ADRA1D

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

Description

Adrenoceptor alpha 1D

Tissue specificity

Tissue enhanced (brain, cervix)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins

Chromosome

20 (4220630 - 4249287)

Ensembl ID

ENSG00000171873  (ver. 103.38)

Orthologs

Mouse Adra1d: ENSMUSG00000027335

UniProt

P25100

neXtProt

NX_P25100

Human splice variants
Mouse splice variants

Protein structure