Antibody data
- Antibody Data
- Antigen structure
- References [85]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 10996-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10996-1-AP, RRID:AB_2090987
- Product name
- DGCR8 C-terminal antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DGCR8 C-terminal antibody (Cat. #10996-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue.
A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation.
METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation.
Essential role of the amino-terminal region of Drosha for the Microprocessor function.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Upregulation of DGCR8, a Candidate Predisposing to Schizophrenia in Han Chinese, Contributes to Phenotypic Deficits and Neuronal Migration Delay.
DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression.
Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats.
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.
Global miRNA dosage control of embryonic germ layer specification.
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.
DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.
Control of ribosomal protein synthesis by the Microprocessor complex.
Tumor evolution selectively inactivates the core microRNA machinery for immune evasion.
HPV16 E6 enhances the radiosensitivity in HPV-positive human head and neck squamous cell carcinoma by regulating the miR-27a-3p/SMG1 axis.
DGCR8/miR-106 Axis Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinomas by Downregulating RUNX3.
Deficient Expression of DGCR8 in Human Testis is Related to Spermatogenesis Dysfunction, Especially in Meiosis I.
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Genetic deletion of microRNA biogenesis in muscle cells reveals a hierarchical non-clustered network that controls focal adhesion signaling during muscle regeneration.
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Biological and RNA regulatory function of MOV10 in mammalian germ cells.
Oncogenic Biogenesis of pri-miR-17∼92 Reveals Hierarchy and Competition among Polycistronic MicroRNAs.
High-Throughput Characterization of Primary microRNA Transcripts.
DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.
Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression.
Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala.
The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.
Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.
Noncanonical function of DGCR8 controls mESC exit from pluripotency.
Canonical microRNAs Enable Differentiation, Protect Against DNA Damage, and Promote Cholesterol Biosynthesis in Neural Stem Cells.
The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells.
MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.
Regulation of HBEGF by Micro-RNA for Survival of Developing Human Trophoblast Cells.
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.
Alternative splicing affects the subcellular localization of Drosha.
Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.
Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Cytoplasmic Drosha activity generated by alternative splicing.
MicroRNA-27b up-regulated by human papillomavirus 16 E7 promotes proliferation and suppresses apoptosis by targeting polo-like kinase2 in cervical cancer.
DGCR8 is essential for tumor progression following PTEN loss in the prostate.
miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.
SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.
The BDNF Val66Met variant affects gene expression through miR-146b.
Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling.
Canonical MicroRNA Activity Facilitates but May Be Dispensable for Transcription Factor-Mediated Reprogramming.
Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs.
Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome.
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.
Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome.
Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination.
Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.
DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts.
Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.
Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.
Efficiency and specificity in microRNA biogenesis.
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.
Modulation of microRNA processing by mismatch repair protein MutLα.
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Dgcr8 controls neural crest cells survival in cardiovascular development.
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.
A primate herpesvirus uses the integrator complex to generate viral microRNAs.
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation.
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression.
Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
MicroRNAs control hepatocyte proliferation during liver regeneration.
Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1.
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.
Existence of a microRNA pathway in anucleate platelets.
Suppression of HIV-1 replication by microRNA effectors.
Post-transcriptional control of DGCR8 expression by the Microprocessor.
The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway.
Modulation of microRNA processing by p53.
Cell-cell contact globally activates microRNA biogenesis.
Primary microRNA transcripts are processed co-transcriptionally.
Li J, Yao H, Zhao F, An J, Wang Q, Mu J, Liu Z, Zou MH, Xie Z
Autophagy 2024 Mar;20(3):629-644
Autophagy 2024 Mar;20(3):629-644
A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation.
Lyu X, Cui Y, Kong Y, Yang M, Shen H, Liao S, Li S, An C, Wang H, Zhang Z, Ong J, Li Y, Du P
Molecular cell 2024 Jul 25;84(14):2665-2681.e13
Molecular cell 2024 Jul 25;84(14):2665-2681.e13
METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation.
Han X, Li G, Yang H, Zhang C, Cao Y, Wang N, Ge L, Fan Z
Stem cells international 2023;2023:8992284
Stem cells international 2023;2023:8992284
Essential role of the amino-terminal region of Drosha for the Microprocessor function.
Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A
iScience 2023 Oct 20;26(10):107971
iScience 2023 Oct 20;26(10):107971
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148
Cell death & disease 2023 Feb 21;14(2):148
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Tao S, Xie SJ, Diao LT, Lv G, Hou YR, Hu YX, Xu WY, Du B, Xiao ZD
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194
Upregulation of DGCR8, a Candidate Predisposing to Schizophrenia in Han Chinese, Contributes to Phenotypic Deficits and Neuronal Migration Delay.
Bi Y, Chen S, Shen Q, Guo Z, Ren D, Yuan F, Niu W, Ji L, Liu L, Han K, Yu T, Yang F, Wu X, Wang L, Li X, Yu S, Xu Y, He L, Shi Y, Zhang J, Li W, He G
Frontiers in psychiatry 2022;13:873873
Frontiers in psychiatry 2022;13:873873
DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.
Ketley RF, Battistini F, Alagia A, Mondielli C, Iehl F, Balikçi E, Huber KVM, Orozco M, Gullerova M
Cell reports 2022 Oct 25;41(4):111526
Cell reports 2022 Oct 25;41(4):111526
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615
Cancer letters 2022 May 28;534:215615
Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression.
Abou Zeid LY, Shanmugapriya S, Rumney RL, Mosser DD
Cell stress & chaperones 2022 Jan;27(1):11-25
Cell stress & chaperones 2022 Jan;27(1):11-25
Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats.
Xu D, Li L, Tang L, Guo M, Yang J
Experimental and therapeutic medicine 2022 Jan;23(1):14
Experimental and therapeutic medicine 2022 Jan;23(1):14
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Bayerl J, Ayyash M, Shani T, Manor YS, Gafni O, Massarwa R, Kalma Y, Aguilera-Castrejon A, Zerbib M, Amir H, Sheban D, Geula S, Mor N, Weinberger L, Naveh Tassa S, Krupalnik V, Oldak B, Livnat N, Tarazi S, Tawil S, Wildschutz E, Ashouokhi S, Lasman L, Rotter V, Hanna S, Ben-Yosef D, Novershtern N, Viukov S, Hanna JH
Cell stem cell 2021 Sep 2;28(9):1549-1565.e12
Cell stem cell 2021 Sep 2;28(9):1549-1565.e12
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.
Li X, Xiong W, Long X, Dai X, Peng Y, Xu Y, Zhang Z, Zhang L, Liu Y
Biology of reproduction 2021 Nov 15;105(5):1221-1233
Biology of reproduction 2021 Nov 15;105(5):1221-1233
Global miRNA dosage control of embryonic germ layer specification.
Cui Y, Lyu X, Ding L, Ke L, Yang D, Pirouz M, Qi Y, Ong J, Gao G, Du P, Gregory RI
Nature 2021 May;593(7860):602-606
Nature 2021 May;593(7860):602-606
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.
Diao LT, Xie SJ, Lei H, Qiu XS, Huang MC, Tao S, Hou YR, Hu YX, Sun YJ, Zhang Q, Xiao ZD
Biochemical and biophysical research communications 2021 May 7;552:52-58
Biochemical and biophysical research communications 2021 May 7;552:52-58
DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
Killy B, Bodendorfer B, Mages J, Ritter K, Schreiber J, Hölscher C, Pracht K, Ekici A, Jäck HM, Lang R
Life science alliance 2021 Jun;4(6)
Life science alliance 2021 Jun;4(6)
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T, Liu HX, Piao HL
Cancer communications (London, England) 2021 Jul;41(7):576-595
Cancer communications (London, England) 2021 Jul;41(7):576-595
DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.
Nogami M, Miyamoto K, Hayakawa-Yano Y, Nakanishi A, Yano M, Okano H
The Journal of biological chemistry 2021 Jan-Jun;296:100409
The Journal of biological chemistry 2021 Jan-Jun;296:100409
Control of ribosomal protein synthesis by the Microprocessor complex.
Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A
Science signaling 2021 Feb 23;14(671)
Science signaling 2021 Feb 23;14(671)
Tumor evolution selectively inactivates the core microRNA machinery for immune evasion.
Song TY, Long M, Zhao HX, Zou MW, Fan HJ, Liu Y, Geng CL, Song MF, Liu YF, Chen JY, Yang YL, Zhou WR, Huang DW, Peng B, Peng ZG, Cang Y
Nature communications 2021 Dec 1;12(1):7003
Nature communications 2021 Dec 1;12(1):7003
HPV16 E6 enhances the radiosensitivity in HPV-positive human head and neck squamous cell carcinoma by regulating the miR-27a-3p/SMG1 axis.
Long D, Xu L, Deng Z, Guo D, Zhang Y, Liu Z, Zhang C
Infectious agents and cancer 2021 Aug 13;16(1):56
Infectious agents and cancer 2021 Aug 13;16(1):56
DGCR8/miR-106 Axis Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinomas by Downregulating RUNX3.
Zhang C, Chen H, Deng Z, Long D, Xu L, Liu Z
Frontiers in medicine 2020;7:582097
Frontiers in medicine 2020;7:582097
Deficient Expression of DGCR8 in Human Testis is Related to Spermatogenesis Dysfunction, Especially in Meiosis I.
Babakhanzadeh E, Khodadadian A, Nazari M, Dehghan Tezerjani M, Aghaei SM, Ghasemifar S, Hosseinnia M, Mazaheri M
International journal of general medicine 2020;13:185-192
International journal of general medicine 2020;13:185-192
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Han K, Wang FW, Cao CH, Ling H, Chen JW, Chen RX, Feng ZH, Luo J, Jin XH, Duan JL, Li SM, Ma NF, Yun JP, Guan XY, Pan ZZ, Lan P, Xu RH, Xie D
Molecular cancer 2020 Mar 18;19(1):60
Molecular cancer 2020 Mar 18;19(1):60
Genetic deletion of microRNA biogenesis in muscle cells reveals a hierarchical non-clustered network that controls focal adhesion signaling during muscle regeneration.
Luca E, Turcekova K, Hartung A, Mathes S, Rehrauer H, Krützfeldt J
Molecular metabolism 2020 Jun;36:100967
Molecular metabolism 2020 Jun;36:100967
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation.
Song J, Zhuang Y, Zhu C, Meng H, Lu B, Xie B, Peng J, Li M, Yi C
Nature chemical biology 2020 Feb;16(2):160-169
Nature chemical biology 2020 Feb;16(2):160-169
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Biological and RNA regulatory function of MOV10 in mammalian germ cells.
Fu K, Tian S, Tan H, Wang C, Wang H, Wang M, Wang Y, Chen Z, Wang Y, Yue Q, Xu Q, Zhang S, Li H, Xie J, Lin M, Luo M, Chen F, Ye L, Zheng K
BMC biology 2019 May 14;17(1):39
BMC biology 2019 May 14;17(1):39
Oncogenic Biogenesis of pri-miR-17∼92 Reveals Hierarchy and Competition among Polycistronic MicroRNAs.
Donayo AO, Johnson RM, Tseng HW, Izreig S, Gariepy A, Mayya VK, Wu E, Alam R, Lussier C, Jones RG, Duchaine TF
Molecular cell 2019 Jul 25;75(2):340-356.e10
Molecular cell 2019 Jul 25;75(2):340-356.e10
High-Throughput Characterization of Primary microRNA Transcripts.
Chang TC, Mendell JT
Methods in molecular biology (Clifton, N.J.) 2018;1823:1-9
Methods in molecular biology (Clifton, N.J.) 2018;1823:1-9
DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Hoffmann N, Weise SC, Marinaro F, Vogel T, De Pietri Tonelli D
Frontiers in neuroscience 2018;12:281
Frontiers in neuroscience 2018;12:281
An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.
Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI
Cell stem cell 2018 Jun 1;22(6):851-864.e5
Cell stem cell 2018 Jun 1;22(6):851-864.e5
Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression.
Choi YJ, Jeong S, Yoon KA, Sung HJ, Cho HS, Kim DW, Cho JY
Bone 2017 Oct;103:287-294
Bone 2017 Oct;103:287-294
Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala.
Eom TY, Bayazitov IT, Anderson K, Yu J, Zakharenko SS
Cell reports 2017 May 23;19(8):1532-1544
Cell reports 2017 May 23;19(8):1532-1544
The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.
Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L, Zhang X
Scientific reports 2017 May 18;7(1):2070
Scientific reports 2017 May 18;7(1):2070
Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.
Suzuki HI, Young RA, Sharp PA
Cell 2017 Mar 9;168(6):1000-1014.e15
Cell 2017 Mar 9;168(6):1000-1014.e15
Noncanonical function of DGCR8 controls mESC exit from pluripotency.
Cirera-Salinas D, Yu J, Bodak M, Ngondo RP, Herbert KM, Ciaudo C
The Journal of cell biology 2017 Feb;216(2):355-366
The Journal of cell biology 2017 Feb;216(2):355-366
Canonical microRNAs Enable Differentiation, Protect Against DNA Damage, and Promote Cholesterol Biosynthesis in Neural Stem Cells.
Liu Z, Zhang C, Khodadadi-Jamayran A, Dang L, Han X, Kim K, Li H, Zhao R
Stem cells and development 2017 Feb 1;26(3):177-188
Stem cells and development 2017 Feb 1;26(3):177-188
The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells.
Ouyang H, Zhang K, Fox-Walsh K, Yang Y, Zhang C, Huang J, Li H, Zhou Y, Fu XD
Nucleic acids research 2017 Dec 1;45(21):12481-12495
Nucleic acids research 2017 Dec 1;45(21):12481-12495
MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Marinaro F, Marzi MJ, Hoffmann N, Amin H, Pelizzoli R, Niola F, Nicassio F, De Pietri Tonelli D
EMBO reports 2017 Apr;18(4):603-618
EMBO reports 2017 Apr;18(4):603-618
Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.
Carmona V, Cunha-Santos J, Onofre I, Simões AT, Vijayakumar U, Davidson BL, Pereira de Almeida L
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Apr 5;25(4):1038-1055
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Apr 5;25(4):1038-1055
Regulation of HBEGF by Micro-RNA for Survival of Developing Human Trophoblast Cells.
Jain CV, Jessmon P, Kilburn BA, Jodar M, Sendler E, Krawetz SA, Armant DR
PloS one 2016;11(10):e0163913
PloS one 2016;11(10):e0163913
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.
Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z, Kalkum M, Riggs AD, Song H, Ming GL, Shi Y
Nature communications 2016 Mar 11;7:10965
Nature communications 2016 Mar 11;7:10965
Alternative splicing affects the subcellular localization of Drosha.
Link S, Grund SE, Diederichs S
Nucleic acids research 2016 Jun 20;44(11):5330-43
Nucleic acids research 2016 Jun 20;44(11):5330-43
Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.
Gao YE, Wang Y, Chen FQ, Feng JY, Yang G, Feng GX, Yang Z, Ye LH, Zhang XD
Acta pharmacologica Sinica 2016 Jul;37(7):898-907
Acta pharmacologica Sinica 2016 Jul;37(7):898-907
Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H
Scientific reports 2016 Feb 2;6:20242
Scientific reports 2016 Feb 2;6:20242
Cytoplasmic Drosha activity generated by alternative splicing.
Dai L, Chen K, Youngren B, Kulina J, Yang A, Guo Z, Li J, Yu P, Gu S
Nucleic acids research 2016 Dec 1;44(21):10454-10466
Nucleic acids research 2016 Dec 1;44(21):10454-10466
MicroRNA-27b up-regulated by human papillomavirus 16 E7 promotes proliferation and suppresses apoptosis by targeting polo-like kinase2 in cervical cancer.
Liu F, Zhang S, Zhao Z, Mao X, Huang J, Wu Z, Zheng L, Wang Q
Oncotarget 2016 Apr 12;7(15):19666-79
Oncotarget 2016 Apr 12;7(15):19666-79
DGCR8 is essential for tumor progression following PTEN loss in the prostate.
Belair CD, Paikari A, Moltzahn F, Shenoy A, Yau C, Dall'Era M, Simko J, Benz C, Blelloch R
EMBO reports 2015 Sep;16(9):1219-32
EMBO reports 2015 Sep;16(9):1219-32
miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes.
Tsujimura K, Irie K, Nakashima H, Egashira Y, Fukao Y, Fujiwara M, Itoh M, Uesaka M, Imamura T, Nakahata Y, Yamashita Y, Abe T, Takamori S, Nakashima K
Cell reports 2015 Sep 22;12(11):1887-901
Cell reports 2015 Sep 22;12(11):1887-901
SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.
Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J
Nucleic acids research 2015 Sep 18;43(16):7945-60
Nucleic acids research 2015 Sep 18;43(16):7945-60
The BDNF Val66Met variant affects gene expression through miR-146b.
Hsu PK, Xu B, Mukai J, Karayiorgou M, Gogos JA
Neurobiology of disease 2015 May;77:228-37
Neurobiology of disease 2015 May;77:228-37
Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling.
Motiño O, Francés DE, Mayoral R, Castro-Sánchez L, Fernández-Velasco M, Boscá L, García-Monzón C, Brea R, Casado M, Agra N, Martín-Sanz P
Molecular and cellular biology 2015 Jul;35(14):2554-67
Molecular and cellular biology 2015 Jul;35(14):2554-67
Canonical MicroRNA Activity Facilitates but May Be Dispensable for Transcription Factor-Mediated Reprogramming.
Liu Z, Skamagki M, Kim K, Zhao R
Stem cell reports 2015 Dec 8;5(6):1119-1127
Stem cell reports 2015 Dec 8;5(6):1119-1127
Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs.
Dhir A, Dhir S, Proudfoot NJ, Jopling CL
Nature structural & molecular biology 2015 Apr;22(4):319-27
Nature structural & molecular biology 2015 Apr;22(4):319-27
Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome.
Sellier C, Hwang VJ, Dandekar R, Durbin-Johnson B, Charlet-Berguerand N, Ander BP, Sharp FR, Angkustsiri K, Simon TJ, Tassone F
PloS one 2014;9(8):e103884
PloS one 2014;9(8):e103884
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.
Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI
Cell 2014 Feb 27;156(5):893-906
Cell 2014 Feb 27;156(5):893-906
Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome.
Agranat-Tamir L, Shomron N, Sperling J, Sperling R
Nucleic acids research 2014 Apr;42(7):4640-51
Nucleic acids research 2014 Apr;42(7):4640-51
Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination.
Tang X, Wen S, Zheng D, Tucker L, Cao L, Pantazatos D, Moss SF, Ramratnam B
PloS one 2013;8(8):e72503
PloS one 2013;8(8):e72503
Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.
Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG
Nature communications 2013;4:2812
Nature communications 2013;4:2812
DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts.
Gómez-Cabello D, Adrados I, Gamarra D, Kobayashi H, Takatsu Y, Takatsu K, Gil J, Palmero I
Aging cell 2013 Oct;12(5):923-31
Aging cell 2013 Oct;12(5):923-31
Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.
Ouchi Y, Banno Y, Shimizu Y, Ando S, Hasegawa H, Adachi K, Iwamoto T
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 29;33(22):9408-19
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 29;33(22):9408-19
Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.
Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, Charlet-Berguerand N
Cell reports 2013 Mar 28;3(3):869-80
Cell reports 2013 Mar 28;3(3):869-80
Efficiency and specificity in microRNA biogenesis.
Barad O, Mann M, Chapnik E, Shenoy A, Blelloch R, Barkai N, Hornstein E
Nature structural & molecular biology 2012 May 13;19(6):650-2
Nature structural & molecular biology 2012 May 13;19(6):650-2
Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.
Grund SE, Polycarpou-Schwarz M, Luo C, Eichmüller SB, Diederichs S
Neoplasia (New York, N.Y.) 2012 Mar;14(3):238-48
Neoplasia (New York, N.Y.) 2012 Mar;14(3):238-48
Modulation of microRNA processing by mismatch repair protein MutLα.
Mao G, Lee S, Ortega J, Gu L, Li GM
Cell research 2012 Jun;22(6):973-85
Cell research 2012 Jun;22(6):973-85
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Kawahara Y, Mieda-Sato A
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3347-52
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 28;109(9):3347-52
Dgcr8 controls neural crest cells survival in cardiovascular development.
Chapnik E, Sasson V, Blelloch R, Hornstein E
Developmental biology 2012 Feb 1;362(1):50-6
Developmental biology 2012 Feb 1;362(1):50-6
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.
Wada T, Kikuchi J, Furukawa Y
EMBO reports 2012 Feb 1;13(2):142-9
EMBO reports 2012 Feb 1;13(2):142-9
A primate herpesvirus uses the integrator complex to generate viral microRNAs.
Cazalla D, Xie M, Steitz JA
Molecular cell 2011 Sep 16;43(6):982-92
Molecular cell 2011 Sep 16;43(6):982-92
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation.
Suzuki HI, Arase M, Matsuyama H, Choi YL, Ueno T, Mano H, Sugimoto K, Miyazono K
Molecular cell 2011 Nov 4;44(3):424-36
Molecular cell 2011 Nov 4;44(3):424-36
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI
Cell 2011 Nov 23;147(5):1066-79
Cell 2011 Nov 23;147(5):1066-79
Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression.
Noh H, Hong S, Dong Z, Pan ZK, Jing Q, Huang S
Genes & cancer 2011 Feb;2(2):140-50
Genes & cancer 2011 Feb;2(2):140-50
Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
Dai L, Tsai-Morris CH, Sato H, Villar J, Kang JH, Zhang J, Dufau ML
The Journal of biological chemistry 2011 Dec 30;286(52):44306-18
The Journal of biological chemistry 2011 Dec 30;286(52):44306-18
MicroRNAs control hepatocyte proliferation during liver regeneration.
Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H
Hepatology (Baltimore, Md.) 2010 May;51(5):1735-43
Hepatology (Baltimore, Md.) 2010 May;51(5):1735-43
Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1.
Gómez-Cabello D, Callejas S, Benguría A, Moreno A, Alonso J, Palmero I
Cancer research 2010 Mar 1;70(5):1866-74
Cancer research 2010 Mar 1;70(5):1866-74
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E
Aging 2010 Jul;2(7):415-31
Aging 2010 Jul;2(7):415-31
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.
Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A
Molecular cell 2010 Aug 13;39(3):373-84
Molecular cell 2010 Aug 13;39(3):373-84
Existence of a microRNA pathway in anucleate platelets.
Landry P, Plante I, Ouellet DL, Perron MP, Rousseau G, Provost P
Nature structural & molecular biology 2009 Sep;16(9):961-6
Nature structural & molecular biology 2009 Sep;16(9):961-6
Suppression of HIV-1 replication by microRNA effectors.
Chable-Bessia C, Meziane O, Latreille D, Triboulet R, Zamborlini A, Wagschal A, Jacquet JM, Reynes J, Levy Y, Saib A, Bennasser Y, Benkirane M
Retrovirology 2009 Mar 9;6:26
Retrovirology 2009 Mar 9;6:26
Post-transcriptional control of DGCR8 expression by the Microprocessor.
Triboulet R, Chang HM, Lapierre RJ, Gregory RI
RNA (New York, N.Y.) 2009 Jun;15(6):1005-11
RNA (New York, N.Y.) 2009 Jun;15(6):1005-11
The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway.
Sakamoto S, Aoki K, Higuchi T, Todaka H, Morisawa K, Tamaki N, Hatano E, Fukushima A, Taniguchi T, Agata Y
Molecular and cellular biology 2009 Jul;29(13):3754-69
Molecular and cellular biology 2009 Jul;29(13):3754-69
Modulation of microRNA processing by p53.
Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K
Nature 2009 Jul 23;460(7254):529-33
Nature 2009 Jul 23;460(7254):529-33
Cell-cell contact globally activates microRNA biogenesis.
Hwang HW, Wentzel EA, Mendell JT
Proceedings of the National Academy of Sciences of the United States of America 2009 Apr 28;106(17):7016-21
Proceedings of the National Academy of Sciences of the United States of America 2009 Apr 28;106(17):7016-21
Primary microRNA transcripts are processed co-transcriptionally.
Morlando M, Ballarino M, Gromak N, Pagano F, Bozzoni I, Proudfoot NJ
Nature structural & molecular biology 2008 Sep;15(9):902-9
Nature structural & molecular biology 2008 Sep;15(9):902-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 10996-1-AP(DGCR8 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SH-SY5Y cells, using DGCR8 antibody 10996-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-DGCR8 (IP:10996-1-AP, 3ug; Detection:10996-1-AP 1:800) with HEK-293 cells lysate 2700ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10996-1-AP(DGCR8 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10996-1-AP(DGCR8 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue