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- Antibody Data
- Antigen structure
- References [25]
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- Product number
- MAB201 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human IL-1 beta/IL-1F2 Monoclonal Antibody (Clone 8516)
- Antibody type
- Monoclonal
- Antigen
- E. coli-derived recombinant human IL-1β/IL-1F2, aa 117-269
- Description
- Protein A or G purified from hybridoma culture supernatant
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P01584- Isotype
- IgG
- Vial size
- 500 µg
Submitted references Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.
Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing.
The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.
Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific.
Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity.
Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression.
Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression.
Downregulation of estrogen receptor and modulation of growth of breast cancer cell lines mediated by paracrine stromal cell signals.
Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses.
NLRP3 inflammasome: a novel link between lipoproteins and atherosclerosis.
Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability.
Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue.
Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium.
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses.
Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation.
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway.
Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.
Vogel K, Pierau M, Arra A, Lampe K, Schlueter D, Arens C, Brunner-Weinzierl MC
Scientific reports 2018 Nov 15;8(1):16904
Scientific reports 2018 Nov 15;8(1):16904
Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing.
Clancy DM, Sullivan GP, Moran HBT, Henry CM, Reeves EP, McElvaney NG, Lavelle EC, Martin SJ
Cell reports 2018 Mar 13;22(11):2937-2950
Cell reports 2018 Mar 13;22(11):2937-2950
The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.
Chambers SEJ, O'Neill CL, Guduric-Fuchs J, McLoughlin KJ, Liew A, Egan AM, O'Brien T, Stitt AW, Medina RJ
Stem cells (Dayton, Ohio) 2018 Jun;36(6):834-843
Stem cells (Dayton, Ohio) 2018 Jun;36(6):834-843
Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific.
Nishijima N, Hirai T, Misato K, Aoyama M, Kuroda E, Ishii KJ, Higashisaka K, Yoshioka Y, Tsutsumi Y
Frontiers in immunology 2017;8:379
Frontiers in immunology 2017;8:379
Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity.
Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Stürzl M, Britzen-Laurent N
Journal of cellular and molecular medicine 2017 Sep;21(9):1954-1966
Journal of cellular and molecular medicine 2017 Sep;21(9):1954-1966
Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression.
Reggiani F, Labanca V, Mancuso P, Rabascio C, Talarico G, Orecchioni S, Manconi A, Bertolini F
Cancer research 2017 Sep 15;77(18):5169-5182
Cancer research 2017 Sep 15;77(18):5169-5182
Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression.
Garstkiewicz M, Strittmatter GE, Grossi S, Sand J, Fenini G, Werner S, French LE, Beer HD
European journal of immunology 2017 May;47(5):806-817
European journal of immunology 2017 May;47(5):806-817
Downregulation of estrogen receptor and modulation of growth of breast cancer cell lines mediated by paracrine stromal cell signals.
Huang J, Woods P, Normolle D, Goff JP, Benos PV, Stehle CJ, Steinman RA
Breast cancer research and treatment 2017 Jan;161(2):229-243
Breast cancer research and treatment 2017 Jan;161(2):229-243
Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses.
Cheng WC, van Asten SD, Burns LA, Evans HG, Walter GJ, Hashim A, Hughes FJ, Taams LS
European journal of immunology 2016 Sep;46(9):2211-21
European journal of immunology 2016 Sep;46(9):2211-21
NLRP3 inflammasome: a novel link between lipoproteins and atherosclerosis.
Li WL, Hua LG, Qu P, Yan WH, Ming C, Jun YD, Yuan LD, Nan N
Archives of medical science : AMS 2016 Oct 1;12(5):950-958
Archives of medical science : AMS 2016 Oct 1;12(5):950-958
Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability.
Hadadi E, Zhang B, Baidžajevas K, Yusof N, Puan KJ, Ong SM, Yeap WH, Rotzschke O, Kiss-Toth E, Wilson H, Wong SC
Scientific reports 2016 Dec 15;6:39035
Scientific reports 2016 Dec 15;6:39035
Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue.
Oliver RA, Lovric V, Yu Y, Christou C, Aiken SS, Cooper JJ, Walsh WR
PloS one 2015;10(8):e0136514
PloS one 2015;10(8):e0136514
Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium.
Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J, Francis S
The Journal of biological chemistry 2015 Oct 2;290(40):24067-78
The Journal of biological chemistry 2015 Oct 2;290(40):24067-78
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses.
Ansari MA, Dutta S, Veettil MV, Dutta D, Iqbal J, Kumar B, Roy A, Chikoti L, Singh VV, Chandran B
PLoS pathogens 2015 Jul;11(7):e1005019
PLoS pathogens 2015 Jul;11(7):e1005019
Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.
Nicolaidou V, Wong MM, Redpath AN, Ersek A, Baban DF, Williams LM, Cope AP, Horwood NJ
PloS one 2012;7(7):e39871
PloS one 2012;7(7):e39871
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation.
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barré B, Audran M, Bouvard B, Saint-André JP, Jeannin P
PLoS biology 2012;10(9):e1001395
PLoS biology 2012;10(9):e1001395
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
Nature 2012 Apr 26;484(7395):514-8
Nature 2012 Apr 26;484(7395):514-8
TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Aliahmadi E, Gramlich R, Grützkau A, Hitzler M, Krüger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
European journal of immunology 2009 May;39(5):1221-30
European journal of immunology 2009 May;39(5):1221-30
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.
Li J, Yin HL, Yuan J
The Journal of cell biology 2008 Apr 21;181(2):321-33
The Journal of cell biology 2008 Apr 21;181(2):321-33
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F
Nature immunology 2007 Sep;8(9):942-9
Nature immunology 2007 Sep;8(9):942-9
Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
Digestive diseases and sciences 2007 Oct;52(10):2775-83
Digestive diseases and sciences 2007 Oct;52(10):2775-83
Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway.
Lee KY, Ho SC, Lin HC, Lin SM, Liu CY, Huang CD, Wang CH, Chung KF, Kuo HP
American journal of respiratory cell and molecular biology 2006 Oct;35(4):407-14
American journal of respiratory cell and molecular biology 2006 Oct;35(4):407-14
Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.
Banks WA, Farr SA, La Scola ME, Morley JE
The Journal of pharmacology and experimental therapeutics 2001 Nov;299(2):536-41
The Journal of pharmacology and experimental therapeutics 2001 Nov;299(2):536-41
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.
Yates SL, Burgess LH, Kocsis-Angle J, Antal JM, Dority MD, Embury PB, Piotrkowski AM, Brunden KR
Journal of neurochemistry 2000 Mar;74(3):1017-25
Journal of neurochemistry 2000 Mar;74(3):1017-25
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.
Yates SL, Burgess LH, Kocsis-Angle J, Antal JM, Dority MD, Embury PB, Piotrkowski AM, Brunden KR
Journal of neurochemistry 2000 Mar;74(3):1017-25
Journal of neurochemistry 2000 Mar;74(3):1017-25
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