4-dependent innate immune responses are mediated by intracrine corticosteroids and activation of glycogen synthase kinase-3β in astrocytes.
Lai W, Huang S, Liu J, Zhou B, Yu Z, Brown J, Hong G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23781
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23781
Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain.
Rong ZJ, Chen M, Cai HH, Liu GH, Chen JB, Wang H, Zhang ZW, Huang YL, Ni SF
Neuropharmacology 2024 Jul 1;252:109939
Neuropharmacology 2024 Jul 1;252:109939
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.
Zheng Y, Yang S, Dai W, Wang J, Bi S, Zhang X, Zheng Z, Sun Y, Wu S, Kong J
International journal of oncology 2024 Jan;64(1)
International journal of oncology 2024 Jan;64(1)
NADase CD38 is a key determinant of ovarian aging.
Yang Q, Chen W, Cong L, Wang M, Li H, Wang H, Luo X, Zhu J, Zeng X, Zhu Z, Xu Y, Lei M, Zhao Y, Wei C, Sun Y
Nature aging 2024 Jan;4(1):110-128
Nature aging 2024 Jan;4(1):110-128
MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation.
An Q, Xia J, Pu F, Shi S
Molecular medicine reports 2024 Jan;29(1)
Molecular medicine reports 2024 Jan;29(1)
Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization.
Liang Y, Chen L, Huang Y, Xie L, Liu X, Zhou W, Cao W, Chen Z, Zhong X
Brain research bulletin 2024 Jan;206:110863
Brain research bulletin 2024 Jan;206:110863
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838
Brain research bulletin 2024 Jan;206:110838
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Tong Z, Kong L, Zhang Y, Hu T, Dai R, Wang Y, Ji J, Huang Z, Hu L
Bioorganic chemistry 2024 Jan;142:106955
Bioorganic chemistry 2024 Jan;142:106955
Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction.
Bi T, Zhou Y, Mao L, Liang P, Liu J, Yang L, Ren G, Mazhar M, Shen H, Liu P, Spáčil R, Guo Q, Luo G, Yang S, Ren W
Journal of traditional and complementary medicine 2024 Jan;14(1):40-54
Journal of traditional and complementary medicine 2024 Jan;14(1):40-54
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
The improvement of homocysteine-induced myocardial inflammation by vitamin D depends on activation of NFE2L2 mediated MTHFR.
Liu N, Su H, Lou Y, Kong J
International immunopharmacology 2024 Jan 25;127:111437
International immunopharmacology 2024 Jan 25;127:111437
Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway.
Zhao X, Wang Z, Wang J, Xu F, Zhang Y, Han D, Fang W
International immunopharmacology 2024 Jan 25;127:111396
International immunopharmacology 2024 Jan 25;127:111396
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
International immunopharmacology 2024 Jan 25;127:111290
International immunopharmacology 2024 Jan 25;127:111290
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Ma G, Dong Q, Li F, Jin Z, Pi J, Wu W, Li J
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells.
Yu H, Zhang B, Zhan Y, Yi Y, Jiang Q, Zhang Q, Wu Y, Wu M
Scientific reports 2024 Jan 17;14(1):1521
Scientific reports 2024 Jan 17;14(1):1521
Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.
Huang H, Sun Z, Xu J, Wang L, Zhao J, Li J, Zhang S, Yuan F, Liu M, Fang Z
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116868
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116868
2-Deoxy-D-glucose ameliorates inflammation and fibrosis in a silicosis mouse model by inhibiting hypoxia-inducible factor-1α in alveolar macrophages.
Lu Y, Mu M, RenChen X, Wang W, Zhu Y, Zhong M, Jiang Y, Tao X
Ecotoxicology and environmental safety 2024 Jan 1;269:115767
Ecotoxicology and environmental safety 2024 Jan 1;269:115767
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666
Brain research 2024 Jan 1;1822:148666
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
Liao Y, Deng C, Wang X
Tissue & cell 2024 Feb;86:102285
Tissue & cell 2024 Feb;86:102285
SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
Liu MH, Lin XL, Xiao LL
Tissue & cell 2024 Feb;86:102276
Tissue & cell 2024 Feb;86:102276
METTL3 promotes microglial inflammation via MEF2C in spinal cord injury.
Wang D, Qian W, Wu D, Wu Y, Lu K, Zou G
Cell and tissue research 2024 Feb;395(2):189-197
Cell and tissue research 2024 Feb;395(2):189-197
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway.
Shen G, Lou C, Li Q, Zhao B, Luo Y, Wu F, Jiao D, Fang M, Geng Y
Anatomical record (Hoboken, N.J. : 2007) 2024 Feb;307(2):372-384
Anatomical record (Hoboken, N.J. : 2007) 2024 Feb;307(2):372-384
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Yuan N, Diao J, Dong J, Yan Y, Chen Y, Yan S, Liu C, He Z, He J, Zhang C, Wang H, Wang M, He F, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Liver toxicity in rats after subchronic exposure to HTP aerosol and cigarette smoke.
Tian Y, Wang H, Han S, Fu Y, Lu F, Wang W, Li X, Ma S, Feng P, Shi Z, Chen H, Hou H
Toxicology research 2024 Feb;13(1):tfae002
Toxicology research 2024 Feb;13(1):tfae002
ENST00000534735 inhibits proliferation and migration, promotes apoptosis and pyroptosis of endometrial cancer via OSBPL3 through APMK/SIRT1/NF-κB pathway.
Shan S, Wang X, Qian L, Wang C, Zhao S
Heliyon 2024 Feb 29;10(4):e25281
Heliyon 2024 Feb 29;10(4):e25281
Protective effect of Tetrandrine on optic nerve by inhibiting glial activation through NF-κB pathway.
Li W, Cao J, Liu J, Chen S, Dai M, Zhang M, Hou X, Wang J, Kang Z
Heliyon 2024 Feb 29;10(4):e24749
Heliyon 2024 Feb 29;10(4):e24749
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury.
Wang BJ, Chen YY, Chang HH, Chen RJ, Wang YJ, Lee YH
Particle and fibre toxicology 2024 Feb 28;21(1):9
Particle and fibre toxicology 2024 Feb 28;21(1):9
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
Cai H, Zhang J, Xu H, Sun W, Wu W, Dong C, Zhou P, Xue C, Nan Y, Ni Y, Wu X, Gu Z, Chen M, Wang Y
Science signaling 2024 Feb 27;17(825):eadh1178
Science signaling 2024 Feb 27;17(825):eadh1178
MKK3 K329 Mutation Attenuates Diabetes-Associated Cognitive Dysfunction by Blocking the MKK3-RAGE Interaction and Inhibiting Neuroinflammation.
Ying C, Li Y, Wu S, Gao L, Zhu Y, Qian Y, Wen X, Li H, Huang C, Hu B, Song Y, Zhou X
Aging and disease 2024 Feb 22;16(1):598-618
Aging and disease 2024 Feb 22;16(1):598-618
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease.
Liu PY, Hong KF, Liu YD, Sun ZY, Zhao TT, Li XL, Lao CC, Tan SF, Zhang HY, Zhao YH, Xie Y, Xu YH
Chinese medicine 2024 Feb 16;19(1):27
Chinese medicine 2024 Feb 16;19(1):27
Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.
He S, Zhang T, Wang YY, Yuan W, Li L, Li J, Yang YY, Wu DM, Xu Y
International immunopharmacology 2024 Feb 15;128:111570
International immunopharmacology 2024 Feb 15;128:111570
Protective Effect and Mechanism of L-Theanine on Acute Alcoholic Liver Injury in Mice.
Liu MY, Xu KH, Liu S, Xiao WJ
Molecular nutrition & food research 2024 Dec;68(23):e2400766
Molecular nutrition & food research 2024 Dec;68(23):e2400766
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells.
Zhao P, Ning J, Huang J, Huang X
Autoimmunity 2024 Dec;57(1):2427094
Autoimmunity 2024 Dec;57(1):2427094
Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.
Yue P, Lv X, Cao H, Zou Y, You J, Luo J, Lu Z, Chen H, Liu Z, Zhong Z, Xiong Y, Fan X, Ye Q
Experimental & molecular medicine 2024 Dec;56(12):2588-2601
Experimental & molecular medicine 2024 Dec;56(12):2588-2601
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Zeng F, Lai Y, Huang Y, Zhu F, Gao J, Chen Z, Zeng L, Feng M, Qiu P, Yuan S, Deng G
Annals of medicine 2024 Dec;56(1):2394584
Annals of medicine 2024 Dec;56(1):2394584
Mesenchymal stem cell-loaded hydrogel to inhibit inflammatory reaction in surgical brain injury via mitochondria transfer.
Wang Y, Yang X, Liu M, Yan Y, Kong F, Wang J, Zhang Z, Chen Y, Chen L, Liang Z, Peng X, Liu F
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:231-240
Biocooperative Regenerative Materials by Harnessing Blood-Clotting and Peptide Self-Assembly.
Padilla-Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H, Rose FRAJ, Iskratsch T, Mata A
Advanced materials (Deerfield Beach, Fla.) 2024 Dec;36(52):e2407156
Advanced materials (Deerfield Beach, Fla.) 2024 Dec;36(52):e2407156
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Li Y, Ji L, Liu C, Li J, Wen D, Li Z, Yu L, Guo M, Zhang S, Duan W, Yi L, Bi Y, Bu H, Li C, Liu Y
The FEBS journal 2024 Dec;291(23):5214-5235
The FEBS journal 2024 Dec;291(23):5214-5235
Dietary sanguinarine supplementation improves the growth performance and intestinal immunity of broilers.
Su Y, Chang G, Liu J, Huang P, Zeng J
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Dec;19:76-89
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Dec;19:76-89
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Yu B, Yuan C, Chen J, Zhou Z, Zhang Y, Su M, Wei D, Wu P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.
Li X, Li J, Ji J, Li S, Yao X, Fan H, Yao R
Journal of neurochemistry 2024 Dec;168(12):3982-4000
Journal of neurochemistry 2024 Dec;168(12):3982-4000
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Li W, Zhong Y, Lin Z, Deng Z, Long D, Li M, Li C, Mao G, Kang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Praelolide alleviates collagen-induced arthritis through increasing catalase activity and activating Nrf2 pathway.
Qi X, Meng J, Li C, Cheng W, Fan A, Huang J, Lin W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156040
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156040
Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy.
Chen X, Wang L, Zhang J, Yan H, Wang S, Xiao J
Advanced healthcare materials 2024 Dec;13(32):e2401507
Advanced healthcare materials 2024 Dec;13(32):e2401507
Lipopolysaccharide-regulated RNF31/NRF2 axis in colonic epithelial cells mediates homeostasis of the intestinal barrier in ulcerative colitis.
Tang CT, Liu ZD, Wang P, Zeng CY, Chen YX
Cellular signalling 2024 Dec;124:111480
Cellular signalling 2024 Dec;124:111480
Protective Effects of Exogenous Melatonin Administration on White Fat Metabolism Disruption Induced by Aging and a High-Fat Diet in Mice.
Lv D, Ren Y, Chen J, Pang Z, Tang Y, Zhang L, Yan L, Ai X, Xv X, Wang D, Cai Z
Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
FGF20 modulates gut microbiota to mitigate dextran sodium sulfate-induced ulcerative colitis in mouse models.
Jin Z, Liu Z, Pan J, Wang S, Cui M, He C, Lin M, Liu X, Yu X, Gong F
International immunopharmacology 2024 Dec 5;142(Pt A):113044
International immunopharmacology 2024 Dec 5;142(Pt A):113044
Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway.
Ouyang J, Wang H, Gan Y, Huang J
Clinical and experimental hypertension (New York, N.Y. : 1993) 2024 Dec 31;46(1):2424834
Clinical and experimental hypertension (New York, N.Y. : 1993) 2024 Dec 31;46(1):2424834
Pinocembrin alleviates LPS-induced depressive-like behavior in mice via the NLRP3/DCC signaling pathway.
Wu YL, Hu T, Zheng H, Feng J, Huang C, Zhou X, Wang W, Jiang CL
Biochemical and biophysical research communications 2024 Dec 3;736:150870
Biochemical and biophysical research communications 2024 Dec 3;736:150870
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Yuan C, Yu B, Li L, Chen J, Qin W, Zhou Z, Su M, Wang D, Zhang Y, Wu Q, He C, Wei D
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
METTL3-mediated m(6)A modification of CD36: Implications for glucose metabolism and inflammatory dysregulation in follicles of polycystic ovary syndrome.
Weng L, Zhu Q, Xiang Y, Cao T, Cai J, Liang N, Hong X, Xue M, Ge H
International immunopharmacology 2024 Dec 25;143(Pt 1):113327
International immunopharmacology 2024 Dec 25;143(Pt 1):113327
Comparison of Endoplasmic Reticulum Stress and Pyroptosis Induced by Pathogenic Calcium Oxalate Monohydrate and Physiologic Calcium Oxalate Dihydrate Crystals in HK-2 Cells: Insights into Kidney Stone Formation.
Nong WJ, Tong XY, Ouyang JM
Cells 2024 Dec 15;13(24)
Cells 2024 Dec 15;13(24)
Empagliflozin reduces renal calcium oxalate deposition in hyperoxaluria rats induced with ethylene glycol-ammonium chloride.
Duan Y, Wang Q, Chen X, Deng G, Huang K, Sun F, Zhu J, Jiang K
Biochemical and biophysical research communications 2024 Dec 10;737:150912
Biochemical and biophysical research communications 2024 Dec 10;737:150912
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Wang XF, Xiang XH, Wei J, Zhang PB, Xu Q, Liu MH, Qu LQ, Wang XX, Yu L, Wu AG, Qing DL, Wu JM, Law BY, Yu CL, Yong-Tang
Neurochemical research 2024 Aug;49(8):2197-2214
Neurochemical research 2024 Aug;49(8):2197-2214
Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice.
Ai W, Casey CA, Mishra PK, Alnouti Y, Daria S, Saraswathi V
Alcohol, clinical & experimental research 2024 Aug;48(8):1529-1540
Alcohol, clinical & experimental research 2024 Aug;48(8):1529-1540
Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension.
Liu SY, Wang Q, Zhou H, Tong N, Chang R, Wang FZ, Guo P, Li X, Zhou YB, Li ZZ
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Aug;47(8):2157-2171
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Aug;47(8):2157-2171
Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.
Ye Z, Sheu WC, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S
Small science 2024 Aug;4(8):2400081
Small science 2024 Aug;4(8):2400081
Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury.
Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J, Song M
iMeta 2024 Aug;3(4):e220
iMeta 2024 Aug;3(4):e220
Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
Dingyi L, Libin H, Jifeng P, Ding Z, Yulong L, Zhangyi W, Yunong Y, Qinghua W, Feng L
Experimental brain research 2024 Aug;242(8):1917-1932
Experimental brain research 2024 Aug;242(8):1917-1932
Homoplantaginin alleviates intervertebral disc degeneration by blocking the NF-κB/MAPK pathways via binding to TAK1.
Li B, Hu Y, Chen Y, Liu K, Rong K, Hua Q, Fu S, Yang X, Zhou T, Cheng X, Zhang K, Zhao J
Biochemical pharmacology 2024 Aug;226:116389
Biochemical pharmacology 2024 Aug;226:116389
PL-Relief(TM)plus Alleviates Atopic Dermatitis and Regulates Inflammatory Responses via Inhibiting NF-κB Signaling Pathway.
Zhang X, Shen Z, Zhu W, Lin L, Fan Y, Cheng X, Yu M, Yu S, Zhao B
Chemistry & biodiversity 2024 Aug;21(8):e202400349
Chemistry & biodiversity 2024 Aug;21(8):e202400349
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Wu Y, Che J, Dong J, Zhang X, Deng Y, Chen W, Zhang J
Neuropharmacology 2024 Aug 15;254:109981
Neuropharmacology 2024 Aug 15;254:109981
Matrine Suppresses Arsenic-Induced Malignant Transformation of SV-HUC-1 Cells via NOX2.
Wang L, Qiu N, Tong S, Yu Y, Xi S, Wang F
International journal of molecular sciences 2024 Aug 15;25(16)
International journal of molecular sciences 2024 Aug 15;25(16)
Capsaicin alleviates acute alcohol-induced pyroptosis by activating ESCRT-III-dependent cell membrane repair in hepatocytes.
Liu M, Guo J, Lu J, Chen Y, Deng X, Zhang S, Guan S
Food & function 2024 Aug 12;15(16):8395-8407
Food & function 2024 Aug 12;15(16):8395-8407
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
Zhao C, Yu Y, Yin G, Xu C, Wang J, Wang L, Zhao G, Ni S, Zhang H, Zhou B, Wang Y
Inflammopharmacology 2024 Apr;32(2):1277-1294
Inflammopharmacology 2024 Apr;32(2):1277-1294
SARS-CoV-2 virus-like particle variants alpha and delta mimic the native viruses in their differential inflammasome activating potential.
Bandyszewska M, Ambrożek-Latecka M, Hoser G, Grzanka M, Hornung F, Deinhardt-Emmer S, Skirecki T
Antiviral research 2024 Apr;224:105857
Antiviral research 2024 Apr;224:105857
Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway.
Liu Y, Sun Z, Dong R, Liu P, Zhang X, Li Y, Lai X, Cheong HF, Wu Y, Wang Y, Zhou H, Gui D, Xu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155437
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155437
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Chen Y, Yuan C, Qin W, Yu B, Wei D, Wu P
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Mycobacterium tuberculosis PE_PGRS38 Enhances Intracellular Survival of Mycobacteria by Inhibiting TLR4/NF-κB-Dependent Inflammation and Apoptosis of the Host.
Ullah H, Shi X, Taj A, Cheng L, Yan Q, Sha S, Ahmad, Kang J, Haris M, Ma X, Ma Y
Biology 2024 Apr 30;13(5)
Biology 2024 Apr 30;13(5)
Naringenin Inhibits Acid Sphingomyelinase-Mediated Membrane Raft Clustering to Reduce NADPH Oxidase Activation and Vascular Inflammation.
Ding M, Zhu Y, Xu X, He H, Jiang T, Mo X, Wang Z, Yu W, Ou H
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7130-7139
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7130-7139
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.
Chen F, Xing Y, Chen Z, Chen X, Li J, Gong S, Luo F, Cai Q
European journal of medical research 2024 Apr 24;29(1):250
European journal of medical research 2024 Apr 24;29(1):250
Investigating the Mechanistic of Danhong Injection in Brain Damage Caused by Cardiac I/R Injury via Bioinformatics, Computer Simulation, and Experimental Validation.
Wang J, Guo Y, Zhou H, Hua Y, Wan H, Yang J
ACS omega 2024 Apr 23;9(16):18341-18357
ACS omega 2024 Apr 23;9(16):18341-18357
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
Yang L, Zhou P, Li R, Yin Y, Xie G, Shi L, Zhang P, Tao K
Molecular biology reports 2024 Apr 20;51(1):533
Molecular biology reports 2024 Apr 20;51(1):533
Biomimetic nanoparticles for effective Celastrol delivery to targeted treatment of rheumatoid arthritis through the ROS-NF-κB inflammasome axis.
Wang B, Shen J, Wang X, Hou R
International immunopharmacology 2024 Apr 20;131:111822
International immunopharmacology 2024 Apr 20;131:111822
The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment.
Zhou J, Jia F, Qu M, Ning P, Huang X, Tan L, Liu D, Zhong P, Wu Q
Electromagnetic biology and medicine 2024 Apr 2;43(1-2):46-60
Electromagnetic biology and medicine 2024 Apr 2;43(1-2):46-60
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Zhao J, Yang T, Yi J, Hu H, Lai Q, Nie L, Liu M, Chu C, Yang J
iScience 2024 Apr 19;27(4):109321
iScience 2024 Apr 19;27(4):109321
Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF-κB/NLRP3 signaling pathway via H(2)S generation.
Dilxat T, Shi Q, Chen X, Liu X
Aging 2024 Apr 12;16(7):6521-6536
Aging 2024 Apr 12;16(7):6521-6536
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF-κB-p65 signaling pathway.
Yang Y, Wang N, Wang Z, Zhao M, Chen L, Shi Z
Chemico-biological interactions 2024 Apr 1;392:110953
Chemico-biological interactions 2024 Apr 1;392:110953
LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1.
Zhang YH, Sun TT, Liu ZH, Li X, Fan XF, Han LP
Scientific reports 2024 Apr 1;14(1):7652
Scientific reports 2024 Apr 1;14(1):7652
LncRNA HCG18 loaded by polymorphonuclear neutrophil-secreted exosomes aggravates sepsis acute lung injury by regulating macrophage polarization.
Zhu L, Yu Y, Wang H, Wang M, Chen M
Clinical hemorheology and microcirculation 2023;85(1):13-30
Clinical hemorheology and microcirculation 2023;85(1):13-30
Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury.
Zheng B, He Y, Yin S, Zhu X, Zhao Q, Yang H, Wang Z, Zhu R, Cheng L
Research (Washington, D.C.) 2023;6:0135
Research (Washington, D.C.) 2023;6:0135
C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.
Chen Y, Liu Y, Li H, Huna R, Tan X, Li N, Zhang Y, Jiao X, Liu M
Journal of applied oral science : revista FOB 2023;31:e20220404
Journal of applied oral science : revista FOB 2023;31:e20220404
Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle.
Li LZ, Wang XM, Feng XJ, Liu K, Li B, Zhu LJ, Xu WF, Zheng X, Dong YJ, He XL, Guan HR, Ding YY, Wu HS, Zhou CJ, Ye SY, Zhang BB, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2023;2023:9990843
Evidence-based complementary and alternative medicine : eCAM 2023;2023:9990843
Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.
Xue L, Huang L, Tian Y, Cao X, Song Y
Journal of ophthalmology 2023;2023:8224752
Journal of ophthalmology 2023;2023:8224752
Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy.
Liu PL, Diao JY, Wang Q, Liu H, Zhang Y, Liang JQ, Zhang F, Liang XJ, Zhao HM
Analytical cellular pathology (Amsterdam) 2023;2023:7573165
Analytical cellular pathology (Amsterdam) 2023;2023:7573165
Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis.
Sun R, Zhu J, Sun K, Gao L, Zheng B, Shi J
International journal of medical sciences 2023;20(13):1679-1697
International journal of medical sciences 2023;20(13):1679-1697
Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
Wang S, Tian Z, Lu Y, Huang Z, Fan Y, Li B, Zheng H, Wu X, Wang M, Zhao J, Xie J
International journal of biological sciences 2023;19(5):1597-1615
International journal of biological sciences 2023;19(5):1597-1615
The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts.
Fan Y, Yang Y, Lin K, Zhou X, Li Y, Lin Q
Open medicine (Warsaw, Poland) 2023;18(1):20230800
Open medicine (Warsaw, Poland) 2023;18(1):20230800
Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro.
Han J, Wu J, Liu H, Huang Y, Ju W, Xing Y, Zhang X, Yang J
Open life sciences 2023;18(1):20220647
Open life sciences 2023;18(1):20220647
Exosome Derived from Mesenchymal Stem Cells Alleviates Hypertrophic Scar by Inhibiting the Fibroblasts via TNFSF-13/HSPG2 Signaling Pathway.
Zhang H, Zang C, Zhao W, Zhang L, Liu R, Feng Z, Wu J, Cui R
International journal of nanomedicine 2023;18:7047-7063
International journal of nanomedicine 2023;18:7047-7063
Synergistic and Long-Lasting Wound Dressings Promote Multidrug-Resistant Staphylococcus Aureus-Infected Wound Healing.
Fu X, Ni Y, Wang G, Nie R, Wang Y, Yao R, Yan D, Guo M, Li N
International journal of nanomedicine 2023;18:4663-4679
International journal of nanomedicine 2023;18:4663-4679
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Ma Y, Chen Y, Xu H, Du N
Frontiers in immunology 2023;14:1228399
Frontiers in immunology 2023;14:1228399
Investigation of He's Yang Chao recipe against oxidative stress-related mitophagy and pyroptosis to improve ovarian function.
Miao C, Zhao Y, Chen Y, Wang R, Ren N, Chen B, Dong P, Zhang Q
Frontiers in endocrinology 2023;14:1077315
Frontiers in endocrinology 2023;14:1077315
Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction.
Chai R, Ye Z, Xue W, Shi S, Wei Y, Hu Y, Wu H
Frontiers in cell and developmental biology 2023;11:1252942
Frontiers in cell and developmental biology 2023;11:1252942
Role of NLRP3 inflammasome activation in HCC cell progression.
Dai B, Cao H, Hu Y, Gong Z, Huang X, Chen Y, Liu F, Peng X, Zhang Y, Lei X
Heliyon 2023 Sep;9(9):e19542
Heliyon 2023 Sep;9(9):e19542
Sophoricoside attenuates autoimmune‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway.
Chen Y, Lei Y, Wang H, Wang L, Xu J, Wang S, Yu M, Peng Z, Xiao F, Tian D, Liu M
International journal of molecular medicine 2023 Sep;52(3)
International journal of molecular medicine 2023 Sep;52(3)
Kartogenin-enhanced dynamic hydrogel ameliorates intervertebral disc degeneration via restoration of local redox homeostasis.
Tian X, Zhang Y, Shen L, Pan G, Yang H, Jiang Z, Zhu X, He F
Journal of orthopaedic translation 2023 Sep;42:15-30
Journal of orthopaedic translation 2023 Sep;42:15-30
Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage.
Song J, Zeng J, Zheng S, Jiang N, Wu A, Guo S, Ye R, Hu L, Huang F, Wang L, Xiaogang Z, Liu B, Wu J, Chen Q
Phytotherapy research : PTR 2023 Sep;37(9):4265-4281
Phytotherapy research : PTR 2023 Sep;37(9):4265-4281
Astragaloside IV attenuates high glucose-induced NF-κB-mediated inflammation through activation of PI3K/AKT-ERK-dependent Nrf2/ARE signaling pathway in glomerular mesangial cells.
Su X, Guo H, Zhou Y, Cao A, Shen Q, Zhu B, Yao X, Wang Y, Wang H, Wang L
Phytotherapy research : PTR 2023 Sep;37(9):4133-4148
Phytotherapy research : PTR 2023 Sep;37(9):4133-4148
PM(2.5) induces the inflammatory response in rat spleen lymphocytes through autophagy activation of NLRP3 inflammasome.
Guan L, Shi H, Tian J, Wang X, Liu N, Wang C, Zhang Z
Molecular immunology 2023 Sep;161:74-81
Molecular immunology 2023 Sep;161:74-81
Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model.
Peng Y, Sun L, Guo W, Liu Z, Wang T, Zou T, Zhou J, Yang X, Fan X
Journal of pharmacological sciences 2023 Sep;153(1):46-54
Journal of pharmacological sciences 2023 Sep;153(1):46-54
MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.
Zhang Y, Zhang Y, Lei Y, Wu J, Kang Y, Zheng S, Shao L
Journal of hazardous materials 2023 Sep 5;457:131750
Journal of hazardous materials 2023 Sep 5;457:131750
A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing.
Zhang L, Yang J, Liu W, Ding Q, Sun S, Zhang S, Wang N, Wang Y, Xi S, Liu C, Ding C, Li C
International journal of biological macromolecules 2023 Sep 30;249:126014
International journal of biological macromolecules 2023 Sep 30;249:126014
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis.
Zhou D, Zhu Y, Jiang P, Zhang T, Zhuang J, Li T, Qi L, Wang Y
Biological research 2023 Sep 27;56(1):50
Biological research 2023 Sep 27;56(1):50
Glymphatic Dysfunction in Migraine Mice Model.
Huang W, Zhang Y, Zhou Y, Zong J, Qiu T, Hu L, Pan S, Xiao Z
Neuroscience 2023 Sep 15;528:64-74
Neuroscience 2023 Sep 15;528:64-74
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Zhang B, Chen ZY, Jiang Z, Huang S, Liu XH, Wang L
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Yang Z, Wu S, He S, Han L, Zhou M, Yang J, Chen J, Wu G
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.
Guo Y, Zhang L
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673
Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure.
Jin Y, Zhang J, Xu Y, Yi K, Li F, Zhou H, Wang H, Chan HF, Lao YH, Lv S, Tao Y, Li M
Bioactive materials 2023 Oct;28:112-131
Bioactive materials 2023 Oct;28:112-131
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Zhao Y, Shao C, Zhou H, Yu L, Bao Y, Mao Q, Yang J, Wan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Yang J, Li L, Li C, Chen W, Liu Y, Luo S, Zhao C, Han Y, Yang M, Zhao H, Jiang N, Xi Y, Tang C, Cai J, Xiao L, Liu H, Sun L
Cell death & disease 2023 Oct 4;14(10):649
Cell death & disease 2023 Oct 4;14(10):649
Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway.
Li H, Zhang C, Zhou Y, Deng Y, Zheng X, Xue X
Aging 2023 Oct 26;15(20):11639-11653
Aging 2023 Oct 26;15(20):11639-11653
Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.
Wang X, Peng Z, Wang L, Zhang J, Zhang K, Guo Z, Xu G, Li J
International journal of molecular sciences 2023 Oct 24;24(21)
International journal of molecular sciences 2023 Oct 24;24(21)
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Deng F
iScience 2023 Oct 20;26(10):107762
iScience 2023 Oct 20;26(10):107762
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Shah W, Zhao Q, Wang S, Zhang M, Ma H, Guan Y, Zhang Y, Liu Y, Zhu C, Wang S, Zhang X, Dong J, Ma H
Scientific reports 2023 Oct 2;13(1):16550
Scientific reports 2023 Oct 2;13(1):16550
Role of SIRT2 in intestinal barrier under cold exposure.
Guo J, Xu J, Chen L, Chen Z, Hu H, Nie J, Yuan J, Ma L, Lu J, Ji H, Xu B
Life sciences 2023 Oct 1;330:121949
Life sciences 2023 Oct 1;330:121949
Complement C1q drives microglia-dependent synaptic loss and cognitive impairments in a mouse model of lipopolysaccharide-induced neuroinflammation.
Wu X, Gao Y, Shi C, Tong J, Ma D, Shen J, Yang J, Ji M
Neuropharmacology 2023 Oct 1;237:109646
Neuropharmacology 2023 Oct 1;237:109646
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Xu W, Li F, Zhu L, Cheng M, Cheng Y
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Lidocaine ameliorates intestinal barrier dysfunction in irritable bowel syndrome by modulating corticotropin-releasing hormone receptor 2.
Wang Y, Qiao M, Yao X, Feng Z, Hu R, Chen J, Liu L, Liu J, Sun Y, Guo Y
Neurogastroenterology and motility 2023 Nov;35(11):e14677
Neurogastroenterology and motility 2023 Nov;35(11):e14677
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
Li S, Xie J, Li K, Bai Y, Jiang Z, Xiong X
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
Dendrobium huoshanense Polysaccharide Improves High-Fat Diet Induced Liver Injury by Regulating the Gut-Liver Axis.
Ma MH, Gao LL, Chen CB, Gu FL, Wu SQ, Li F, Han BX
Chemistry & biodiversity 2023 Nov;20(11):e202300980
Chemistry & biodiversity 2023 Nov;20(11):e202300980
Carnosine alleviates cisplatin-induced acute kidney injury by targeting Caspase-1 regulated pyroptosis.
Luo X, Li Y, Wang B, Zhu S, Liu X, Liu X, Qi X, Wu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115563
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115563
GBP2 upregulated in LPS-stimulated macrophages-derived exosomes accelerates septic lung injury by activating epithelial cell NLRP3 signaling.
Huang W, Zhang Y, Zheng B, Ling X, Wang G, Li L, Wang W, Pan M, Li X, Meng Y
International immunopharmacology 2023 Nov;124(Pt B):111017
International immunopharmacology 2023 Nov;124(Pt B):111017
Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity.
Zhang H, Liu C, Zhai X, Zhang Q, Zhou Y, Huang H, Ding M, Shi Q, Liu Y, Tang Y, Liu G, Wang H
International immunopharmacology 2023 Nov;124(Pt A):110907
International immunopharmacology 2023 Nov;124(Pt A):110907
The STING inhibitor C-176 attenuates MPTP-induced neuroinflammation and neurodegeneration in mouse parkinsonian models.
Wang B, Wang Y, Qiu J, Gao S, Yu S, Sun D, Lou H
International immunopharmacology 2023 Nov;124(Pt A):110827
International immunopharmacology 2023 Nov;124(Pt A):110827
Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131
Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway.
Zhu Q, Han Y, He Y, Fu Y, Yang H, Chen Y, Shi Y
Frontiers in bioscience (Landmark edition) 2023 Nov 28;28(11):311
Frontiers in bioscience (Landmark edition) 2023 Nov 28;28(11):311
Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.
Lv W, Wu X, Dou Y, Yan Y, Chen L, Fei Z, Fei F
International journal of molecular sciences 2023 Nov 27;24(23)
International journal of molecular sciences 2023 Nov 27;24(23)
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
Application of Dominant Gut Microbiota Promises to Replace Fecal Microbiota Transplantation as a New Treatment for Alzheimer's Disease.
Li M, Yang H, Shao C, Liu Y, Wen S, Tang L
Microorganisms 2023 Nov 24;11(12)
Microorganisms 2023 Nov 24;11(12)
Injectable kaempferol-loaded fibrin glue regulates the metabolic balance and inhibits inflammation in intervertebral disc degeneration.
Gao W, Bao J, Zhang Y, He D, Zhang L, Zhang J, Pan H, Wang D
Scientific reports 2023 Nov 15;13(1):20001
Scientific reports 2023 Nov 15;13(1):20001
Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response.
Godse S, Zhou L, Sinha N, Kodidela S, Kumar A, Singh UP, Kumar S
Scientific reports 2023 Nov 14;13(1):19864
Scientific reports 2023 Nov 14;13(1):19864
Sleep deprivation alleviates depression-like behaviors in mice via inhibiting immune and inflammatory pathways and improving neuroplasticity.
Shi S, Zhang M, Xie W, Ju P, Chen N, Wang F, Lyu D, Wang M, Hong W
Journal of affective disorders 2023 Nov 1;340:100-112
Journal of affective disorders 2023 Nov 1;340:100-112
Activation of LXRα attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction.
Zhang Y, Liang J, Gu H, Du T, Xu P, Yu T, He Q, Huang Z, Lei S, Li J
Ecotoxicology and environmental safety 2023 Nov 1;266:115605
Ecotoxicology and environmental safety 2023 Nov 1;266:115605
Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid.
Huang L, Liu B, Yu XW, Pan GQ, Xu JY, Yan D, Wang YL, Guo QN
Environmental science and pollution research international 2023 May;30(22):62201-62212
Environmental science and pollution research international 2023 May;30(22):62201-62212
Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration.
Zhu J, Sun R, Yan C, Sun K, Gao L, Zheng B, Shi J
Cell cycle (Georgetown, Tex.) 2023 May;22(10):1196-1214
Cell cycle (Georgetown, Tex.) 2023 May;22(10):1196-1214
Selenium Deficiency Promotes the Expression of LncRNA-MORC3, Activating NLRP3-Caspase-1/IL-1β Signaling to Induce Inflammatory Damage and Disrupt Tight Junctions in Piglets.
Xue Y, Wang H, Tian B, Wang S, Gao XJ
Biological trace element research 2023 May;201(5):2365-2376
Biological trace element research 2023 May;201(5):2365-2376
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
Li J, Wang H, Liu D, Li X, He L, Pan J, Shen Q, Peng Y
Brain, behavior, and immunity 2023 May;110:60-79
Brain, behavior, and immunity 2023 May;110:60-79
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Li W, Tao C, Mao M, Zhu K
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages.
Lu Y, Zhang H, Pan H, Zhang Z, Zeng H, Xie H, Yin J, Tang W, Lin R, Zeng C, Cai D
Journal of translational medicine 2023 May 22;21(1):339
Journal of translational medicine 2023 May 22;21(1):339
Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility.
Zhang MF, Wan SC, Chen WB, Yang DH, Liu WQ, Li BL, Aierken A, Du XM, Li YX, Wu WP, Yang XC, Wei YD, Li N, Peng S, Li XL, Li GP, Hua JL
Zoological research 2023 May 18;44(3):505-521
Zoological research 2023 May 18;44(3):505-521
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N
Journal of ethnopharmacology 2023 May 10;307:116013
Journal of ethnopharmacology 2023 May 10;307:116013
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Zhong X, Wang Y, Liu D, Liang Y, Liu W, Huang Y, Xie L, Cao W, Xu Y, Chen L
Neuroscience 2023 May 1;517:117-127
Neuroscience 2023 May 1;517:117-127
Role of nuclear factor of activated T Cells-1 in Sepsis-induced behavioral deficits in mice.
Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y, Shi H
Brain research 2023 May 1;1806:148299
Brain research 2023 May 1;1806:148299
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Fan HX, Sheng S, Li DD, Li JJ, Wang GQ, Zhang F
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Lysosomal control of senescence and inflammation through cholesterol partitioning.
Roh K, Noh J, Kim Y, Jang Y, Kim J, Choi H, Lee Y, Ji M, Kang D, Kim MS, Paik MJ, Chung J, Kim JH, Kang C
Nature metabolism 2023 Mar;5(3):398-413
Nature metabolism 2023 Mar;5(3):398-413
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
Li J, Wang G, Zhang Y, Fan X, Yao M
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury.
Zhou Z, Shang L, Zhang Q, Hu X, Huang JF, Xiong K
Biochimica et biophysica acta. Molecular cell research 2023 Mar;1870(3):119433
Biochimica et biophysica acta. Molecular cell research 2023 Mar;1870(3):119433
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Guan X, Shen S, Liu J, Song H, Chang J, Mao X, Song J, Zhang L, Liu C
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia.
Luo D, Ye W, Chen L, Yuan X, Zhang Y, Chen C, Jin X, Zhou Y
Biomedicines 2023 Mar 21;11(3)
Biomedicines 2023 Mar 21;11(3)
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-κB/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages.
Wu H, Lin T, Chen Y, Chen F, Zhang S, Pang H, Huang L, Yu C, Wang G, Wu C
Molecules (Basel, Switzerland) 2023 Mar 20;28(6)
Molecules (Basel, Switzerland) 2023 Mar 20;28(6)
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.
Han S, He Z, Hu X, Li X, Zheng K, Huang Y, Xiao P, Xie Q, Ni J, Liu Q
Antioxidants (Basel, Switzerland) 2023 Mar 15;12(3)
Antioxidants (Basel, Switzerland) 2023 Mar 15;12(3)
Metformin Attenuates the Inflammatory Response via the Regulation of Synovial M1 Macrophage in Osteoarthritis.
Zheng M, Zhu Y, Wei K, Pu H, Peng R, Xiao J, Liu C, Sun X
International journal of molecular sciences 2023 Mar 10;24(6)
International journal of molecular sciences 2023 Mar 10;24(6)
Novel long non-coding RNAs associated with inflammation and macrophage activation in human.
Chini A, Guha P, Malladi VS, Guo Z, Mandal SS
Scientific reports 2023 Mar 10;13(1):4036
Scientific reports 2023 Mar 10;13(1):4036
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.
Xu W, Yang T, Lou X, Chen J, Wang X, Hu M, An D, Gao R, Wang J, Chen X
ACS chemical neuroscience 2023 Mar 1;14(5):864-874
ACS chemical neuroscience 2023 Mar 1;14(5):864-874
The expression of cyclic GMP-AMP synthase in human apical periodontitis: A laboratory investigation.
Yang F, Liu L, Wang L, Ji X, Zeng Y, Du J, Zhang L, Huang D
International endodontic journal 2023 Jun;56(6):710-721
International endodontic journal 2023 Jun;56(6):710-721
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
He W, Duan L, Zhang L
Korean circulation journal 2023 Jun;53(6):387-403
Korean circulation journal 2023 Jun;53(6):387-403
microRNA-149-5p mediates the PM(2.5)-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.
Li Q, Li S, Xu C, Zhao J, Hou L, Jiang F, Zhu Z, Wang Y, Tian L
Cell biology and toxicology 2023 Jun;39(3):703-717
Cell biology and toxicology 2023 Jun;39(3):703-717
Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency.
Zhang W, Chen H, Ding L, Huang J, Zhang M, Liu Y, Ma R, Zheng S, Gong J, Piña-Crespo JC, Zhang Y
Exploration (Beijing, China) 2023 Jun;3(3):20220160
Exploration (Beijing, China) 2023 Jun;3(3):20220160
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Wang HL, Cheng YC, Yeh TH, Liu HF, Weng YH, Chen RS, Chen YC, Lu JC, Hwang TL, Wei KC, Liu YC, Wang YT, Hsu CC, Chiu TJ, Chiu CC
Biochemical pharmacology 2023 Jun;212:115524
Biochemical pharmacology 2023 Jun;212:115524
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.
Chen WJ, Zhuang Y, Peng W, Cui W, Zhang SJ, Wang JW
Chinese medicine 2023 Jun 29;18(1):80
Chinese medicine 2023 Jun 29;18(1):80
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Deng CM, Zhang GG, Liu QW, Xu JJ, Liu ZC, Yang J, Xu TY, Li ZG, Zhang F, Li B
Cancer research 2023 Jun 2;83(11):1851-1865
Cancer research 2023 Jun 2;83(11):1851-1865
Gastroprotective Effects of the Aqueous Extract of Finger Citron Pickled Products against Ethanol-Induced Gastric Damage: In Vitro and In Vivo Studies.
Chen X, Yang D, Wang Q, Zhou A
Foods (Basel, Switzerland) 2023 Jun 13;12(12)
Foods (Basel, Switzerland) 2023 Jun 13;12(12)
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.
Yang X, Ou Y, Yang Y, Wang L, Zhang Y, Zhao F, Shui P, Qing J
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Liu M, Liu R, Yang M, Ba Y, Deng Q, Zhang Y, Han L, Gao L, Huang H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113857
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113857
Stigmasterol Protects Against Steatohepatitis Induced by High-Fat and High-Cholesterol Diet in Mice by Enhancing the Alternative Bile Acid Synthesis Pathway.
Xin Y, Li X, Zhu X, Lin X, Luo M, Xiao Y, Ruan Y, Guo H
The Journal of nutrition 2023 Jul;153(7):1903-1914
The Journal of nutrition 2023 Jul;153(7):1903-1914
Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis.
Yuan X, Li L, Zhang Y, Ai R, Li D, Dou Y, Hou M, Zhao D, Zhao S, Nan Y
Lipids in health and disease 2023 Jul 8;22(1):99
Lipids in health and disease 2023 Jul 8;22(1):99
Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy.
Bao J, Gao W, Zhang W, Wang D, Pan H
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Journal of orthopaedic surgery and research 2023 Jul 6;18(1):485
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Zhou W, Wang C, Zhang B, Gou S
European journal of pharmacology 2023 Jul 5;950:175751
European journal of pharmacology 2023 Jul 5;950:175751
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Liu J, Cao C, Jin Y, Wang Y, Ma X, Li J, Guo S, Yang J, Niu J, Liang X
iScience 2023 Jul 21;26(7):107022
iScience 2023 Jul 21;26(7):107022
SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway.
Fan M, Chen Z, Shao W, Chen Y, Lin Z, Yi C, Li Y, Lu L, Zhou Y, Lin J
Acta biochimica et biophysica Sinica 2023 Jul 11;55(9):1479-1486
Acta biochimica et biophysica Sinica 2023 Jul 11;55(9):1479-1486
NF-κB pathway affects silica nanoparticle-induced fibrosis via inhibited inflammatory response and epithelial-mesenchymal transition in 3D co-culture.
Yang X, Zhang J, Xiong M, Yang Y, Yang P, Li N, Shi F, Zhu Y, Guo K, Jin Y
Toxicology letters 2023 Jul 1;383:141-151
Toxicology letters 2023 Jul 1;383:141-151
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Wang CQ, Su Z, Dai CG, Song JL, Qian B
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model.
Gao F, Chen R, Li S, Li A, Bai B, Mi R, Xue G
Brain research 2023 Jul 1;1810:148382
Brain research 2023 Jul 1;1810:148382
Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.
Feng Y, Yang L, Ma X, Huang Z, Zong X, Citadin CT, Lin HW, Zhang Q
Neurochemistry international 2023 Jan;162:105464
Neurochemistry international 2023 Jan;162:105464
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation.
Mu G, Ren C, Zhang Y, Lu B, Feng J, Wu D, Xu X, Ou C
International immunopharmacology 2023 Jan;114:109544
International immunopharmacology 2023 Jan;114:109544
Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.
Cheng D, Qin ZS, Zheng Y, Xie JY, Liang SS, Zhang JL, Feng YB, Zhang ZJ
Brain, behavior, and immunity 2023 Jan;107:305-318
Brain, behavior, and immunity 2023 Jan;107:305-318
Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.
Wei J, Zhang J, Jiang Y, Lian T, Zhang P, Hoffman RM, Zhu G, Zhuang Z
In vivo (Athens, Greece) 2023 Jan-Feb;37(1):79-87
In vivo (Athens, Greece) 2023 Jan-Feb;37(1):79-87
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Tang L, Mei X, Ye M, Liu Y, Huang Y, Yu J, Zhang L, Zhuge S, Jiang G, Zhu J
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Liu H, Yu L, Ding Y, Peng M, Deng Y
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway.
Zhang JW, Zhang D, Yin HS, Zhang H, Hong KQ, Yuan JP, Yu BP
Gut microbes 2023 Jan-Dec;15(1):2197836
Gut microbes 2023 Jan-Dec;15(1):2197836
Role of NF-κB in lead exposure-induced activation of astrocytes based on bioinformatics analysis of hippocampal proteomics.
Fan S, Weixuan W, Han H, Liansheng Z, Gang L, Jierui W, Yanshu Z
Chemico-biological interactions 2023 Jan 25;370:110310
Chemico-biological interactions 2023 Jan 25;370:110310
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Wang F, Zhan Y, Li M, Wang L, Zheng A, Liu C, Wang H, Wang T
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
The combined effect of deoxynivalenol and Fumonisin B(1) on small intestinal inflammation mediated by pyroptosis in vivo and in vitro.
Mao X, Zhang P, Du H, Ge L, Liu S, Huang K, Chen X
Toxicology letters 2023 Jan 1;372:25-35
Toxicology letters 2023 Jan 1;372:25-35
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Tao H, Zhao H, Mo A, Shao L, Ge D, Liu J, Hu W, Xu K, Ma Q, Wang W, Wang W, Cao H, Mu M, Tao X, Wang J
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
Yan M, Jin H, Pan C, Han X
Molecular neurobiology 2023 Feb;60(2):884-900
Molecular neurobiology 2023 Feb;60(2):884-900
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway.
Hu H, Lu X, Huang L, He Y, Liu X, Wang Y, Duan C
Metabolic brain disease 2023 Feb;38(2):699-708
Metabolic brain disease 2023 Feb;38(2):699-708
Taurine alleviates ochratoxin A-induced pyroptosis in PK-15 cells by inhibiting oxidative stress.
Qu J, Liu K, Liu S, Yue D, Zhang P, Mao X, He W, Huang K, Chen X
Journal of biochemical and molecular toxicology 2023 Feb;37(2):e23249
Journal of biochemical and molecular toxicology 2023 Feb;37(2):e23249
Atractylodin targets GLA to regulate D-mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification.
Qu L, Wang C, Xu H, Li L, Liu Y, Wan Q, Xu K
Phytotherapy research : PTR 2023 Feb;37(2):477-489
Phytotherapy research : PTR 2023 Feb;37(2):477-489
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
Zou X, Liao Y, Liu Z, Xu X, Sun W, Qin H, Wang H, Liu J, Jing T
Journal of cardiovascular translational research 2023 Feb;16(1):112-126
Journal of cardiovascular translational research 2023 Feb;16(1):112-126
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
Xu C, Jiang Y, Wang H, Zhang Y, Ye Y, Qin H, Gao J, Dan Q, Du L, Liu L, Peng F, Li Y, Tu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(4):e2204881
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(4):e2204881
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury.
Yang Y, Wang N, Xu L, Liu Y, Huang L, Gu M, Wu Y, Guo W, Sun H
Cell death & disease 2023 Feb 8;14(2):92
Cell death & disease 2023 Feb 8;14(2):92
A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis.
Li Y, Jin T, Liu N, Wang J, Qin Z, Yin S, Zhang Y, Fu Z, Wu Y, Wang Y, Liu Y, Yang M, Pang A, Sun J, Wang Y, Yang X
Journal of neuroinflammation 2023 Feb 28;20(1):53
Journal of neuroinflammation 2023 Feb 28;20(1):53
Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus Infection In Vitro.
Yu H, Li JR, Xiao HY, Cao SK, Chen B, Li N, Chen G, Huang GH
mBio 2023 Feb 28;14(1):e0311922
mBio 2023 Feb 28;14(1):e0311922
Extracellular vesicles released from macrophages modulates interleukin-1β in astrocytic and neuronal cells.
Kodidela S, Sinha N, Kumar A, Zhou L, Godse S, Kumar S
Scientific reports 2023 Feb 21;13(1):3005
Scientific reports 2023 Feb 21;13(1):3005
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Wang T, Yu M, Li H, Qin S, Ren W, Ma Y, Bo W, Xi Y, Cai M, Tian Z
International journal of molecular sciences 2023 Feb 19;24(4)
International journal of molecular sciences 2023 Feb 19;24(4)
Adrenomedullin Improves Hypertension and Vascular Remodeling partly through the Receptor-Mediated AMPK Pathway in Rats with Obesity-Related Hypertension.
Wang HY, Wang FZ, Chang R, Wang Q, Liu SY, Cheng ZX, Gao Q, Zhou H, Zhou YB
International journal of molecular sciences 2023 Feb 15;24(4)
International journal of molecular sciences 2023 Feb 15;24(4)
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
Yu H, Yu Q, Mi Y, Wang P, Jin S, Xiao L, Guo Q, Wu Y
Biomedicines 2023 Feb 15;11(2)
Biomedicines 2023 Feb 15;11(2)
Exosomal RBP4 potentiated hepatic lipid accumulation and inflammation in high-fat-diet-fed mice by promoting M1 polarization of Kupffer cells.
Yao JM, Ying HZ, Zhang HH, Qiu FS, Wu JQ, Yu CH
Free radical biology & medicine 2023 Feb 1;195:58-73
Free radical biology & medicine 2023 Feb 1;195:58-73
Multilayer amnion-PCL nanofibrous membrane loaded with celecoxib exerts a therapeutic effect against tendon adhesion by improving the inflammatory microenvironment.
Liu C, Zhang X, Zhao L, Hui L, Liu D
Heliyon 2023 Dec;9(12):e23214
Heliyon 2023 Dec;9(12):e23214
LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3/AMPKα.
Luo M, Peng Y, Lv D, Xue Y, Huang L, Hu Y, Zhu W, Luo S, Shen J, Li X
Heliyon 2023 Dec;9(12):e22939
Heliyon 2023 Dec;9(12):e22939
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia.
Wang M, Zhang F, Ning X, Wu C, Zhou Y, Gou Z, Fan Y, Duan R, Li Z, Shao C, Lu L
Inflammation 2023 Dec;46(6):2386-2401
Inflammation 2023 Dec;46(6):2386-2401
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Tang L, Zhang D, Zhang Y, Peng Y, Li M, Song H, Chen H, Li W, Li X
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1618-1627
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1618-1627
Vitamin D/Vitamin D receptor mitigates cisplatin-induced acute kidney injury by down-regulating C5aR.
Wen Z, Sun C, Lou Y, Kong J
Journal of immunotoxicology 2023 Dec;20(1):2248267
Journal of immunotoxicology 2023 Dec;20(1):2248267
Resveratrol and its analogs suppress HIV replication, oxidative stress, and inflammation in macrophages.
Kumar S, Sinha N, Kodidela S, Godse S, Singla B, Singh UP, Bhat HK
NeuroImmune pharmacology and therapeutics 2023 Dec;2(4):365-374
NeuroImmune pharmacology and therapeutics 2023 Dec;2(4):365-374
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Zhong B, Sun S, Tan KS, Ong HH, Du J, Liu F, Liu Y, Liu S, Ba L, Li J, Wang Y, Liu J
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition.
Jiang X, Yu G, Zhu L, Siddique A, Zhan D, Zhou L, Yue M
Virulence 2023 Dec;14(1):2249779
Virulence 2023 Dec;14(1):2249779
The E3 ubiquitin ligase RNF31 mediates the development of ulcerative colitis by regulating NLRP3 inflammasome activation.
Wang P, Tang CT, Li J, Huang X, Jin R, Yin F, Liu Z, Chen Y, Zeng C
International immunopharmacology 2023 Dec;125(Pt B):111194
International immunopharmacology 2023 Dec;125(Pt B):111194
Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome.
Zhou J, Wang C, Zhang X, Wu Z, Wu Y, Li D, Gao J
Journal of ethnopharmacology 2023 Dec 5;317:116777
Journal of ethnopharmacology 2023 Dec 5;317:116777
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Kharazinejad E, Hassanzadeh G, Sahebkar A, Yousefi B, Reza Sameni H, Majidpoor J, Golchini E, Taghdiri Nooshabadi V, Mousavi M
Neuroscience 2023 Dec 15;535:1-12
Neuroscience 2023 Dec 15;535:1-12
Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice.
Sun QY, Wang XY, Huang ZP, Song J, Zheng ED, Gong FH, Huang XW
World journal of diabetes 2023 Dec 15;14(12):1824-1838
World journal of diabetes 2023 Dec 15;14(12):1824-1838
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
He X, Liu J, Jiang K, Lian S, Shi Y, Fu S, Zhao P, Xiao J, Sun D, Guo D
Anaerobe 2023 Aug;82:102768
Anaerobe 2023 Aug;82:102768
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
He JY, Li DD, Wen Q, Qin TY, Long H, Zhang SB, Zhang F
CNS neuroscience & therapeutics 2023 Aug;29(8):2281-2291
CNS neuroscience & therapeutics 2023 Aug;29(8):2281-2291
M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.
Sun J, Ju F, Jin J, Wang HL, Li ZJ, Sun YC, Chen QZ, Yang QQ, Tan J, Zhou YL
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(33):e2300326
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(33):e2300326
MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia.
Feng DD, Chen JH, Chen YF, Cao Q, Li BJ, Chen XQ, Jin R, Zhou GP
Molecular immunology 2023 Aug;160:67-79
Molecular immunology 2023 Aug;160:67-79
Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.
Li M, Wang C, Xu WT, Zhong X
Molecular immunology 2023 Aug;160:103-111
Molecular immunology 2023 Aug;160:103-111
Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response.
Godse S, Zhou L, Sinha N, Kodidela S, Kumar A, Singh UP, Kumar S
Research square 2023 Aug 9;
Research square 2023 Aug 9;
Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine.
Zhao T, Zhang Y, Liu L, Deng X, Guo J, Cao S, Zhu D, Xu J, Nikolaevna UV, Maratbek S, Wang Z, Sun Z, Gu X, Zhang H
ACS omega 2023 Aug 8;8(31):28797-28812
ACS omega 2023 Aug 8;8(31):28797-28812
Berberine-loaded MSC-derived sEVs encapsulated in injectable GelMA hydrogel for spinal cord injury repair.
Wang H, Tang Q, Lu Y, Chen C, Zhao YL, Xu T, Yang CW, Chen XQ
International journal of pharmaceutics 2023 Aug 25;643:123283
International journal of pharmaceutics 2023 Aug 25;643:123283
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
Hou B, Li D, Wang D, Jiang C, Wang G, Wang D, Yan G, Guo X, Zhao L, Wan Z, Fan C, Cao W, Ren H
Neuroscience 2023 Aug 21;526:74-84
Neuroscience 2023 Aug 21;526:74-84
Transcriptomics Reveals Molecular Features of the Bilateral Pelvic Nerve Injury Rat Model of Detrusor Underactivity.
Wang J, Ren L, Liu X, Xu W, Liu M, Hu P, Wang T, Liu J, Ling Q
Biomolecules 2023 Aug 18;13(8)
Biomolecules 2023 Aug 18;13(8)
Purple Yam Polyphenol Extracts Exert Anticolitis and Anticolitis-Associated Colorectal Cancer Effects through Inactivation of NF-κB/p65 and STAT3 Signaling Pathways.
Yang X, Wang Q, Zhang X, Li L, Cao X, Zhou L, Huang Y, Sun G, Chen Y
Journal of agricultural and food chemistry 2023 Aug 16;71(32):12177-12189
Journal of agricultural and food chemistry 2023 Aug 16;71(32):12177-12189
Repairing gastric ulcer with hyaluronic acid/extracellular matrix composite through promoting M2-type polarization of macrophages.
Ni R, Luo Y, Jiang L, Mao X, Feng Y, Tuersun S, Hu Z, Zhu Y
International journal of biological macromolecules 2023 Aug 1;245:125556
International journal of biological macromolecules 2023 Aug 1;245:125556
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.
Zhang F, Ke C, Zhou Z, Xu K, Wang Y, Liu Y, Tu J
Planta medica 2023 Apr;89(5):493-507
Planta medica 2023 Apr;89(5):493-507
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
An D, Qi X, Li K, Xu W, Wang Y, Chen X, Sha S, Wu C, Du Y, Chen L
Cellular and molecular neurobiology 2023 Apr;43(3):1283-1300
Cellular and molecular neurobiology 2023 Apr;43(3):1283-1300
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
Amelioration of nerve demyelination by hydrogen-producing silicon-based agent in neuropathic pain rats.
Mu G, Li Q, Lu B, Yu X
International immunopharmacology 2023 Apr;117:110033
International immunopharmacology 2023 Apr;117:110033
Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis.
Wang W, Zhao B, Gao W, Song W, Hou J, Zhang L, Xia Z
ACS chemical neuroscience 2023 Apr 5;14(7):1249-1260
ACS chemical neuroscience 2023 Apr 5;14(7):1249-1260
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway.
Wang M, Zhang F, Zhou J, Gong K, Chen S, Zhu X, Zhang M, Duan Y, Liao C, Han J, Yin Z
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability.
Wu T, Zhang X, Liu X, Cai X, Shen T, Pan D, Liang R, Ding R, Hu R, Dong J, Li F, Li J, Xie L, Wang C, Geng S, Yang Z, Xing L, Li Y
BMC medicine 2023 Apr 27;21(1):161
BMC medicine 2023 Apr 27;21(1):161
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, Xi Y, Sun L, He L, Tang C, Sun L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
PM(2.5) induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway.
Jia R, Wei M, Lei J, Meng X, Du R, Yang M, Lu X, Jiang Y, Cao R, Wang L, Song L
Ecotoxicology and environmental safety 2023 Apr 1;254:114699
Ecotoxicology and environmental safety 2023 Apr 1;254:114699
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Chen Z, Tang Z, Kong J, Chen L, Liu J, Li Y, Huang W, Li W, Wu J, Zhao W, Meng X, Fan H
Frontiers in nutrition 2022;9:914323
Frontiers in nutrition 2022;9:914323
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Liu Y, Wei Y, Wu L, Lin X, Sun R, Chen H, Shen S, Deng G
Frontiers in nutrition 2022;9:839174
Frontiers in nutrition 2022;9:839174
Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking.
Ding J, Wu J, Wei H, Li S, Huang M, Wang Y, Fang Q
Frontiers in cardiovascular medicine 2022;9:804801
Frontiers in cardiovascular medicine 2022;9:804801
Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing.
Gong X, Liu L, Li X, Xiong J, Xu J, Mao D, Liu L
Frontiers in nutrition 2022;9:1028459
Frontiers in nutrition 2022;9:1028459
Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease.
Ma X, Zhang Y, Gou D, Ma J, Du J, Wang C, Li S, Cui H
Journal of Alzheimer's disease : JAD 2022;88(2):771-785
Journal of Alzheimer's disease : JAD 2022;88(2):771-785
Transfer of Tumor-Bearing Mice Intestinal Flora Can Ameliorate Cognition in Alzheimer's Disease Mice.
Hang Z, Cai S, Lei T, Zhang X, Xiao Z, Wang D, Li Y, Bi W, Yang Y, Deng S, Wang L, Li Q, Du H
Journal of Alzheimer's disease : JAD 2022;86(3):1287-1300
Journal of Alzheimer's disease : JAD 2022;86(3):1287-1300
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-[Formula: see text]B Signaling Pathway.
Huang ZW, Tan P, Yi XK, Chen H, Sun B, Shi H, Mou ZQ, Cheng YL, Li TX, Li Q, Fu WG
The American journal of Chinese medicine 2022;50(8):2185-2197
The American journal of Chinese medicine 2022;50(8):2185-2197
Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites.
Qu L, Liu C, Ke C, Zhan X, Li L, Xu H, Xu K, Liu Y
The American journal of Chinese medicine 2022;50(2):525-552
The American journal of Chinese medicine 2022;50(2):525-552
HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation.
Chang Y, Wu Y, Jiang X, Zhu J, Wang C, Ma R, Li G
Oxidative medicine and cellular longevity 2022;2022:9251835
Oxidative medicine and cellular longevity 2022;2022:9251835
ETC-1002 Attenuates Porphyromonas gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-κB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice.
Li H, Zhang P, Lin H, Gao H, Yin J
Disease markers 2022;2022:8583674
Disease markers 2022;2022:8583674
OPN Promotes Cell Proliferation and Invasion through NF-κB in Human Esophageal Squamous Cell Carcinoma.
Chen B, Liang S, Guo H, Xu L, Li J, Peng J
Genetics research 2022;2022:3154827
Genetics research 2022;2022:3154827
Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-α/TRAF6 Axis in Mice Affected by Breast-Cancer-Related Depression.
Zhu Q, Meng P, Han Y, Yang H, Yang Q, Liu Z, Wang Y, Long M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2715325
Enriched Environment-Induced Neuroprotection against Cerebral Ischemia-Reperfusion Injury Might Be Mediated via Enhancing Autophagy Flux and Mitophagy Flux.
Zhang QQ, Luo L, Liu MX, Wang CJ, Wu Y, Yu KW
Mediators of inflammation 2022;2022:2396487
Mediators of inflammation 2022;2022:2396487
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats.
Fan R, Dai F, Zhang C, Zhou L, Qiu X, Li Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2112359
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2112359
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.
Bai L, Dai J, Xia Y, He K, Xue H, Guo Q, Tian D, Xiao L, Zhang X, Teng X, Wu Y, Jin S
Oxidative medicine and cellular longevity 2022;2022:1392896
Oxidative medicine and cellular longevity 2022;2022:1392896
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury.
Qin X, Zhou Y, Jia C, Chao Z, Qin H, Liang J, Liu X, Liu Z, Sun T, Yuan Y, Zhang H
International journal of biological sciences 2022;18(4):1521-1538
International journal of biological sciences 2022;18(4):1521-1538
Supplementation with dietary omega-3 PUFA mitigates fetal brain inflammation and mitochondrial damage caused by high doses of sodium nitrite in maternal rats.
Sun J, Zhang W
PloS one 2022;17(3):e0266084
PloS one 2022;17(3):e0266084
Effect of benzo(a)pyrene on oxidative stress and inflammatory mediators in astrocytes and HIV-infected macrophages.
Kumar A, Sinha N, Kodidela S, Zhou L, Singh UP, Kumar S
PloS one 2022;17(10):e0275874
PloS one 2022;17(10):e0275874
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Hu Y, Tang W, Liu W, Hu Z, Pan C
Drug design, development and therapy 2022;16:1605-1620
Drug design, development and therapy 2022;16:1605-1620
Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis.
Zhu J, Chen H, Guo J, Zha C, Lu D
Journal of inflammation research 2022;15:6293-6306
Journal of inflammation research 2022;15:6293-6306
Yishen Capsule Alleviated Symptoms of Diabetic Nephropathy via NOD-like Receptor Signaling Pathway.
Zhang Z, Hu Y, Liu W, Zhang X, Wang R, Li H, Sun D, Fang J
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:2183-2195
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:2183-2195
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26
Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
He K, Zhang J, Zhang W, Wang S, Li D, Ma X, Wu X, Chai X, Liu Q
Frontiers in aging neuroscience 2022;14:772066
Frontiers in aging neuroscience 2022;14:772066
Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α-Syn and tau fragments.
Yang X, Wang J, Zeng W, Zhang X, Yang X, Xu Y, Xu Y, Cao X
Frontiers in aging neuroscience 2022;14:1049418
Frontiers in aging neuroscience 2022;14:1049418
The role of APTX4870 peptide in reducing cellular inflammatory responses by inhibiting Mycobacterium tuberculosis-derived mycolic acid-induced cytotoxicity.
Lin X, Jia W, Feng G, Su Y, Kang Y, Zhang C, Liu W, Lu Z, Xue D
Frontiers in microbiology 2022;13:993897
Frontiers in microbiology 2022;13:993897
The Assessment on Synergistic Activity of Ebselen and Silver Ion Against Yersinia pseudotuberculosis.
Dong C, Chen W, Zou L, Liu B, Deng K, Guo D, Wang P, Chen H, Wang H, Wang J
Frontiers in microbiology 2022;13:963901
Frontiers in microbiology 2022;13:963901
Tongluo Yishen Decoction Ameliorates Renal Fibrosis via NLRP3-Mediated Pyroptosis In Vivo and In Vitro.
Jia Q, Zhang X, Hao G, Zhao Y, Lowe S, Han L, Qin J
Frontiers in pharmacology 2022;13:936853
Frontiers in pharmacology 2022;13:936853
Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β.
Yang G, Chen J, He Y, Luo H, Yuan H, Chen L, Huang L, Mao F, Hu S, Qian Y, Miao C, Feng R
Frontiers in immunology 2022;13:925702
Frontiers in immunology 2022;13:925702
Oridonin Delays Aging Through the AKT Signaling Pathway.
An Y, Zhu J, Wang X, Sun X, Luo C, Zhang Y, Ye Y, Li X, Abulizi A, Huang Z, Zhang H, Yang B, Xie Z
Frontiers in pharmacology 2022;13:888247
Frontiers in pharmacology 2022;13:888247
AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFκB-p65 Pathway Following Intracerebral Hemorrhage.
Deng S, Chen X, Lei Q, Lu W
Frontiers in immunology 2022;13:847360
Frontiers in immunology 2022;13:847360
Neutrophil Extracellular Traps Regulate HMGB1 Translocation and Kupffer Cell M1 Polarization During Acute Liver Transplantation Rejection.
Liu Y, Pu X, Qin X, Gong J, Huang Z, Luo Y, Mou T, Zhou B, Shen A, Wu Z
Frontiers in immunology 2022;13:823511
Frontiers in immunology 2022;13:823511
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
Chai Y, Cai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in pharmacology 2022;13:812362
Frontiers in pharmacology 2022;13:812362
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.
Wu K, Liu X, Meng X, Cao L, Li H, Bi Y, Wang M, Wang M, Jiang Y
Frontiers in microbiology 2022;13:1084257
Frontiers in microbiology 2022;13:1084257
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Frontiers in immunology 2022;13:1062225
Frontiers in immunology 2022;13:1062225
Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p.
Song JJ, Li H, Wang N, Zhou XY, Liu Y, Zhang Z, Feng Q, Chen YL, Liu D, Liang J, Ma XY, Wen XR, Fu YY
Frontiers in pharmacology 2022;13:1044375
Frontiers in pharmacology 2022;13:1044375
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Wang J, Yang X, Zeng W, Zhang X, Yang X, Xu Y, Liu K, Zhang Z, Xu Y, Cao X
Journal of Parkinson's disease 2022;12(7):2097-2116
Journal of Parkinson's disease 2022;12(7):2097-2116
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Yu J, Tang R, Li J
Frontiers in oncology 2022;12:991165
Frontiers in oncology 2022;12:991165
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Wang FF, Zhao PY, He XJ, Jiang K, Wang TS, Xiao JW, Sun DB, Guo DH
Frontiers in cellular and infection microbiology 2022;12:827750
Frontiers in cellular and infection microbiology 2022;12:827750
Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases.
Zhang Y, Li Y, Zhou L, Yuan X, Wang Y, Deng Q, Deng Z, Xu S, Wang Q, Xie H, Li J
Redox biology 2022 Sep;55:102427
Redox biology 2022 Sep;55:102427
NLRP3 inflammasome contributes to endothelial dysfunction in angiotensin II-induced hypertension in mice.
Li X, Zhang Z, Luo M, Cheng Z, Wang R, Liu Q, Lv D, Yan J, Shang F, Luo S, Xia Y
Microvascular research 2022 Sep;143:104384
Microvascular research 2022 Sep;143:104384
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Long Q, Li L, Yang H, Lu Y, Yang H, Zhu Y, Tang Y, Liu C, Yuan J
International immunopharmacology 2022 Sep;110:109024
International immunopharmacology 2022 Sep;110:109024
Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation.
Zhu H, Zhang L, Jia H, Xu L, Cao Y, Zhai M, Li K, Xia L, Jiang L, Li X, Zhou Y, Liu J, Yu S, Duan W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154283
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154283
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Khodayari N, Oshins R, Mehrad B, Lascano JE, Qiang X, West JR, Holliday LS, Lee J, Wiesemann G, Eydgahi S, Brantly M
Respiratory research 2022 Sep 6;23(1):232
Respiratory research 2022 Sep 6;23(1):232
Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury.
Cai X, Hua S, Deng J, Du Z, Zhang D, Liu Z, Khan NU, Zhou M, Chen Z
ACS applied materials & interfaces 2022 Sep 28;14(38):42887-42903
ACS applied materials & interfaces 2022 Sep 28;14(38):42887-42903
Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation.
Hu S, Shen P, Chen B, Tian SW, You Y
Neuroscience letters 2022 Sep 25;788:136850
Neuroscience letters 2022 Sep 25;788:136850
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286
Journal of food biochemistry 2022 Oct;46(10):e14286
Effects of intraperitoneal injection of lipopolysaccharide-induced peripheral inflammation on dopamine neuron damage in rat midbrain.
Yang QY, Li XW, Yang R, Qin TY, Long H, Zhang SB, Zhang F
CNS neuroscience & therapeutics 2022 Oct;28(10):1624-1636
CNS neuroscience & therapeutics 2022 Oct;28(10):1624-1636
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Bisdemethoxycurcumin Alleviates Dextran Sodium Sulfate-Induced Colitis via Inhibiting NLRP3 Inflammasome Activation and Modulating the Gut Microbiota in Mice.
Zhang J, Li Q, Zhang X, Chen Y, Lu Y, Wang X, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 7;11(10)
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
Wang X, Li Q, He S, Bai J, Ma C, Zhang L, Guan X, Yuan H, Li Y, Zhu X, Mei J, Gao F, Zhu D
Molecular medicine (Cambridge, Mass.) 2022 Oct 25;28(1):126
Molecular medicine (Cambridge, Mass.) 2022 Oct 25;28(1):126
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Zhong X, Chen Z, Wang Y, Mao M, Deng Y, Shi M, Xu Y, Chen L, Cao W
Brain research bulletin 2022 Oct 15;189:174-183
Brain research bulletin 2022 Oct 15;189:174-183
Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation.
Zhou Z, Ying C, Zhou X, Shi Y, Xu J, Zhu Y, Wang M, Li Y, Li X, Xiang J
Experimental gerontology 2022 Oct 15;168:111934
Experimental gerontology 2022 Oct 15;168:111934
Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia.
Zhou W, Wang C, Liu Z, Gou S
Journal of medicinal chemistry 2022 Oct 13;65(19):13436-13451
Journal of medicinal chemistry 2022 Oct 13;65(19):13436-13451
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis.
Chen L, Liu D, Mao M, Liu W, Wang Y, Liang Y, Cao W, Zhong X
Molecular nutrition & food research 2022 Nov;66(22):e2200341
Molecular nutrition & food research 2022 Nov;66(22):e2200341
Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function.
Zhang YW, Cao MM, Li YJ, Lu PP, Dai GC, Zhang M, Wang H, Rui YF
Journal of orthopaedic translation 2022 Nov;37:46-60
Journal of orthopaedic translation 2022 Nov;37:46-60
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling.
Wu P, Wu X, Zhou G, Wang Y, Liu X, Lv R, Liu Y, Wen Q
Pain physician 2022 Nov;25(8):E1199-E1210
Pain physician 2022 Nov;25(8):E1199-E1210
Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice.
Zhou Z, Wang M, Huang C, Li Y, Gao L, Zhu Y, Ying C, Zhou X
Brain research bulletin 2022 Nov;190:84-96
Brain research bulletin 2022 Nov;190:84-96
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Yi Y, Yang N, Yang Z, Tao X, Li Y
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury.
Wang N, Yang Y, Liu Y, Huang L, Gu M, Wu Y, Xu L, Sun H, Guo W
International immunopharmacology 2022 Nov;112:109242
International immunopharmacology 2022 Nov;112:109242
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice.
Zhao W, Xu D, Hong W, Zhang L, Wu Q, Gao M, Wang J
International immunopharmacology 2022 Nov;112:109190
International immunopharmacology 2022 Nov;112:109190
Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2-Signal Transducer and Activator of Transcription 6 Pathway.
Wang J, Zhang G, Yang Y, Zhang X, Shi K, Zhang X, Yan T, Jia Y
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14157-14169
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14157-14169
Effect of Lactobacillus with Feruloyl Esterase-Producing Ability on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.
Shen D, Ma S, Li X, Lu Y
Journal of agricultural and food chemistry 2022 Nov 30;70(47):14817-14830
Journal of agricultural and food chemistry 2022 Nov 30;70(47):14817-14830
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
Xiao Q, Kang Z, Liu C, Tang B
Frontiers in bioscience (Landmark edition) 2022 Nov 3;27(11):300
Frontiers in bioscience (Landmark edition) 2022 Nov 3;27(11):300
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Fu HY, Xu JM, Ai X, Dang FT, Tan X, Yu HY, Feng J, Yang WX, Ma HT, Tu RF, Gupta AK, Manandhar LK, Bao WM, Tang YM
Cells 2022 Nov 26;11(23)
Cells 2022 Nov 26;11(23)
Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity.
Qu D, Ye Z, Zhang W, Dai B, Chen G, Wang L, Shao X, Xiang A, Lu Z, Shi J
ACS chemical neuroscience 2022 Nov 2;13(21):3023-3033
ACS chemical neuroscience 2022 Nov 2;13(21):3023-3033
linc00174 deteriorates the pathogenesis of diabetic retinopathy via miR-26a-5p/PTEN/Akt signalling cascade-mediated pyroptosis.
Wang JJ, Chen ZL, Wang DD, Wu KF, Huang WB, Zhang LQ
Biochemical and biophysical research communications 2022 Nov 19;630:92-100
Biochemical and biophysical research communications 2022 Nov 19;630:92-100
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L
Cells 2022 Nov 12;11(22)
Cells 2022 Nov 12;11(22)
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
Dai HB, Wang HY, Wang FZ, Qian P, Gao Q, Zhou H, Zhou YB
Acta diabetologica 2022 May;59(5):661-673
Acta diabetologica 2022 May;59(5):661-673
The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.
Chen L, Li Y, Zeng S, Duan S, Huang Z, Liang Y
In vitro cellular & developmental biology. Animal 2022 May;58(5):408-418
In vitro cellular & developmental biology. Animal 2022 May;58(5):408-418
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Yan K, Hu J, Hou T, Ci X, Peng L
Phytotherapy research : PTR 2022 May;36(5):2161-2172
Phytotherapy research : PTR 2022 May;36(5):2161-2172
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Gu J, Shi JZ, Wang YX, Liu L, Wang SB, Sun JT, Shan TK, Wang H, Wang QM, Wang LS
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
Xiong T, Zheng X, Zhang K, Wu H, Dong Y, Zhou F, Cheng B, Li L, Xu W, Su J, Huang J, Jiang Z, Li B, Zhang B, Lv G, Chen S
Journal of ethnopharmacology 2022 May 10;289:115001
Journal of ethnopharmacology 2022 May 10;289:115001
Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration.
Chen J, Zhu H, Zhu Y, Zhao C, Wang S, Zheng Y, Xie Z, Jin Y, Song H, Yang L, Zhang J, Dai J, Hu Z, Wang H
Bioactive materials 2022 Mar;9:29-43
Bioactive materials 2022 Mar;9:29-43
Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway.
Li G, Duan L, Yang F, Yang L, Deng Y, Yu Y, Xu Y, Zhang Y
Phytotherapy research : PTR 2022 Mar;36(3):1326-1337
Phytotherapy research : PTR 2022 Mar;36(3):1326-1337
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Luo J, Tan J, Jiang N, Yang C, Chen J, Zhao J, Li L, Zhao Y
Brain research bulletin 2022 Mar;180:12-23
Brain research bulletin 2022 Mar;180:12-23
Interleukin-4 activates the PI3K/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells.
Han Y, Yao R, Yang Z, Li S, Meng W, Zhang Y, Zhang Y, Luo H
Experimental cell research 2022 Mar 1;412(1):113002
Experimental cell research 2022 Mar 1;412(1):113002
Rescuing ischemic stroke by biomimetic nanovesicles through accelerated thrombolysis and sequential ischemia-reperfusion protection.
Yu W, Yin N, Yang Y, Xuan C, Liu X, Liu W, Zhang Z, Zhang K, Liu J, Shi J
Acta biomaterialia 2022 Mar 1;140:625-640
Acta biomaterialia 2022 Mar 1;140:625-640
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.
Xiao K, Shang J, Liu Y, Chen Z, Wang L, Long Q
Cutaneous and ocular toxicology 2022 Jun;41(2):107-112
Cutaneous and ocular toxicology 2022 Jun;41(2):107-112
Mild inflammation persists in the glenohumeral joint of patients with shoulder instability: Cross-sectional study.
Muneshige K, Kenmoku T, Uchida K, Arendt-Nielsen L, Tazawa R, Nakawaki M, Ishii D, Satoh M, Inoue G, Takaso M
Osteoarthritis and cartilage open 2022 Jun;4(2):100241
Osteoarthritis and cartilage open 2022 Jun;4(2):100241
Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets.
Wang Z, Liang M, Liu B, Yang L
Food science and biotechnology 2022 Jun;31(6):745-758
Food science and biotechnology 2022 Jun;31(6):745-758
Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4(+) T cells in chronic liver injury.
Zhang Y, Yang X, Bi T, Wu X, Wang L, Ren Y, Ou Y, Xie C, Li K, Ran H, Wang J, Zhao F, Shui P, Qing J
International immunopharmacology 2022 Jun;107:108639
International immunopharmacology 2022 Jun;107:108639
Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension.
Qian P, Wang Q, Wang FZ, Dai HB, Wang HY, Gao Q, Zhou H, Zhou YB
Pharmaceuticals (Basel, Switzerland) 2022 Jun 6;15(6)
Pharmaceuticals (Basel, Switzerland) 2022 Jun 6;15(6)
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).
Zhao S, Tan Y, Qin J, Xu H, Liu L, Wan H, Zhang C, Fan W, Qu S
Toxicology 2022 Jun 30;476:153252
Toxicology 2022 Jun 30;476:153252
Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling.
Li B, Ji Y, Yi C, Wang X, Liu C, Wang C, Lu X, Xu X, Wang X
Molecules (Basel, Switzerland) 2022 Jun 29;27(13)
Molecules (Basel, Switzerland) 2022 Jun 29;27(13)
L-Se-methylselenocysteine loaded mucoadhesive thermogel for effective treatment of Vulvar candidiasis.
Yang X, Wang M, Kang X, Mo F, Si P, Ma J, Zhang P, Zheng S, Li J, Wang Y, Li Q, Zhang J
International journal of pharmaceutics 2022 Jun 25;622:121851
International journal of pharmaceutics 2022 Jun 25;622:121851
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice.
Zhou P, Song NC, Zheng ZK, Li YQ, Li JS
BMC pulmonary medicine 2022 Jun 15;22(1):230
BMC pulmonary medicine 2022 Jun 15;22(1):230
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Yan S, Chen J, Zhu L, Guo T, Qin D, Hu Z, Han S, Zhou Y, Akan OD, Wang J, Luo F, Lin Q
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6429-6443
Role of salivary glycopatterns for oral microbiota associated with gastric cancer.
Shu J, Yu H, Ren X, Wang Y, Zhang K, Tang Z, Dang L, Chen W, Li B, Xie H, Li Z
International journal of biological macromolecules 2022 Jun 1;209(Pt A):1368-1378
International journal of biological macromolecules 2022 Jun 1;209(Pt A):1368-1378
Construction and comprehensive analysis of a lncRNA-mRNA interactive network to reveal a potential lncRNA for hepatic encephalopathy development.
Zhang C, Ni W, Zhu Y, Lin J, Li H, Zhao Z, Wang K, Huo H, Luo M
Human cell 2022 Jul;35(4):1060-1070
Human cell 2022 Jul;35(4):1060-1070
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Liu Y, Sun R, Lin X, Wu L, Chen H, Shen S, Li Y, Wei Y, Deng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus.
Li Y, Mao M, Zhu L, Sun Q, Tong J, Zhou Z
International immunopharmacology 2022 Jul;108:108898
International immunopharmacology 2022 Jul;108:108898
Reduced inhibition underlies early life LPS exposure induced-cognitive impairment: Prevention by environmental enrichment.
Wu XM, Ji MH, Yin XY, Gu HW, Zhu TT, Wang RZ, Yang JJ, Shen JC
International immunopharmacology 2022 Jul;108:108724
International immunopharmacology 2022 Jul;108:108724
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2.
Yang RC, Huang K, Zhang HP, Li L, Tan C, Chen HC, Jin ML, Wang XR
BMC neuroscience 2022 Jul 6;23(1):43
BMC neuroscience 2022 Jul 6;23(1):43
Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.
Yan B, Liu C, Wang S, Li H, Jiao J, Lee WSV, Zhang S, Hou Y, Hou Y, Ma X, Fan H, Lv Y, Liu X
Journal of materials chemistry. B 2022 Jul 20;10(28):5364-5374
Journal of materials chemistry. B 2022 Jul 20;10(28):5364-5374
Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells.
Mao X, Li H, Ge L, Liu S, Hou L, Yue D, Du H, Pan C, Gan F, Liu Y, Huang K, Chen X
Journal of biochemical and molecular toxicology 2022 Jan;36(1):e22933
Journal of biochemical and molecular toxicology 2022 Jan;36(1):e22933
Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression.
Itoh G, Takagane K, Fukushi Y, Kuriyama S, Umakoshi M, Goto A, Yanagihara K, Yashiro M, Tanaka M
Molecular oncology 2022 Jan;16(1):166-187
Molecular oncology 2022 Jan;16(1):166-187
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter.
Mu N, Wang H, Chen D, Wang F, Ji L, Zhang C, Li M, Lu P
Investigative ophthalmology & visual science 2022 Jan 3;63(1):39
Investigative ophthalmology & visual science 2022 Jan 3;63(1):39
Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats.
Liu J, Huang X, Zhou J, Li L, Xiao H, Qu M, Sun Z
Electromagnetic biology and medicine 2022 Jan 2;41(1):101-107
Electromagnetic biology and medicine 2022 Jan 2;41(1):101-107
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308
Translational neuroscience 2022 Jan 1;13(1):301-308
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
Wang L, Kong L, Xu S, Wang X, Huang K, Wang S, Wu J, Wang C, Sun H, Liu K, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153845
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153845
Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.
Ying C, Zhou Z, Dai J, Wang M, Xiang J, Sun D, Zhou X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Feb;71(2):191-204
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Feb;71(2):191-204
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response.
Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, Hara E
Nature aging 2022 Feb;2(2):115-124
Nature aging 2022 Feb;2(2):115-124
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Yong W, Zhao Y, Jiang X, Li P
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms.
Tan L, Chen Z, Sun F, Zhou Z, Zhang B, Wang B, Chen J, Li M, Xiao T, Neuman RI, Niu J, Verdonk K, Lu X, Zhang JV, Danser AHJ, Yang Q, Fan X
Clinical science (London, England : 1979) 2022 Feb 25;136(4):257-272
Clinical science (London, England : 1979) 2022 Feb 25;136(4):257-272
Mutant C/EBPα p30 alleviates immunosuppression of CD8(+) T cells by inhibiting autophagy-associated secretion of IL-1β in AML.
Wang JD, Xu JQ, Zhang XN, Huang ZW, Liu LL, Zhang L, Lei XX, Xue MJ, Weng JY, Long ZJ
Cell proliferation 2022 Dec;55(12):e13331
Cell proliferation 2022 Dec;55(12):e13331
Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics.
Luo P, Chen J, Zhang Q, Xia F, Wang C, Bai Y, Tang H, Liu D, Gu L, Du Q, Xiao W, Yang C, Wang J
Precision clinical medicine 2022 Dec;5(4):pbac023
Precision clinical medicine 2022 Dec;5(4):pbac023
Morin Inhibits Dox-Induced Vascular Inflammation By Regulating PTEN/AKT/NF-κB Pathway.
Yu J, Qi HL, Zhang H, Zhao ZY, Jing-Zhao, Nie ZY
Inflammation 2022 Dec;45(6):2406-2418
Inflammation 2022 Dec;45(6):2406-2418
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Guan G, Zhang Q, Jiang Z, Liu J, Wan J, Jin P, Lv Q
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
A novel Atlantic salmon (Salmo salar) bone collagen peptide delays osteoarthritis development by inhibiting cartilage matrix degradation and anti-inflammatory.
Luo X, Liu W, Zhao M, Liu T, Xiong F, Lei L, Jia F, Feng F
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt B):112148
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt B):112148
Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas.
Zhang H, Zhang N, Dai Z, Wang Z, Zhang X, Liang X, Zhang L, Feng S, Wu W, Ye W, Zhang J, Luo P, Liu Z, Cheng Q, Liu Z
Molecular oncology 2022 Dec;16(22):3927-3948
Molecular oncology 2022 Dec;16(22):3927-3948
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
Fan W, Wang Y, Jiang S, Li Y, Yao X, Wang M, Zhao J, Sun X, Jiang X, Zhong L, Han Y, Song H, Xu Y
Virulence 2022 Dec;13(1):1884-1899
Virulence 2022 Dec;13(1):1884-1899
Inhibition of glutamine transporter ASCT2 mitigates bleomycin-induced pulmonary fibrosis in mice.
Lian N, Jin H, Zhu W, Zhang C, Qi Y, Jiang M, Mao J, Lu X, Zhao F, Xi B, Qi X, Li Y
Acta histochemica 2022 Dec;124(8):151961
Acta histochemica 2022 Dec;124(8):151961
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Sun Y, Li H, Liu L, Bai X, Wu L, Shan J, Sun X, Wang Q, Guo Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Calcium phosphate cement with icariin-loaded gelatin microspheres as a local drug delivery system for bone regeneration.
Liu N, Huang S, Guo F, Zhai S, Wang D, Li F, Liu C
Biomedical engineering online 2022 Dec 22;21(1):89
Biomedical engineering online 2022 Dec 22;21(1):89
Treadmill training mitigates bone deterioration via inhibiting NLRP3/Caspase1/IL-1β signaling in aged rats.
Wu Q, Zhong P, Ning P, Tan L, Huang X, Peng T, Yin L, Luo F, Qu M, Zhou J
BMC musculoskeletal disorders 2022 Dec 13;23(1):1089
BMC musculoskeletal disorders 2022 Dec 13;23(1):1089
Betaine supplementation alleviates dextran sulfate sodium-induced colitis via regulating the inflammatory response, enhancing the intestinal barrier, and altering gut microbiota.
Zhao N, Yang Y, Chen C, Jing T, Hu Y, Xu H, Wang S, He Y, Liu E, Cui J
Food & function 2022 Dec 13;13(24):12814-12826
Food & function 2022 Dec 13;13(24):12814-12826
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Pekkle Lam HY, Hung MY, Cheng PC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Aug;55(4):757-765
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Aug;55(4):757-765
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Zhou Z, Li C, Bao T, Zhao X, Xiong W, Luo C, Yin G, Fan J
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Pyroptosis participates in PM(2.5)-induced air-blood barrier dysfunction.
Jia R, Wei M, Zhang X, Du R, Sun W, Wang L, Song L
Environmental science and pollution research international 2022 Aug;29(40):60987-60997
Environmental science and pollution research international 2022 Aug;29(40):60987-60997
Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway.
Ding Q, Chen K, Liu X, Ding C, Zhao Y, Sun S, Zhang Y, Zhang J, Liu S, Liu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113242
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113242
Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy.
Chen J, Luo P, Wang C, Yang C, Bai Y, He X, Zhang Q, Zhang J, Yang J, Wang S, Wang J
JCI insight 2022 Aug 22;7(16)
JCI insight 2022 Aug 22;7(16)
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Zhang Q, Luo P, Xia F, Tang H, Chen J, Zhang J, Liu D, Zhu Y, Liu Y, Gu L, Zheng L, Li Z, Yang F, Dai L, Liao F, Xu C, Wang J
Cell chemical biology 2022 Aug 18;29(8):1248-1259.e6
Cell chemical biology 2022 Aug 18;29(8):1248-1259.e6
Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.
Wang Y, Cheng Z, Zhang H, Li S, Pan Y, Zhang W, Huang S, He X, Zou F, Yuan Z, Yan W, Huang H
Toxicology and applied pharmacology 2022 Aug 15;449:116114
Toxicology and applied pharmacology 2022 Aug 15;449:116114
CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice.
Pei Z, Ma L, Li Y, Yang J, Yang Q, Yao W, Li S
Frontiers in bioscience (Landmark edition) 2022 Aug 15;27(8):244
Frontiers in bioscience (Landmark edition) 2022 Aug 15;27(8):244
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1.
Zhou S, Xue J, Shan J, Hong Y, Zhu W, Nie Z, Zhang Y, Ji N, Luo X, Zhang T, Ma W
Nutrients 2022 Aug 15;14(16)
Nutrients 2022 Aug 15;14(16)
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787
Neuroscience letters 2022 Aug 10;785:136787
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Wang Z, Liang M, Li H, Liu B, Yang L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis.
Qu L, Shi K, Xu J, Liu C, Ke C, Zhan X, Xu K, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153945
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153945
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Lam HYP, Cheng PC, Peng SY
International journal for parasitology 2022 Apr;52(5):275-284
International journal for parasitology 2022 Apr;52(5):275-284
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain.
Peng Z, Yang F, Huang S, Tang Y, Wan L
Molecular pain 2022 Apr;18:17448069221094528
Molecular pain 2022 Apr;18:17448069221094528
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Song Z, Wang L, Cao Y, Liu Z, Zhang M, Zhang Z, Jiang S, Fan R, Hao T, Yang R, Wang B, Guan Z, Zhu L, Liu Z, Zhang S, Zhao L, Xu Z, Xu H, Dai G
International immunopharmacology 2022 Apr;105:108539
International immunopharmacology 2022 Apr;105:108539
Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury.
Gong F, Ge T, Liu J, Xiao J, Wu X, Wang H, Zhu Y, Xia D, Hu B
Aging 2022 Apr 10;14(7):3216-3232
Aging 2022 Apr 10;14(7):3216-3232
Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model.
Qiu J, Chen Y, Zhuo J, Zhang L, Liu J, Wang B, Sun D, Yu S, Lou H
Neuropharmacology 2022 Apr 1;207:108963
Neuropharmacology 2022 Apr 1;207:108963
F-Box Protein FBXW17-Mediated Proteasomal Degradation of Protein Methyltransferase PRMT6 Exaggerates CSE-Induced Lung Epithelial Inflammation and Apoptosis.
Li T, He X, Luo L, Zeng H, Ren S, Chen Y
Frontiers in cell and developmental biology 2021;9:599020
Frontiers in cell and developmental biology 2021;9:599020
Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.
Li C, Zhu Y, Wu Y, Fu M, Wu Y, Wu Y, Qiu Y, Zhang H, Ding M
Frontiers in medicine 2021;8:813047
Frontiers in medicine 2021;8:813047
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
Yu YW, Que JQ, Liu S, Huang KY, Qian L, Weng YB, Rong FN, Wang L, Zhou YY, Xue YJ, Ji KT
Frontiers in cardiovascular medicine 2021;8:768214
Frontiers in cardiovascular medicine 2021;8:768214
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction.
Tan J, Dai A, Pan L, Zhang L, Wang Z, Ke T, Sun W, Wu Y, Ding PH, Chen L
Journal of immunology research 2021;2021:9919024
Journal of immunology research 2021;2021:9919024
Benefit Effect of Dendrobium officinale Ultrafine Powder on DSS-Induced Ulcerative Colitis Rats by Improving Colon Mucosal Barrier.
Zheng X, Xiong TX, Zhang K, Zhou FC, Wang HY, Li B, Dong YJ, He X, Li LZ, Yu QX, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9658638
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9658638
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Wang Y, Wang J, Yang J, Kang J, Xue F, Chang S, Ji H, Zang H, Zhou X, Wang G, Fan W, Yan X, Guo J, Ren X, Tian J
Oxidative medicine and cellular longevity 2021;2021:8889408
Oxidative medicine and cellular longevity 2021;2021:8889408
Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.
Xu HL, Li SK, Xue XA, Chen ZY, Hua YH
BioMed research international 2021;2021:6641701
BioMed research international 2021;2021:6641701
Berberine Protects against TNF-α-Induced Injury of Human Umbilical Vein Endothelial Cells via the AMPK/NF-κB/YY1 Signaling Pathway.
Chen L, Fan XD, Qu H, Bai RN, Shi DZ
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6518355
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6518355
Dihydroartemisinin inhibits activation of the AIM2 inflammasome pathway and NF-κB/HIF-1α/VEGF pathway by inducing autophagy in A431 human cutaneous squamous cell carcinoma cells.
Wang Y, Li Z, Teng M, Liu J
International journal of medical sciences 2021;18(12):2705-2715
International journal of medical sciences 2021;18(12):2705-2715
Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice.
Chang Y, Yao Y, Ma R, Wang Z, Hu J, Wu Y, Jiang X, Li L, Li G
Frontiers in neuroscience 2021;15:620176
Frontiers in neuroscience 2021;15:620176
KCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease.
Zheng F, Tao Y, Liu J, Geng Z, Wang Y, Wang Y, Fu S, Wang W, Xie C, Zhang Y, Gong F
Journal of inflammation research 2021;14:719-735
Journal of inflammation research 2021;14:719-735
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Wang D, Zhan X, Wu R, You Y, Chen W, Duan L
Journal of inflammation research 2021;14:3185-3196
Journal of inflammation research 2021;14:3185-3196
The cardioprotective effect of the sodium-glucose cotransporter 2 inhibitor dapagliflozin in rats with isoproterenol-induced cardiomyopathy.
Wang FZ, Wei WB, Li X, Huo JY, Jiang WY, Wang HY, Qian P, Li ZZ, Zhou YB
American journal of translational research 2021;13(9):10950-10961
American journal of translational research 2021;13(9):10950-10961
A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway.
Zuo D, Tan B, Jia G, Wu D, Yu L, Jia L
American journal of translational research 2021;13(5):3987-4006
American journal of translational research 2021;13(5):3987-4006
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Cai Y, Chai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in aging neuroscience 2021;13:809433
Frontiers in aging neuroscience 2021;13:809433
Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells.
Yan S, Ye P, Aleem MT, Chen X, Xie N, Zhang Y
Frontiers in immunology 2021;12:796744
Frontiers in immunology 2021;12:796744
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Que R, Zheng J, Chang Z, Zhang W, Li H, Xie Z, Huang Z, Wang HT, Xu J, Jin D, Yang W, Tan EK, Wang Q
Frontiers in immunology 2021;12:794770
Frontiers in immunology 2021;12:794770
Extracellular CIRP Induces Macrophage Extracellular Trap Formation Via Gasdermin D Activation.
Lee Y, Reilly B, Tan C, Wang P, Aziz M
Frontiers in immunology 2021;12:780210
Frontiers in immunology 2021;12:780210
The Protective Effects of Zornia diphylla (L.) Pers. Against Acute Liver Injury Induced by Carbon Tetrachloride in Mice.
Xie SZ, Zhai XY, Xi SY, Qiu YK, Zhang YM, Kong XJ, Li YH, Zhu L, Wang Z, Zhang SG, Huang SQ, Lu DW, Wang Z
Frontiers in pharmacology 2021;12:764282
Frontiers in pharmacology 2021;12:764282
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Kong L, Zhang H, Lu C, Shi K, Huang H, Zheng Y, Wang Y, Wang D, Wang H, Huang W
Frontiers in pharmacology 2021;12:724514
Frontiers in pharmacology 2021;12:724514
Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4.
Bolourani S, Sari E, Brenner M, Wang P
Frontiers in immunology 2021;12:721970
Frontiers in immunology 2021;12:721970
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway.
Qu L, Lin X, Liu C, Ke C, Zhou Z, Xu K, Cao G, Liu Y
Frontiers in pharmacology 2021;12:665376
Frontiers in pharmacology 2021;12:665376
CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis.
Li X, Tang X, Wang Y, Chai C, Zhao Z, Zhang H, Peng Y, Wu L
Frontiers in pharmacology 2021;12:655101
Frontiers in pharmacology 2021;12:655101
Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury.
Ma H, Liu J, Du Y, Zhang S, Cao W, Jia Z, Gong W, Zhang A
Frontiers in pharmacology 2021;12:626166
Frontiers in pharmacology 2021;12:626166
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.
Chen L, Zhong X, Cao W, Mao M, Li W, Yang H, Li M, Shi M, Zhang Y, Deng Y, Zu X, Liu J
Frontiers in immunology 2021;12:609319
Frontiers in immunology 2021;12:609319
Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering.
Zhang B, Xu H, Chen J, Zhu X, Xue Y, Yang Y, Ao J, Hua Y, Ji M
Theranostics 2021;11(7):3074-3088
Theranostics 2021;11(7):3074-3088
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Tang B, Song M, Xie X, Le D, Tu Q, Wu X, Chen M
Neurochemical research 2021 Sep;46(9):2387-2402
Neurochemical research 2021 Sep;46(9):2387-2402
Magnesium-L-threonate alleviate colonic inflammation and memory impairment in chronic-plus-binge alcohol feeding mice.
Liu C, Cheng Y, Guo Y, Qian H
Brain research bulletin 2021 Sep;174:184-193
Brain research bulletin 2021 Sep;174:184-193
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Cui J, Xu G, Bian F
International journal of cardiology 2021 Sep 1;338:215-225
International journal of cardiology 2021 Sep 1;338:215-225
Anti-NAFLD Effect of Djulis Hull and Its Major Compound, Rutin, in Mice with High-Fat Diet (HFD)-Induced Obesity.
Tung YT, Zeng JL, Ho ST, Xu JW, Li S, Wu JH
Antioxidants (Basel, Switzerland) 2021 Oct 27;10(11)
Antioxidants (Basel, Switzerland) 2021 Oct 27;10(11)
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway.
Zhao K, Zhang J, Xu T, Yang C, Weng L, Wu T, Wu X, Miao J, Guo X, Tu J, Zhang D, Zhou B, Sun W, Kong X
Journal of Zhejiang University. Science. B 2021 Oct 15;22(10):818-838
Journal of Zhejiang University. Science. B 2021 Oct 15;22(10):818-838
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Journal of medical virology 2021 Nov;93(11):6229-6235
Journal of medical virology 2021 Nov;93(11):6229-6235
Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway.
Liu J, Ma W, Zang CH, Wang GD, Zhang SJ, Wu HJ, Zhu KW, Xiang XL, Li CY, Liu KP, Guo JH, Li LY
Annals of translational medicine 2021 Nov;9(22):1694
Annals of translational medicine 2021 Nov;9(22):1694
Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.
Kitayama K, Kawamoto T, Kawakami Y, Hara H, Takemori T, Fujiwara S, Yahiro S, Miyamoto T, Mifune Y, Hoshino Y, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Kuroda R, Akisue T
International journal of oncology 2021 Nov;59(5)
International journal of oncology 2021 Nov;59(5)
miR‑4792 regulates inflammatory responses in Cryptococcus neoformans‑infected microglia.
Yao G, Wang X, Wang Y, Hou Q, Gao R, Wang Y, Teng L, Lin W, Wang Z, Jin Y, Chen J
International journal of molecular medicine 2021 Nov;48(5)
International journal of molecular medicine 2021 Nov;48(5)
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Zhai J, Gao H, Wang S, Zhang S, Qu X, Zhang Y, Tao L, Sun J, Song Y, Fu L
Journal of biochemical and molecular toxicology 2021 Nov;35(11):e22896
Journal of biochemical and molecular toxicology 2021 Nov;35(11):e22896
The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction.
Huang Y, Li L, Chen H, Liao Q, Yang X, Yang D, Xia X, Wang H, Wang WE, Chen L, Zeng C
Journal of the American Heart Association 2021 Nov 2;10(21):e021895
Journal of the American Heart Association 2021 Nov 2;10(21):e021895
Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation.
Du L, Qi R, Wang J, Liu Z, Wu Z
International journal of molecular sciences 2021 Nov 18;22(22)
International journal of molecular sciences 2021 Nov 18;22(22)
c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.
Huang Y, Wang S, Huang F, Zhang Q, Qin B, Liao L, Wang M, Wan H, Yan W, Chen D, Liu F, Jiang B, Ji D, Xia X, Huang J, Xiong K
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2021 May;235:151672
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2021 May;235:151672
Maternal immune activation alters adult behavior, intestinal integrity, gut microbiota and the gut inflammation.
Li W, Chen M, Feng X, Song M, Shao M, Yang Y, Zhang L, Liu Q, Lv L, Su X
Brain and behavior 2021 May;11(5):e02133
Brain and behavior 2021 May;11(5):e02133
Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.
Cai D, Han JJ
Nature aging 2021 May;1(5):438-453
Nature aging 2021 May;1(5):438-453
Anti-HIV Activity of Cucurbitacin-D against Cigarette Smoke Condensate-Induced HIV Replication in the U1 Macrophages.
Kodidela S, Sinha N, Kumar A, Kumar S
Viruses 2021 May 27;13(6)
Viruses 2021 May 27;13(6)
Resveratrol attenuates radiation enteritis through the SIRT1/FOXO3a and PI3K/AKT signaling pathways.
Qin H, Zhang H, Zhang X, Zhang S, Zhu S, Wang H
Biochemical and biophysical research communications 2021 May 21;554:199-205
Biochemical and biophysical research communications 2021 May 21;554:199-205
Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6.
Zhang W, Li J, Yao H, Li T
Nanoscale research letters 2021 May 21;16(1):89
Nanoscale research letters 2021 May 21;16(1):89
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Yao H, Shen H, Yu H, Wang C, Ding R, Lan X, Tash D, Wu X, Wang X, Zhang G
Physiology & behavior 2021 May 15;234:113387
Physiology & behavior 2021 May 15;234:113387
Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis.
Hou M, Zhang Y, Zhou X, Liu T, Yang H, Chen X, He F, Zhu X
Cell death & disease 2021 May 13;12(5):483
Cell death & disease 2021 May 13;12(5):483
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
Li H, Zhao K, Li Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis.
Xie Y, Liu B, Pan J, Liu J, Li X, Li H, Qiu S, Xiang X, Zheng P, Chen J, Yuan Y, Dong Z, Zhang D
Molecular therapy. Nucleic acids 2021 Mar 5;23:76-88
Molecular therapy. Nucleic acids 2021 Mar 5;23:76-88
Therapeutic targets of rosuvastatin on heart failure and associated biological mechanisms: A study of network pharmacology and experimental validation.
Lian Z, Song JX, Yu SR, Su LN, Cui YX, Li SF, Lee CY, Liang HZ, Chen H
European journal of pharmacology 2021 Mar 15;895:173888
European journal of pharmacology 2021 Mar 15;895:173888
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1.
Zeng J, Tao J, Xia L, Zeng Z, Chen J, Wang Z, Meng J, Liu L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Jun;99(3):339-347
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Jun;99(3):339-347
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Lam HYP, Liang TR, Peng SY
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.
Duan A, Shen K, Li B, Li C, Zhou H, Kong R, Shao Y, Qin J, Yuan T, Ji J, Guo W, Wang X, Xue T, Li L, Huang X, Sun Y, Cai Z, Liu W, Liu F
Stem cell research & therapy 2021 Jul 28;12(1):427
Stem cell research & therapy 2021 Jul 28;12(1):427
Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease.
Qin Y, Qiu J, Wang P, Liu J, Zhao Y, Jiang F, Lou H
Brain, behavior, and immunity 2021 Jan;91:324-338
Brain, behavior, and immunity 2021 Jan;91:324-338
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Wang Y, Song Y, Zhong Q, Wu Y, Zhuang J, Qu F, Xu C
International immunopharmacology 2021 Jan;90:107129
International immunopharmacology 2021 Jan;90:107129
Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor-Mediated PKA Pathway.
Dai HB, Wang FZ, Kang Y, Sun J, Zhou H, Gao Q, Li ZZ, Qian P, Zhu GQ, Zhou YB
Obesity (Silver Spring, Md.) 2021 Jan;29(1):86-97
Obesity (Silver Spring, Md.) 2021 Jan;29(1):86-97
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Tian D, Teng X, Jin S, Chen Y, Xue H, Xiao L, Wu Y
Journal of advanced research 2021 Jan;27:115-125
Journal of advanced research 2021 Jan;27:115-125
Microcystin-LR Induces NLRP3 Inflammasome Activation via FOXO1 Phosphorylation, Resulting in Interleukin-1β Secretion and Pyroptosis in Hepatocytes.
Zhang Y, Zhu P, Wu X, Yuan T, Su Z, Chen S, Zhou Y, Tao WA
Toxicological sciences : an official journal of the Society of Toxicology 2021 Jan 6;179(1):53-69
Toxicological sciences : an official journal of the Society of Toxicology 2021 Jan 6;179(1):53-69
Circ_0001438 participates in the pathogenesis of preeclampsia via the circ_0001438/miR-942/NLRP3 regulatory network.
Li X, Yang R, Xu Y, Zhang Y
Placenta 2021 Jan 15;104:40-50
Placenta 2021 Jan 15;104:40-50
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Wang Y, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Cell death & disease 2021 Jan 11;12(1):55
Cell death & disease 2021 Jan 11;12(1):55
Adrenomedullin 2 attenuates LPS-induced inflammation in microglia cells by receptor-mediated cAMP-PKA pathway.
Sun J, Qian P, Kang Y, Dai HB, Wang FZ, Wang HY, Zhou H, Gao Q, Zhou YB
Neuropeptides 2021 Feb;85:102109
Neuropeptides 2021 Feb;85:102109
Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4.
Zhang H, Luan S, Xiao X, Lin L, Zhao X, Liu X
Life sciences 2021 Feb 1;266:118850
Life sciences 2021 Feb 1;266:118850
Long-term ketamine administration induces bladder damage and upregulates autophagy-associated proteins in bladder smooth muscle tissue.
Li Y, Dong Z, Wen G, Ren X, Ren W, Yan L, Wang X, Yu H, Wu X, Xia X, Lu Y, Wu X
Environmental toxicology 2021 Dec;36(12):2521-2529
Environmental toxicology 2021 Dec;36(12):2521-2529
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Zhao W, He F, Barkema HW, Xu S, Gao J, Liu G, Deng Z, Shahid M, Shi Y, Kastelic JP, Han B
Veterinary research 2021 Dec 11;52(1):144
Veterinary research 2021 Dec 11;52(1):144
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.
Zhu JX, Yang HY, Hu WQ, Cheng J, Liu Y, Yi LT, Cheng HY
Inflammopharmacology 2021 Aug;29(4):1187-1200
Inflammopharmacology 2021 Aug;29(4):1187-1200
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.
Yang G, Song W, Xu J, Postoak JL, Cheng F, Martinez J, Zhang J, Wu L, Van Kaer L
Cellular & molecular immunology 2021 Aug;18(8):2024-2039
Cellular & molecular immunology 2021 Aug;18(8):2024-2039
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Tian L, Wang S, Zhao L, Lu X, Zhu C, Gong H, Yang W
FEBS open bio 2021 Aug;11(8):2236-2244
FEBS open bio 2021 Aug;11(8):2236-2244
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Li H, Yuan L, Li X, Luo Y, Zhang Z, Li J
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Luo L, Jian X, Sun H, Qin J, Wang Y, Zhang J, Shen Z, Yang D, Li C, Zhao P, Liu M, Tian Z, Zhou Y
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481
Loss of Arf Guanine Nucleotide Exchange Factor GBF1 Activity Disturbs Organelle Dynamics in Mouse Oocytes.
Zou YJ, Shan MM, Pan ZN, Pan MH, Li XH, Sun SC
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2021 Apr;27(2):400-408
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2021 Apr;27(2):400-408
CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes.
Jiang H, Niu F, Zheng Y, Xu Y
Molecular medicine reports 2021 Apr;23(4)
Molecular medicine reports 2021 Apr;23(4)
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Tian S, Liao L, Zhou Q, Huang X, Zheng P, Guo Y, Deng T, Tian X
Oncology letters 2021 Apr;21(4):286
Oncology letters 2021 Apr;21(4):286
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
Fang Y, Li F, Qi C, Mao X, Wang F, Zhao Z, Chen JK, Zhang Z, Wu H
Cell death discovery 2020;6:52
Cell death discovery 2020;6:52
Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.
Han L, Zhang Y, Zhang M, Guo L, Wang J, Zeng F, Xu D, Yin Z, Xu Y, Wang D, Zhou H
Kidney & blood pressure research 2020;45(2):314-330
Kidney & blood pressure research 2020;45(2):314-330
Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells.
Zheng P, Tian X, Zhang W, Yang Z, Zhou J, Zheng J, Cui H, Tang T, Luo J, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7210627
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7210627
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 Axis Inhibits the Hippocampal Inflammatory Response in T2DM With OSA.
Du P, Wang J, Han Y, Feng J
Frontiers in cellular neuroscience 2020;14:97
Frontiers in cellular neuroscience 2020;14:97
Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.
Wu X, Mao X, Huang Y, Zhu Q, Guan J, Wu L
International journal of clinical and experimental pathology 2020;13(6):1408-1414
International journal of clinical and experimental pathology 2020;13(6):1408-1414
17-Allylamino-Demethoxygeldanamycin Ameliorate Microthrombosis Via HSP90/RIP3/NLRP3 Pathway After Subarachnoid Hemorrhage in Rats.
Zuo Y, He T, Liao P, Zhuang K, Yan X, Liu F
Acta neurochirurgica. Supplement 2020;127:69-75
Acta neurochirurgica. Supplement 2020;127:69-75
Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease.
Yan S, Wei X, Jian W, Qin Y, Liu J, Zhu S, Jiang F, Lou H, Zhang B
Frontiers in aging neuroscience 2020;12:78
Frontiers in aging neuroscience 2020;12:78
Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation.
Lin G, Li X, Cheng X, Zhao N, Zheng W
Frontiers in aging neuroscience 2020;12:556008
Frontiers in aging neuroscience 2020;12:556008
Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer's disease.
Li Z, Gan L, Yan S, Yan Y, Huang W
Translational neuroscience 2020;11(1):161-172
Translational neuroscience 2020;11(1):161-172
Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia.
Wang K, Sun Z, Ru J, Wang S, Huang L, Ruan L, Lin X, Jin K, Zhuge Q, Yang S
Frontiers in neurology 2020;11:577927
Frontiers in neurology 2020;11:577927
Role of Endoplasmic Reticulum Stress in Otitis Media.
Zhao H, Wang Y, Li B, Zheng T, Liu X, Hu BH, Che J, Zhao T, Chen J, Hatzoglou M, Zhang X, Fan Z, Zheng Q
Frontiers in genetics 2020;11:495
Frontiers in genetics 2020;11:495
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Zhang Q, Wang L, Jiang J, Lin S, Luo A, Zhao P, Tan W, Zhang M
Frontiers in immunology 2020;11:2040
Frontiers in immunology 2020;11:2040
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Ding PH, Yang MX, Wang NN, Jin LJ, Dong Y, Cai X, Chen LL
Frontiers in microbiology 2020;11:1881
Frontiers in microbiology 2020;11:1881
Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.
Zhuang C, Liu G, Barkema HW, Zhou M, Xu S, Ur Rahman S, Liu Y, Kastelic JP, Gao J, Han B
Frontiers in microbiology 2020;11:1461
Frontiers in microbiology 2020;11:1461
Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome.
Dai G, Jiang Z, Sun B, Liu C, Meng Q, Ding K, Jing W, Ju W
Frontiers in oncology 2020;10:721
Frontiers in oncology 2020;10:721
Fucoidan inhibits tooth movement by promoting restorative macrophage polarization through the STAT3 pathway.
Zhang S, Zhang H, Jin Z, Wang S, Wang Y, Zhu L, Sun W, Yan B
Journal of cellular physiology 2020 Sep;235(9):5938-5950
Journal of cellular physiology 2020 Sep;235(9):5938-5950
Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants.
Wang Y, Zhang L, Wu Y, Zhu R, Wang Y, Cao Y, Long W, Ji C, Wang H, You L
Stem cell research & therapy 2020 Sep 23;11(1):414
Stem cell research & therapy 2020 Sep 23;11(1):414
Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-κB signaling and NLRP3 inflammasome.
Chen Y, Lu Y, Pei C, Liang J, Ding P, Chen S, Hou SZ
European journal of pharmacology 2020 Sep 15;883:173358
European journal of pharmacology 2020 Sep 15;883:173358
Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats.
Wang QS, Ding HG, Chen SL, Liu XQ, Deng YY, Jiang WQ, Li Y, Huang LQ, Han YL, Wen MY, Wang MQ, Zeng HK
CNS neuroscience & therapeutics 2020 Oct;26(10):1045-1057
CNS neuroscience & therapeutics 2020 Oct;26(10):1045-1057
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response.
Fadul MM, Heath PR, Cooper-Knock J, Kurz JM, Al-Azzawi HA, Ali Z, Smith T, Matthews FE, Brayne C, Wharton SB, Simpson JE
International journal of molecular sciences 2020 Oct 25;21(21)
International journal of molecular sciences 2020 Oct 25;21(21)
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Xu Y, Fang H, Xu Q, Xu C, Yang L, Huang C
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.
Liu YC, Wang HL, Huang YZ, Weng YH, Chen RS, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW, Chen YJ, Hsu CC, Chiu CH, Chiu CC
Biochemical pharmacology 2020 May;175:113919
Biochemical pharmacology 2020 May;175:113919
The Differential Expression of Cytokines and Growth Factors After SMILE Compared With FS-LASIK in Rabbits.
Liu L, Cheng W, Wu D, Chen L, Yu S, Zuo T, Zhang L, Yang K, Li H, Zhang H, Wei P, Ng ALK, Cheng GP, Woo VC, Yin J, Chiu K, Wang Y
Investigative ophthalmology & visual science 2020 May 11;61(5):55
Investigative ophthalmology & visual science 2020 May 11;61(5):55
LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell.
Wang T, Cao L, Dong X, Wu F, De W, Huang L, Wan Q
Cell death & disease 2020 May 1;11(5):302
Cell death & disease 2020 May 1;11(5):302
Aging alters Hv1-mediated microglial polarization and enhances neuroinflammation after peripheral surgery.
Zhang ZJ, Zheng XX, Zhang XY, Zhang Y, Huang BY, Luo T
CNS neuroscience & therapeutics 2020 Mar;26(3):374-384
CNS neuroscience & therapeutics 2020 Mar;26(3):374-384
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.
Dong X, Zheng Z, Lin P, Fu X, Li F, Jiang J, Zhu P
Cellular & molecular immunology 2020 Mar;17(3):261-271
Cellular & molecular immunology 2020 Mar;17(3):261-271
The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis.
Zhang P, Yi L, Qu S, Dai J, Li X, Liu B, Li H, Ai K, Zheng P, Qiu S, Li Y, Wang Y, Xiang X, Chai X, Dong Z, Zhang D
Molecular therapy. Nucleic acids 2020 Mar 6;19:1027-1042
Molecular therapy. Nucleic acids 2020 Mar 6;19:1027-1042
Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats.
Zhou S, Chen S, Xie W, Guo X, Zhao J
Neuropeptides 2020 Jun;81:102006
Neuropeptides 2020 Jun;81:102006
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Luo X, Li Y, Yang P, Chen Y, Wei L, Yu T, Xia J, Ruan XZ, Zhao L, Chen Y
EBioMedicine 2020 Jun;56:102797
EBioMedicine 2020 Jun;56:102797
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z
Cell proliferation 2020 Jun;53(6):e12829
Cell proliferation 2020 Jun;53(6):e12829
Anti-human serum albumin autoantibody may be involved in the pathogenesis of autoimmune bullous skin diseases.
Qian H, Cao Y, Sun J, Zu J, Ma L, Zhou H, Tang X, Li Y, Yu H, Zhang M, Bai Y, Xu C, Ishii N, Hashimoto T, Li X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8574-8595
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8574-8595
Corneal epithelial injury-induced norepinephrine promotes Pseudomonas aeruginosa keratitis.
Ma X, Wang Q, Song F, Li Y, Li J, Dou S, Xie L, Zhou Q
Experimental eye research 2020 Jun;195:108048
Experimental eye research 2020 Jun;195:108048
CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats.
Ho CY, Lin YT, Chen HH, Ho WY, Sun GC, Hsiao M, Lu PJ, Cheng PW, Tseng CJ
Journal of neuroinflammation 2020 Jun 12;17(1):185
Journal of neuroinflammation 2020 Jun 12;17(1):185
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Lam HYP, Liang TR, Jiang SJ, Peng SY
Biomolecules 2020 Jul 5;10(7)
Biomolecules 2020 Jul 5;10(7)
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Chang Y, Zhu J, Wang D, Li H, He Y, Liu K, Wang X, Peng Y, Pan S, Huang K
Journal of neuroinflammation 2020 Jul 23;17(1):219
Journal of neuroinflammation 2020 Jul 23;17(1):219
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
Liu D, Dong Z, Xiang F, Liu H, Wang Y, Wang Q, Rao J
Neurochemical research 2020 Feb;45(2):437-454
Neurochemical research 2020 Feb;45(2):437-454
α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y, Gao F
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
Experimental and therapeutic medicine 2020 Feb;19(2):931-938
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation.
Mo Z, Tang C, Li H, Lei J, Zhu L, Kou L, Li H, Luo S, Li C, Chen W, Zhang L
Life sciences 2020 Feb 1;242:117133
Life sciences 2020 Feb 1;242:117133
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Zhang P, Yin Y, Wang T, Li W, Li C, Zeng X, Yang W, Zhang R, Tang Y, Shi L, Li R, Tao K
Free radical biology & medicine 2020 Feb 1;147:23-36
Free radical biology & medicine 2020 Feb 1;147:23-36
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF‑κB signaling pathway.
Duan L, Ma Y, Wang Y, Liu J, Tan Z, Wu Q, Wu Y, Yu X
International journal of molecular medicine 2020 Dec;46(6):2260-2270
International journal of molecular medicine 2020 Dec;46(6):2260-2270
A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
Zhang Z, Hou WB, Zhang C, Tan YE, Zhang DD, An W, Pan SW, Wu WD, Chen QC, Xu HM
Journal of cellular and molecular medicine 2020 Dec;24(24):14217-14230
Journal of cellular and molecular medicine 2020 Dec;24(24):14217-14230
Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice.
Wang X, Yu H, Wang C, Liu Y, You J, Wang P, Xu G, Shen H, Yao H, Lan X, Zhao R, Wu X, Zhang G
Toxicology 2020 Dec 15;446:152625
Toxicology 2020 Dec 15;446:152625
Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation.
Liu JH, Yue T, Luo ZW, Cao J, Yan ZQ, Jin L, Wan TF, Shuai CJ, Wang ZG, Zhou Y, Xu R, Xie H
Disease models & mechanisms 2020 Dec 1;13(11)
Disease models & mechanisms 2020 Dec 1;13(11)
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Lam HYP, Chen TT, Chen CC, Yang TH, Cheng PC, Peng SY
Parasitology international 2020 Aug;77:102119
Parasitology international 2020 Aug;77:102119
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Lan Y, Yan R, Shan W, Chu J, Sun R, Wang R, Zhao Y, Wang Z, Zhang N, Yao J
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Zeng Z, Zheng Q, Chen J, Tan X, Li Q, Ding L, Zhang R, Lin X
Experimental cell research 2020 Aug 15;393(2):112108
Experimental cell research 2020 Aug 15;393(2):112108
Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis.
Xing SS, Yang J, Li WJ, Li J, Chen L, Yang YT, Lei X, Li J, Wang K, Liu X
Inflammation 2020 Apr;43(2):433-440
Inflammation 2020 Apr;43(2):433-440
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Chen JJ, Tao J, Zhang XL, Xia LZ, Zeng JF, Zhang H, Wei DH, Lv YC, Li GH, Wang Z
DNA and cell biology 2020 Apr;39(4):661-670
DNA and cell biology 2020 Apr;39(4):661-670
COMP in the Infrapatellar Fat Pad-Results of a Prospective Histological, Immunohistological, and Biochemical Case-Control Study.
Grevenstein D, Heilig J, Dargel J, Oppermann J, Eysel P, Brochhausen C, Niehoff A
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Apr;38(4):747-758
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Apr;38(4):747-758
High- and low-virulent bovine Pasteurella multocida induced differential NLRP3 inflammasome activation and subsequent IL-1β secretion.
Fang R, Lei G, Jiang J, Du H, Liu Y, Lei Z, Ye C, Li N, Peng Y
Veterinary microbiology 2020 Apr;243:108646
Veterinary microbiology 2020 Apr;243:108646
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J
Theranostics 2019;9(5):1510-1522
Theranostics 2019;9(5):1510-1522
Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release.
Tong L, Xie C, Wei Y, Qu Y, Liang H, Zhang Y, Xu T, Qian X, Qiu H, Deng H
Frontiers in oncology 2019;9:364
Frontiers in oncology 2019;9:364
NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs.
Zhang X, Hong S, Qi S, Liu W, Zhang X, Shi Z, Chen W, Zhao M, Yin X
Mediators of inflammation 2019;2019:6847087
Mediators of inflammation 2019;2019:6847087
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Zheng GH, Shan Q, Mu JJ, Wang YJ, Zhang ZF, Fan SH, Hu B, Li MQ, Xie J, Chen P, Wu DM, Lu J, Zheng YL
Oxidative medicine and cellular longevity 2019;2019:5189819
Oxidative medicine and cellular longevity 2019;2019:5189819
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Zhuang K, Zuo YC, Sherchan P, Wang JK, Yan XX, Liu F
Frontiers in neuroscience 2019;13:1441
Frontiers in neuroscience 2019;13:1441
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Dia VP, Bradwell J, Pangloli P
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Vaccaria n-Butanol Extract Lower the Production of Proinflammatory Cytokines and the Infection Risk of T. spiralis In Vivo.
Xu F, Hou B, Zhu X, Liu Y, Shi X, Li S, Li Z, Cai W, Zhou Y, Qiu L
Acta parasitologica 2019 Sep;64(3):520-527
Acta parasitologica 2019 Sep;64(3):520-527
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
Wu G, Chen Z, Wang P, Zhao M, Fujino M, Zhang C, Zhou W, Hirano SI, Li XK, Zhao L
Experimental biology and medicine (Maywood, N.J.) 2019 Sep;244(12):1017-1027
Experimental biology and medicine (Maywood, N.J.) 2019 Sep;244(12):1017-1027
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Zhong X, Xiao Q, Liu Z, Wang W, Lai CH, Yang W, Yue P, Ye Q, Xiao J
Molecular medicine reports 2019 Sep;20(3):2101-2110
Molecular medicine reports 2019 Sep;20(3):2101-2110
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Zhou Z, Dong Y, Zhou H, Liu J, Zhao W
Biochemical and biophysical research communications 2019 Sep 24;517(3):413-420
Biochemical and biophysical research communications 2019 Sep 24;517(3):413-420
Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation.
Su Q, Zhang P, Yu D, Wu Z, Li D, Shen F, Liao P, Yin G
Aging 2019 Sep 20;11(18):7570-7586
Aging 2019 Sep 20;11(18):7570-7586
Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System.
Zhu Y, Crowley SC, Latimer AJ, Lewis GM, Nash R, Kucenas S
Cell 2019 Sep 19;179(1):74-89.e10
Cell 2019 Sep 19;179(1):74-89.e10
Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection.
Wu Z, Li Y, Liu Q, Liu Y, Chen L, Zhao H, Guo H, Zhu K, Zhou N, Chai TC, Shi B
American journal of physiology. Cell physiology 2019 Sep 1;317(3):C544-C555
American journal of physiology. Cell physiology 2019 Sep 1;317(3):C544-C555
LncRNA HIF1A-AS1 contributes to ventricular remodeling after myocardial ischemia/reperfusion injury by adsorption of microRNA-204 to regulating SOCS2 expression.
Xue X, Luo L
Cell cycle (Georgetown, Tex.) 2019 Oct;18(19):2465-2480
Cell cycle (Georgetown, Tex.) 2019 Oct;18(19):2465-2480
Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
Chen Y, Li C, Duan S, Yuan X, Liang J, Hou S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109195
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109195
IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling.
Yu J, Ming H, Li HY, Yu B, Chu M, Zhu H, Zhu X
Toxicology and applied pharmacology 2019 Oct 15;381:114732
Toxicology and applied pharmacology 2019 Oct 15;381:114732
SETD7 mediates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.
Shen Y, Ding Z, Ma S, Ding Z, Zhang Y, Zou Y, Xu F, Yang X, Schäfer MKE, Guo Q, Huang C
Brain, behavior, and immunity 2019 Nov;82:382-395
Brain, behavior, and immunity 2019 Nov;82:382-395
Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis.
Li S, Wang Y, Zhao C, Zhang M, Wang W, Yu X, Huang J, Wang Z, Zhu B, Yin C, Cai H
Iranian journal of basic medical sciences 2019 Nov;22(11):1275-1282
Iranian journal of basic medical sciences 2019 Nov;22(11):1275-1282
Iguratimod (T-614) attenuates severe acute pancreatitis by inhibiting the NLRP3 inflammasome and NF-κB pathway.
Hou C, Zhu X, Shi C, Peng Y, Huang D, Li Q, Miao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109455
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Gao S, Xu T, Guo H, Deng Q, Xun C, Liang W, Sheng W
Life sciences 2019 Nov 15;237:116978
Life sciences 2019 Nov 15;237:116978
Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension.
Rafikov R, Nair V, Sinari S, Babu H, Sullivan JC, Yuan JX, Desai AA, Rafikova O
Antioxidants & redox signaling 2019 Nov 1;31(13):917-932
Antioxidants & redox signaling 2019 Nov 1;31(13):917-932
OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway.
Zhaolin Z, Jiaojiao C, Peng W, Yami L, Tingting Z, Jun T, Shiyuan W, Jinyan X, Dangheng W, Zhisheng J, Zuo W
Journal of cellular physiology 2019 May;234(5):7475-7491
Journal of cellular physiology 2019 May;234(5):7475-7491
Purple sweet potato color attenuated NLRP3 inflammasome by inducing autophagy to delay endothelial senescence.
Sun C, Diao Q, Lu J, Zhang Z, Wu D, Wang X, Xie J, Zheng G, Shan Q, Fan S, Hu B, Zheng Y
Journal of cellular physiology 2019 May;234(5):5926-5939
Journal of cellular physiology 2019 May;234(5):5926-5939
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Tougu Xiaotong capsule exerts a therapeutic effect on knee osteoarthritis by regulating subchondral bone remodeling.
Wu G, Zhang J, Chen W, Chen S, Huang Y, Lin R, Huang M, Li Z, Zheng L, Li X
Molecular medicine reports 2019 Mar;19(3):1858-1866
Molecular medicine reports 2019 Mar;19(3):1858-1866
Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.
Wang R, Dong Z, Lan X, Liao Z, Chen M
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1.
Miao NJ, Xie HY, Xu D, Yin JY, Wang YZ, Wang B, Yin F, Zhou ZL, Cheng Q, Chen PP, Zhou L, Xue H, Zhang W, Wang XX, Liu J, Lu LM
Acta pharmacologica Sinica 2019 Jun;40(6):790-800
Acta pharmacologica Sinica 2019 Jun;40(6):790-800
Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB.
Yuan G, Xu L, Cai T, Hua B, Sun N, Yan Z, Lu C, Qian R
Osteoarthritis and cartilage 2019 Jun;27(6):922-931
Osteoarthritis and cartilage 2019 Jun;27(6):922-931
STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q
Redox biology 2019 Jun;24:101215
Redox biology 2019 Jun;24:101215
An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).
Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A
PLoS pathogens 2019 Jun;15(6):e1007795
PLoS pathogens 2019 Jun;15(6):e1007795
Chitosan Hydrogel Delivery System Containing Herbal Compound Functions as a Potential Antineuroinflammatory Agent.
Zhou J, Zheng J, Zhang Y, Zheng P, Tang T, Luo JK, Cui HJ, Song RR, Wang Y
ACS omega 2019 Jun 30;4(6):10185-10191
ACS omega 2019 Jun 30;4(6):10185-10191
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Wang H, Zhong D, Chen H, Jin J, Liu Q, Li G
Life sciences 2019 Jun 15;227:101-113
Life sciences 2019 Jun 15;227:101-113
Helicobacter pylori-induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL-1β expression.
Wu Y, Shen L, Liang X, Li S, Ma L, Zheng L, Li T, Yu H, Chan H, Chen C, Yu J, Jia J
Cancer medicine 2019 Jul;8(8):3965-3980
Cancer medicine 2019 Jul;8(8):3965-3980
Pioglitazone decreased renal calcium oxalate crystal formation by suppressing M1 macrophage polarization via the PPAR-γ-miR-23 axis.
Chen Z, Yuan P, Sun X, Tang K, Liu H, Han S, Ye T, Liu X, Yang X, Zeng J, Yan L, Xing J, Xiao K, Ye Z, Xu H
American journal of physiology. Renal physiology 2019 Jul 1;317(1):F137-F151
American journal of physiology. Renal physiology 2019 Jul 1;317(1):F137-F151
The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation.
Li J, Li B, Cheng Y, Meng Q, Wei L, Li W, Zhang J, Huang S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):87-95
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):87-95
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Relationship between serum IL-1β and insomnia and liver depression in patients with perimenopausal non-organic sleep disorder.
Li H, Chen Y, Wu H, Huang J, Ma K, Zheng J, Lv S
Experimental and therapeutic medicine 2019 Jan;17(1):759-763
Experimental and therapeutic medicine 2019 Jan;17(1):759-763
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Wang K, Xu T, Ruan H, Xiao H, Liu J, Song Z, Cao Q, Bao L, Liu D, Wang C, Cheng G, Liang H, Chen Z, Yang H, Chen K, Zhang X
Cell death & disease 2019 Feb 15;10(3):159
Cell death & disease 2019 Feb 15;10(3):159
Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.
Meng Y, Pan M, Zheng B, Chen Y, Li W, Yang Q, Zheng Z, Sun N, Zhang Y, Li X
Antioxidants & redox signaling 2019 Feb 1;30(4):520-541
Antioxidants & redox signaling 2019 Feb 1;30(4):520-541
Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset Still's disease.
Rao S, Li Q, Wu H, Zhao M, Wang A, Zhang G, Li J, Lu L, Shi W, Lu Q
Expert review of clinical immunology 2019 Dec;15(12):1341-1350
Expert review of clinical immunology 2019 Dec;15(12):1341-1350
Differential immune responses of C57BL/6 mice to infection by Salmonella enterica serovar Typhimurium strain SL1344, CVCC541 and CMCC50115.
Wei S, Huang J, Liu Z, Wang M, Zhang B, Lian Z, Guo Y, Han H
Virulence 2019 Dec;10(1):248-259
Virulence 2019 Dec;10(1):248-259
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy.
Yu X, Hao M, Liu Y, Ma X, Lin W, Xu Q, Zhou H, Shao N, Kuang H
European journal of pharmacology 2019 Dec 1;864:172715
European journal of pharmacology 2019 Dec 1;864:172715
Schwann cell transplantation exerts neuroprotective roles in rat model of spinal cord injury by combating inflammasome activation and improving motor recovery and remyelination.
Mousavi M, Hedayatpour A, Mortezaee K, Mohamadi Y, Abolhassani F, Hassanzadeh G
Metabolic brain disease 2019 Aug;34(4):1117-1130
Metabolic brain disease 2019 Aug;34(4):1117-1130
Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model.
Fan H, Chen Z, Lin R, Liu Y, Wu X, Puthiyakunnon S, Wang Y, Zhu B, Zhang Q, Bai Y, Zhi F
mSystems 2019 Aug 6;4(4)
mSystems 2019 Aug 6;4(4)
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell.
Yao M, Fan X, Yuan B, Takagi N, Liu S, Han X, Ren J, Liu J
BMC complementary and alternative medicine 2019 Aug 14;19(1):216
BMC complementary and alternative medicine 2019 Aug 14;19(1):216
Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.
Zhuang J, Wang Y, Qu F, Wu Y, Zhao D, Xu C
Inflammation 2019 Apr;42(2):548-558
Inflammation 2019 Apr;42(2):548-558
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z
Inflammation 2019 Apr;42(2):516-525
Inflammation 2019 Apr;42(2):516-525
NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1β secretion in macrophages infected with Pasteurella multocida.
Fang R, Du H, Lei G, Liu Y, Feng S, Ye C, Li N, Peng Y
Veterinary microbiology 2019 Apr;231:207-213
Veterinary microbiology 2019 Apr;231:207-213
Protective effects of ginsenoside Rk3 against chronic alcohol-induced liver injury in mice through inhibition of inflammation, oxidative stress, and apoptosis.
Qu L, Zhu Y, Liu Y, Yang H, Zhu C, Ma P, Deng J, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Apr;126:277-284
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Apr;126:277-284
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Zheng J, Fan R, Wu H, Yao H, Yan Y, Liu J, Ran L, Sun Z, Yi L, Dang L, Gan P, Zheng P, Yang T, Zhang Y, Tang T, Wang Y
Nature communications 2019 Apr 8;10(1):1604
Nature communications 2019 Apr 8;10(1):1604
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Zhang X, Li X, Liu N, Zheng P, Ma L, Guo F, Sun T, Zhou R, Yu J
Molecules (Basel, Switzerland) 2019 Apr 24;24(8)
Molecules (Basel, Switzerland) 2019 Apr 24;24(8)
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Mao J, Yi M, Wang R, Huang Y, Chen M
Frontiers in pharmacology 2018;9:1469
Frontiers in pharmacology 2018;9:1469
Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.
Rao SS, Hu Y, Xie PL, Cao J, Wang ZX, Liu JH, Yin H, Huang J, Tan YJ, Luo J, Luo MJ, Tang SY, Chen TH, Yuan LQ, Liao EY, Xu R, Liu ZZ, Chen CY, Xie H
Bone research 2018;6:9
Bone research 2018;6:9
Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress.
Jia Y, Li Z, Feng Y, Cui R, Dong Y, Zhang X, Xiang X, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2018;2018:4756846
Oxidative medicine and cellular longevity 2018;2018:4756846
Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus.
Ma ZZ, Sun HS, Lv JC, Guo L, Yang QR
Journal of inflammation (London, England) 2018;15:16
Journal of inflammation (London, England) 2018;15:16
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
Zuo Y, Wang J, Liao F, Yan X, Li J, Huang L, Liu F
Frontiers in molecular neuroscience 2018;11:401
Frontiers in molecular neuroscience 2018;11:401
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
Lu DS, Chen C, Zheng YX, Li DD, Wang GQ, Liu J, Shi J, Zhang F
Frontiers in molecular neuroscience 2018;11:155
Frontiers in molecular neuroscience 2018;11:155
NADH protect against radiation enteritis by enhancing autophagy and inhibiting inflammation through PI3K/AKT pathway.
Wang JT, Xie WQ, Liu FQ, Bi Y, Zhu XJ, Wang QE, Zheng YF
American journal of translational research 2018;10(6):1713-1721
American journal of translational research 2018;10(6):1713-1721
Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.
Yang W, Zhou K, Zhou Y, An Y, Hu T, Lu J, Huang S, Pei G
Frontiers in aging neuroscience 2018;10:169
Frontiers in aging neuroscience 2018;10:169
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.
Ma J, Yin G, Lu Z, Xie P, Zhou H, Liu J, Yu L
Phytotherapy research : PTR 2018 Sep;32(9):1770-1783
Phytotherapy research : PTR 2018 Sep;32(9):1770-1783
Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.
Yang R, Cai TT, Wu XJ, Liu YN, He J, Zhang XS, Ma G, Li J
Immunology 2018 Oct;155(2):263-272
Immunology 2018 Oct;155(2):263-272
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.
Tsarouchas TM, Wehner D, Cavone L, Munir T, Keatinge M, Lambertus M, Underhill A, Barrett T, Kassapis E, Ogryzko N, Feng Y, van Ham TJ, Becker T, Becker CG
Nature communications 2018 Nov 7;9(1):4670
Nature communications 2018 Nov 7;9(1):4670
Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome.
Zhang C, Ma J, Wang W, Sun Y, Sun K
Human reproduction (Oxford, England) 2018 Nov 1;33(11):2096-2106
Human reproduction (Oxford, England) 2018 Nov 1;33(11):2096-2106
Autocrine IL-1β mediates the promotion of corneal neovascularization by senescent fibroblasts.
Dong M, Yang L, Qu M, Hu X, Duan H, Zhang X, Shi W, Zhou Q
American journal of physiology. Cell physiology 2018 Nov 1;315(5):C734-C743
American journal of physiology. Cell physiology 2018 Nov 1;315(5):C734-C743
Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.
Cai J, Jiang Y, Zhang M, Zhao H, Li H, Li K, Zhang X, Qiao T
Journal of physiology and biochemistry 2018 May;74(2):335-343
Journal of physiology and biochemistry 2018 May;74(2):335-343
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats.
Wei P, Zheng Q, Liu H, Wan T, Zhou J, Li D, Zhou H, Li J, Ji F, Tang W, Li J
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2018 Mar 6;20(4):515-522
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2018 Mar 6;20(4):515-522
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E
Nature communications 2018 Mar 28;9(1):1249
Nature communications 2018 Mar 28;9(1):1249
The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.
Li TR, Jia YJ, Ma C, Qiu WY, Wang Q, Shao XQ, Lv RJ
Disease models & mechanisms 2018 Mar 23;11(3)
Disease models & mechanisms 2018 Mar 23;11(3)
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption.
Wang J, Zhang D, Fu X, Yu L, Lu Z, Gao Y, Liu X, Man J, Li S, Li N, Chen X, Hong M, Yang Q, Wang J
Journal of neuroinflammation 2018 Jun 21;15(1):188
Journal of neuroinflammation 2018 Jun 21;15(1):188
Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain.
Ding S, Zhu T, Tian Y, Xu P, Chen Z, Huang X, Zhang X
Reproductive sciences (Thousand Oaks, Calif.) 2018 Jul;25(7):1045-1057
Reproductive sciences (Thousand Oaks, Calif.) 2018 Jul;25(7):1045-1057
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Lu X, Liu T, Chen K, Xia Y, Dai W, Xu S, Xu L, Wang F, Wu L, Li J, Li S, Wang W, Yu Q, Feng J, Fan X, Zhou Y, Niu P, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Effects of Dandelion Extract on the Proliferation of Rat Skeletal Muscle Cells and the Inhibition of a Lipopolysaccharide-Induced Inflammatory Reaction.
Liu Q, Zhao H, Gao Y, Meng Y, Zhao XX, Pan SN
Chinese medical journal 2018 Jul 20;131(14):1724-1731
Chinese medical journal 2018 Jul 20;131(14):1724-1731
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Lian S, Wang D, Xu B, Guo W, Wang L, Li W, Ji H, Wang J, Kong F, Zhen L, Li S, Zhang L, Guo J, Yang H
Behavioural brain research 2018 Jul 2;346:1-10
Behavioural brain research 2018 Jul 2;346:1-10
Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects.
Yan X, Lei F, Hu Y, Nie L, Jia Q, Zhou H, Zhao F, Zheng Y
Environmental toxicology and pharmacology 2018 Jan;57:151-158
Environmental toxicology and pharmacology 2018 Jan;57:151-158
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
Cai W, Zhang Z, Huang Y, Sun H, Qiu L
Experimental and therapeutic medicine 2018 Jan;15(1):924-932
Experimental and therapeutic medicine 2018 Jan;15(1):924-932
Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala.
Liu Z, Liu F, Liu X, Ma C, Zhao J
Molecular pain 2018 Jan-Dec;14:1744806918805902
Molecular pain 2018 Jan-Dec;14:1744806918805902
Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury.
Fan Y, Luo Q, Wei J, Lin R, Lin L, Li Y, Chen Z, Lin W, Chen Q
Brain research 2018 Jan 15;1679:125-133
Brain research 2018 Jan 15;1679:125-133
NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-β1/SMADs Pathway.
Guan Y, Tan Y, Liu W, Yang J, Wang D, Pan D, Sun Y, Zheng C
Digestive diseases and sciences 2018 Feb;63(2):366-380
Digestive diseases and sciences 2018 Feb;63(2):366-380
Telbivudine attenuates UUO-induced renal fibrosis via TGF-β/Smad and NF-κB signaling.
Chen J, Li D
International immunopharmacology 2018 Feb;55:1-8
International immunopharmacology 2018 Feb;55:1-8
Fungal β-Glucan Activates the NLRP3 Inflammasome in Human Bronchial Epithelial Cells Through ROS Production.
Huang Y, Hua M, Cui X
Inflammation 2018 Feb;41(1):164-173
Inflammation 2018 Feb;41(1):164-173
Effects of platelet-rich plasma on the activity of human menstrual blood-derived stromal cells in vitro.
Zhang S, Li P, Yuan Z, Tan J
Stem cell research & therapy 2018 Feb 26;9(1):48
Stem cell research & therapy 2018 Feb 26;9(1):48
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Wang Y, Qin Y, Wang T, Chen Y, Lang X, Zheng J, Gao S, Chen S, Zhong X, Mu Y, Wu X, Zhang F, Zhao W, Zhong Z
Scientific reports 2018 Feb 13;8(1):2887
Scientific reports 2018 Feb 13;8(1):2887
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, Zhao X, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Influence of vitamin D deficiency on T cell subsets and related indices during spinal tuberculosis.
Zhou SH, Wang X, Fan MY, Li HL, Bian F, Huang T, Fang HY
Experimental and therapeutic medicine 2018 Aug;16(2):718-722
Experimental and therapeutic medicine 2018 Aug;16(2):718-722
Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection.
Zhang D, Sun X, Ren L, Yang C, Liu X, Zhang H, Jiang Y, Hu X
Journal of proteomics 2018 Aug 30;186:28-37
Journal of proteomics 2018 Aug 30;186:28-37
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
Geng W, Qin F, Ren J, Xiao S, Wang A
Experimental cell research 2018 Aug 15;369(2):243-250
Experimental cell research 2018 Aug 15;369(2):243-250
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Wang N, Zou C, Zhao S, Wang Y, Han C, Zheng Z
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Establishment of experimental autoimmune prostatitis model by T(2) peptide in aluminium hydroxide adjuvant.
Zhang L, Ihsan AU, Cao Y, Cheng Y, Zhou X
Andrologia 2018 Apr;50(3)
Andrologia 2018 Apr;50(3)
Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer.
Zhang D, Li L, Jiang H, Li Q, Wang-Gillam A, Yu J, Head R, Liu J, Ruzinova MB, Lim KH
Cancer research 2018 Apr 1;78(7):1700-1712
Cancer research 2018 Apr 1;78(7):1700-1712
Aliskiren Improves Ischemia- and Oxygen Glucose Deprivation-Induced Cardiac Injury through Activation of Autophagy and AMP-Activated Protein Kinase.
Chiang MH, Liang CJ, Liu CW, Pan BJ, Chen WP, Yang YF, Lee IT, Tsai JS, Lee CW, Chen YL
Frontiers in pharmacology 2017;8:819
Frontiers in pharmacology 2017;8:819
NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling.
Ren XS, Tong Y, Ling L, Chen D, Sun HJ, Zhou H, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2269-2280
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(6):2269-2280
Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
Sun HJ, Chen D, Wang PY, Wan MY, Zhang CX, Zhang ZX, Lin W, Zhang F
Oxidative medicine and cellular longevity 2017;2017:6905217
Oxidative medicine and cellular longevity 2017;2017:6905217
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
Huang C, Zhu L, Li H, Shi FG, Wang GQ, Wei YZ, Liu J, Zhang F
Frontiers in molecular neuroscience 2017;10:131
Frontiers in molecular neuroscience 2017;10:131
GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.
Zhang L, Li Z, Ding G, La X, Yang P, Li Z
Cellular signalling 2017 Sep;37:136-148
Cellular signalling 2017 Sep;37:136-148
Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.
Tsai TH, Lin CJ, Chua S, Chung SY, Yang CH, Tong MS, Hang CL
Oncotarget 2017 Sep 26;8(43):74320-74330
Oncotarget 2017 Sep 26;8(43):74320-74330
NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.
Sun HJ, Ren XS, Xiong XQ, Chen YZ, Zhao MX, Wang JJ, Zhou YB, Han Y, Chen Q, Li YH, Kang YM, Zhu GQ
Cell death & disease 2017 Oct 5;8(10):e3074
Cell death & disease 2017 Oct 5;8(10):e3074
Role of NF-κB/GATA3 in the inhibition of lysyl oxidase by IL-1β in human amnion fibroblasts.
Zhang C, Wang W, Liu C, Lu J, Sun K
Immunology and cell biology 2017 Nov;95(10):943-952
Immunology and cell biology 2017 Nov;95(10):943-952
LOX-1 is involved in IL-1β production and extracellular matrix breakdown in dental peri-implantitis.
Che C, Liu J, Ma L, Xu H, Bai N, Zhang Q
International immunopharmacology 2017 Nov;52:127-135
International immunopharmacology 2017 Nov;52:127-135
Neuroprotective Effect of Chitosan Oligosaccharide on Hypoxic-Ischemic Brain Damage in Neonatal Rats.
Wu W, Wei W, Lu M, Zhu X, Liu N, Niu Y, Sun T, Li Y, Yu J
Neurochemical research 2017 Nov;42(11):3186-3198
Neurochemical research 2017 Nov;42(11):3186-3198
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat.
Liu F, Wang Z, Qiu Y, Wei M, Li C, Xie Y, Shen L, Huang Y, Ma C
Journal of neuroinflammation 2017 Mar 31;14(1):70
Journal of neuroinflammation 2017 Mar 31;14(1):70
Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer's disease.
Xia Z, Peng W, Cheng S, Zhong B, Sheng C, Zhang C, Gong W, Cheng S, Li J, Wang Z
Oncotarget 2017 Jun 27;8(26):42648-42663
Oncotarget 2017 Jun 27;8(26):42648-42663
Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.
Zhao Z, Lu Z, Sun X, Zhao T, Zhang J, Zhou C, Zheng X, Zhang H, Shi G
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jul;26(7):1622-1634
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jul;26(7):1622-1634
Rapamycin suppresses Aβ(25-35)- or LPS-induced neuronal inflammation via modulation of NF-κB signaling.
Liu YC, Gao XX, Chen L, You XQ
Neuroscience 2017 Jul 4;355:188-199
Neuroscience 2017 Jul 4;355:188-199
Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.
Xu G, Qin Q, Yang M, Qiao Z, Gu Y, Niu J
Diabetes research and clinical practice 2017 Feb;124:30-40
Diabetes research and clinical practice 2017 Feb;124:30-40
Dopamine D(2) receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, Wu D, Ni J, Zhang R, Xue J, Wan R, Wang X, Hu G
British journal of pharmacology 2017 Dec;174(24):4751-4770
British journal of pharmacology 2017 Dec;174(24):4751-4770
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation.
Li X, Wang X, Hu Z, Chen Z, Li H, Liu X, Yong ZY, Wang S, Wei Z, Han Y, Tan J, Li C, He XB, Sun G, Wu D, Li L
Scientific reports 2017 Aug 7;7(1):7403
Scientific reports 2017 Aug 7;7(1):7403
Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8(+) T cells.
Schmidt JD, Ahlström MG, Johansen JD, Dyring-Andersen B, Agerbeck C, Nielsen MM, Poulsen SS, Woetmann A, Ødum N, Thomsen AR, Geisler C, Bonefeld CM
Contact dermatitis 2017 Apr;76(4):218-227
Contact dermatitis 2017 Apr;76(4):218-227
Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice.
Wu W, Zhao L, Yang P, Zhou W, Li B, Moorhead JF, Varghese Z, Ruan XZ, Chen Y
PloS one 2016;11(7):e0159512
PloS one 2016;11(7):e0159512
A recombinant TGF-β1 vaccine ameliorates diabetic nephropathy in OLETF rats.
Zhang H, Wang H, Yan M, Zhao T, Lu X, Zhu B, Gong Y, Li P
Immunotherapy 2016 Sep;8(9):1045-57
Immunotherapy 2016 Sep;8(9):1045-57
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Chen K, Li J, Li S, Feng J, Wu L, Liu T, Zhang R, Xu S, Cheng K, Zhou Y, Zhou S, Wang F, Dai W, Xia Y, Lu J, Zhou Y, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation.
Hu QP, Mao DA
BMC neuroscience 2016 May 18;17(1):22
BMC neuroscience 2016 May 18;17(1):22
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Liu C, Yue R, Yang Y, Cui Y, Yang L, Zhao D, Zhou X
Oncotarget 2016 Jul 26;7(30):46972-46987
Oncotarget 2016 Jul 26;7(30):46972-46987
Dendrobium officinale Kimura et Migo attenuates diabetic cardiomyopathy through inhibiting oxidative stress, inflammation and fibrosis in streptozotocin-induced mice.
Zhang Z, Zhang D, Dou M, Li Z, Zhang J, Zhao X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1350-1358
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1350-1358
Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit.
Zhang LL, Huang S, Ma XX, Zhang WY, Wang D, Jin SY, Zhang YP, Li Y, Li X
Free radical biology & medicine 2016 Aug;97:531-543
Free radical biology & medicine 2016 Aug;97:531-543
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
Owusu L, Wang B, Du Y, Li W, Xin Y
Journal of Cancer 2015;6(2):128-38
Journal of Cancer 2015;6(2):128-38
Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction.
Morikawa A, Takeuchi T, Kito Y, Saigo C, Sakuratani T, Futamura M, Yoshida K
PloS one 2015;10(5):e0125762
PloS one 2015;10(5):e0125762
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.
Zeng W, Shan W, Gao L, Gao D, Hu Y, Wang G, Zhang N, Li Z, Tian X, Xu W, Peng J, Ma X, Yao J
Scientific reports 2015 Nov 3;5:16013
Scientific reports 2015 Nov 3;5:16013
P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation.
Peng K, Liu L, Wei D, Lv Y, Wang G, Xiong W, Wang X, Altaf A, Wang L, He D, Wang H, Qu P
International journal of molecular medicine 2015 May;35(5):1179-88
International journal of molecular medicine 2015 May;35(5):1179-88
Aging increases the susceptibility of cisplatin-induced nephrotoxicity.
Wen J, Zeng M, Shu Y, Guo D, Sun Y, Guo Z, Wang Y, Liu Z, Zhou H, Zhang W
Age (Dordrecht, Netherlands) 2015 Dec;37(6):112
Age (Dordrecht, Netherlands) 2015 Dec;37(6):112
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Shi Q, Song X, Fu J, Su C, Xia X, Song E, Song Y
International immunopharmacology 2015 Dec;29(2):722-729
International immunopharmacology 2015 Dec;29(2):722-729
Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction.
Wu X, He L, Chen F, He X, Cai Y, Zhang G, Yi Q, He M, Luo J
PloS one 2014;9(11):e112891
PloS one 2014;9(11):e112891
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Wang CP, Zhang LZ, Li GC, Shi YW, Li JL, Zhang XC, Wang ZW, Ding F, Liang XM
Journal of neuroscience research 2014 Jul;92(7):944-54
Journal of neuroscience research 2014 Jul;92(7):944-54
Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α.
Zhang RN, Zheng B, Li LM, Zhang J, Zhang XH, Wen JK
American journal of physiology. Heart and circulatory physiology 2014 Aug 15;307(4):H552-62
American journal of physiology. Heart and circulatory physiology 2014 Aug 15;307(4):H552-62
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R
Immunity 2013 Jun 27;38(6):1154-63
Immunity 2013 Jun 27;38(6):1154-63
NDGA reduces secondary damage after spinal cord injury in rats via anti-inflammatory effects.
Xue H, Zhang XY, Liu JM, Song Y, Liu TT, Chen D
Brain research 2013 Jun 21;1516:83-92
Brain research 2013 Jun 21;1516:83-92
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 16806-1-AP( IL1B Antibody) at dilution of 1:700
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human adrenal gland tissue were subjected to SDS PAGE followed by western blot with 16806-1-AP(IL1B antibody) at dilution of 1:100
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 16806-1-AP(IL1B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IL1 beta antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IL1 beta. This antibody recognizes human,mouse,rat antigen. The IL1 beta antibody has been validated for the following applications: ELISA, IHC, WB analysis.
