Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 301341 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#301341, RRID:AB_2563371
- Product name
- APC/Cy7 anti-human CD11b
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and Factor X.
- Reactivity
- Human, Porcine
- Host
- Mouse
- Antibody clone number
- ICRF44
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood granulocytes were stained with CD11b (clone ICRF44) APC/Cy7 (filled histogram), or mouse IgG1, κ APC/Cy7 isotype control (open histogram).